The Mayo team invented a simpler method for using modified viruses to transport therapeutic genes to tumors. They demonstrated that retrovirus particles could successfully attach to T cells and safely hitchhike to reach tumors, transferring genes that infected cancer cells.
A Phase II study found erlotinib to be relatively well-tolerated and demonstrated encouraging activity in previously untreated patients 70 years or older with advanced lung cancer. The study showed a median survival of 46 weeks, with 60% of patients experiencing partial response or stable disease.
A study published in BMC found that regular exercise can significantly reduce musculoskeletal pain in older adults. Participants who exercised regularly experienced 25% less pain than those who were less active, with the reduction persisting until age 62-76.
According to a meta-analysis of studies, males and females show more similarity than difference in cognitive abilities, communication, social traits, and well-being. However, motor behaviors, sex-specific aspects, and aggression exhibit marked differences.
A team of UCSD biochemists has discovered a mechanism for generating 10 trillion varieties of a single protein, providing a new tool for developing novel drugs. This finding, published in Nature Structural and Molecular Biology, uses the genetic mechanism used by a virus that infects bacteria to create a kaleidoscope of variants.