Articles tagged with Dementia
Researchers at Hebrew University created a molecule that reduces brain cell death in diabetic rats by lowering inflammatory processes. This finding represents the first evidence of high blood sugar's link to an inflammatory pathway in the brain.
A recent study found that men are more likely to experience memory problems than women, with 8 out of 9 questions showing higher rates of forgetting among men. This phenomenon holds true across all ages, from 30 to 60 years old, and is associated with higher education levels and a lower risk of dementia.
A new study by Johns Hopkins Medicine finds that most people with dementia living at home have multiple unmet health and welfare needs. Routine assessments and interventions in safety, medical care, and supportive services can help keep patients at home longer.
Researchers at Lund University are studying the connection between type 2 diabetes and dementia, specifically focusing on insulin resistance and pericyte cells in the brain. They hope to discover new biomarkers that can signal early stages of dementia in diabetes patients, allowing for potential treatment targets.
A recent study published in Diabetes Care found that Native Americans and African-Americans with type 2 diabetes have a significantly higher risk of developing dementia. The study analyzed data from over 22,000 patients aged 60 or older with type 2 diabetes and found that dementia rates were highest among these groups.
A 35-year study by Cardiff University found that regular exercise significantly reduces the risk of dementia and cognitive decline. The study identified five healthy behaviors as key to a disease-free lifestyle, with exercise being the strongest mitigating factor.
Research suggests that age-adjusted rates of dementia have declined for people born later, particularly those at higher risk. Lifestyle factors such as exercise and diet are being studied as potential contributors to this trend.
Researchers developed a statistical model that can identify individuals with mild cognitive impairment who are at risk of developing dementia, enabling earlier diagnosis and treatment. The model takes into account various factors such as age, sex, race, and education to provide a more accurate prognosis.
Research shows that speaking two languages can delay the onset of three types of dementias, including Alzheimer's disease, frontotemporal dementia, and vascular dementia. The study found that people who spoke two languages developed dementia four and a half years later than those who only spoke one language.
A study of almost 650 dementia patients found that bilingual individuals experience a later onset of Alzheimer's disease, vascular dementia, and frontotemporal dementia. Bilingualism appears to be a natural brain training that delays dementia onset.
HS-AGING affects older adults, causing cognitive decline and memory impairment. Recent studies reveal around 20% of dementia cases are misdiagnosed as HS-Aging, highlighting the need for accurate diagnosis and exploration of new therapeutic targets to alter disease progression.
Scientists at UCL Institute of Neurology identified a genetic mutation that leads to the production of toxic RNA molecules, potentially responsible for frontotemporal dementia and motor neuron disease. The build-up of these molecules may be key to causing the diseases.
The American College of Physicians recommends against routine screening for chronic kidney disease (CKD) in asymptomatic adults without risk factors. In contrast, patients with hypertension and stage 1-3 CKD should be treated with ACE inhibitors or ARBs to manage elevated low-density lipoprotein levels. The evidence review suggests tha...
The UCI's 90+ Study, a five-year research project focused on the health and lifestyle issues of Americans in their 90s or older, has received renewed funding. Researchers plan to use PET and MRI scans to investigate factors associated with Alzheimer's disease and dementia, as well as monitor blood pressure and oxygen saturation.
Researchers have discovered how an ALS mutation kills neurons and developed a therapeutic strategy to block this neurodegeneration. They used human skin cells from patients and converted them into neurons, finding that the abnormal genetic expansion causes cell death, dysregulated gene expression, and RNA toxicity.
Researchers have developed a new therapy that targets the C9ORF72 gene mutation causing dementia and ALS. The stem cell-based approach manipulates brain cells in test tube studies, discovering compounds that counteract the genetic glitch.
Researchers found that older participants experienced more tip-of-the-tongue moments, but these experiences were not associated with actual memory problems. The study suggests that these frustrating occurrences are largely independent of each other.
A Johns Hopkins-led analysis suggests that taking certain blood pressure medications may reduce the risk of dementia due to Alzheimer's disease by at least 50 percent. The study found that diuretics and ACE inhibitors were associated with a reduced risk in people over 75 with normal cognition.
Researchers found significant cortical thinning and subcortical atrophy in Parkinson's patients with mild cognitive impairment, indicating faster neurodegeneration. This pattern may serve as a predictor of dementia in PD patients in the future.
A 40-year study of Swedish women found that experiencing multiple stressful life events in mid-life increases the risk of developing dementia in late life. The research, published in BMJ Open, suggests that stress management and behavioral therapy may help mitigate this risk.
A University of Michigan study explores how divorce and remarriage impact caregivers, finding that adult stepchildren can be a source of stress. The research highlights the need for tailored interventions to address the unique needs of re-partnered older adults in complex family situations.
Researchers found that patients with pre-existing dementia who developed delirium while hospitalized had a 25% chance of dying within 30 days. Early detection and treatment of delirium can improve patient functioning and reduce mortality rates.
A review of 8 trials found no long-term benefits from cognitive enhancers like donepezil and rivastigmine for patients with mild cognitive impairment. These medications were associated with increased nausea, diarrhea, vomiting, and headaches, but no cognitive improvement.
A study of residents in Olmsted County, Minn., over 15 years found the incidence of dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) to be higher among older adults. The study also identified age-related increases in both DLB and PDD rates.
Researchers link brain atrophy to cognitive decline in Type 2 diabetes, challenging previous assumptions. Brain atrophy is found to be the primary cause of cognitive impairment associated with T2DM, exceeding cerebrovascular lesions.
Experts warn that UK and US policies to screen for pre-dementia may lead to unnecessary investigation and treatment. Up to 65% of people aged over 80 may be incorrectly diagnosed with Alzheimer's disease.
A Loyola University Chicago Stritch School of Medicine study found that a fish oil compound protected brain cells from inflammation and cell death in rats exposed to high levels of alcohol. This finding could support the use of fish oil as a potential preventive measure for alcohol-related dementia.
A study published in Neural Regeneration Research found that resveratrol improved learning and memory ability in rats with vascular dementia. The compound also reduced malonyldialdehyde levels and increased superoxide dismutase activity and glutathione levels, indicating a potential therapeutic effect.
A systematic review of 12 studies confirms a positive impact on cognitive function associated with higher adherence to a Mediterranean diet. However, results for mild cognitive impairment are inconsistent, highlighting the need for further research.
A large-scale study of 1 million patients found that high-dose statin use was associated with a significant reduction in the risk of developing dementia. The protective effect of statins remained consistent across different age, gender, and cardiovascular risk subgroups.
Researchers at Gladstone Institutes and UCSF uncovered a molecular process causing neurons to degenerate, a hallmark of conditions like Alzheimer's disease and frontotemporal dementia. The study used human stem cells with genetic mutations, allowing for the comparison of diseased and healthy neurons.
Patients with dementia have a higher rate of urinary and fecal incontinence diagnoses, which can affect treatment decisions. The study analyzed data from 54,816 people with dementia and found that those with both dementia and incontinence were more likely to receive medications and indwelling catheters.
A Canadian sculptor's artistic abilities remained intact despite advanced vascular dementia, according to a new study. The artist, Mary Hecht, was able to draw spur-of-the-moment and detailed sketches from memory, showcasing cognitive reserve in the brain.
A new scoring system developed by researchers allows clinicians to predict the risk of dementia in older people with type 2 diabetes. The scores are based on six health complications, education, and age, accurately predicting patients' risk of developing dementia.
Researchers created the first risk score predicting 10-year dementia risk for type 2 diabetes patients based on medical history and electronic health records. The Diabetes-Specific Dementia Risk Score assigns a value to eight predictive factors, including microvascular disease and diabetic foot.
A study found that only half of the identified ethical issues in dementia care were addressed in national clinical practice guidelines. Four critical issues, including advance directives and coercive medication, were consistently overlooked. The authors emphasize the importance of addressing these issues to improve patient care and pro...
Researchers developed a test to measure the ability to recognize and name famous people, finding that those with early onset dementia performed significantly worse on the test. The study also found correlations between brain tissue loss and difficulty in recalling names or faces.
Researchers developed a new test to identify early-onset dementia in individuals aged 40-65 using face recognition tests, distinguishing between name and facial recognition. The study found significant differences in brain tissue loss between those with and without dementia, providing valuable insights into cognitive impairment.
Researchers found nine risk factors, most associated with adolescence, account for most cases of young-onset dementia. These include alcohol intoxication, stroke, depression, and low cognitive function at conscription.
Researchers have discovered that L-3-n-butylphthalide can improve cognitive function and protect nerve cells in animal models of vascular dementia. The compound has been shown to activate the Akt kinase pathway, suggesting its potential as a new treatment option for vascular dementia.
A study of over 2,000 patients aged 65+ found a strong association between higher blood sugar levels and increased dementia risk. Higher glucose levels were linked to a 40% increased risk in people with diabetes.
A study published by the American Academy of Neurology found that anemia is associated with a nearly 41% higher risk of developing dementia. People with anemia at the start of the study were more likely to develop dementia over 11 years.
A recent study found that over 90% of dementia cases in China are undiagnosed, with a high level of undiagnosed dementia in rural areas. The study highlights the need for improved mental health education targeting high-risk populations to increase diagnosis rates.
Research published in BMJ Open suggests that ACE inhibitors slow cognitive decline typical of dementia, even boosting brain power in patients. Compared to those not taking these drugs, patients on ACE inhibitors experienced marginally slower rates of cognitive decline.
Researchers found that ginkgo biloba extract EGb761 promoted and prolonged the proliferation of neural stem cells in rats with vascular dementia. The treatment significantly improved learning and memory in these animals.
A study found that many family caregivers of older adults with dementia are willing to consider stopping cancer screening, which can reduce patient burden, healthcare costs, and family caregiver distress. Caregivers are most open to discussions when focusing on quality of life and burdens and benefits for the person with dementia.
A meta-analysis of Chinese herbal medicines for vascular dementia found that these treatments appear to be safer and more effective than control measures. The studies suggest that Chinese herbal medicine has good potential in the clinic for treating vascular dementia.
A study by Rhode Island Hospital researchers found that caregivers of people with Alzheimer's and other forms of dementia can benefit from tailored interventions. The factors contributing to caregiver burden include direct impact on their lives, feelings of guilt, frustration, or embarrassment.
Experts from NYU Langone Medical Center will present new research on advanced treatments for neurodegenerative diseases, including Alzheimer's disease. The Comprehensive Center on Brain Aging is devoted to research and clinical advances toward the treatment and cure of all neurodegenerative diseases.
New data presents promising evidence for novel therapies targeting hippocampal neurogenesis and adrenergic receptors in Alzheimer's patients. Computerized cognitive tests show potential in improving attention and memory in Parkinson's disease dementia and dementia with Lewy Bodies.
New research suggests that dementia prevalence in the UK has fallen from 8.3% in 1991 to 6.5% in 2011, a reduction of 24.1%. This decline is attributed to lower rates among women and no change in prevalence among men.
Researchers at Neuroscience Research Australia discovered that the orbitofrontal cortex plays a key role in linking emotion and memories in frontotemporal dementia patients. This finding explains why FTD patients struggle to recall emotionally charged events, highlighting new potential for diagnostic tools.
A new University of South Florida study explores the relationship between caregiver sleep and heart disease, testing an innovative night monitoring system to improve sleep quality and overall health. The research seeks to determine if better sleep can lower the risk of heart disease in caregivers caring for people with dementia.
A recent Penn study found a significant association between cerebrovascular disease and dementia, particularly in younger patients with Alzheimer's disease. The researchers suggest that early management of vascular risk factors and healthy lifestyles may delay or prevent the onset of dementia due to Alzheimer's and Parkinson's disease.
A recent UCLA-led study highlights the crucial role nurse practitioners play in treating chronic geriatric conditions. Nurse practitioners were found to improve the satisfaction of quality indicators for patients with falls, urinary incontinence, dementia, and depression when co-managed with primary care physicians.
A creative storytelling program called TimeSlips helps medical students see people with dementia as fully-fledged individuals, rather than just diagnoses. The program, which encourages participants to use their imagination and share stories in poem form, leads to significant improvements in student attitudes towards dementia patients.
A new web-based intervention, Family-Health Information Management System (Family-HIMS), aims to enhance caregiving management for dementia patients and their Hispanic caregivers. The system will be designed and tested with English- and Spanish-speaking family caregivers to address unique needs and stressors.
Researchers found hospitalization for severe hypoglycemia doubled dementia risk, while dementia patients experienced twice as likely severe hypoglycemic events. Cognitive impairment may lead to poor diabetes management and worse health.
Researchers from U-M and Johns Hopkins will create a web-based tool called WeCare to track, understand, and treat behavioral symptoms of dementia. The goal is to improve caregiver skills and provide tailored strategies for in-home care, aiming to reduce stress and burden on families.
A study of 783 older adults with diabetes found a two-fold increased risk for dementia among those experiencing hypoglycemia events. Clinically significant hypoglycemia was also associated with a greater risk for subsequent severe hypoglycemic events.