A recent study highlights the need for better treatments for malaria in pregnancy, where the use of new medicines is often restricted due to limited clinical data. The authors argue that this 'catch-22' situation can lead to inferior drugs being prescribed, putting pregnant women's lives at risk.
Researchers at Tufts University School of Medicine identify adenomatous polyposis coli (APC) as a central organizer of neuronal cholinergic synapse assembly. This discovery sheds light on the mechanisms directing synapse formation, potentially shedding new insights into learning and memory disorders such as Alzheimer's disease and schi...
Researchers used PET imaging to detect structural and functional alterations in the circulatory system of asymptomatic diabetic patients. The study found that PET revealed coronary vascular dysfunction as a precursor to coronary artery disease, which may precede structural changes in the arterial wall.
Researchers are developing unique brain maps using microscopic imaging to enhance accuracy of brain surgery and disease diagnosis. The new technology will revolutionize the field by providing detailed views of individual brains.
A team of European astronomers has discovered a triple system of super-Earths around the star HD 40307 using the HARPS instrument. The planets have masses between 4.2 and 9.4 times that of Earth, and orbit the star with periods ranging from 4.3 to 20.4 days.
Researchers used PET imaging to assess the effects of methylphenidate on brain function in healthy adults. The study found that MP improved performance in those who needed it, but deteriorated it in others.
A gene variation called alternative splicing may explain why some people don't respond well to cholesterol-lowering drugs. Researchers found that this variation accounted for 9% of the reduced power of statins in lowering low-density lipoprotein (LDL) levels.
A study of over 7,600 Swedish twins found that genetic factors and the individual's unique environment play a significant role in determining their choice of sexual partner. The results suggest that familial and public attitudes have a minimal impact on this decision.
Older adults experience increased bone loss, but antiresorptive medications can attenuate this process. Researchers found that even in women aged 50-54, bone loss was only 1.3% per year.
Researchers developed a method to track mesenchymal stem cells in tumors using noninvasive molecular imaging technology. The technique offers promise for personalized medicine and gene-modified stem cell therapies to fight cancer.
Researchers found that hormone replacement therapy maintained coronary endothelial function, while those without HRT experienced worsening endothelium function. Postmenopausal women who gave up HRT demonstrated the most severe drop in endothelial function.
Researchers have identified a new family of compounds that can effectively treat estrogen receptor-positive breast cancers resistant to tamoxifen. The compounds, including TPBM and related agents, work by inhibiting the growth of cancer cells stimulated by estrogen.
Researchers developed a therapeutic system targeting HIF-1 activated cancer cells, showing success in laboratory tests. The system uses a reporter gene to detect and treat hypoxic cancer cells that are resistant to traditional treatments.
A new gene therapy has helped pet dogs with cancer live longer by increasing muscle strength and correcting common complications. The treatment has been shown to improve quality of life and survival rates, with 54% of dogs responding to the therapy and surviving 84% longer.
A new study presents radioimmunotherapy targeting viral antigens as a novel option to treat or prevent many viral cancers. The therapy offers 'exquisite specificity' in targeting cancer cells expressing viral antigens, allowing for more precise diagnosis and treatment.
A new nuclear medicine imaging test, scintigraphy, has been shown to be highly effective in detecting gastroesophageal reflux disease (GERD) in children with respiratory problems. The test detected GERD in 66.6% of children with asthma or lower respiratory tract infections, outperforming traditional barium X-ray technology.
Researchers found that misoprostol suppresses key immune responses and allows deadly infection to occur. The study has implications for understanding rare but life-threatening infections during pregnancy. More than a half-million women have taken the two-drug combination safely since its FDA approval in 2000.
The Rong Li Lab has discovered that TNF-alpha disrupts the localization of polycystin 2, promoting cyst formation in ADPKD. Inhibiting TNF-alpha with etanercept may prevent cyst development, providing a potential treatment for PKD.
A new study found that three months of aerobic exercise decreased body fat and calorie intake in overweight and obese people, with increased levels of brain-derived neurotrophic factor (BDNF) linked to reduced hunger and weight loss.
Researchers at Oregon State University successfully relocated Caspian terns to a new nesting site at Crump Lake, finding over 135 nesting pairs. The move aims to reduce the birds' impact on threatened and endangered salmon populations in the Columbia River estuary.
Research highlights the association between diabetes and hearing loss, as well as the potential health benefits of moderate coffee consumption. A new study also examines the cost-effectiveness of HIV screening in patients over 55 years old, finding it a viable option for this age group.
Researchers use monoclonal antibodies attached to carbon nanotubes that heat up when exposed to near-infrared light, killing cancer cells. The technique shows promise for targeting specific sites on lymphoma cells and potentially delivering a deadly payload.
Researchers used molecular imaging to monitor Alzheimer's disease progression, identifying those at risk and assessing therapy effectiveness. The study found that beta-amyloid imaging can detect AD earlier and distinguish it from other dementias.
Researchers at Hebrew University of Jerusalem developed a real-time test to monitor bacterial syringe activity, discovering new properties that could lead to drug development. This breakthrough has the potential to combat diseases caused by pathogens like Salmonella and E. coli.
Researchers found that resveratrol inhibits the growth of pre-fat cells and prevents them from converting into mature fat cells. Resveratrol also reduces production of cytokines linked to obesity-related disorders, such as diabetes and clogged coronary arteries.
A study by researchers at the University of Illinois Chicago found that women experience underreported hot flashes and these symptoms are linked to poor verbal memory. Objective measurement of hot flashes reveals a strong relationship between the number of hot flashes and memory performance.
Researchers are investigating the effectiveness of dietary changes and complementary medicine to control inflammatory bowel diseases (IBD) flare-ups. The studies aim to find alternative treatments with fewer side effects, targeting stress reduction and gut bacteria balance.
Researchers at the University of Illinois have identified a key detoxifying protein in Anopheles mosquitoes that metabolizes DDT, a synthetic insecticide used to control malaria-spreading mosquitoes. The protein CYP6Z1 belongs to a class of cytochrome P450 monooxygenases that play key roles in insect defenses against plant toxins.
Researchers discovered that BK channels become abnormally active after a seizure, leading to neuronal overexcitability, which may be associated with epilepsy development. A BK channel antagonist reversed abnormal excitability, offering new hope for individuals suffering from epilepsy.
The first semiconductor-based PET scanner demonstrates improved spatial resolution and reduced noise, enabling better characterization of diseases such as partial epilepsy and nasopharyngeal cancer. This technology holds promise for advancing early-stage diagnoses and assessing patient responses to therapies.
The study found that implementing endovascular abdominal aortic aneurysm repair reduces overall mortality in patients. Older patients and those who are hemodynamically stable experience the largest improvements in survival, shifting high-risk patients to this treatment option.
Carbon nanotubes have been engineered to improve the properties of solar cells by introducing defects, resulting in increased catalytic activity and reduced costs. The new material has the potential to replace traditional layers used in solar cells, leading to improved performance and more affordable energy technologies.
Researchers at the University of Missouri discovered significant changes in the brain's vascular system after menopause. The study advises extreme caution when using estrogen-based hormone therapies due to potential complications and adverse effects on vascular health.
Injury-related deaths among black males ages 15 to 24 decreased by 24% from 1999 to 2005, while injury death rates among white males increased by 7%. This reduction was attributed to a decrease in motor vehicle crashes and firearm suicides among black males.
The Canadian Multicentre Osteoporosis Study (CaMos) reveals that for women, menopause marks a critical period of decreased bone mineral density, with an average loss of 6.8% over 5 years in the hip. In men, BMD decreases more gradually, starting earlier around age 40, with a second period of decline after age 70.
Ben-Gurion University of the Negev researchers have developed a hand gesture recognition system that enables doctors to manipulate digital images during surgeries by motioning instead of touching screens. This system reduces sterility risks and prevents the spread of infection, which is particularly important in hospital operating rooms.
The Self Cleansing Intrusion Tolerance (SCIT) technology developed by George Mason University researchers limits the damage caused by unknown cyber-attacks by restricting exposure time. By periodically cleansing servers, SCIT reduces the risk of data theft and provides an additional layer of defense against intrusions.
A team of international researchers led by Professor Rajeev Ahuja has discovered an atomic-level mechanism for releasing hydrogen from magnesium nanoparticles, which could lead to more efficient hydrogen storage. The finding opens up new possibilities for fuel cells using hydrogen as a clean and environmentally friendly energy source.
Researchers discovered misfolded proteins TDP-43 accumulate throughout the brain of ALS patients, indicating broader neurological effects. The findings suggest new therapies for ALS should target molecular targets beyond just motor neurons.
Two images, one showing neuroendocrine cancer relapse and the other a foot infection, demonstrate molecular imaging's ability to provide precise snapshots of disease anatomy. Imaging techniques are increasingly being used in combination to improve treatment planning and patient outcomes.
Research into crystal meth addiction has been limited to animal studies, but potential therapeutic agents targeting dopamine and non-dopamine systems are in clinical testing. The article highlights the need for accelerated clinical trials to address the public health importance of this issue.
Scientists used Exploratory Investigational New Drug (ExpIND) to evaluate four 18F-labeled imaging agents in patients with Alzheimer's disease, identifying the best detector of amyloid plaque deposits. The study suggested that ExpIND could speed up the development of new radiopharmaceuticals while ensuring patient safety.
Research shows that people with temporal arteritis, an inflammatory artery disease, are three times more likely to experience blindness due to swollen arteries restricting blood flow. The disease is often accompanied by symptoms like headaches and jaw soreness, and if left untreated can lead to severe vision loss or stroke.
A systematic review found short-term medical cannabinoid use linked to higher rates of non-serious adverse events, particularly dizziness. However, longer-term effects in chronic illness remain unexplored.
Researchers found adult stem cells can improve fracture healing by increasing bone and cartilage formation at the fracture site. This approach may lead to a new treatment for people suffering from non-healing fractures, which can cause pain, deformities, and even death.
Researchers recommend HIV screening for most adults aged 55 to 75 due to its cost-effectiveness and potential to prolong life. The study found that screening in this age group could add half a year to the life of an HIV-positive patient under 65 and four months for those over 65.
Scientists at La Jolla Institute for Immunology discovered a previously unknown mechanism in how the body responds to viruses, illuminating a new approach to developing vaccines. The finding reveals that B cells and CD4 T cells recognize the same piece of the virus, narrowing down the search for antigens.
The new scanner enables physicians to determine stages of breast cancer in patients already diagnosed, rather than as a mammography screening tool. It also helps plan breast cancer surgeries and detect early whether drug treatments are effective.
Researchers used PET scans to analyze 38 patients with non-Hodgkin's lymphoma treated with 90 ibritumomab tiuxetan. The study found that 89% of patients were in complete or partial remission after treatment, with a higher response rate for patients with limited cancer progression.
Researchers have developed a model to explain the mechanism behind the molecular switch, which could fit more than a trillion switches onto a centimeter-square chip. The model reveals a quantum phase transition that could enable the creation of a new type of switch with promise as a digital electronics foundation.
Researchers at the University of Illinois have identified a new family of agents that inhibit the growth of estrogen-dependent breast cancer cells. These compounds specifically target the binding of estrogen-receptor complex to regulatory regions of genes, effectively retarding protein production and cell proliferation.
Research by Professor Adam Galinsky and colleagues reveals that legitimate power leads to increased action, while illegitimate power motivates resistance. The study's findings have significant implications for our understanding of power dynamics and behavior.
A team of Florida scientists, including Mark Atkinson, Michael Haller, and Desmond Schatz, have received the sixth annual Excellence in Clinical Research Award from JDRF International. The award recognizes their innovative work on using umbilical cord blood stem cells and drug treatments to prevent and reverse type 1 diabetes.
Researchers at SNM's 55th Annual Meeting present a study on pre-targeting strategies that combine molecular imaging techniques with targeted therapy, offering personalized medicine to cancer patients. This approach can increase the effectiveness of therapies and minimize discomfort during treatment.
Researchers found a faster disease course and increased HIV entry in patients with the apoE4 allele. The study suggests apoE4 may have clinical applicability in treating both Alzheimer's and HIV diseases.
Researchers say combined PET/CT scanning can enable doctors to determine if ovarian cancer has spread without surgery, reducing unnecessary surgeries and complications. The technology showed promising results in accurately staging early-stage ovarian cancer patients.
Recent studies in Papua and New Guinea reveal P. vivax cases, particularly in young children, are more likely to develop severe disease and experience cerebral malaria.
A meta-analysis of 51 studies found that ultrasonic equipment was at least as effective and safe as conventional equipment, with reduced average blood loss in most procedures. Ultrasonic instruments also resulted in shorter surgery times and fewer complications such as blood clots and nerve injuries.
Researchers found that total hip replacements improve physical functioning and increase ability to care for oneself in seniors with osteoarthritis. The study also showed cost savings for the healthcare system due to reduced long-term disability costs.
Adults with diabetes are more likely to experience hearing loss due to the disease's impact on nerves and blood vessels in the inner ear. Researchers discovered a strong association between high-frequency sound sensitivity and diabetes, which may be linked to nerve damage and increased risk of heart disease.