Articles tagged with Dementia
A new study found that older adults with dementia visit emergency departments at higher rates, are admitted to hospitals more often, and have a higher death rate after ED visits compared to those without dementia. The study also highlights the need for better care in fast-paced emergency departments.
Elderly individuals living in UK care homes are at high risk of dehydration due to conditions like dementia, diabetes, and kidney problems. Research finds dehydration is associated with poor health outcomes, including disability and death.
A study published in Neurology found that raloxifene, an estrogen-like drug, had no demonstrated benefit on memory and thinking skills for women with mild to moderate Alzheimer's disease. The results suggest that the drug may not be effective as a treatment for this condition.
Researchers at Temple University Health System have identified a regulatory enzyme defect in Down syndrome that also malfunctions in Alzheimer's disease, leading to the formation of toxic amyloid plaques in the brain. This discovery could lead to the development of a targeted therapy to mitigate dementia in Down syndrome.
A study published in Annals of Internal Medicine found that the average total cost for deceased patients with dementia was $287,038 in the last five years of life, significantly higher than those who died from other causes. Out-of-pocket spending for dementia patients was 81% higher.
Young adults with genetically increased Alzheimer's risk show altered activation patterns in the entorhinal cortex, a key region for spatial navigation. This alteration may contribute to the development of Alzheimer's dementia in the long term.
Researchers found that antipsychotic prescriptions for seniors increased with age after 65, with nearly half of those over 80 using the drugs in excess of 120 days. The study highlights concerns about safety and calls for alternative treatments.
Researchers at Columbia University Irving Medical Center analyzed data from 8,846 individuals over 50 years old with celiac disease, finding no increased risk of dementia before or after diagnosis. However, a small increase in vascular dementia was observed in patients with celiac disease.
A University of Copenhagen study reveals that an immune gene, Interferon-beta, may prevent Parkinson's disease and dementia. IFNβ-gene therapy successfully prevented neuronal death in experimental models.
Ryohei Yasuda, Max Planck Florida Institute for Neuroscience Scientific Director, has received a $4.8 million NIH Pioneer Award to support his lab's high-risk, high-reward projects in biochemical signaling and mental disorders like dementia and autism.
Scientists tracked proteins from the C9orf72 gene, finding a specific protein helps transport essential proteins into motor neuron cells' nuclei. Misplacement of this protein can lead to cell death in diseases like ALS and FTD.
Patients taking benzodiazepines for psychiatric conditions face increased risk of dementia and death due to the class of drugs' potential negative effects. Alternative therapies like anti-depressants are recommended for safer and more effective treatment.
Dr. Sharon K. Inouye has received the 2015 M. Powell Lawton Award from the Gerontological Society of America (GSA) for her significant contributions to gerontology. Her work focuses on delirium prevention and treatment, and she has developed evidence-based interventions such as the Hospital Elder Life Program (HELP), which has been sho...
Katie Maslow, MSW, of the Institute of Medicine, has been chosen as the 2015 recipient of the Maxwell A. Pollack Award for Productive Aging. She will receive the award for her innovative programs that demonstrate excellence in translating research into practical application or policy.
Researchers repurposed salsalate to reverse tau-related dysfunction in an animal model of frontotemporal dementia, effectively lowering tau levels and rescuing memory impairments.
A study of 2176 cognitively normal participants found that those with multiple chronic conditions were 38% more likely to develop mild cognitive impairment or dementia. Preventing chronic diseases may help maintain mental health in aging adults.
Researchers investigate remote conditioning, a technique that uses blood pressure cuffs to restrict blood flow to limbs and activate natural protective mechanisms in the brain, potentially reducing dementia symptoms. The approach has shown promise in improving white matter health and may help prevent dementia.
A recent study by Dr. Sylvie Belleville and her team has identified typical patterns of brain progression towards Alzheimer's disease, revealing a complex path characterized by periods of stability followed by accelerated decline. The study suggests that rapid memory decline is a key indicator of risk, allowing for earlier treatment.
A study published in JAMA Neurology found that people with low vitamin D levels experience rapid cognitive decline over time compared to those with adequate levels. Researchers recommend daily vitamin D supplements for individuals 60-plus due to the association between low vitamin D and faster cognitive decline.
A study of nearly 400 participants aged 76+ found that low vitamin D levels accelerate cognitive decline and increase dementia risk. Individuals with dark skin or insufficiency were disproportionately affected.
A study found that vitamin D insufficiency was associated with a faster decline in cognitive functions among older adults. The research, published in JAMA Neurology, revealed that African American and Hispanic individuals were more likely to have vitamin D insufficiency or deficiency. Participants with inadequate vitamin D levels exper...
A study of 350,000 patients with type 2 diabetes found those with poor blood sugar control have a 50% higher risk of being admitted to hospital for dementia compared to those with good control. Improved blood sugar control may prevent many cases of dementia in these patients.
A new study found that people with type 2 diabetes have double the risk of developing dementia and exhibit higher levels of tau protein in the spinal fluid. Diabetes was also associated with reduced cortical thickness, suggesting a potential link to brain cell death.
Researchers emphasize the need to improve brain imaging accuracy for dementia diagnosis and progression prediction. MRI scans and PET scans show promise, but current methods are not sensitive or accurate enough for widespread adoption.
Researchers have discovered how a common gene mutation causes long strands of RNA to block pathways that move proteins into a cell's nucleus, leading to molecular traffic jams. Molecular therapy has been shown to reopen blocked pathways in human and fly cells, providing hope for treatments for ALS and dementia.
A new study published in Neurology found that people who develop dementia experience a decline in awareness of their memory problems two to three years before the disease onset. The study also identified several dementia-related brain changes associated with this decline.
Two studies found that moderate-intensity physical activity did not improve cognitive function, while oral supplementation with nutrients had no significant effect on cognitive decline. However, participants over 80 or with poor baseline physical performance showed better changes in executive function composite scores.
Experts claim number of people with dementia in some Western European countries is stabilizing. The findings suggest a decrease in prevalence and incidence of dementia across specific age groups.
Studies show that changes in moral behavior, not memory loss, cause loved ones to say the patient isn't 'the same person' anymore. Moral faculties form core of individual identity perception, according to researchers.
Researchers discovered TDP-43 normally prevents unwanted RNA stretches from being used by nerve cells. When TDP-43 accumulates, it malfunctions, leading to a cascade of events that kills brain or spinal cord cells.
A recent study found that older adults who followed the MIND diet more rigorously showed equivalent cognitive abilities to those 7.5 years younger, suggesting a potential delay of dementia's onset. The MIND diet emphasizes brain-healthy food groups and limits unhealthy foods, with berries being a key component.
African-American participants showed a significant decline in dementia incidence rates from 1992 to 2011 compared to a stable rate among Yoruba individuals in Nigeria. The study suggests that medication for cardiovascular conditions may contribute to the decline.
A recent study found that dementia patients and caregivers prefer increased funding for caregiving support and resources over research for an Alzheimer's cure. The majority of respondents ranked financial resources for respite care, long-term care support, and advocacy as top priorities.
Cholinesterase inhibitors used to treat dementia can lead to significant weight loss in older adults. Clinicians should monitor patients for weight loss and consider discontinuing these medications if necessary, according to a new study.
A study found that medical students who visited an art museum with people with dementia showed improved attitudes towards the disease. The experience helped students understand how patients and caregivers maintain relationships despite diagnosis.
Researchers from NYU Langone Medical Center presented new findings on Alzheimer's disease treatment at the 2015 Alzheimer's Association Conference. The studies focused on the development of monoclonal antibodies that can recognize oligomeric tau and Aβ, as well as pathological structures in Parkinson's disease human brains. Additionall...
Ralph A. Nixon, a renowned neuroscientist, received the prestigious Zaven Khachaturian Award for his groundbreaking research on early brain changes associated with Alzheimer's disease. His work has helped scientists better understand the process of Alzheimer's development and progression.
Researchers at Einstein College of Medicine presented multiple studies on risk factors and predictors of aMCI and dementia in older adults, including the impact of perceived stress, diet, and coping mechanisms. The findings suggest that early detection of cognitive decline is crucial for implementing effective preventive interventions.
Dr. Li Gan receives the Inge Grundke-Iqbal Award for her influential research on progranulin and amyloid accumulation in mouse models of Alzheimer's disease. Her work may protect against brain changes associated with the disease.
The Alzheimer's Association recognized MetLife Foundation and GHR Foundation for their significant investments in Alzheimer's research and public information programs. These foundations have supported over $32 million in research initiatives, including prevention studies and innovative approaches to Alzheimer's care.
The Alzheimer's Association honored four leading scientists, including Alison Goate, Bengt Winblad, John Hodges, and Ian McKeith, for their groundbreaking research on Alzheimer's disease and dementia. The recognition aims to accelerate the global effort to eliminate Alzheimer's and advance research towards new treatments.
Researchers found that high blood pressure at a younger age can affect cognitive performance many years later. Participants with high blood pressure scored more poorly on tests of attention and executive function, highlighting the importance of managing factors that impact brain aging.
A study of approximately 500 older adults found that two-thirds who screened positive for cognitive impairment refused diagnostic assessment. Living alone was a significant factor, as well as negative preconceptions about dementia stigma.
A study published by the American Academy of Neurology found that Alzheimer's disease causes different changes in the brain, or pathologies, in African-Americans compared to white Americans of European descent. African-Americans were more likely to have mixed pathologies and blood vessel disease in their brains.
A nationwide study found that people with diabetes and high rates of complications are more likely to develop dementia as they age. Better blood sugar control is crucial for preventing the onset of dementia.
A study analyzing health insurance data found that long-term treatment with pioglitazone significantly decreases the risk of developing dementia in patients with type 2 diabetes. The medication lowers the risk by approximately half compared to non-diabetics, with a notable protective effect against Alzheimer's disease.
A new study by Indiana University researchers finds that the Aging Brain Care Medical Home program reduces depressive symptoms in two-thirds of patients and caregiver stress by 50%.
A Cochrane Review found a lack of conclusive evidence on how to care for patients with dementia who suffer from hip fractures. The review highlights the need for better research into post-operative care strategies, particularly in hospital settings and the community.
Research suggests that clear and strong environmental stimulation can lower apathy levels in nursing home residents with dementia. Apathy is a common neurobehavioral symptom in dementia, affecting up to 90% of older adults, and can lead to faster cognitive decline and caregiver burnout.
A study published in Neurology found that people with mild cognitive impairment or dementia due to Alzheimer's disease have abnormal levels of lysosomal proteins in their blood. These proteins, found in tiny nerve cell-derived blood particles called exosomes, may serve as biomarkers for early treatment and prevention.
A new study found that calcineurin inhibitor-based medications used by organ transplant recipients significantly lower the prevalence of dementia and Alzheimer's disease compared to national data. The research suggests that this treatment strategy may offer a protective effect against the development and progression of Alzheimer's.
Researchers have successfully created mice that mimic the symptoms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two devastating neurodegenerative disorders. The mice exhibit key hallmarks of the diseases, including toxic RNA clusters and TDP-43 protein inclusions.
Two studies analyze amyloid prevalence among adults of varying ages and its association with cognitive impairment. The findings indicate that key risk factors for Alzheimer's disease are also risk factors for amyloid positivity in cognitively normal persons.
Researchers at Mayo Clinic developed a mouse model exhibiting neuropathological and behavioral features associated with C9ORF72 mutation. The study suggests a link between the repeat expansion in C9ORF72 and TDP-43 pathology, potentially leading to therapeutic agents targeting RNA foci and c9RAN proteins.
Researchers found that a medical marijuana pill was safe and well-tolerated, but did not show significant improvement in behavioral symptoms of dementia. The study suggests further research is needed to test the effectiveness of higher doses.
A study of 855 Gothenburg men born in 1913 found that factors such as not smoking, maintaining healthy cholesterol levels, and a strong socio-economic standard contributed to their longevity. Additionally, correlations with maternal longevity and robust working capacity were also identified.
A study published in Neurology found that individuals with higher occupational levels, such as professionals and engineers, lived up to three years longer than those with lower-level occupations. This suggests that mentally demanding jobs may help protect the brain from the effects of frontotemporal dementia.
A new study found that people with more challenging jobs may live up to three years longer than those with less skilled jobs after developing frontotemporal dementia. The cognitive reserve theory suggests that higher occupational levels build connections in the brain, creating a buffer against disease.
A new tool has been developed to improve dementia care for south Asian people, addressing cultural barriers to diagnosis. The adapted BEMI-C tool takes into account sensitivities that can act as barriers to effective diagnosis and treatment.
A study of over 2.4 million Danish citizens found that depression, type 2 diabetes, or both are associated with a higher risk of dementia. Individuals diagnosed with depression or type 2 diabetes alone have an increased risk, while those with both conditions experience the greatest increase in risk.