Researchers developed an interactive 3D molecular model of GRK2, a crucial regulator of neurotransmitter and hormone receptors. The model allowed scientists to interact with the molecular structure, facilitating the identification of new lead compounds as inhibitors of GRK2.
The Neisseria meningitidis genome contains hundreds of repetitive elements that facilitate genome fluidity and antigenic variation. The most abundant element is the neisserial DNA uptake sequence, which enables transformation among different species.
A study by Ulf Dimberg found that facial muscle activity can be spontaneously evoked without conscious awareness, suggesting subconscious emotional communication. The results support the theory that important aspects of face-to-face interaction can occur on a subconscious level.
Tiny gold nanoclusters exhibit distinctly chiral properties, dramatically affecting polarized light absorption. The clusters' unique structure and conduction electron circulation produce a helical effect comparable to naturally-helical structures.
Scientists at the University of Chicago have discovered exactly how beta-lactamase deactivates penicillin, a crucial step in understanding the mechanism of resistance. This breakthrough could lead to improved antibiotic design and help combat hospital-acquired infections caused by resistant bacteria.
The University of Pittsburgh has developed a new organ culture model to study HIV transmission in women, which could lead to breakthroughs in barrier medications and prevention strategies. The model, described in the journal Nature Medicine, closely mimics the stratified cell layers present at sites of sexual transmission in women.
Researchers at Rockefeller University have discovered an immune-cell mechanism that boosts the potency of therapeutic antibodies. The finding could lead to more effective cancer treatments by manipulating the interaction between antibodies and Fc receptors on immune cells.
Researchers at Cornell University have identified and cloned a key gene in the reproductive system of male cockroaches, which could lead to the development of safe and effective birth control. The goal is to create a pesticide that specifically targets pests without harming other insects or humans.
A study by Duke University psychologists found that specific drugs for treating AIDS, heart disease, and depression have foul or bitter tastes that can stop patients from taking their medication. This phenomenon affects not only nutrition but also mood and well-being.
A University of Toronto study has shown that botox injections can effectively relieve headache pain, especially for patients with neck-related headaches. The treatment group experienced a substantial reduction in pain and improvement in range of motion after just four weeks.
Researchers at Virginia Tech have created a gel that allows women to control their fertility and reduce the risk of infection from HIV, yeast infections, and other STDs. The acylcarnitium analog, Z-15, has demonstrated in vitro effectiveness as a spermicide and inhibits multiple STDs.
The 96th Annual Meeting of the Association of American Geographers features presentations on various topics, including urban heat islands, research with blind pedestrians, and analysis of divorce trends. The meeting highlights innovative technologies to aid visually impaired individuals and explores population growth patterns in small ...
Researchers found that individuals with severe mental illnesses can achieve long-term residential stability when given access to safe, affordable housing linked to outpatient services. Substance abuse was a major factor in disrupting residential stability, highlighting the need for new strategies to improve housing alternatives.
The South Central Section of the Geological Society of America will explore the effects of animal waste on groundwater quality. Scientists will present studies on the survival rate of bacteria in groundwater, hydrogeologic investigations revealing interbasin recharge's impact on nutrient loads.
A new research center at the University of Michigan will study new ways to see cancer using sophisticated medical imaging technology, including MRI and PET scans. The center aims to improve diagnosis and treatment by spotting important molecular events during cancer growth, potentially laying the groundwork for new therapies.
Researchers at the University of Toronto found that teasing young girls about their weight can lead to serious eating disorders, poor body image, and distorted eating patterns. The study involved approximately 100 girls in grades seven and eight from schools in Kitchener and Waterloo areas.
Researchers at USC found no significant change in average sperm count over three decades, contradicting previous studies. Sperm abnormalities were common, but did not impact overall fertility.
Researchers are studying reading development in young twins to understand the environmental and genetic influences on early reading skills. The CU-Boulder portion of the project aims to identify factors that contribute to reading difficulties in preschool children.
Dr. Guoray Cai's research highlights the importance of considering geographical space in understanding cyberspace. The study found that variations in access bandwidth can generate feelings of distance due to faster communication channels, and existing infrastructure biases towards certain categories of consumers.
Studies found that individuals with major depressive episodes and borderline personality disorder are at greater risk of suicide, while those with high serum cholesterol experience a doubled risk of violent suicide. Comprehensive mental health care is essential to address these co-existing illnesses.
The Ecological Society of America has released three new publications on biodiversity, biotic invasions, and forest management. The reports provide insights into how changes in ecosystems affect productivity, stability, and environmental damage. The ESA also offers expert advice for managing U.S. National Forests sustainably.
A new method devised by Purdue engineers can prevent disconnections for roaming cell phone users by allowing two adjacent cells to share channels, ensuring a continuity of service as a caller travels from one cell to the next. This technique could increase network efficiency by up to 60% and reduce disconnections by up to 100 times.
A new longitudinal study by UW researchers predicts marital stability with 87% accuracy, helping therapists diagnose marriage issues. The Oral History Interview explores a couple's relationship history and global perceptions of their marriage.
Researchers have found that CD8 cells can stop human immunodeficiency virus (HIV) in its tracks even when added to infected CD4 cells. This finding suggests a new approach to controlling the spread of HIV and could lead to potential therapeutic strategies.
A study published in Molecular Psychiatry reveals that individuals with schizophrenia, bipolar disorder, and major depression have lower levels of a certain brain protein, leading to less 'plastic' brains. Researchers hope to improve current therapeutics by targeting the cascade of events responsible for phosphorylating this protein.
Researchers at Washington University in St. Louis have developed new theoretical calculations on how life might have arisen from volcanic gases on Earth and other celestial bodies. The calculations suggest that environmental and chemical conditions are ripe for basic hydrocarbons to form, potentially leading to the emergence of life.
Scientists have identified a tobacco compound that may explain why smokers are less vulnerable to Parkinson's disease. The naphthoquinone derivative works by interfering with an enzyme in the brain that breaks down neurotransmitters.
Long-term methamphetamine abuse can cause permanent brain cell damage, similar to Alzheimer's disease and stroke. The study found reduced levels of N-acetyl-aspartate and increased levels of myo-inositol and choline-containing compounds in the brains of abusers.
A new synthetic rubber material has been developed that kills bacteria, viruses, and fungi on contact, making it ideal for medical supplies and consumer products. The material uses a different mechanism to fight infection than conventional coatings and protective plastics.
Cornell University materials engineers have created a polyvinylalcohol (PVA) nanocomposite that can be used to deliver drugs to the human brain or bloodstream. The material, with chains of polymer molecules controlling drug flow, has potential applications in tissue engineering and enzyme carriers.
Researchers are developing new compounds, including epothilones and bryostatins, derived from natural products to inhibit cancer growth. Vaccines targeting tumor-specific antigens are also being explored to prevent recurrence after conventional treatment.
Research has revealed that pharmaceuticals and personal care products can contaminate groundwater, rivers, and sewage, posing significant risks to human health and the environment. Studies have shown that these substances can enter the aquatic food chain, affecting marine life, and are also found in human tissues and breast milk.
Researchers are developing a bioartificial liver that can filter blood toxins and provide temporary support for patients with severe liver failure. The device is being upgraded with freshly isolated pig liver cells and a pulsating bioreactor to improve performance, and the first human clinical trials are scheduled to begin soon.
The tortoise beetle uses its own feces to create a shield that deters most predators, but one predator, the carabid beetle, can penetrate it. The larvae attach fecal strands to their bodies and repair them if damaged, creating an almost impenetrable defense mechanism.
Researchers are exploring alternative methods for delivering drugs, including handheld electronic inhalers, dry powder injection and implantable microchips. These innovative systems have the potential to deliver precise doses of medication in a faster and more efficient manner than traditional hypodermic needles.
Missouri has officially designated the life sciences industry as one of its Lead Industries to promote economic development and growth. The state is home to over 100 life sciences companies, with research funding from the National Institutes of Health increasing by 46% between 1995 and 1999.
The Mid-Atlantic Regional Assessment of climate change impacts identifies severe consequences for the region's population and ecosystems. The study finds that rising temperatures, sea-level rise, and extreme weather events will have devastating effects on agriculture, water resources, and coastal communities.
Researchers explore biotechnology for healthier foods, enzymes for proper digestion, rapid pathogen detection, and advanced packaging materials. These advancements aim to delay chronic disease, improve mental and physical performance, and enhance food safety.
Scientists report new evidence for the origin of life, including homochirality in meteorite compounds and 1,4-naphthaquinone formed through early solar system chemistry. The discovery may shed light on the start of life on Earth and potentially finding remnants of life on Mars, Europa, and other extraterrestrial bodies.
Purdue University researchers develop a technique for machining brittle ceramic materials using heat from a laser, reducing costs and increasing precision. This method can cut in half the cost of making components for the growing $10 billion U.S. market, enabling more complex geometries and lower manufacturing costs.
Scientists at Georgia Tech have developed a recipe book to precisely control the size and magnetic properties of magnetic nanoparticles. This allows for consistent application in drug delivery, MRI contrast enhancement, and cancer detection.
A new study from Toronto researchers has found a way to more accurately predict the cognitive recovery of severe head injury patients. By combining predictive methods with factors such as age and duration of unconsciousness, doctors can now make more informed decisions about patient discharge, reducing the risk of premature discharge.
A Purdue University researcher has developed a soy-based feed for farm-raised fish, reducing phosphorus and nitrogen excretion and minimizing pollution. This alternative feed is expected to meet growing demand in the aquaculture industry, which is struggling with declining wild fish populations.
New single-molecule magnets have been discovered by Indiana University researchers, offering a promising solution for increasing the density of digital information in hard drives and other devices. The breakthrough could enable storage densities up to 30 terabits per square centimeter, surpassing current bests.
Researchers at Virginia Tech are developing new proton exchange membrane (PEM) materials for fuel cells, which can operate at higher temperatures and improve efficiency. The materials being developed have demonstrated better results than existing materials in terms of heat tolerance.
Researchers at Cornell University have developed a standard spectrum of smell to identify individuals with specific anosmia, which can distort data in sensory research labs. The new approach uses gas chromatography olfactometry to categorize people into three sensitivity levels: hyperosmic, hyposmic, and anosmic.
A new study found that adolescents from different ethnic groups share similar levels of illegal drug use with their friends. The study suggests that historical and cultural circumstances may influence the selection of friends, but not to an extent that identical friends are avoided.
Scientists discovered how ecdysone initiates a biochemical cascade controlling genes that destroy salivary gland tissues during Drosophila metamorphosis. The study reveals key components of the 'death cascade' and suggests potential connections to mammalian cell death programs.
The Drosophila melanogaster fruit fly genome has been sequenced in full, with a focus on physical maps to ensure accuracy. The completion of the genome sequence is significant, as it reveals connections between fruit fly and human genes, offering insights into diseases such as cancer, kidney disease, and metabolic disorders.
Researchers at the University of Glasgow have identified a complex of proteins that activate cell growth and division protein E2F, leading to excessive cell division and cancer. This breakthrough provides an opportunity to develop small molecule drugs that can arrest E2F activity and prevent tumour cell proliferation.
The Drosophila genome sequence has been completed, providing valuable insights into human diseases and animal development. The sequence data reveals homologues for 60% of known genetic flaws causing disease in humans and 70% of genes involved in human cancers.
Researchers at Virginia Tech found that the amount of lead in the environment from bullets on battlefields is not a significant concern for water quality, with no contamination detected off range. However, they discovered that shot impacts cause significant damage to trees up to 140 meters beyond the range.
The Manatee Protection System uses acoustic sensors to detect manatees in the Port Canaveral locks, preventing collisions and saving their lives. The system's advanced technology, developed by ONR-supported scientists, has already saved five manatees during installation and early testing.
A new study suggests that mothers' depression may cause their daughters to enter puberty earlier. Researchers found a correlation between maternal depression and the timing of puberty in adolescent girls. The study also discovered a link between exposure to unrelated adult men, such as stepfathers, and early puberty in girls.
Researchers studying clumsy fruit flies have identified a central component of the sensory machinery that underlies balance, touch and hearing. They discovered a molecule called an ion channel, which is pried open when a bristle is deflected, triggering a nerve impulse.
Researchers at Cold Spring Harbor Laboratory uncovered a new link in the molecular chain of events thought to underlie learning and memory. Strengthening of nerve cell connections can be largely explained by the movement of AMPA receptors into synapses.
Researchers found that diabetics under specialist care had significantly lower blood glucose levels and higher participation in self-care practices. The effect was particularly notable among patients with lower education levels.
A new study found that hospital distress, particularly depression and anxiety, can predict poor heart attack outcomes and quality of life. Distressed patients reported more chest pain, poorer overall well-being, and increased healthcare usage.
Researchers have created a fly model of Parkinson's disease, replicating the dense protein inclusions and symptoms of the disease. The flies exhibit loss of dopamine-producing neurons and motor deficits, similar to those found in humans, making them an ideal model for testing new drugs and therapeutic approaches.
A new study by the Gladstone Institute of Neurological Disease and UCSF team found that apoE3 can inhibit memory problems associated with Alzheimer's disease, while apoE4 cannot. This discovery could lead to the development of new drugs simulating apoE3's protective quality.