Research on dementia and cognitive decline. Covers Alzheimer's screening, brain injury recovery, attention training, and gaps in diagnosis and care.
A new study published in Neurology found that people with sleep apnea or reduced deep sleep are more likely to have brain abnormalities associated with dementia. The study also discovered that those who spent less time in slow wave sleep had loss of brain cells, a risk factor for Alzheimer's disease.
A study at Plymouth University is exploring how proteins interact to build up in nerve cells, potentially leading to dementia diseases like Alzheimer's and Parkinson's. The research aims to understand the mechanism behind protein deposits and may one day lead to new therapies for patients with dementia with Lewy bodies.
People diagnosed with diabetes in midlife experience significant memory and cognitive problems over the next 20 years, aging their minds five years faster. Controlling blood sugar levels at age 50 can help prevent this decline and delay dementia.
A new study published in Neurology suggests that approximately 1.8 million Americans over the age of 70 with dementia have never had an evaluation of their cognitive abilities. Early evaluation and identification can help families make plans for care, improve quality of life.
A new study by the University of Michigan found that more than half of seniors with signs of dementia haven't received a medical evaluation. The study suggests that as many as 1.8 million Americans over 70 with dementia are not being evaluated for cognitive symptoms, which can lead to modifiable causes of thinking or memory impairment.
A brief coping strategies therapy significantly improves dementia carers' mental health and quality of life, reducing depression and anxiety by 7 times. The START programme is a cost-neutral intervention that can be widely available to support family carers.
A new study reveals that computer-based cognitive training can improve memory, speed, and visuospatial skills in older adults. However, self-directed brain training at home has no therapeutic effect on cognition. Training frequency is also crucial, with one to three sessions per week being most effective.
A study published in the Asia Pacific Journal of Clinical Nutrition found that adding one gram of turmeric to breakfast improved working memory in older adults with pre-diabetes. The spice's active compound, curcumin, has been shown to reduce the risk of dementia and improve cognitive function.
Research suggests that long-term use of anti-clotting drugs like warfarin and aspirin or clopidigrel can increase the risk of dementia in people with atrial fibrillation. Patients with abnormally slow blood clotting times were found to be more likely to develop dementia.
A study published in Molecular Neurodegeneration finds that tau, not amyloid-beta plaque, causes neuronal death in Alzheimer's disease. The researchers suggest that remaining Abeta inside the neuron destroys cells, while malfunctioning tau prevents cells from clearing toxic proteins.
A recent traumatic brain injury (TBI) is associated with an increased risk of developing dementia in middle-aged and older adults. The study found that moderate to severe TBI was linked to higher dementia rates at age 55, while mild TBI at age 65 increased the risk.
Eight new research projects will explore various techniques for detecting dementia, including microstructure-sensitive MRI and graphene-based biosensors. The projects aim to develop diagnostic tools that can identify biomarkers of dementia at the point of care.
Researchers at Plymouth University are developing a new graphene-based diagnostic technique to detect biomarkers of dementia in bodily fluids. The technology aims to provide real-time data and conclusive test results within minutes, increasing the accuracy of dementia detection and tracking disease progression.
Research found that physical exercise improves brain perfusion and visual memory in younger adults, but this effect decreases with age. The study used magnetic resonance imaging to examine the brains of 40 healthy volunteers aged 60-77, with half receiving treadmill exercise for 3 months.
The American Society for Parenteral and Enteral Nutrition recommends withholding or withdrawing gastrostomy tubes in patients with advanced dementia. Current scientific evidence suggests that tube feeding does not improve outcomes in this population, instead leading to high mortality rates.
A nearly 40-year-long study found that middle-aged women experiencing anxiety, jealousy, and moodiness are at a higher risk of developing Alzheimer's disease. Women who scored highest on neuroticism tests had double the risk of dementia, with those who were both easily distressed and withdrawn having the highest risk.
The report shows an almost doubling of dementia in people with Down syndrome and significantly reduced rates of heart attack and hypertension. People with ID experience unique health challenges, including poor bone health and low physical activity levels.
Researchers at Gladstone Institutes found that progranulin deficiency can increase amyloid-beta plaque formation, neuroinflammation, and cognitive dysfunction in a mouse model of Alzheimer's disease. Increasing progranulin levels via gene therapy effectively prevented these abnormalities and protected against cell death.
A study published in Neurology found that people who notice their memory slipping may be on to something, with 56% of participants reporting changes in their memory. The study suggests a significant window of opportunity for intervention before diagnosable problems show up, approximately 12 years after initial complaints began.
Research suggests that people with memory issues without dementia are at higher risk of developing the disease. A 12-year study found nearly three times more likelihood of memory problems in those reporting changes, emphasizing the importance of taking such complaints seriously.
Researchers at Northwestern University have created the first mouse model for ALS dementia, allowing scientists to directly view the brains of living mice under anesthesia. This breakthrough enables rapid testing and real-time monitoring of test drugs, paving the way for accelerated development of effective therapies.
A large case-control study found that long-term benzodiazepine use is associated with an increased risk of Alzheimer's disease. The study suggests that the strongest association was seen with long-acting benzodiazepines, emphasizing the need for careful balance between benefits and risks in elderly patients.
A recent study found that more than 60% of people with dementia have three or more other conditions, but these are often not adequately described in clinical trials. The combined effects of co-morbidities like diabetes and chronic heart failure can lead to worsening symptoms and increased risk of preventable dementia admissions.
A recent study published in JAMA Internal Medicine found that patients with advanced dementia are still being prescribed medications with little to no proven benefit. The study analyzed data from over 5,400 nursing home residents and found that nearly 54% received at least one questionable medication.
A new study finds that volunteering is associated with reductions in depression symptoms, better overall health, and greater longevity. Volunteering appears to peak at a moderate level, with benefits diminishing beyond 100 hours annually.
Researchers at the University of Warwick found that a lack of the MK2/3 protein is linked to structural and physiological changes in the nervous system, leading to early signs of dementia. These changes restrict learning and memory formation capabilities, but not memory formation itself.
Researchers found retinal thinning as an early marker for frontotemporal dementia, prior to cognitive symptoms. The retina acts as a 'window to the brain,' and studying it can track changes in neurons.
A new study published in the American Journal of Alzheimer's Disease and Other Dementias found that mindfulness training can brighten outlooks on life for both individuals with memory loss and their caregivers. The training eased depression, improved sleep quality, and enhanced overall quality of life.
Research reveals that being obese in one's 30s triples the risk of developing dementia later in life. The study found an incremental decrease in dementia risk with age, suggesting that weight loss or delayed onset of obesity may lower the risk of dementia.
Researchers have identified a small molecule capable of interrupting the disease process in cells carrying the C9ORF72 gene, a variant associated with ALS and FTD. The compound selectively targets abnormal RNA molecules, reducing their accumulation and potentially serving as a biomarker for clinical trials.
Researchers developed small-molecule drug candidates that interfere with the synthesis of an abnormal protein, playing a key role in both diseases. The study also discovered biomarkers to test the efficacy of these therapies and found toxic proteins in spinal fluid that could become an enrollment tool in human clinical trials.
Scientists at Mayo Clinic and Scripps Research Institute developed a new therapeutic strategy to combat the most common genetic risk factor for ALS and FTD. They discovered a potential biomarker that can track disease progression and measure the efficacy of therapies.
A study found that altered brain activity, measured by PET scans, is associated with impaired daily living activities in individuals with mild cognitive impairment and dementia. The researchers identified changes in frontal and temporal areas of the brain linked to memory and decision-making.
Researchers found that autophagy is activated in the hippocampus of vascular dementia model rats, leading to neuronal injury. Inhibiting autophagy has shown neuroprotective effects, suggesting it as a novel pathway and target for drug treatment of vascular dementia.
A recent study published in the medical journal Neurology has confirmed a substantial link between vitamin D deficiency and an increased risk of dementia and Alzheimer's disease in older adults. The research found that participants with severe vitamin D deficiency were more than twice as likely to develop dementia and Alzheimer's disease.
A study published in Neurology found that low vitamin D levels double the risk of developing dementia and Alzheimer's disease in older people. Researchers analyzed blood levels of vitamin D and found a significant association between low vitamin D levels and increased dementia risk.
A new SUNY research project aims to understand the connection between frailty and dementia, with the goal of maximizing patient outcomes and enhancing quality of life. The project will develop tools to assess frailty risk factors and determine their correlation with cognitive assessments.
A 20-year study found that midlife hypertension was associated with a moderate decline in cognition compared to individuals with normal blood pressure. The study used the Atherosclerosis Risk in Communities (ARIC) study and analyzed data from 13,476 participants.
A new study indicates that depression is a true risk factor for dementia and that targeting depression may help prevent cognitive decline. People with mild cognitive impairment were more likely to have higher levels of depression symptoms before diagnosis.
A new study by Rush University Medical Center researchers found that depression is independently associated with an increased risk of developing dementia. The study suggests that targeting and treating depression could help prevent or delay cognitive decline in older adults.
A telephone-based support program has been shown to significantly reduce depression and symptoms in informal caregivers of individuals with dementia. This study, published in the journal Alzheimer's & Dementia, highlights the benefits of convenient and accessible support for caregivers who often face significant pressure and stress.
A study published in the American Journal of Geriatric Psychiatry indicates that middle-aged adults with a history of problem drinking are more than twice as likely to suffer from severe memory impairment in later life. The research highlights the link between harmful patterns of alcohol consumption and problems with memory, which may ...
Gitlin, a renowned gerontologist, has made significant contributions to nonpharmacologic approaches in dementia care and aging in place. Her work aims to improve the lives of chronically disabled older adults and their family caregivers.
A study by University of Pittsburgh researchers found dementia patients are more likely to receive a pacemaker for atrial fibrillation than those without cognitive impairment, despite being diagnosed with less aggressive interventions. The likelihood was highest among dementia patients, even after accounting for clinical factors.
Researchers found that patients with dementia were more likely to receive a pacemaker, even after adjusting for clinical risk factors. The study suggests that patients with serious life-limiting illnesses may be treated more aggressively than expected.
A new test diagnoses motoric cognitive risk syndrome (MCR), which combines gait speed measurement with cognitive questions. People who test positive for MCR are twice as likely to develop dementia within 12 years, emphasizing the importance of early diagnosis and potential underlying cause identification.
Researchers focus on areas of memory and learning to treat obesity, suggesting a link between the two diseases. The 'vicious cycle' model proposes that overeating leads to brain pathologies, which can weaken control over thoughts and behaviors.
A study found that fish oil compound protected against inflammation and neuronal cell death in brain cells exposed to high levels of alcohol. The findings suggest limited amounts of alcohol may make brain cells more fit, reducing the risk of neurodegeneration and dementia.
A systematic review of 17 research studies found that outdoor spaces can reduce residents' agitation and provide environments for relaxation and social interaction. Gardens could offer welcome spaces for visitors to stimulate memories for dementia patients.
Research at the Alzheimer's Association International Conference 2014 found that participating in mentally stimulating activities and moderate physical exercise in middle age may help protect against Alzheimer's disease. Additionally, high blood pressure was seen to protect against cognitive decline in people aged 90 and older.
The Lancet Neurology calls for sports authorities to consider long-term neurological problems caused by repeated concussions in footballers. Many sporting organisations have drawn up new protocols to protect athletes who sustain a head injury, but the decision on return-to-play should be made solely by healthcare professionals.
Montefiore and Einstein researchers present data at the 2014 Alzheimer's Association International Conference, focusing on triggers for mild cognitive impairment and dementia. The research aims to identify potential strategies to preserve cognitive function and delay or prevent Alzheimer's disease onset.
Alzheimer's disease is a neurodegenerative disorder characterized by memory problems, orientation issues, and behavioral changes. A simplified diagnosis using specific biomarkers improves the accuracy of early-stage diagnoses.
Researchers have found that boosting autophagy, a cell-cleaning process, can help clear abnormal protein buildup in brain cells. Three drugs that enhance autophagy showed promise in keeping brain cells alive longer, potentially offering new treatment options for conditions like ALS and dementia.
A common genetic defect affects neurodegenerative diseases like Alzheimer's and Parkinson's by impairing microglial waste removal. This leads to accumulation of toxic protein deposits, triggering inflammatory reactions that promote further nerve-cell loss.
A recent study published in Neurology suggests that veterans with a history of traumatic brain injury (TBI) are 60% more likely to develop dementia than those without TBI. The study found that veterans with TBI developed dementia about two years earlier, highlighting the potential long-term consequences of TBI on cognitive health.
A RAND Corporation study emphasizes the urgent need to improve long-term care services for people with dementia and their caregivers. The study offers 25 high-impact policy options to address this growing concern, including increasing public awareness, improving access to services, and reducing financial burdens.
A study examining lifetime intellectual enrichment found that it may delay the onset of cognitive impairment and reduce the risk of dementia. The research suggests that engaging in mentally stimulating activities throughout life could be a successful preventive intervention to combat the impending dementia epidemic.
A new diagnostic tool, combining data from multiple sources, can help clinicians diagnose Alzheimer's disease, frontotemporal dementia, and mild cognitive impairment with a Disease State Index. The tool also provides a visual representation of the findings in a Disease State Fingerprint.
A group of experts examines whether people with advanced dementia have the right to use advance directives to stop receiving food and water by mouth, despite lacking decision-making capacity. Key findings include the potential benefits and harms of such directives, as well as proposed guidelines for implementation.