Researchers have discovered a precise timer formed by Period and Timeless proteins that counts off six hours, creating an 'interval timer' that governs the cell's circadian rhythm. This discovery opens up new questions about the complex interactions between proteins in the cellular clock.
Researchers used novel antisense drugs to interrupt normal Ebola virus replication, showing protection in non-human primates. The therapy directly targets the virus and may be more potent than current anti-viral treatments.
Research suggests that iron and folic acid supplementation may not benefit all children, particularly those without iron deficiency. However, it may still be beneficial for young children in low-malaria transmission areas due to its role in motor and cognitive development.
Researchers found a biochemical pathway, called RISC, that facilitates protein synthesis at synapses during learning, enabling long-term memory formation. By manipulating this pathway, scientists increased flies' memory and altered their behavioral responses to stimuli.
The USGS and ICDP successfully retrieved a nearly complete set of core samples from the Chesapeake Bay impact crater, allowing for unprecedented understanding of post-impact sediments and rocks. The recovered core will enable researchers to study global sea-level changes and the distribution of water-bearing units in the coastal plain.
Researchers found that individuals carrying the Epsilon4 allele showed reduced activation in the medial temporal lobe of the brain. This suggests that these individuals may be at risk for Alzheimer's disease and could potentially benefit from early interventions designed to delay or prevent its onset.
Researchers found that group B coxsackieviruses infect cells through an indirect route, utilizing signaling pathways and exploiting more accessible receptors. This understanding may lead to future therapies to block viral infections and contribute to clinical benefits.
Research reveals that blocking the fat hormone leptin can slow disease progression and reduce symptoms in multiple sclerosis. Leptin blockade improves clinical symptoms, slows disease progression, reduces disease relapses, and decreases antigen-specific T cells.
Researchers analyzed bone fragments at the Donner Family campsite in California's Tahoe National Forest, finding no conclusive evidence of cannibalism. The team discovered domestic and wild animals were consumed, but human bone was not identified.
Scientists have found that plants can turn excess sunlight into heat by altering protein structure, preventing damage and promoting growth. A special carotenoid molecule called zeaxanthin aids in this process, making some plants more resistant to harmful radiation.
A team of scientists discovered a massive genomic island containing a large number of antibiotic resistance genes in the A. baumannii bacterium, which has become a major public health concern globally. The island was found to contain new and previously unknown resistance genes that have enabled the bacterium to acquire resistance quickly.
The NIH supports expansive basic and clinical research portfolios on obesity and type 2 diabetes, including genetic studies, nuclear receptors, and lifestyle interventions. Epidemiological studies provide insights into risk factors and inform future clinical endeavors.
Researchers found a correlation between armpit odor and female fertility, suggesting that volatile organic compounds (VOCs) may play a role in reproductive health. The study suggests that women with higher VOC levels in their armpits may have better fertility prospects.
Researchers precisely measured the mass of a millisecond pulsar, PSR J1909-3744, using precise pulse arrival time measurements and disentangled the Shapiro delay effect from Roemer delay. The result reveals the white dwarf companion's mass to be 1.44 times that of the sun with an uncertainty of 0.02 solar masses.
Recent developments in depression treatment highlight the effectiveness of antidepressants and electroconvulsive therapy (ECT) as mainstay treatments. ECT is particularly recommended for patients presenting with psychotic symptoms, while antidepressants remain a primary choice for most patients due to their widespread availability and ...
Scientists discover an unusual X-ray tunnel large enough to fit the entire Milky Way galaxy inside a galaxy cluster. The tunnel is filled with old particles likely originating from past black hole outbursts, shedding light on the complex battle between the inward flow of hot gas and outward radio jets.
A regional study found that 92% of contemporary movies depicted alcohol use, with kids exposed to about 8 hours of it through films. Higher exposure to movie alcohol use at age 10-14 predicted future drinking in teens.
A team of UCSD researchers has identified a 24-member family of bacterial proteins called effector proteins that help pathogenic bacteria such as Salmonella and E-coli infect human cells by hijacking the body's communication network. The findings could lead to novel ways to fight bacterial diseases.
Scientists at Gladstone Institutes have successfully imaged the native state of apoE4, a key protein in Alzheimer's and cardiovascular diseases. This breakthrough has significant implications for developing future therapeutic interventions by providing a complete understanding of the protein's configuration.
Astronomers have long hoped to find magnetic forces shaping interstellar clouds, and now they've done so. A helical magnetic field was detected around the Orion Molecular Cloud, providing the first evidence of its structure.
Research found that calorie-restricted individuals had hearts with improved elasticity and function, similar to those of younger people. Their low levels of inflammation may have played a key role in preventing primary aging.
A team of scientists has shed light on the molecular mechanism of Dicer, an enzyme involved in RNA interference, a process that governs key developmental events. The study reveals that Dicer not only cleaves RNA but also measures and snips it into precise increments.
A review of 56 studies found that liquid-based cytology did not detect more high-grade lesions and had equivalent performance to conventional Pap smear. However, the technique may have other advantages such as concurrent HPV DNA testing or reduced reading times.
The SAVE-U project developed an innovative pre-impact sensing platform that combines sensors, radar, and cameras to protect cyclists and pedestrians. The system can identify potential collisions and apply automatic braking to prevent them, even in challenging weather and light conditions.
A new approach to understanding gene expression regulation has been developed by Finnish scientists. By analyzing DNA sequences and identifying regulatory elements, the researchers have uncovered a potential mechanism explaining why many genes are linked to cancer.
Astronomers have detected ionizing radiation leaking from a dwarf galaxy undergoing star formation, providing insights into the early universe's evolution. The study suggests that hot stars in Haro 11 allowed for some ionization to escape into intergalactic space.
Researchers found that leptin blockade improved clinical symptoms of disease, slowed progression, reduced relapses, and reduced antigen-specific T cells in experimental autoimmune encephalomyelitis. Additionally, the study suggests that leptin neutralization may be a potential way to treat multiple sclerosis.
Researchers have gained a detailed understanding of Dicer's molecular structure, which serves as a 'molecular ruler' for processing RNA fragments. This discovery has significant implications for gene-silencing processes and could lead to new treatments for diseases.