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Science News for July 13, 2006


Asthma -- obesity connection

A study published in the Journal of Clinical Investigation found that a fatty acid binding protein called aP2 plays a crucial role in controlling inflammation in asthma. The research suggests that blocking aP2 function may be a novel approach for asthma treatment and other inflammatory lung diseases.

SourceResearch Australia·JournalJournal of Clinical Investigation·DateJul 13, 2006

Tumor wizardry wards off attacks from the immune system

Researchers found that pancreatic tumors surround themselves with regulatory T cells to avoid detection by the immune system. Depleting these cells slowed tumor growth and increased survival time in mice. The study suggests a potential way to block tumor recruitment of regulatory T cells and revive cancer immunotherapy.

SourceWashU Medicine·JournalJournal of Immunotherapy·DateJul 13, 2006

Fear of liability risks patient care

Doctors are practicing defensive medicine due to fear of legal liability, resulting in unnecessary treatment and wasted resources. The study suggests that limiting damages and increasing competition can improve medical practice and enhance patient access to care.

SourceThe Lancet_DELETED·JournalThe Lancet·DateJul 13, 2006

JCI Table of Contents: July 13, 3006

Australian researchers identified a new protein in human airway epithelial cells that regulates allergic airway inflammation. A study suggests the protein aP2 plays an essential role in both type 2 diabetes and allergic airway diseases like asthma.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateJul 13, 2006

Researchers discover inhibitor of infection by HPV

Researchers have discovered a potent inhibitor of HPV infection in the compound carrageenan, found in sexual lubricants and baby food. The study suggests that carrageenan could be effective in preventing HPV-related genital disease, complementing existing vaccines and treatments.

SourcePLOS·JournalPLOS Pathogens·DateJul 13, 2006

Protein potentially links diet, obesity and asthma

The study reveals that protein aP2 is present in human epithelial cells lining the airways and its expression is increased by interleukin-4 and -13. Mice lacking aP2 exhibit reduced airway inflammation, highlighting the importance of lipids in inflammation and metabolism.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateJul 13, 2006