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Decoding fear: KAIST identifies an affective brain circuit crucial for fear memory formation by non-nociceptive threat stimulus​

A KAIST research team has identified a key neural pathway involved in forming fear memories triggered by psychological threats. The pIC-PBN circuit processes psychological distress and drives fear memory formation, offering a significant advance in understanding how psychological distress is processed.

SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalScience Advances·TypeMeta-analysis·DateMay 19, 2025

How the brain allows us to infer emotions

Researchers have identified the medial prefrontal cortex (mPFC) as the basis of emotional inference in animals and humans. In a study published in Nature, Xiaowei Gu and Joshua Johansen found that rats can learn inferred emotions by associating a neutral stimulus with an unpleasant experience.

SourceRIKEN·JournalNature·DateMay 14, 2025

Mouse memory hinges on a nine-letter protein fragment exclusive to neurons

Researchers at the Center for Genomic Regulation discovered a nine-letter microexon in DAAM1 exclusively in neurons that is critical for neuronal development and memory. Deleting this microexon in mice resulted in reduced learning spines and impaired memory function, with animals remembering roughly 40% less in standard memory tasks.

SourceCenter for Genomic Regulation·JournalNature Communications·TypeExperimental study·DateMay 13, 2025

Long working hours may alter brain structure, preliminary findings suggest

Preliminary research suggests that long working hours can induce neuroadaptive changes in the brain, particularly in areas associated with emotional regulation and executive function. The study found increased brain volumes in regions such as the middle frontal gyrus, which is involved in attention and problem-solving.

SourceBMJ Group·JournalOccupational and Environmental Medicine·TypeExperimental study·DateMay 13, 2025

The pupil as a window to the sleeping brain

Researchers at ETH Zurich discovered that pupil dynamics is related to specific patterns of brain activity and arousal levels, contradicting previous assumptions about low arousal during sleep. The study uses pupil measurements to monitor brain activity in humans for the first time.

SourceETH Zurich·JournalNature Communications·DateMar 5, 2025

Rice researchers examine why people remember certain things and not others

Researchers Fernanda Morales-Calva and Stephanie Leal explored the three Ws of memory - what, where, and when - to understand why people remember certain things. They found that emotional content, personal significance, repetition, and attention can influence memory retention. The study highlights the importance of considering individu...

SourceRice University·JournalCognitive Affective & Behavioral Neuroscience·TypeLiterature review·DateDec 6, 2024

Can everyday physical activity improve cognitive health in middle age?

A new study found that middle-aged people who engage in everyday physical activity show improvements in cognitive processing speed, which can counteract the natural decline in cognitive abilities with age. The study, led by Penn State researcher Jonathan Hakun, used ecological momentary assessment to track participants' daily activitie...

SourcePenn State·JournalAnnals of Behavioral Medicine·TypeObservational study·DateNov 12, 2024

Can a positive outlook on aging lead to better cognitive performance?

A new study published in the journal Aging & Mental Health found that people with more positive expectations of aging tend to report less frequent cognitive problems and are less likely to perceive a decline in their cognitive performance over time. Researchers suggest that modifying older adults' aging expectations could support healt...

SourcePenn State·JournalAging & Mental Health·TypeSurvey·DateOct 29, 2024

Fearful memories of others seen in mouse brain

Researchers found that the hippocampal CA2 region helps mice distinguish between safe and threatening social interactions, with implications for understanding social anxiety and post-traumatic stress disorder. The study suggests targeting this brain region could aid in diagnosing or treating disorders linked to a fear of others.

SourceColumbia University·JournalNature Neuroscience·TypeExperimental study·DateOct 15, 2024

Autobiographical memory in the digital age: Our lives in the mirror of our data

Researchers explore the influence of digital resources on autobiographical memory, highlighting its potential benefits, such as supporting people with memory difficulties, and risks, like manipulation through deepfakes. The study aims to better understand the interplay between recorded data and memories stored in our minds.

SourceUniversity of Würzburg·JournalPsychological Inquiry·TypeCommentary/editorial·DateOct 7, 2024

Memory problems in old age linked to a key enzyme, study in mice finds

A team of researchers from Penn State has identified HDAC3 as a key contributor to age-related impairments in memory updating. When blocked, older mice performed similarly to their younger counterparts, suggesting potential therapeutic targets for improving cognitive flexibility in old age.

SourcePenn State·JournalFrontiers in Molecular Neuroscience·TypeExperimental study·DateAug 9, 2024

Many children with symptoms of brain injuries and concussions are missing out on vital checks, national US study finds

A national US study found that nearly a quarter of children with symptoms of brain injuries or concussions were not checked for the condition. Younger children were more likely to be overlooked. Routine checks can help ensure these children receive necessary care and support their mental and social well-being.

SourceTaylor & Francis Group·JournalBrain Injury·TypeSurvey·DateApr 26, 2024

Yoga provides unique cognitive benefits to older women at risk of Alzheimer’s disease, study finds

A UCLA Health study suggests Kundalini yoga can improve cognitive function, memory and brain health for postmenopausal women. The study found that yoga prevented brain matter decline, reversed aging and inflammation-associated biomarkers – improvements not seen in a group who received standard memory training exercises.

SourceUniversity of California - Los Angeles Health Sciences·JournalTranslational Psychiatry·TypeRandomized controlled/clinical trial·DateFeb 26, 2024