Articles tagged with Dementia
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Researchers at The Mount Sinai School of Medicine presented a study demonstrating IRX4204's ability to alleviate cognitive decline in animal models of Alzheimer's disease. The compound also prevents neuropathological features associated with abnormal tau processing, a common feature of Parkinson's disease with dementia.
A study published in Archives of Neurology found a strong association between poor physical performance and increased dementia risk in individuals aged 90 and older. The study revealed that even modest declines in physical performance were associated with higher dementia odds, particularly gait slowing and grip strength.
Researchers developed a method to differentiate patients with Alzheimer's disease from those with other types of dementia using biomarkers in cerebrospinal fluid. The study analyzed five proteins and found that they could accurately diagnose Alzheimer's disease, as well as distinguish it from Parkinson's disease and Lewy body dementia.
A study has found a key difference between brains of people with Alzheimer's disease and those who are cognitively normal but have brain plaques. Researchers detected smaller molecules of amyloid beta called oligomers, which were more closely correlated with dementia symptoms.
Researchers found that people with dementia received an anti-psychotic at a rate of 15.3%, compared to the national audit's 10.5%. A multi-disciplinary approach to care can reduce or withdraw low-dose anti-psychotics for more than 60% of patients. Further clinical trials are needed to confirm effectiveness.
UC Irvine's Program in Geriatrics has been awarded a three-year, $1 million grant from the U.S. Administration on Aging to implement a new federal initiative combating elder abuse. The program will test promising community-based practices to prevent the abuse of people with dementia, with the goal of reducing this complex and interrela...
Researchers at Gladstone Institutes discover how a protein deficiency contributes to neurodegenerative disease frontotemporal dementia (FTD). Progranulin prevents microglia from becoming hyperactive, leading to inflammation that destroys neurons and causes debilitating symptoms.
A comparative analysis of elderly individuals found that benzodiazepine use was associated with a 50% increased risk of developing dementia. The study recommends limiting prescriptions to periods of a few weeks and ensuring proper use to mitigate potential adverse effects.
A medical record review study found that a correct diagnosis of sporadic Jakob-Creutzfeldt disease was often delayed due to misdiagnoses, with an average of 3.8 misdiagnoses per patient. The study suggests that improving early and accurate diagnosis is valuable for public health reasons.
The American Academy of Neurology has released a new guideline to help doctors diagnose Creutzfeldt-Jakob disease, a rare and always fatal brain disorder. The guideline suggests that the 14-3-3 protein test can be useful in reducing uncertainty when the probability of the disease is between 20% and 90%.
A consensus document developed by leading Alzheimer's researchers, advocates, and clinicians provides prioritized goals for the nation's healthcare system. The plan aims to advance understanding of the disease, develop effective treatments, and integrate healthcare and social services.
A five-year randomized controlled trial of 2854 elderly patients found no significant difference between ginkgo biloba extract and placebo in preventing Alzheimer's disease diagnosis. No significant difference was also observed in mortality or stroke rates between the groups. The results confirm previous findings from a US-based study.
A new study found that people with high levels of inflammation-linked protein are less likely to develop dementia and have relatives who avoid the disease. Higher protein levels were associated with a lower risk for dementia in parents and siblings, suggesting a possible genetic link.
Cornelia Beck, PhD, RN, FAAN, has been recognized with the 2012 M. Powell Lawton Award for her groundbreaking work in gerontology, focusing on non-drug interventions to improve care for persons with dementia. Her research has demonstrated the retention of ability to perform daily activities and improved outcomes.
Dr. Bruce L. Miller will receive the 2012 Gene D. Cohen Research Award for his work on dementia diagnosis and treatment. The award recognizes his seminal contributions to understanding the relationship between brain function and behavior in older adults.
Ann Kolanowski, a renowned expert in gerontological nursing research, has been awarded the 2012 Doris Schwartz Gerontological Nursing Research Award. Her work focuses on developing theory-based non-pharmacological interventions for behavioral symptoms in persons with dementia and delirium.
Consuming cocoa flavanol-rich products daily may improve memory and cognition in elderly individuals with mild cognitive impairment. Researchers found significant improvements in cognitive scores, insulin resistance, blood pressure, and oxidative stress for those drinking high and intermediate levels of flavanols.
A study published in the journal Brain found that episodes of delirium increase the risk of developing new dementia eight-fold in older patients. Delirium also worsens the severity of dementia and accelerates cognitive decline in those already diagnosed with dementia.
Researchers found that a specific type of yogic meditation, Kirtan Kriya Meditation, reduced inflammation and stress levels in dementia caregivers. This 12-minute daily practice for eight weeks led to changes in 68 genes related to inflammation, resulting in improved well-being.
Experts from NYU Langone Medical Center will present research on non-invasive evaluation of tau targeted immunotherapy, physician intention to screen for dementia, and remission of pre-mild cognitive impairment. These studies aim to improve diagnosis and treatment of Alzheimer's disease.
A recent study by the Peninsula College of Medicine and Dentistry found that binge drinking in older adults is associated with an increased risk of cognitive decline. Participants who reported binge drinking at least once a month were 62% more likely to experience significant declines in cognitive function and memory.
A German study found that focusing on high blood pressure, smoking, high cholesterol, diabetes, irregular heartbeat, and depression reduced the need for long-term care by 10% in women and 9.6% in men. The study also showed a decrease in death rates, with 2,112 expected deaths vs. 1,939 actual deaths.
Researchers at Georgetown University Medical Center have discovered a potential cause of HIV-associated dementia: reduced production of mature brain-derived neurotrophic factor (mature BDNF), a protein essential for brain neuron health. This finding may lead to a therapeutic solution and provide a biomarker for risk assessment.
Researchers discovered that older honey bees effectively reverse brain aging when they take on nest responsibilities typically handled by younger bees. The study found changes in molecular structure of their brains, including the presence of proteins that can help protect against dementia.
Experts say lack of privacy, safety fears and ageism deny elderly care home residents the right to consensual sex. Formal policies are needed to address this, despite research showing residents want their sexual expression acknowledged.
A recent study found that almost 90% of older adults aged 65-96 were willing to undergo dementia screening, with refusal rates higher among those between 70-79 years old. The study's results suggest that age is the primary factor affecting willingness, with no significant impact from sex, race, or income level.
A new, user-friendly tool called the Healthy Aging Brain Care Monitor has been found to be a reliable and valid way to measure dementia symptoms. The study, published by Indiana University School of Medicine, shows that the monitor can detect changes in symptoms and distinguish between patients with varying levels of impairment.
A new study by the University of Exeter found that seniors who perceive themselves as older are five times more likely to meet dementia criteria on standard screening tests. The research highlights the significant impact of age attitude on mental functioning and clinical tools used in dementia diagnosis.
A new study found that people with mild cognitive impairment were nine times more likely to be slow walkers than moderate or fast walkers. The study used a new technique to detect changes in walking speed and found that fluctuations in walking speed were also associated with MCI.
Longitudinal studies suggest that light-to-moderate alcohol consumption may lower the risk of cognitive decline and dementia by approximately 35-45%. Moderate drinking patterns may also offer cardiovascular benefits. However, further research is needed to understand the optimal pattern of drinking for protection against cognitive decline.
A large study suggests dementia incidence in middle-income countries is similar to higher-income countries, with education and literacy providing significant protection against the disease. Individuals with dementia face a nearly three-fold increased risk of dying compared to those without.
A new study from the Regenstrief Institute and Indiana University has found that individuals with dementia are more likely to die at home rather than in a nursing home. The majority of care for those with dementia is provided in the community by families, contradicting previous assumptions.
A new study published in Archives of Internal Medicine reports that gastric feeding tubes may not prevent but rather increase the risk of pressure ulcers in people with advanced dementia. The analysis of thousands of nursing home patients found that those with a feeding tube were 2.27 times more likely to develop a stage II ulcer, and ...
Research suggests that lifelong depression increases the risk of developing vascular dementia, while late-life depression may be an early symptom of Alzheimer's disease. A study of over 13,000 participants found a significant association between depressive symptoms in midlife and late life with increased risk of dementia.
A study of 13,535 individuals found that depressive symptoms in midlife and late life are associated with a higher risk of developing dementia. Those with chronic depression during their lifetime had a two-fold increase in Alzheimer's disease risk, while those with depression in both midlife and late life had a three-fold increase in v...
The Regenstrief Institute's Aging Brain Care Program is launching a global initiative to provide collaborative dementia care. The program's tools and resources aim to reduce emergency room and hospital visits by up to 45%, improving the quality of care for those with dementia.
Researchers at UBC and VCH found that a senior's exercise program using resistance-training can improve executive cognitive functions, associative memory, and brain plasticity. The study suggests that resistance training can be an effective prevention strategy for dementia.
Researchers found a significant relationship between decreased CSF αβ 1-42 and clinical decline in participants with elevated CSF p-tau 181p, suggesting p-tau as an important marker of AD-associated degeneration. The study suggests that targeting tau may be crucial for therapy development.
A Mayo Clinic study found that therapeutic hypothermia, also known as body cooling, has reduced in-hospital deaths among sudden cardiac arrest patients. The research analyzed over 1 million patients and found mortality rates dropped from 69.6% to 57.8% between 2001 and 2009.
A new MRI technique uses computer modeling to predict the rate and physical path of degenerative brain diseases like Alzheimer's and frontotemporal dementia. The study supports the idea that these diseases spread through the brain along specific neuronal pathways, similar to prion diseases.
Bilingualism has been shown to improve cognitive reserve and sustain better cognitive performance throughout the lifespan, potentially delaying dementia onset. Lifelong experience managing multiple languages reorganizes specific brain networks, creating a more effective basis for executive control.
Researchers found that many dementia patients' delusions have logical explanations and can be treated through behavioral therapy. The study suggests a better understanding of delusions can lead to more humane and compassionate treatment, considering the patient's context and circumstances.
A meta-analysis of 13 studies found a significant association between lower Aβ42: Aβ40 ratios and development of Alzheimer disease and dementia. The analysis suggests that measuring this ratio may have value in predicting the risk for later development of dementia or AD.
A study found that antipsychotic medication is associated with a modest and time-limited increased risk of heart attack among older patients treated for dementia. The risk was highest at the beginning of treatment, decreasing after the first month.
Researchers developed a computer program to track dementia spread in the human brain, predicting future cognitive declines. The model identifies neural sub-networks where misfolded proteins collect, altering normal brain function across affected areas.
Researchers found that Alzheimer's disease and other dementias spread within nerve networks by moving directly between connected neurons. The study used magnetic resonance imaging research to predict the course of dementias based on a nerve region's connectivity to a disease hot spot.
Two studies published in Neuron have developed groundbreaking models that predict the landscape of degeneration in various forms of dementia. The models, which focus on structural and functional connectivity networks, suggest that dementias target specific networks of neurons linked by connectivity rather than spatial proximity.
A new study suggests that extending treatment to moderate to severe Alzheimer's disease patients with the commonly used dementia drug donepezil can help treat more patients worldwide. The trial found that continued treatment resulted in improved cognitive and functional abilities, with benefits noticeable to patients for at least a year.
A new study led by Michigan State University sociologist Zhenmei Zhang investigates the racial gap in dementia, revealing that blacks are four times more likely to experience mild cognitive impairment than whites. The research aims to identify windows of opportunity for intervention and reduce disparities.
Researchers at University College London have discovered specific antibodies that block the toxic effect of Amyloid-ß on synapses, raising hopes for a treatment to combat early cognitive decline. The findings suggest targeting the secreted protein Dkk1 could offer an effective treatment to protect synapses.
Research found that middle-aged individuals with slower walking speed are one-and-a-half times more likely to develop dementia, while those with weaker hand grip strength are at a higher risk of stroke. Conversely, faster walkers and stronger grippers have lower risks, according to the study.
A UCLA-developed brain-imaging tool detects abnormal protein deposits associated with Alzheimer's disease and tracks progression over time. The technique, using FDDNP-PET scans, predicts cognitive decline in individuals with mild cognitive impairment and normal aging, offering potential early detection and treatment of Alzheimer's.
A new study published in the Journal of the American Geriatrics Society reveals that brief cognitive screenings combined with further evaluation increased diagnoses of cognitive impairment by two to three fold. Researchers found that veterans aged 70 and older who failed the screen were more likely to have dementia.
A large study found that mild cognitive impairment is consistently associated with higher disability and neuropsychiatric symptoms, particularly anxiety, apathy, and irritability. The prevalence of mild cognitive impairment ranged from 0.8% to 4.3% in eight low- and middle-income countries.
According to a study published in Archives of Neurology, revised criteria for mild cognitive impairment (MCI) may reclassify patients with very mild or mild Alzheimer's disease dementia. The new guidelines allow for more flexibility in defining functional independence, potentially affecting diagnostic approaches and treatment options.
The study found rare variants in key Alzheimer's-related genes in 13% of analyzed samples, with 5% likely contributing to the disease. The findings suggest a common disease mechanism for both early- and late-onset Alzheimer's, leading to potential changes in classification.
A recent study published in Neurology found that men are at higher risk of experiencing mild cognitive impairment (MCI) than women. The study, which analyzed data from 1,450 participants aged 70-89, revealed that the number of new cases of MCI per year was higher in men, affecting 72 per 1,000 people.
More than 6 percent of Americans age 70 to 89 develop mild cognitive impairment (MCI) each year, with men and those with lower education levels more affected. MCI affects the stage between normal forgetfulness and dementia, such as Alzheimer's disease.
A study found that nursing home residents with dementia who use average doses of selective serotonin reuptake inhibitors (SSRIs) are three times more likely to have an injurious fall than those who don't. The risk increases as people take higher doses of SSRIs, and combining them with hypnotic or sedative drugs further elevates the risk.
Research found that individuals with dementia had a significantly higher rate of hospital admissions for all causes and ambulatory care-sensitive conditions. These findings suggest opportunities to improve outpatient care for seniors with dementia by identifying preventive strategies for common conditions like pneumonia, heart failure,...