Miller develops accurate chemical models by simulating traffic flow and manipulating equations to predict real-world outcomes. He aims to use these models to save laboratory time, money, and point to new avenues of research.
Reider's innovative method of integrating drug discovery and development led to the rapid approval of life-saving treatments, including indinavir and Singulair. His approach prioritized getting effective drugs to patients faster, despite acknowledging the risks involved.
Hancock's pioneering work on separating proteins using HPLC has significantly contributed to understanding complex disorders like cancer and Alzheimer's disease. His research utilizes mass spectrometry to analyze protein fragments and identify patterns in blood, paving the way for personalized medicine.
High levels of AIB1 expression in breast cancer tumors are associated with poorer tamoxifen treatment outcomes. Patients with both high AIB1 and HER-2 expression have significantly worse disease-free survival compared to other patient groups.
A study found that adding an extra hour of sleep to children's daily routine significantly improved their neurobehavioral functioning, including finger-tapping speed and reaction time. In contrast, reducing sleep by one hour had the opposite effect, with decreased night-wakings and increased percentage of sleep.
A study of wild black bears found that they recover from bone loss caused by inactivity through a mechanism involving increased bone formation during remobilization. This suggests that hibernating bears may minimize bone loss and completely recover lost bone, providing potential insights for treating osteoporosis.
Scientists have discovered a possible acceleration of type 1 diabetes in proinsulin 2-deficient non-obese diabetic mice, while promoting lymphangiogenesis as a potential treatment for lymphedema. Additionally, researchers found that CD44 is involved in the binding and uptake of Mycobacterium tuberculosis, suggesting its role in tubercu...
Dalton's research team has developed new theory about the chemical behavior of solids, leading to innovative materials with effortless conversion capabilities. These materials have applications in intelligent sensors, remote monitoring, and medical diagnosis, as well as routing information on mobile military platforms.
A study found that higher plasma folate levels were associated with lower risk of breast cancer, while higher plasma vitamin B6 levels increased breast cancer risk. Plasma vitamin B12 levels inversely associated with breast cancer risk among premenopausal women. Cystic fibrosis patients may have an increased risk of digestive tract can...
Jacox, a leading expert on free radicals, has been recognized for her contributions to spectroscopy. Her work reveals the importance of free radicals in driving chemical reactions and understanding their role in various molecular processes.
Researchers at Indiana University School of Medicine have localized the original mineral deposit site for most common stone formers and determined the composition of calcium phosphate crystals. This discovery refutes current theories on kidney stone formation, shedding new light on the disease's complex physiology.
Warner, a Baton Rouge chemist, has won a national award for his efforts to mentor minority students in chemistry. He has opened his laboratory to high school, college, and bachelor's level students, providing them with hands-on experience and inspiring them to continue formal studies in science.
Researchers have developed the first mathematical theory for RNA's possible states, showing that high temperatures allow it to fold into many shapes, while low temperatures cause it to collapse. This discovery has implications for understanding protein folding and the role of RNA in early life.
A renowned chemist at UC Berkeley has won a national award for his groundbreaking work on soft contact lens design. His research focuses on developing safer, more comfortable, and effective lenses through advanced materials and computational modeling.
A Rochester chemist has developed a new method to activate hydrocarbons directly with small, extremely reactive metals, cutting out an inefficient middle step in the process. This breakthrough could lead to more efficient production of plastics and other products.
Dr. Lerman received the Parsons Award for her tireless efforts to bring Chinese dissident Fang Li-Zhi to safety after the Tiananmen Square crackdown. She also developed an innovative science teaching method at Columbia College using dance, empowering underprivileged students.
USC researchers have discovered an oral cancer drug, zebularine, that can reactivate silenced genes and reduce tumor size in mice. The study found that zebularine is effective in both intraperitoneal and oral administration routes.
The study found that 50% of patients started taking dietary supplements, 40% made dietary changes, and 20% began new physical activities. Lifestyle changes were common among cancer patients up to two years after diagnosis and were often associated with improved health and well-being.
Roth's discovery led to the development of Lipitor, which has logged more than 36-million patient years of experience and involved over 400 clinical trials. His innovative approach to statin structure resulted in a simpler molecule with equal efficacy.
Beauchamp's team has developed a method to trap only molecules with certain shapes, allowing for the analysis of specific proteins in complex mixtures. This breakthrough technique enables chemists to detect and analyze unique protein patterns, holding promise for applications such as detecting HIV infection.
A Rutgers University chemist has developed innovative solid-state materials with broad applications, including sensors. Her research also addresses critical manufacturing needs, such as humidity control.
A Pennsylvania chemist has won a prestigious national award for his groundbreaking work on peptides, which have the potential to revolutionize the treatment of neurological conditions. The researcher designed lactams, chemical bridges that stabilize peptides and make them less digestible to enzymes.
A University of Michigan professor has developed a new sorbent material that can selectively remove sulfur from gasoline and diesel fuel, a key step in reducing acid rain. The innovative technology could help industries meet upcoming federal standards by reducing reactor sizes and energy consumption.
Researchers are using Arabidopsis plant mutants to study salt stress in plants and potential connections to HIV research. Mutants with altered genes have been identified, offering insights into the mechanisms behind these complex conditions.
Robeson, a chemical engineer, has developed numerous polymers to solve problems, including an orthopedic splint compound that molds at body temperature and reduces scarring by 95 percent. His work also includes flame-retardant materials for televisions, aircraft interiors, and camera housings.
Indoxacarb, a new crop-protection insecticide, blocks nerve membrane channels, making it effective against insects like the Helicoverpa armigera caterpillar. Developed by a team of chemists, indoxacarb breaks down rapidly in the environment, reducing its impact on crops and the ecosystem.
Nuzzo and colleague David L. Allara developed stain-repellent coatings, lubricants that cling in harsh weather, and materials for artificial hearts and protein protection. Their discovery attached molecules to gold surfaces, changing interactions with other substances.
Birks, a renowned Boulder chemist, has won the ACS Award for Creative Advances in Environmental Science and Technology. He is developing smaller instruments to measure atmospheric gases using balloons, which may have medical benefits, such as tracking nitric oxide levels for asthma treatment.
A yearlong study of 932 children found that emotional distress can lead to negative views of oneself and the world, ultimately decreasing perceptions of competence. Children tend to blame themselves for failures and uncertainty in meeting performance standards, further exacerbating this issue.
A Texas chemist has won a national award for his work on vitamin B12, a natural product he has worked with for about 30 years. He is now working on recreating the pathway for taxol, an anti-cancer drug derived from yew trees.
Scientists found that elevated levels of sFlt1 protein mediate the progression to preeclampsia by reducing angiogenic factors. Reducing VEGF-A in kidney cells also caused similar kidney disease, suggesting a plausible scenario for preeclampsia
A Phase III randomized trial found that a combination of vinorelbine and gemcitabine did not improve overall and progression-free survival in elderly NSCLC patients. However, the study suggests that certain chemotherapy combinations, particularly cisplatin-based regimens, may be more effective than single-agent therapy. The results als...
Dr. Linhardt developed low-molecular-weight heparins, a type of anticoagulant that can be administered as daily shots, reducing hospital costs and improving patient outcomes. His research also aims to manufacture the drug in labs rather than harvesting it from animal tissue.
Researchers found that women with high levels of AIB1 and HER-2 proteins in their tumors are more likely to experience poor outcomes with tamoxifen therapy. When either protein level is low, the risk of adverse effects decreases significantly.
Chemist Denmark develops reactions to make mirror-image compounds with simpler, cheaper materials. His work impacts the pharmaceutical industry and improves access to essential substances.
Dixon's research uses computers to solve complex equations and predict the assembly of fluorine compounds, leading to the development of HFC 134A. His work also balances stability, safety, and environmental concerns in the creation of cost-efficient refrigerants.
Christensen studies carotenoids' role in photosynthesis, a process by which plants turn light into chemical energy. His work draws students to the basics of physical chemistry, influencing his teaching at Bowdoin College.
Ganguly's work involves designing drugs from natural molecules, targeting disease-causing compounds, and exploring new mechanisms of treatment. His notable achievements include developing Ziracin, a natural antibiotic, and Zetia, a cholesterol-lowering drug with a synergistic effect with statins.
Despite challenges, public support for devolution remains strong, with 43% of people backing the system. However, sectarian divisions and pessimism about community relations are on the rise, according to new research.
Researchers identified sFlt1 as the root cause of preeclampsia, a condition characterized by high blood pressure and organ damage. The study's findings hold promise for developing diagnostic tools and therapies for this deadly condition.
A two-year planning process in high-poverty neighborhoods with diverse communities was successful, while others lacked interest and leadership. Effective communication methods, community involvement, and strong ties to local churches were key factors in the most successful neighborhoods.
The Berkeley chemist has made significant contributions to understanding chemical reactions, including the discovery of the Bergman reaction. His work on intermediates has revealed their key role in chemical processes, with potential applications in fields such as medicine.
Computer modeling helps explain experimental results and predict successful reactions, leading to breakthroughs in understanding how new drugs work. Proline, a simple protein building block, was solved using computational methods after decades of uncertainty.
Manzer has led the development of commercially viable replacements for CFCs, including HFC 134A in automobile air conditioners. He also designed catalysts that can make polycarbonate without generating another ozone-depleting compound as a byproduct.
A Pacific Northwest chemist has developed increasingly selective methods to separate and analyze biological mixtures using capillary liquid chromatography and mass spectrometry. The techniques enable researchers to predict the effect of complex perturbations on biological systems, such as drug side effects and virus exposure.
Maryanoff, a renowned medicinal chemist, has developed topiramate, a successful drug approved in over 70 countries to treat epilepsy and other central nervous system disorders. His work also focuses on structure-based drug design, with recent breakthroughs in human clinical trials.
The US Fish and Wildlife Service has awarded Virginia Tech's Conservation Management Institute a contract to develop a national database for chronic wasting disease (CWD) research. The database will enable scientists to share information on the disease, improving their ability to address it nationwide.
Grubbs designs catalysts that target carbons in molecules, breaking open double bonds to form new materials with tailored properties for plastics or pharmaceuticals. The ACS Award for Creative Research in Homogeneous or Heterogeneous Catalysts recognizes his work in improving reaction rates and efficiency.
Walsh's research team has focused on developing selective antibiotics that target bacterial enzymes while leaving human ones intact. His work has helped design new variants of vancomycin, some of which are now in human trials to combat antibiotic-resistant bacteria.
Nicolaou and his graduate student Phil Baran have synthesized highly complicated compounds from a species of juniper, showing potential as cholesterol-lowering and anti-cancer drugs. The breakthrough was achieved in an international race to synthesize CP molecules, showcasing the team's expertise in organic synthesis.
Rochester chemist Rich Eisenberg has won a national award for his outstanding contributions to the field of inorganic chemistry, including advancements in artificial photosynthesis and flat-panel displays. His work has been recognized for its potential impact on energy production and electronic device technology.
Bodner's approach to teaching chemistry emphasizes the importance of understanding the underlying ideas and history behind chemical concepts. He has successfully developed a division of chemical education at Purdue, which has granted over 40 doctorate degrees to graduates who become chemistry professors or train future teachers.
Baran and his adviser K.C. Nicolaou led a team to synthesize CP molecules, a highly complicated compound with potential as cholesterol-lowering and anti-cancer drugs. Their innovative methods have also led to new techniques and tools for molecule synthesis.
A renowned chemist, Stang has made significant contributions to the field of petroleum refining, including the discovery of vinyl carbocations and self-assembly. His work has the potential to redefine the industry with its innovative compounds.
A study of 274 depressed patients found relatively low satisfaction with their care, particularly in treatment choices and follow-up care. The researchers also discovered that only a third of the patients received educational recommendations or materials to aid in managing depression.
Researchers at the University of Pittsburgh Cancer Institute are testing acupuncture's efficacy in alleviating symptom distress and promoting emotional well-being in terminally ill colorectal cancer patients. The four-year study will compare acupuncture, sham acupuncture, and usual care to determine its benefits.
Allara and Nuzzo developed a model that allows researchers to study how molecules arrange themselves on surfaces, packing tightly and responding to their environment. This discovery has been used to advance various fields, including the development of artificial hearts, lubricated surfaces, and complex plastics.
Los Angeles-based chemist Christe has developed a new form of nitrogen that can release large amounts of energy when decomposed, making it potentially useful for propulsion applications. The discovery, which was made in collaboration with his research team, is the latest breakthrough in Christe's ongoing work on energetic materials.
A St. Louis chemist has developed innovative methods to spin and shape atomic nuclei, which can affect their decay rates. His team has achieved incredibly fast spin speeds, such as 2 million-billion-billion revolutions per second, using specialized instruments.
Ford, a veteran teacher, has been recognized for her unique approach to teaching chemistry, which combines process-based learning with interactive activities to capture students' enthusiasm. Her efforts have led to numerous civic awards and recognition within the scientific community.
Researchers at Boston Children's Hospital found that providing extra nitric oxide through inhalation may reverse or stop vaso-occlusive crisis symptoms. The treatment reduced pain scores and morphine use in patients with severe sickle cell disease, warranting further investigation.
Theoretical chemist Schaefer wins the ACS Award for his groundbreaking work on simulating genetic material responses to electron bombardment. His research uses computer programs to derive new formulations and concepts, shedding light on complex chemical behavior and emerging properties of materials.
A study published in the Journal of Clinical Investigation reveals that M-CSF and alphaV beta3 integrin collaborate to regulate osteoclast differentiation. The discovery brings scientists closer to understanding the mechanisms behind osteoporosis, a condition affecting 50% of Caucasian and Asian women after age 65.
A Rutgers researcher has made a groundbreaking discovery that the brains of dyslexic children can be rewired to improve reading skills through intensive training. Dyslexia, affecting 5-10% of Americans, is characterized by difficulties in processing language.
Brookhart's research team has made new polymers by constructing metal catalysts that insert monomers in the middle of chains, resulting in branched polypropylene with improved properties. His work expands the range of available polymers, with several licensed for commercialization.
Researchers at UW-Madison developed a novel diamond film that can be used as a stable platform for biological sensing. The films have proven to be remarkably durable and can withstand multiple cycles of processing DNA, making them suitable for continuous monitoring in high-risk environments.
Buriak's innovative approach to semiconductor technology enables direct communication between molecular features and devices, allowing for new applications in drug delivery and biological interfaces. Her research has been licensed to a company for in vivo drug delivery, potentially enabling direct interaction with the brain.