Prostate cancer cell lines exhibit high levels of free radical damage and defective repair mechanisms, leading to a cascade of events culminating in further DNA damage and cellular dysfunction. The new research provides solid evidence for the critical role of free radicals and repair in prostate cancer development.
A new three-step process developed by NIST's Office of Applied Economics evaluates the vulnerability of facilities to terrorist threats, considering engineering, management, and financial strategies. The tool assesses the most cost-effective combination of risk reduction strategies to protect facilities from damages.
The study reveals that oysters' immune blood cells contain rhombohedral-shaped crystals used to form shell. The research aims to understand biomineralization for potential breakthroughs in medical and material sciences.
Children in poorer families face greater family turmoil, violence, instability and smaller social networks, living in more polluted and crowded environments with inadequate services. They attend underfunded schools and spend less time reading, watching fewer books at home.
Researchers at Purdue University have discovered self-assembling nanotubes that attach better to titanium-coated implants than uncoated ones, promoting new cell growth and potentially leading to longer-lasting artificial joints. The nanotubes offer promise in biomedical applications and could be tailored for specific parts of the body.
NIST's new reference material, calibrated microspheres coated with fluorescent dye, provides an authoritative national fluorescence measurement scale. This improvement enables more accurate measurements of signal intensity, reflecting numbers of target molecules in samples.
A study by UC Berkeley researchers found that even brief contact with wood or leaf litter increases the risk of tick exposure. Precautions such as avoiding prolonged contact and inspecting skin carefully are recommended for people frequenting endemic areas.
Researchers at Lawrence Livermore National Laboratory have developed a novel technique to quantify stratospheric ozone in the upper troposphere. This allows for better understanding of how much ozone is transported from the stratosphere to the upper troposphere, affecting climate and atmospheric chemistry.
The aquarium trade poses a significant threat to marine and freshwater ecosystems due to the introduction of invasive species. Experts recommend regulating the industry by listing safer alternatives and using bonds to cover potential damage costs.
Researchers have found that Earth's magnetic field reversal events occur within certain time-frames, regardless of the polarity of the reversal. The overall average duration is 7,000 years, but variation depends on latitude, with changes taking half as long at low-latitude sites.
A new experimental drug has shown to completely prevent arrhythmia-related deaths in mice with the same molecular defect as people with heart failure. The drug works by patching a leak in the heart's calcium channel, which can trigger fatal arrhythmias, and has great potential for slowing the progression of heart failure.
Researchers use X-ray detectors and rocket-triggered lightning to study lightning's complexities. They found that lightning flickers in X-rays at 10,000 times the speed of visible light, with X-ray energies extending up to twice those of a chest X-ray.
The web-based program calculates thermal radiation, seismic shaking, ejecta deposition, and air-blast effects based on user input distance from impact site. It provides detailed descriptions of damage severity, including ignition times for grass and wood, shaking intensity levels, and debris particle sizes.
A new study reveals that torcetrapib significantly increases levels of HDL cholesterol in patients with low levels, which can help reduce the risk of heart disease. The drug works by inhibiting the transfer of cholesterol from HDL to LDL, and its effectiveness is maintained when given in combination with a statin.
Indiana University professors Christopher Beckwith, Mary Ellen Brown, Ellen Ketterson, and Loren Rieseberg have been awarded the prestigious 2004 Guggenheim Fellowships. The grants will support their research on topics including bird sexual behavior, plant species evolution, and Central Eurasian history.
Researchers found that children taking additional zinc sulphate on a daily basis showed faster improvement in their ADHD symptoms compared to those taking a placebo. The study's results suggest a potential role of zinc deficiency in the pathogenesis of ADHD and highlight the need for further research.
A 10-year study found that laparoscopic surgery for colorectal cancer has the same prognosis as conventional surgery, with a 76% 5-year survival rate. The procedure resulted in shorter postoperative recovery times but longer surgery durations compared to conventional surgery.
A study found that large and rapid workplace expansions increase the risk of long-term sickness absence and hospital admissions. Moderate expansion, however, showed a decreased risk of hospital admission. The authors suggest centralisation of workplace functions as a possible cause.
Researchers have discovered the remains of a 9,500-year-old human-cat burial on Cyprus, providing the oldest known evidence of cat taming. The find, published in Science journal, suggests that humans may have begun taming wild cats earlier than previously thought, around 11,000 years ago.
Researchers have discovered that insect-derived antimicrobial peptides, such as pyrrhocoricin, can penetrate human dendritic cells and fibroblasts, potentially leading to new vaccine and immune therapies. The peptides are being explored as drug-delivery vehicles for peptide or peptide-based drugs that normally cannot cross cell membranes.
Individuals with first-time epileptic seizures after 60 years are three times more likely to experience a subsequent stroke. This increased risk justifies screening for vascular risk factors and treatment to prevent stroke in elderly patients with epilepsy.
Researchers have created a microgel that can recover costly enzymes, overcoming significant obstacles in using natural enzymes in laboratory and industrial settings. The microgel enables efficient enzyme recovery, allowing for repeated use in catalyzing commercially important reactions.
A new study by researchers at Case Western Reserve University has found that an abnormal form of the prion protein from one mammal species can infect another species, bypassing natural barriers. This discovery sheds light on the mechanisms behind prion diseases like mad cow disease and Creutzfeldt-Jakob disease.
Scientists discovered that rapid Arctic warming is releasing ancient carbon into the ocean. Researchers also found a correlation between plasmasphere rotation and Earth's rotation lag, which affects models simulating Earth's plasmaspheric dynamics. Additionally, new models of North Atlantic Ocean circulation can now be run on personal ...
Astronomers have successfully detected their first two near-Earth asteroids (NEAs) using a refurbished telescope at the Australian National University's Siding Spring Observatory. The discoveries, made on March 29, include an 100-meter and 300-meter asteroid that pose no direct threat to Earth.
Alpine tree lines are shifting up-slope due to global warming, threatening regional plant populations. The study suggests that pine trees could help protect drinking water catchments from erosion and pollution in the City of Vienna.
Researchers at U.Va. Health System devise method to extract membrane proteins by using chemicals that allow them to be reversibly folded and refolded. This allows for structural and functional studies of the proteins using crystallography or nuclear magnetic resonance imaging.
A new study found that only 2% of patients who experienced an allergic-like event after the first penicillin prescription had another reaction, despite previous estimates suggesting a 60% rate. The researchers suggest that some patients labeled as penicillin-allergic can safely receive the antibiotic in emergency situations.
Scientists have found that magnetic field reversal events occur within certain time-frames, regardless of polarity, with an average duration of 7,000 years. The variation in duration is influenced by latitude, taking half as long at low-latitude sites compared to mid- and high-latitude sites.
A study published in Neuron found that a lack of RIM1 alpha protein leads to profound deficits in learning and memory, impacting mice with symptoms similar to schizophrenia. The discovery offers insights into the molecular events underlying learning and memory processes.
Michelle Edwards, a UH College of Pharmacy student, took first place in the Patient Counseling Competition at the American Pharmacists Association (APhA) national convention. She demonstrated exceptional ability to communicate under pressure and will receive $1000 and an all-expense-paid trip to judge the 2005 competition.
A study found 16 non-native species of fish in ocean waters off the southeast coast of Florida, released from home aquariums. Aquarium owners are often unaware of the potential pitfalls of releasing pets into the wild, and education programs can help curtail exotic species introductions.
Researchers analyzed data from 96,545 galaxies to track star formation history. They found that massive galaxies formed stars earlier than smaller ones, and star formation has decreased since then, contributing to the gradual dimming of the universe.
Research suggests that sloths expel larger particles more efficiently than expected, potentially due to unique digestive adaptations. This study challenges the conventional wisdom on sloth behavior and highlights the importance of considering the interplay between resting posture, digestive anatomy, and ingesta characteristics.
A recent analysis of 11,633 species published in Nature found that more than 300 critically endangered species are completely unprotected. The study emphasizes the need for a major shift in conservation strategies to prevent large-scale species extinctions over the next few decades.
Rett Syndrome researchers successfully introduced the 'Rett protein' into post-mitotic neurons, reversing symptoms in mice. This breakthrough could pave the way for new treatments and potentially even cures for Rett Syndrome, a devastating neurological disorder primarily affecting girls.
The NSF-funded Collaborative Undergraduate Experiences program pairs US students with international mentors at top institutions in Japan, Taiwan, and Australia. Students work on projects related to cyberinfrastructure, exploring its potential impact on science and global collaboration.
AstraZeneca has submitted a regulatory application to the European Union for the use of Atacand in treating heart failure. The CHARM study programme showed that Atacand reduces both cardiovascular deaths and hospital admissions across a broad spectrum of patients with chronic heart failure.
Researchers at Stanford University challenge the existence of a single supercolony of Argentine ants spanning California. Instead, they propose that multiple genetically distinct colonies have colonized the state over the past century.
Time-reversal acoustics (TRA) systems hold promise for precise medical imaging, diagnostic techniques, and incision-free surgical methods. TRA's ability to focus sound waves accurately in dense environments makes it an attractive solution for imaging the human body or targeting tumors non-surgically.
A 12-month quality of life study with Parkinson's patients shows significant improvement in movement and quality of life after receiving a transplant or sham surgery, regardless of actual treatment. The study suggests that the placebo effect plays a crucial role in this disease.
Australian researchers introduce a simple method to collect, archive and process DNA from wildlife samples using FTA databasing paper, which preserves DNA integrity despite temperature fluctuations. This technique enables the transport of large reference collections over long distances, enabling extensive wildlife studies.
Genetic studies of leukemia patients have led to the identification of specific gene mutations linked to treatment responses and drug resistance. This information is guiding the development of new drugs targeting specific cell molecules, reducing toxic side effects.
Researchers at the University of Illinois developed an activity called 'See it, Do it, Teach it' to help people understand nutrition labels and increase their calcium intake. The eight-week study showed that participants significantly increased their calcium consumption, getting closer to daily requirements.
A new study found that children who stayed in the ICU for more than 48 hours after cardiac surgery were at a higher risk of developing post-traumatic stress disorder (PTSD). Five out of 43 children met diagnostic criteria for PTSD, with symptoms including disorganized behavior, nightmares, and concentration problems.
Researchers create maps of science from vast digital data collections, enabling exploration and analysis of interconnected scientific disciplines. The results provide insights into how scientists and their work are connected, with potential applications in education, funding, and industry.
A recent study published in JAMA found that approximately four out of five newly-disabled older people regain independence within six months. However, recovery is often short-lived, with many experiencing recurrent episodes of disability.
A University of Pittsburgh study found that over half a million Americans die annually in ICUs after admission, with average lengths of stay ranging from 8.9 days and cost $8,548 for non-ICU hospitalization. The researchers recommend improving prediction models to reduce ICU admissions at end-of-life
A UCR study found that exposure to second-hand smoke compromises the ability of fibroblasts to move towards damaged tissue, leading to abnormal healing and excessive scarring. The research team discovered that components of second-hand smoke alter the cells' cytoskeleton, increasing adhesive properties and reducing mobility.
Researchers found that exercise-induced high blood pressure may be caused by cells failing to relax and expand blood vessels. This impairment can be a common factor among various risk factors for heart disease, including aging, menopause, and diabetes.
A study of Dutch women exposed to famine during World War II found a significant association between short-term famine and increased breast cancer risk. Women who experienced severe hunger and weight loss had a 48% higher risk of breast cancer compared to those with no exposure.
A study compared different clinical guidelines for diagnosing and treating sore throats, finding that the selective use of throat cultures can help reduce unnecessary antibiotic prescriptions. The researchers also found that children require throat culture confirmation to ensure optimal identification of GAS pharyngitis.
A team of researchers from Cornell University and Gene Network Sciences Inc. has developed a 3D computer model of the canine heart to simulate ventricular fibrillation. The model aims to help understand the causes of this life-threatening condition, currently treated with electrical shocks that can damage the heart.
Researchers at the University of South Florida have developed a biosensor-regulated gene therapy that protects heart muscle cells from further injury after a heart attack. The therapy uses an oxygen-sensitive switch to turn on protective genes, which were shown to limit tissue scarring and improve heart function in mice.
Researchers at the University of Warwick have discovered that a hormone associated with obesity also plays a key role in male fertility, influencing testosterone production and sperm transport. Orexin receptors were found in areas of the testis, epididymis, and penis, suggesting its potential involvement in penile function and erection.
A study by Dr. Terri H. Finkel and colleagues identifies a gene called HALP that plays a crucial role in protecting HIV-infected cells from apoptosis. The discovery may provide clues for new treatments, including ways to prevent latent infection.
University at Buffalo researchers have created an innovative animal model to study tinnitus treatment, allowing them to monitor individual neurons in the brain during phantom sound perception. The model, developed with a $167,000 grant, enables researchers to measure changes in neural activity before and after inducing tinnitus.
A recent study by Cardiff University found that the Human Rights Act has had a limited impact on solicitors' work in the Cynon Valley, an area with high social deprivation. Solicitors cited lack of training and inadequate public funding as major concerns.
A recent study led by University of Rochester Medical Center professor Günter Oberdörster investigates the link between nanotechnology and human health. The research suggests that nano-sized particles may accumulate in the body and cause harmful inflammation, potentially leading to brain damage or central nervous system disorders.
The study found that Experience Corps volunteers experienced increased physical, cognitive, and social activity, which could lead to improved health outcomes. Volunteers also reported feeling stronger and had a reduced need for canes. In contrast, the control group showed a decline in social activity and an increase in TV viewing.