Researchers have discovered that phospholipids, a crucial component of cell membranes, directly influence the folding of membrane proteins. The absence of phosphatidylethanolamine (PE) led to misfolding and reduced protein activity in E. coli bacteria.
Researchers found that PGE2 up-regulates T-regulatory cells, suppressing immune function and fueling cancer growth. The study suggests using COX-2 inhibitors like Celebrex to augment immune responses in cancer patients.
Researchers have discovered a shared genetic core among three deadly parasites, which could lead to the development of new drugs targeting these diseases. The genome studies found that the parasites share approximately 6,200 conserved genes, providing potential targets for treatment.
Researchers develop a computer model simulating signal transmission at a synapse in chick embryos, finding that 90% of neurotransmitter release occurs outside of synapses. This discovery opens up new possibilities for cell-to-cell communication in the nervous system and challenges traditional definitions of synapses.
Researchers find biglycan acts as endogenous ligand of Toll-like receptor 4 in macrophages, increasing responses and leading to improved survival in sepsis. Mice lacking biglycan show increased survival benefit, highlighting the protein's pro-inflammatory role.
Researchers found that genetic factors explain only a small extent of social aggression (20%), with environmental factors such as parental behavior and peer influence having a greater impact. The study also suggests that reducing physically aggressive behavior in early childhood may help prevent the development of social aggression.
A panel of experts published recommendations to minimize the risk of altering non-human primates' cognitive capacity, focusing on grafting human stem cells into their brains. The panel concluded that healthy adult members of species distantly related to humans are least likely to experience morally significant changes.
Researchers at Ludwig Maximillians University report that AML1-ETO cooperates with FLT3 to induce rapid and aggressive acute leukemia in mice. This study supports a pathogenetic model of acute leukemia, which requires activating mutations in signal transduction pathways and transcription factors for leukemogenesis.
The National Academy of Engineering selected three Rice University researchers for the prestigious Frontiers of Engineering symposium. Researchers Deem, Drezek, and O'Malley will present their work in cutting-edge fields such as statistical mechanics, nanobiotechnology, and haptic interfaces.
The NIAID-funded CHAVI center will focus on understanding early stages of HIV infection, developing new research tools, and designing improved HIV vaccines. The center aims to accelerate the development of a safe and effective preventive vaccine for HIV/AIDS through collaborative research.
UCSB has been awarded two NIH Program of Excellence (PEN) grants in nanotechnology, totaling $25.5 million, to develop nanoscale agents for diagnosing and treating pulmonary artery disease and detecting vulnerable plaque. The projects aim to create targeted nanoparticles that can deliver diagnostic systems and therapeutic agents direct...
A new study links aging to genetic mutations in mitochondria, accelerating cell death and critical organ failure. Researchers found that accumulated mitochondrial DNA damage triggers cell death, leading to symptoms like hair loss, weight loss and vision impairment.
A comparative genomics study highlights the significance of non-protein-coding DNA sequences in complex species, revealing conserved elements outside protein-coding regions. The study also introduces a new computational tool, phastCons, to identify evolutionarily conserved DNA elements.
Researchers at NIST have developed an improved experimental X-ray detector that can detect X-rays across a broad range of energies with pinpoint energy resolution. The new detector uses quantum-level, transition edge sensors and improved temperature control systems, eliminating the need for constant recalibrations.
Researchers emphasize the need for early detection and monitoring of alcohol abuse to prevent dependence issues. Emerging biomarkers, such as genetic analysis, hold promise for accurate diagnosis and treatment compliance.
Despite conflicting studies on obesity, most Americans believe it remains a serious public health issue. Approximately 75% of Americans rate obesity as extremely or very serious, and the majority think experts have accurately portrayed its health risks. However, there is mixed trust in scientific experts' advice on weight control.
Research at Cold Spring Harbor Laboratory explores novel approaches to preventing muscle atrophy by optimizing exercise and nutritional interventions. The study highlights the importance of combining resistance training with specific nutrient profiles to maintain muscle mass and function.
A randomized controlled trial in Pakistan found that handwashing with soap reduced the incidence of pneumonia by 50% and diarrhoea by 53% in children under 5. Handwashing also prevented impetigo. The study highlights the importance of regular handwashing as a cost-effective technique for preventing childhood diseases.
Research finds that after-school program participation significantly improves reading achievement and motivates students. Highly engaged program staff also boosts motivation, highlighting the importance of engaging content and activities to foster long-term academic improvements in disadvantaged children.
Researchers at Georgia Tech have developed two augmented reality systems to improve communication between automated inspection systems and workers who trim birds on processing lines. The systems use location-tracked displays or laser scanners to project graphical instructions, providing advance warning of workload and reducing errors.
Researchers at U of MN successfully reversed memory loss in mice with dementia, using a transgene to halt disease progression and even increase tangles. This breakthrough study suggests that reversing effects of memory loss may be possible in humans.
A new 24-item scale measures the continuum of alcohol problems in college students, providing excellent distributional properties and retaining meaningful variance. The scale is brief, efficient, and suitable for self-assessment, surveillance, and treatment-needs change measure.
Research on the genetics of alcohol use has identified polymorphisms in ADH and ALDH enzymes that may explain individual differences in alcohol metabolism, as well as chromosomal regions linked to suicidal behavior, conduct disorder symptoms, and alcohol dependence. Additionally, serotonin receptor variations have been found to play a ...
The genome sequences of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major have been completed, providing a blueprint for developing new drugs. The shared core of genes among the three parasites offers potential targets for a class of drugs that can target all three diseases.
A recent study has found that abdominal injuries in children under 14 are twice as likely to be caused by abuse as road-traffic accidents. The researchers analyzed data from over 180 injured children and found that small-bowel injuries are more common in abused children, especially those under five.
Researchers at NIST found a significant difference between white light interferometric microscopes and phase shifting interferometers in measuring surface roughness, with discrepancies peaking at 100 nanometers. The study evaluated five instruments from three vendors and compared them to stylus profiling instruments.
Researchers have identified 34 mutations resulting in embryonic lethality, attributing it to defects in cellular proliferation, gastrulation, and other developmental processes. The study predicts that between 13.7% and 19% of all mouse genes are necessary for embryonic viability.
The Australasian Kidney Trials Network will focus on new and innovative clinical research to provide better treatments and outcomes for patients. The network aims to address the growing health issue of chronic kidney disease affecting one in seven Australian adults.
A new clinical trial has shown that the oral treatment RBX may reduce the risk of moderate vision loss caused by macular edema in patients with type 1 or type 2 diabetes. The study, led by Joslin Diabetes Center, evaluated the safety and effect of RBX on retinopathy progression and visual loss.
Researchers have identified gene sequences involved in the host-parasite relationship and parasite metabolism, providing potential vaccine candidates. The sequencing of trypanosome genomes has significant challenges due to repetitive sequences but promises to advance tropical medicine by helping develop new drugs against these diseases.
Researchers found that intermittent IL-2 administration induces high CD4 and CD8 cell proliferation followed by prolonged CD4 cell survival. This effect helps explain the preferential increase of CD4 cells in patients treated with IL-2 therapy.
A study found that boys with supportive parents are less likely to engage in violent behavior after witnessing violence, while girls with high levels of social understanding are also at risk. Interventions focusing on improving the parent-adolescent relationship and teaching social understanding may reduce violence in both boys and girls.
Researchers found that NIPA levels act as a switch to regulate cell division by degrading cyclin B1 during the 'resting' phase. Blocking NIPA causes premature cell division, leading to unhealthy daughter cells. The study sheds light on the role of SCFNIPA in controlling mitosis.
A recent study has shown that buccal midazolam is more effective and faster-acting than rectal diazepam in treating seizures in children. The research, published in The Lancet, found that buccal midazolam was successful in 61% of episodes compared to 27% for rectal diazepam.
The Kentucky Geological Survey is involved in global climate change research, studying opportunities to sequester carbon in the Midwest and Southeast regions. The survey will continue to examine subsurface formations for carbon storage and investigate coal seams along the Virginia-Kentucky border.
Parents affect adolescents' substance use behaviors by influencing their images of typical smokers and drinkers, as well as their willingness to try substances. Strong parenting, especially in high-risk neighborhoods, has a positive impact on reducing substance use among teens.
Researchers found that heterotrimeric G proteins regulate cell division orientation, influencing brain size. Impairing Gβγ signaling leads to overproduction of neurons, potentially contributing to inherited disorders like microcephaly or macrocephaly.
A study by Christine Gieseke and Prue Talbot found that cigarette smoke significantly reduces the transport of hamster eggs through the oviduct. The researchers exposed cumulus-coated eggs to six types of cigarette smoke, resulting in a 40-55% increase in adhesion to the infundibulum and a 20-35% decrease in egg transportation rates.
Researchers recommend a five-step approach to diagnose and manage insomnia in older adults, which may lead to reduced sleep disturbances and improved health outcomes. The steps include detection, elaboration, medical or psychiatric emergency assessment, further evaluation, and intervention with lifestyle or medication changes.
A recent study by the University of Cardiff's Economic & Social Research Council found that fast turnaround times on car carriers lead to a decline in seafarers' lives, causing fatigue, social isolation, and limited free time. The research highlights the need for better working conditions and labor protections for crew members.
A UK-led project measured public services performance and found significant differences in education sector output compared to the US. The research also highlighted a lack of correlation between healthcare expenditure and outcomes across the EU, but found links between system organization and disease outcomes at a micro level.
Research involving human stem cells in nonhuman primate brains may be necessary and effective, but oversight boards must consider six key factors to ensure ethics are maintained. The number of human cells used and animal brain size are among the factors considered.
The study reveals that overexpression of Pkn protein leads to a cell shape defect. The findings suggest that this mechanism is widely conserved among gram-positive bacteria, with related signaling molecules present in multiple species.
Researchers have discovered a cullin-dependent E3 ligase as a crucial component of the Clr4 methyltransferase complex, controlling histone methylation and heterochromatin assembly. The study suggests that polyubiquitylation of regulatory proteins may play a key role in regulating these processes.
A new UF study suggests that mitochondrial mutations leading to programmed cell death could be a central mechanism driving aging in mammals. The research finds no correlation between oxidative stress and increased mortality, contradicting the previously believed 'vicious cycle' theory of aging.
Researchers at UGA have conducted the first global survey of protein expression in Trypanosoma cruzi, a parasite that causes Chagas disease. The study identified patterns of protein expression across the parasite's four lifecycle stages, providing new criteria for selecting vaccine targets and potential drug candidates.
Researchers at Yale University have identified unique infrared laser spectrum signatures for free protons associated with one to three water molecules. The study reveals that the proton's vibrations are driven by changes in its hydration environment, leading to significant shifts in spectral signatures.
Researchers have developed a biologically accurate computer simulation of synaptic function, indicating that the synapse may behave like a shotgun firing buckshot-like bursts of neurotransmitter to reach receptors arrayed beyond known receiving sites. The new data suggest an alternative mode of neurotransmission called ectopic release.
Research discovers T-cell 'traffic control' system that prevents autoimmune disease and rejection of transplanted organs, promising new treatment for multiple sclerosis and transplant rejection. The system is controlled by a fat-like compound called S1P, which can be blocked with experimental drugs to prevent excessive T cell activity.
Research by King's College London and City University found that shared environments, including prenatal factors and socialization effects, contribute significantly to gender-role behavior in early childhood. The study suggests that environmental influences are more important in shaping behavior than genetic factors during this age group.
A recent study found that foreign-born Asian American and Pacific Island women are significantly less likely to receive breast-conserving surgery than non-Hispanic white women, despite similar demographic and tumor characteristics. Language barriers and cultural factors may contribute to these disparities.
Researchers at Vanderbilt University have identified a DNA polymorphism that interferes with the binding of antiarrhythmic drugs to a specific ion channel in the heart. This structural change allows for variable drug access to its target site, leading to increased drug resistance in some individuals.
A new study from the University of Washington suggests that parent training is the most effective tool in dealing with conduct disorder. The research found that interventions used for boys with similar problems can also be effective for girls, and that programs targeting parents, children, and teachers yield the best results.
A study by the NICHD Early Child Care Research Network found that children from families experiencing poverty at any age during early childhood did not perform as well as those who were never poor. The quality of home environments also dropped over time if families became poor after the child was 4.
The sequencing of three deadly parasite genomes has revealed a core of 6,200 genes in common among the parasites, providing new targets for drug development. This discovery also highlights the potential for designing targeted vaccines and improved diagnostics for each parasite.
The University of California, Santa Barbara, has been awarded a $12.5 million grant to develop nanoscale systems for early diagnosis and treatment of vascular diseases. Led by Professor Craig Hawker, the team will use nanoparticles as carriers for diagnostic systems and therapeutic agents.
A study by researchers at Penn State and Washington state universities found that relying on others outside the family for information is associated with parents being less knowledgeable about their child. In contrast, parents in relational groups were more likely to be informed and had teens engaging in less risky behavior.
A study of over 700 patients undergoing coronary procedures found that distant prayer did not improve clinical outcomes, but patients receiving music therapy had less emotional distress and slightly lower mortality rates.
Scientists at JILA developed a method to study RNA dynamics, revealing the 'stickiness' between specific loops and sequences that stabilize folding. This information is crucial for understanding RNA structure and its effects on function.
Researchers found that increasing water vapor levels caused less damage to mirrors, possibly due to increased ambient hydrocarbon levels. Introducing methanol mitigates water-induced damage, paving the way for accelerated testing and broader illumination capabilities.