Scientists at Cold Spring Harbor Laboratory develop a new method to set the level of gene activity in stem cells using RNA interference, revealing distinct forms of lymphoma based on p53 levels. The study establishes RNAi as a convenient alternative to traditional gene knockout strategies.
Researchers found that the arginine variant of p53 is more efficient at killing cells and travels out of the nucleus to function in the mitochondria. This discovery could lead to personalized cancer treatment by tailoring therapy based on a patient's p53 variant type.
Researchers at Duke University Medical Center have found that oxygen levels play a crucial role in transforming adult stem cells from fat into cartilage cells. Under low-oxygen conditions, the stem cells differentiate into chondrocytes, which can potentially repair damaged cartilage.