A comprehensive analysis of the genomic changes underlying lung cancer has uncovered a critical gene alteration not previously linked to any form of cancer. The study revealed over 50 genomic regions frequently gained or lost in lung adenocarcinoma, with one region pinpointing an important gene that controls lung cell growth.
A rare hereditary disorder, Li-Fraumeni syndrome, has been identified in an Asian female with early onset breast cancer. Genetic testing may help diagnose LFS in young women with a family history of the condition, which increases the risk of developing multiple primary tumors.
Researchers at the University of Manchester have identified a genetic variant on chromosome 6 associated with rheumatoid arthritis. The discovery may influence the behavior of a nearby gene, tumour necrosis factor associated protein (TNFAIP3), which is involved in inflammatory processes.
A small, implantable device supporting the heart works equally well for men and women, benefiting twice as many women awaiting transplants. The device helps patients with severe congestive heart failure, enabling them to leave hospitals and return to active life.
The study provides a comprehensive view of the altered genetic background of lung adenocarcinoma, revealing new insights into its biology. The identification of the NKX2-1 gene highlights the importance of understanding the molecular properties of tumors to develop effective cancer diagnosis and therapy strategies.
Shigetada Nakanishi's work has led to new tools and drug targets in neuroscience. His discoveries are bringing a full understanding of the human brain closer.
Marc Alan Pfeffer identified destructive structural changes in the diseased heart and led clinical trials showing ACE inhibitors can slow or reverse these changes. His work expanded knowledge of hypertension and heart attacks' impact on cardiac muscle tissue, paving the way for effective treatment approaches.
Kenneth E. Bernstein identified key components of blood pressure control and was awarded the American Heart Association's Basic Research Prize for his work. His discoveries have led to a major approach in treating hypertension, coronary artery disease, heart failure, and diabetic nephropathy.
A comprehensive genome analysis of lung cancer cells has identified more than 50 frequent genetic changes, with less than half involving known cancer genes. The study also uncovered a critical gene alteration not previously linked to any form of cancer, shedding light on the disease's biological basis.
Recent studies have linked widely used osteoporosis drugs and bowel prep solutions to kidney damage. Nephrologists must be aware of these emerging causes of kidney problems and take steps to prevent them.
Dr. Paul K. Whelton has been awarded the American Heart Association's Population Research Prize for his pioneering work in documenting the burden of cardiovascular diseases. His research has provided vital data on hypertension and its impact on populations worldwide.
Researchers found that routine mammograms for breast cancer screening in older women on dialysis are unlikely to outweigh the costs, given their reduced life expectancy. The study suggests that breast cancer screening may not provide significant benefits for this population.
Research comparing music conductors and non-musicians found that experienced conductors
Researchers found that PAD prevalence increased from 3.7% to 4.6% among asymptomatic adults aged 40-70 between 1999-2004. The study suggests a link between rising obesity, diabetes, hypertension, and smoking rates, emphasizing the importance of screening for PAD in asymptomatic patients.
Researchers predict a sharp increase in the US ESRD population by 2020, with over 785,000 patients expected to be affected. The study attributes this growth to the aging of Baby Boomers and rising diabetes rates.
A large-scale study has found no significant increase in cardiovascular risk for living kidney donors, but higher rates of high blood pressure were detected. The study analyzed data from 1,278 patients and compared them to 6,369 healthy adults.
Researchers used fMRI to investigate a woman's guilt in a poisoning case. The study found that when she agreed with her accusers' account, her brain activated extensive regions, indicating potential deception.
A new study suggests that treatment can lower the risk of stroke in people with rare lung disease. The research, published in the journal Thorax, found that seemingly healthy patients with pulmonary arteriovenous malformations (pulmonary AVMs) have the same risk of stroke as those who are obviously unwell.
The National Professional Science Master's Association will promote and support professional master's degree programs across the nation, encouraging their expansion and excellence. The organization aims to improve workforce preparation and employment opportunities for graduates of these programs.
A study published in Medical Care found that people infected with HIV continue to die and suffer from AIDS complications due to delayed diagnosis and treatment. Researchers discovered that patients who had received medical care for other illnesses were often not diagnosed with HIV infections earlier, leading to severe complications.
Yi Hua Ma, a Worcester Polytechnic Institute professor, is honored for his research on hydrogen separation using ultra-thin palladium membranes. His work has reduced the cost of generating hydrogen pure enough to power fuel cells.
Researchers found that children of parents who died from these cancers have significantly worse survival rates than those with good parental survival. The risk of death was increased by 75% for breast cancer and 107% for prostate cancer.
Two new studies, led by the University of Michigan Stroke Program, reveal that 69% of stroke victims don't reach the hospital within three hours of symptom onset, resulting in delayed tPA treatment. A middle-school education program shows promising results in improving recognition and response to stroke symptoms.
Researchers at UCLA will use a new super-resolution stimulated emission depletion (STED) microscope to investigate molecular assemblies and biological processes, including chromatin structure and cell signaling. The instrument will also enable the development of new family of STED probes based on semiconductor nanocrystals.
A two-year study found that cooperative activities enhanced students' higher-level skills, such as application of concepts and analysis, compared to traditional lecture methods. Students also developed valuable real-world skills, including communication, conflict resolution, and time management.
Arizona State University has partnered with BP and Science Foundation Arizona to develop a renewable source of biofuel using photosynthetic bacteria. This project aims to produce sustainable high-energy fuel that can be used in conventional engines, reducing our transportation economy's dependency on oil.
The study found that children who received continuous peripheral nerve blockade (CPNB) for pain management after orthopaedic surgery had better pain control and a shorter hospital stay. The catheter system offers continuous relief for up to 100 hours, potentially cheaper than alternative treatments and long hospital stays.
A study published in World Journal of Gastroenterology found that plasma serotonin levels significantly increase in patients with liver cirrhosis, correlating with the degree of liver damage. This discovery provides a potential non-invasive diagnostic method for assessing liver insufficiency.
Scientists question mandatory folic acid fortification in flour, citing risks of unmetabolised folic acid entering the bloodstream and causing problems for people with certain medical conditions. The study suggests that even low doses of folic acid could lead to overconsumption and health issues.
The project aims to create 'smart, self-assembling nano-biomaterials' that can control bacterial adhesion on synthetic surfaces. Successful development of these materials will enable the creation of more resistant biomedical implants.
Research investigates the role of NCAM-180 as a tumor suppressor in colorectal cancer, finding low frequency and lack of prognostic value. The study concludes that routine use of NCAM-180 expression is not feasible due to its rarity.
A new study by Dr. Eric Fombonne found that social skills training groups for autistic adolescents can lead to significant improvements in social and interpersonal skills. The groups, which involve role-playing and peer validation, have been shown to be efficient and effective in reducing problems with irritability and sensitivity.
A 24-week course of interferon-alpha therapy after curative treatment for HCV-associated HCC significantly reduces tumor recurrence rates and improves patient survival compared to those without interferon therapy. Patients who achieved a sustained virological response also exhibit improved liver function and prolonged overall survival.
Italian researchers propose that copper transport protein Ctr1 binds platinum ion from cisplatin, stabilizing the trimeric channel structure and enabling endocytosis. This process allows cisplatin to accumulate in organelles, including the nucleus, where it exerts its antitumor effects.
Mice rely on a highly specialised set of proteins in their urine to recognise different individuals, suggesting this may also be true for other animals. The team found that female mice distinguish between dominant and weaker males by the freshness of male scent-marks.
A novel way to remove iron from ferritin has been discovered by scientists, which could lead to the development of new medications for patients with blood diseases. The study found that a small protein or heptapeptide can bind to ferritin and accelerate its iron removal rate.
A large dose of dexamethasone has been found to improve survival rates and reduce inflammation in rats with severe acute pancreatitis. The treatment also alleviated pancreatic tissue damage and induced apoptosis in acinar cells.
A study by UNC researchers concludes that people over 60 with high blood pressure are less likely to receive lifestyle modification advice from their doctors compared to younger groups. Despite this, most patients remember receiving some type of advice on making healthier choices to lower their blood pressure.
A study by Jason Dyck at the University of Alberta found that a protein responsible for transporting fat into heart cells may be a key to preventing age-related decline in heart function. Genetically modified mice with this protein deficiency showed no accumulated fat in their hearts and outperformed normal aged mice on a treadmill test.
A recent study reveals that coating diamond surfaces with heavier hydrogen isotopes can significantly reduce friction forces. The research, led by Argonne scientist Anirudha Sumant, used single-crystal diamond surfaces coated with layers of atomic or deuterium to investigate the effect on surface vibrations.
Researchers developed a hairpin-shaped molecule that imitates the spatial structure of an important viral protein, preventing the discharge of viral RNA from the cell nucleus. This breakthrough could lead to the development of a new class of HIV treatment drugs.
The study highlights key constraints affecting sweetpotato productivity in developing countries, including control of viruses, improvement of planting material, and development of high-yield cultivars. Small-scale farmers are expected to benefit from emerging technologies based on research, with potential impact within 5-10 years.
Three anesthesiologists and a medical ethicist discuss whether doctors should participate in state-ordered executions, citing technical problems with lethal injection. They argue that doctors can minimize suffering, but others propose replacing anesthesia-related drugs with alternative personnel.
A case report published in the World Journal of Gastroenterology presents a new technique for biliary drainage using endosonography (ES) guidance. The study shows that ESBD is a safe and effective method without pain or restriction, potentially replacing percutaneous transhepatic cholangio-drainage (PTCD).
Researchers discovered that peroxynitrite plays a critical role in developing morphine tolerance. Therapeutic manipulation of peroxynitrite can prevent its formation or decomposition to maintain the pain-relieving effect of morphine, reducing side effects and improving patient outcomes.
A five-year longitudinal observational cohort study found that anxiety is strongly associated with sleep disturbances. Those who experience severe life events are more likely to develop sleep disturbances, especially if they already have a predisposition to anxiety.
Severe US wildfires can release as much CO2 as the entire transportation sector of a state, posing challenges for emissions tracking. The study found that fires in Western and Southeastern states account for a disproportionate share of carbon emissions.
The Lancet report highlights Australia's poor indigenous health statistics, including a 17-year gap in life expectancy between indigenous and non-indigenous Australians. Improving access to quality care, prevention strategies, and increasing the number of indigenous health workers are key recommendations.
A review of international research into resuscitation found that slow codes, where healthcare professionals resuscitate patients too slowly, are still an issue. Researchers agree that all decisions relating to cardiac resuscitation should be made in accordance with up-to-date clinical guidelines.
A study published in the journal SLEEP found that children with Asperger syndrome (AS) have a high prevalence of sleep disorders, particularly those related to initiating sleep and sleep restlessness. The study also showed unique patterns of cyclic alternating pattern (CAP) activity in AS subjects.
A panel of experts proposes a definition of recovery as a voluntarily maintained lifestyle characterized by sobriety, personal health, and citizenship. The proposed definition includes classification of duration of sobriety and recognition of the importance of personal health and citizenship in achieving true recovery.
The UMass Chan Medical School Heat Shock Protein Consortium will investigate the causes of type 1 diabetes with dual grants from the Juvenile Diabetes Research Foundation (JDRF) and The Iacocca Foundation. The research aims to understand the role of cellular stress in autoimmune diabetes, with specific focus on endoplasmic reticulum st...
The new protocol allows scientists to identify cell-cycle stages and analyze cell growth in mixed populations. It has been used to characterize immune cells in human blood, providing insight into their activity patterns.
Researchers at the University of Texas M. D. Anderson Cancer Center and Rice University have successfully destroyed liver cancer tumors using radio waves that heat up carbon nanotubes embedded in them. While there were some side effects on healthy tissue, the study shows promise for a new therapy.
The new NIST mini-sensor is almost 1000 times more sensitive than the original chip-scale magnetometer and can detect magnetic fields in the range of 3-40 femtoteslas. The device has potential applications in non-invasive biomagnetic measurements, such as fetal heart monitoring and brain activity measurement.
Dexamethasone treatment disrupts sleep and causes profound fatigue in children with ALL, according to a new St. Jude study. The research suggests that altering timing or dosing of the drug could lessen these side effects and improve quality of life.
UMMS associate professor JeanMarie Houghton received a Presidential Early Career Award for Scientists and Engineers, recognizing her work on the link between gastric cancers and bone marrow-derived stem cells. Her research aims to understand the progression of events leading to cancer development and develop targeted treatments.
UK government's focus on cannabis reclassification may divert attention from more pressing health concerns. Experts argue that increasing penalties have limited impact on cannabis use and harm, highlighting the need for better public communication about the risks of substance abuse.
Researchers at the National Physical Laboratory are working towards a redefinition of the kilogram, which could shift from a physical object to a fundamental physical constant. The goal is to improve accuracy and consistency in measurements, but current results show a significant discrepancy with previous data.
A team of researchers crafted a working radio from a single carbon nanotube, performing four critical roles: antenna, tunable filter, amplifier, and demodulator. The tiny device could have applications in radio-controlled devices, cell phones, and other fields.