A seven-year study of over 400 patients found that delivering chemotherapy directly into the abdomen via a catheter increases survival and relapse-free survival rates compared to intravenous chemotherapy alone. However, side effects are significantly worse for the abdominal group.
The National Cancer Institute has issued a clinical announcement recommending a combination of chemotherapy regimens for women with advanced ovarian cancer. The treatment involves delivering chemotherapy directly into the abdominal cavity (intraperitoneal, or IP) in addition to traditional IV chemotherapy. This approach appears to be m...
A study by CU-Boulder researchers found that male mice with hypertrophic cardiomyopathy developed enlarged hearts and heart failure on a soy diet, but not female mice. The team hypothesized that plant-based estrogens in the soy diet triggered biochemical reactions leading to programmed cell death in the heart.
Scientists discover carrier multiplication occurs in nanocrystals of various compositions, including cadmium selenide, boosting photovoltaic technologies. The effect relies on strong electron-electron interactions and can enhance the production of hydrogen through photo-catalytic water splitting.
Researchers have discovered that breast stem cells with genetic errors can produce tumours even after chemotherapy. The discovery could lead to the development of new treatments targeting these faulty stem cells.
Researchers have discovered a potential treatment for Alzheimer's disease by combining gold nanoparticles with microwave radiation. The approach breaks up beta amyloid fibrils and reduces protein re-aggregation, offering hope for other neurodegenerative diseases like Parkinson's and Huntington's.
A study by Arizona State University researchers found a connection between a bee's reproductive traits and its social behavior. The findings suggest that elements of a solitary ancestor's reproductive behavior may have evolved into the complex social structure and divisions of labor seen in highly social bees.
Researchers found that treating severe gum disease can lower systemic inflammatory markers associated with cardiovascular risk, suggesting a potential link between gum disease and heart health. The study suggests improving periodontal health could significantly reduce the risk of cardiovascular disease.
Research on Martian aurorae reveals localized ultraviolet emissions near magnetic field lines. Air pollution reduction could exacerbate global warming due to increased solar radiation scattering. A new study detects potential oilfield brine leaks in Nueces Bay, Texas, using sediment resistivity and radium isotope analysis.
A new study from Children's Hospital of Philadelphia and State Farm Insurance Companies reveals that SUVs do not provide superior protection for child occupants in rollover crashes. In fact, children involved in these crashes are three times more likely to be injured than those in non-rollovers.
A study found that genetic differences account for approximately 30% of variability in response to COX-2 inhibitors, such as celecoxib and rofecoxib. This suggests a potential target for developing diagnostic methods to identify patients at increased risk of cardiovascular events.
Researchers have detected gamma rays from radioactive aluminium (26Al) originating from the central regions of the Galaxy, indicating an ongoing process of new atomic nucleus production. The estimated total amount of radioactive 26Al is equivalent to three solar masses, corresponding to a galactic rate of supernovae every 50 years.
A new UCSD laser technique allows researchers to precisely create and image blood clots in the brain in real time, shedding light on small strokes implicated in dementia. The study enables controlled observation of brain response to stroke, paving the way for potential prevention strategies.
PlasmaSol developed Capillary Discharge Non-Thermal Plasma technology at Stevens, which has large market potential in environmental applications. The company secured major contracts with the US Army and NASA after conducting a marketability study.
A team of scientists has found that artificially increasing the activity of the p53 protein in laboratory mice with a hereditary predisposition for cancer significantly reduces tumor development. The study suggests that giving p53 just enough slack in its leash could help patients avoid developing cancer.
A new oral vaccine, Rotateq, has been shown to virtually eliminate the most severe cases of rotavirus, a common childhood virus. The vaccine nearly eliminated serious rotavirus-related gastroenteritis and reduced hospital admissions by 96%.
Researchers found alphaB-crystallin protein promotes uncontrolled growth in breast cancer cells, suggesting it as a molecular marker for aggressive breast cancer. The study identified a key pathway activated by alphaB-crystallin and found drug inhibitors block its effects, paving the way for new targeted therapies.
The researchers determined the pre-fusion structure of the F protein using X-ray diffraction, providing a complete picture of how paramyxovirus F protein works to infect cells. This discovery has significant implications for developing improved protein-based vaccines and designing novel anti-viral agents.
Scientists used ancient sea creature shells to uncover a monumental reversal in deep-ocean circulation patterns around the world. The shift was triggered by global warming and led to drastic climatological and biological changes.
Researchers found that people exposed to loud noise over several years were 1.5 times more likely to develop acoustic neuroma, a slow-growing tumor that presses the cranial nerve responsible for sensing sound and balance. Wearing ear protection was associated with similar risk levels as non-exposure.
A study found that hospitals performing few breast cancer operations a year have high readmission rates and poorer outcomes. Experts agree that breast cancer surgery requires significant surgical expertise.
Researchers found that a soy-based diet caused significant growth in the hearts of male mice, whereas female mice showed no such effect. The study suggests that phytoestrogens may play a role in exacerbating heart disease, particularly in males.
A new study confirms the survival benefit of intra-abdominal chemotherapy, also known as intraperitoneal (IP) chemotherapy, for most women with advanced ovarian cancer. The treatment has shown an overall survival period of approximately one year after optimal debulking surgery.
Researchers solved the structure of a viral harpoon protein, revealing its role in viral entry and fusion with host cells. The discovery sheds light on how viruses hijack cellular machinery to produce and spread more virus, and may lead to new treatments for infections caused by enveloped RNA viruses.
Researchers found that anandamide, a brain's own cannabis compound, protects neurons from inflammation after damage. Adding AEA to damaged brain tissue abolished inflammatory damage, but not primary excitotoxic damage.
Researchers identified over 200 cases of TIC involving 421 human genes, finding that genes often reside closer together and share standard splicing machinery. The discovery challenges the 'one gene, one protein' rule and may lead to the development of non-toxic engineered fused proteins for drug applications.
A team of astronomers used a rare stellar occultation to determine Charon's radius with great accuracy, finding it to be 603.6 km. They also set an upper limit on the existence and pressure of Charon's atmosphere, suggesting it is likely icy with little or no nitrogen.
Scientists used fMRI to study how humans learn to associate brand preferences with rewards, finding key activity in the ventral midbrain and ventral striatum. The study sheds light on the neural mechanisms behind consumer behavior and advertising effectiveness.
Researchers identified long tracks of genomic segments devoid of transposable elements, known as TFRs, which occur across multiple species. These regions are evolutionarily conserved and associated with critical biological processes.
Researchers found that elevated homocysteine in blood may be a biomarker for increased AMD risk, particularly among advanced stages. High levels were also associated with higher AMD risk, highlighting the need for further study on prevention and treatment.
A recent Ohio State University study found that exercise significantly speeds up wound healing in older adults, with wounds healing an average of 10 days faster in the exercising group. The study suggests that exercise may play a role in regulating cortisol levels, which could be a key biological pathway for enhanced wound healing.
Researchers found that mice fed a soy-based diet had significantly worse heart problems than those on a milk protein-based diet. This is the first study to show an environmental influence can affect the heart.
Researchers at UT Austin capture as few as sixty atoms in a laser trap, achieving repeated measurements of quantum atom statistics. The study creates a new field and places scientists one step closer to realizing quantum computing by controlling individual atoms.
Intrinsically photosensitive retinal ganglion cells (ipRGCs) adapt to lighting conditions, sending signals about overall brightness to the brain. This adaptation allows ipRGCs to regulate pupil size and circadian rhythms.
A team of astronomers from MIT and Williams College observed the light from a star as it disappeared behind Charon and reappeared on the other side. They determined Charon's radius to be 606 ± 8 km, roughly twice the width of Massachusetts, and established a density of 1.72 g/cm3.
Researchers have identified a gene called caspase 8 that plays a crucial role in preventing tumor cells from metastasizing, or spreading to distant sites. By activating this mechanism, the researchers aim to develop targeted therapies to halt the spread of neuroblastoma and possibly other cancers.
The rotavirus vaccine candidate demonstrated 85% protection against severe disease and 100% protection against more severe disease in a double-blind, placebo-controlled trial. The vaccine also showed lower incidence of serious adverse events compared to placebo, with no increased risk of intussusception observed.
Brookhaven scientists used sliced ion imaging to analyze energy flow during ketene fragmentation, a small molecule stand-in for complicated fuels. They found agreement with variational transition state theory predictions, refuting earlier work on the theory.
A New England Journal of Medicine study found that women who received intraperitoneal chemotherapy had a median survival time 16 months longer than those receiving IV chemotherapy alone. The importance of referral to physicians with expertise in surgical management of ovarian cancer is highlighted.
Atrium Health Wake Forest Baptist professor Curt Furberg recommends using proven methods from international countries to lower U.S. prescription drug costs, including government-established reimbursement rates and price cuts. These strategies could lead to a 30-50% reduction in expenditures.
The American College of Cardiology has introduced Clinical Performance Measures to ensure eligible patients receive proven therapies, including aspirin prescription and cholesterol-lowering therapy. By implementing these measures, physicians and hospitals can improve healthcare quality and prepare for the future.
A study published in JCI Journal reveals that alpha-basic-crystallin is overexpressed in breast cancer tumors and triggers tumor development. The protein causes dysregulated growth, changes in cell structure, and diminished programmed cell death, ultimately leading to poor clinical outcomes.
A gradient of Wnt3 counterbalances EphrinB1-EphB signaling to establish a carefully controlled pattern of nerve connections required for conveying spatial information from the eye to the brain. This balance is necessary for topographic mapping, which allows positional information to be smoothly transferred to the brain.
DrugBank is the world's largest database on drugs and drug targets, providing detailed information on over 3000 drug targets and 4100 approved or experimental drugs. The database supports advanced searches and queries for biologists and chemists, enabling them to discover new drug leads.
Researchers at University of Pittsburgh discovered that loss of pol zeta's activity in mouse cells leads to chromosomal instability and tumor development. The study suggests that pol zeta may act as a tumor suppressor gene, preventing double-stranded breaks in chromosomes.
A recent Carnegie Mellon University study found that most teens learn about sexually transmitted diseases when they are diagnosed with them. The survey of 300 adolescent girls revealed that those who reported having been diagnosed with a disease knew more about that specific disease but not the others.
Scientists have identified the DNA sequence controlling the malaria parasite's ability to change its disguises, a key virulence factor. This breakthrough could lead to the design of a drug candidate molecule that freezes the parasite's disguise capability, allowing the human immune system to respond effectively.
Researchers designed a new trinuclear platinum compound with enhanced cellular absorption, which targets cancer cells and reduces resistance. The novel compound's non-covalent interactions minimize side effects and improve its effectiveness against common human cancers.
Researchers found that urban coyote populations are larger than expected, live longer, and are more active at night. They help control Canada goose populations by eating eggs from nests and burying them for later consumption.
Researchers found that hospital caregivers need to tailor their resuscitations to a patient's situation, with respiratory failure more common than arrhythmia in adults. The study suggests that CPR may succeed more often than physicians believe, leading to better survival rates and neurological outcomes for children and adults.
Researchers at UVA Health System are investigating a novel approach to combat chronic kidney disease by targeting inflammation with adenosine drugs. Preliminary results show promising decreases in inflammation, urinary protein loss, and kidney scarring.
Researchers found a strong link between smoking, HLA-DR SE genes, and anticitrulline antibodies in early rheumatoid arthritis patients. Smoking significantly raises RA risk for individuals testing positive for these antibodies, regardless of SE gene status.
A new study by Matthew Gentzkow and Jesse M. Shapiro finds that media bias arises from a desire to maximize reputation, rather than personal beliefs or values. The authors argue that supporting the growth of independent media in competitive markets can counteract this bias.
The Stardust spacecraft is returning to Earth after a 2.88 billion-mile journey, carrying samples of comet Wild 2 and interstellar dust. The samples are expected to provide key information on the formation of the solar system 4.6 billion years ago.
Research shows female rats less sensitive to sedating effects of alcohol, cycling hormonal levels mediate effects; adult women may become less sensitive to sedation as they mature. The study emphasizes the need to explore how factors associated with the estrous cycle affect sex differences in alcohol's effects.
Researchers have developed a new system of 'self-exploding' microcapsules that can release medication without external triggers. This technology has the potential to transform how vaccines are administered, allowing for more efficient and targeted treatments.
Two new studies uncover significant associations between certain autoimmune disorders and an increased risk of non-Hodgkin lymphoma. Meanwhile, a separate study suggests that consuming carbonated soft drinks may decrease the risk of esophageal adenocarcinoma, contrary to previous findings.
The University of Iowa and Universidad de Puerto Rico's Summer Institute for Mathematics programs have successfully increased diversity among U.S. graduate students from underrepresented minority groups, with notable retention rates and career outcomes.
A meta-analysis of 36 clinical trials reveals that optimal radiation therapy significantly improves patient survival rates in breast cancer patients. The analysis found a 2.9% and 6.4% absolute increase in survival at 5 and 10 years, respectively.
Researchers at Yale University found no direct evidence to support the theory that carbonated soft drinks contribute to esophageal adenocarcinoma risk. Instead, they discovered an inverse association between diet soda consumption and reduced risk of this cancer subtype in men and women.