Researchers at the University of Texas M.D. Anderson Cancer Center have discovered a natural mechanism to prevent apoptosis, or programmed cell death, in cancer cells. The discovery reveals that adding ATP to cancer cells may actually impede apoptosis, highlighting a new potential target for cancer therapies.
The study found that B7-H4, an immune system blocker, is present in aggressive kidney cancers and vessels, allowing the cancer to grow and spread. This discovery may lead to better treatment options for patients with renal cell carcinoma, a deadly form of kidney cancer.
Researchers identified a new protein, JET, required for the circadian response to light in fruit flies. The protein's mutation disrupts the body's internal clock, leading to jetlag-like behaviors.
The University of Washington's Restoration Ecology Network empowers students to take on real-world restoration projects, from streamside restorations to neighborhood revitalization. By developing stewardship plans and working with clients, teams gain hands-on experience and create lasting bonds between the university and the public.
A nationwide study found that there is no consensus across the US on whether to teach K-12 students about human-environmental interactions. Research suggests that most states prioritize teaching about human impacts on the environment over environmental impacts on humans and society.
The publication of consensus recommendations for FDG PET usage is expected to reduce variability in clinical trials, leading to shorter trials and improved treatment outcomes. The guidelines provide a valuable reference for incorporating PET into clinical trials and promoting drug development.
A new study by Princeton University researchers shows that people respond to social out-groups with disgust, not fellow humanity. Brain imaging confirms this prejudice at an unconscious level, dehumanizing individuals from these groups.
Scientists have made a breakthrough in understanding how legumes interact with nitrogen-fixing bacteria, which could lead to the development of new crop plants that can fix nitrogen themselves. This discovery has the potential to reduce the environmental impact of intensive agriculture and lower energy consumption.
Research from eight countries highlights the need for improved oral health services, particularly in juvenile detention and low-income communities. Key findings include the high prevalence of dental caries among young children and the importance of parental education and access to oral health promotion services.
Dr. Ferracane is recognized for his pioneering work on dental composites, behavior of mercury in amalgam, and Fourier transform infrared techniques. He is also an esteemed teacher and has made significant contributions to the dental materials community through his research, teaching, and service.
A study of over 600 newborns found that reducing exposure to house dust mites and increasing omega-3 fatty acids through diet had no impact on the development of asthma. Researchers recommend further research into alternative interventions for preventing asthma and allergic disease in children.
Researchers found that cranberry flavonoids can inhibit the formation of dental plaque polysaccharide matrix, block bacteria adherence, prevent acid formation, and reduce acid tolerance of cariogenic organisms. These compounds may serve as potential anti-caries/anti-plaque agents.
The Mayo Clinic has pioneered a novel method of jaw reconstruction for oral cancer patients, utilizing distraction osteogenesis after tumor removal surgery. This approach enables patients to receive both radiation therapy and reconstruction concurrently, minimizing scar tissue and improving patient tolerance.
The International Association for Dental Research (IADR) presented several awards and fellowships to recognize outstanding contributions in dental research. The IADR Honorary Membership was bestowed upon Robert V. Blanden, while the E.W. Borrow Memorial Award went to Poul Erik Petersen. Fellowships were also awarded to Janet D.C. Kan, ...
A new study found that mobile home-dwellers in rural areas face numerous challenges, including high-interest loans, social instability, and stigmatization. The researchers recommend policy changes to address these issues, such as reclassifying mobile homes in the tax code to reduce interest rates.
Two studies evaluate health effects of dental amalgam fillings in children, finding no detectable loss of intelligence or kidney function. Children with mercury exposure showed low and stable levels without correlation to symptoms.
Dr. Lamont is recognized for his exceptional contributions to understanding oral micro-organism interactions with human host tissues. He has published widely and serves on editorial boards, receiving the award at the 84th IADR General Session.
A study found that 45% of patients with REM sleep behaviour disorder developed neurodegenerative diseases, highlighting its potential as an early detection tool. Patients who had suffered from the disorder for longer time were more likely to develop a neurodegenerative disease.
A recent study by Lauren Gerson, MD, found no evidence that typical dietary restrictions for heartburn make a difference. However, losing weight and raising the head of your bed can help reduce symptoms. The study's results challenge long-standing recommendations from professional organizations.
Researchers found that practicing a combination of Qigong and Tai Chi improved balance, lower body strength, and stance width in healthy senior citizens. Participants also reported enhanced mental, emotional, and spiritual well-being after just two months of practice.
The study presents a comprehensive overview of oral health research worldwide, highlighting the high risk of dental caries in rural children and adolescents. It emphasizes the importance of preventive efforts, education, and public awareness to improve oral health outcomes.
Researchers identified two genes that can produce liver cancer and a gene important to melanoma spread. Genes in these pathways are promising targets for cancer drugs, according to the study. Improvements in genome technology have enabled researchers to filter out non-causal genetic changes and focus on functionally relevant ones.
Dental stem cells have been characterized for their potential to differentiate into various tooth tissue types. The study aims to define the molecular and differentiation profiles of these cells, enabling ongoing tooth tissue engineering efforts.
Professor Ainamo's decades-long research on older adults' oral health care needs has shaped treatment guidelines and improved understanding of stomatological disorders. The IADR Award recognizes her outstanding contributions to geriatric oral research, stimulating progress in basic and clinical epidemiology.
Dr. Polverini, a renowned expert in oral pathology, has received the prestigious IADR Oral Medicine and Pathology Research Award for his groundbreaking work on angiogenesis and oral cancer. The award is supported by Sunstar Butler and recognizes his contributions to the field.
Dr. Marquis has been recognized with the IADR Research in Dental Caries Award for his groundbreaking work on fluoride's effects on bacterial metabolism and acid-base metabolism in dental plaque. His research has elucidated key mechanisms of acid tolerance and contributed to a better understanding of oral biofilms.
A new guideline called SCRATCH helps pediatricians recognize the source of a rash by considering symmetry, clusters, age, target/time, confused, and household factors. The tool aims to prevent misdiagnoses and costly tests by providing a simple and memorable acronym.
Research suggests that seismic shaking can temporarily increase groundwater permeability, which could be exploited to enhance oil extraction. This phenomenon is caused by the gravitational effects of the moon on the solid Earth, forcing water in and out of wells.
Researchers at Columbia University Irving Medical Center have discovered that a cancer-causing protein can promote growth of axons in damaged spinal cord and brain cells. This discovery could lead to new therapies for treating neurological diseases.
Familial idiopathic pulmonary fibrosis (IPF) is linked to the ELMOD2 gene, which regulates apoptosis and cell migration. The study identified a susceptibility haplotype associated with an increased risk of IPF, supporting ELMOD2 as a prime candidate gene.
A study found that nearly half of elementary school teachers admitted to bullying students, with a strong correlation between those who were bullied in childhood and those who bully others as adults. This highlights the need for teacher support and effective discipline methods to prevent bullying.
The IADR/GSK Oral Care Awards recognized three innovative research teams for their work on preventing cariogenic biofilm formation, treating aggressive periodontitis, and targeting IKK/NF-êB to improve oral health. The winning projects focus on developing alternative therapeutic pathways and products to combat tooth decay and periodont...
Researchers from Gladstone Institutes have gained a better understanding of the use of stem cells to generate replacement cells for damaged heart muscle and vessels. The study highlights several challenges ahead, including guiding stem cells into cardiac lineage and integrating them safely within patients' heart tissue.
Researchers found that brittle prion particles can spread infection quickly by breaking into new seeds. This discovery boosts basic understanding of prion infections and could lead to new ideas for designing drugs to prevent or discourage prion seeding.
Dr. Progulske-Fox received the Basic Research in Periodontal Disease Award for her work on P. gingivalis and its interactions with human cardiovascular cells. Her research aims to identify virulence genes that could lead to the development of new diagnostic tests, vaccines, and treatments for periodontal and cardiovascular diseases.
Dr. Turner's research on the Na-K-2Cl co-transporter (NKCC1) has significantly advanced our understanding of salivation and fluid secretion. His work has led to the development of valuable experimental tools, benefiting researchers worldwide.
The lack of national guidelines in the UK poses a significant challenge for clinicians managing DNAR orders, which could lead to litigation and accusations of euthanasia. The Mental Capacity Act and European Convention on Human Rights have reinforced the need for clear guidance.
Dr. Mina has researched fundamental aspects of craniofacial development for 18 years, focusing on tooth formation and patterning. Her work has been well-supported by grants and has successfully supervised numerous doctoral fellows.
Dr. Holst receives the IADR Distinguished Scientist Award in Behavioral Sciences & Health Services Research, sponsored by Sunstar Butler, for her expertise in dental service delivery and public health programs. The award recognizes her contributions to oral health trends and research among various populations.
Researchers found that the nuclear lamina shell in HGPS patients is stiffer than normal, but this stiffness can lead to brittle fractures. The study suggests that understanding the cause of this stiffness may hold key to reversing or stopping the disease.
Researchers have developed a new method using GPS technology that can determine the true size of an earthquake within minutes, allowing for faster tsunami warnings. This is much faster than current methods and has the potential to improve future tsunami danger assessments.
Dr. Bonewald will receive the IADR Basic Research in Biological Mineralization Award for her groundbreaking work on biological mineralization, a prestigious recognition of her expertise in dental and oral science. The award acknowledges her outstanding contributions to the field, solidifying her position as a leading researcher.
New nanomaterials created using naturally occurring enzymes can be broken down into biologically compatible building blocks, enabling applications in tissue engineering and drug delivery. The materials have potential uses in delivering pharmaceuticals and preserving food and cosmetics.
Dr. Meechan has received the IADR Pharmacology, Therapeutics, & Toxicology Research Award for his contributions to dental care management and medically compromised patients. The award recognizes his research interests in local anesthesia and pain control.
Dr. Koo has received the IADR Young Investigator Award, a prestigious honor recognizing his groundbreaking work on microbial biofilms in dental and oral craniofacial research. The award, supported by Procter & Gamble Co., is designed to stimulate basic research in all dental disciplines.
Researchers at Cold Spring Harbor Laboratory have identified two human genes, Yap and cIAP1, that contribute to liver cancer. The study reveals these proteins are overexpressed in both mouse and human tumors, suggesting they could be targeted for novel cancer therapies.
A national study found that violence from male partners increases the risk of serious health complications during pregnancy and birth. Abused women were more likely to experience high blood pressure, premature delivery, and low birth weight, posing grave health risks to newborns.
Dr. Goldberg's research on dentin-pulp complex has significantly impacted the field, with over 150 publications and a strong clinical application focus.
A study published in Biochemistry reveals that damage to proteins caused by oxidative stress is linked to a natural byproduct called nitration, which could be used to predict the earliest stages of brain impairment. The research uses the most detailed proteomic analysis of a mammalian brain to date.
Dr. Feine has made significant contributions to prosthodontics through her research on implant-supported prostheses and maxillary implant prostheses on speech. She is recognized for her outstanding research accomplishments in the field of prosthodontics with the Research in Prosthodontics and Implants Award.
The ESF launched EuroBioFund to bring together funding bodies and life sciences researchers for coordinated research strategy development. The initiative aims to facilitate joint research initiatives, organize research communities, and shape a new funding way in Europe.
Professor Blinkhorn has received the prestigious Dean Memorial Award for his significant contributions to oral health research and public health. He is recognized as a leader in Europe's Oral Health Services Research, with an impressive publication record and expertise in team leadership.
Researchers at UCLA Engineering have developed a novel approach to silicon devices that combines light amplification with a photovoltaic effect, enabling the generation of power normally wasted as heat. This breakthrough has significant implications for the photonics industry and the traditional stronghold of semiconductors.
Researchers have developed a radioactive version of scorpion venom that targets and kills glioma cells, offering a promising new treatment for high-grade brain cancer. The therapy involves injecting the compound into patients, which releases radiation to kill the tumor cells.
A randomized controlled trial found CBT to significantly improve total wake time, sleep efficiency, and slow-wave sleep compared to zopiclone. CBT-based interventions are not widely available in clinical practice, but future research should focus on implementing low-threshold treatment options.
A new study used 'diffusion tensor' MRI to track brain development in infants with and without perinatal hypoxic ischemia. The results showed distinct fiber patterns in the brains of affected infants, which often persisted into later childhood and correlated with motor problems.
The HHMI Physician-Scientist Early Career Award program provides flexible funding and time for young physicians to pursue research careers. Thirteen awardees have made impressive contributions to various fields, including genomics, proteomics, and cancer research.
Scientists have discovered that sperm and male proteins trigger a cascade of gene activity in female fruit flies' reproductive tracts six hours after mating. This finding provides new insights into reproduction and could lead to innovative methods for controlling insect pests.
A study found that increased nighttime blood pressure may be associated with a higher risk of developing congestive heart failure. Analyzing data from 951 elderly men, researchers discovered that a 9–mm Hg increase in nighttime ambulatory diastolic blood pressure and non-dipping blood pressure patterns were significant predictors of CHF.
Researchers have uncovered three disease-relevant genes in synovial tissue from identical twins with RA, shedding light on the genetic components of this inflammatory disease. The study identifies laeverin, 11ß-HSD2, and Cyr61 as key enzymes linked to protein degradation, inflammation, and new blood vessel formation.