Researchers found that extensive liver resection impairs the regenerative capacity of the liver on a molecular and cellular level. Key findings include delayed activation of NF-kappa B and increased programmed cellular death in regenerating livers.
Prisons have high-risk environments for HIV transmission due to needle-sharing. Implementing needle/syringe programs (NSPs) and opioid substitution therapy (OST) can reduce risky behavior, overdose deaths, and improve relationships between prisoners and staff. These measures are essential for protecting prisoners' health.
The Institute for Research in Biomedicine (IRB Barcelona) will coordinate two European health research projects on malaria and diabetes. The Mephitis project aims to find new anti-malarial compounds, while the MITIN Project applies bioinformatics to understand complex diseases like diabetes.
Researchers discovered that compounds like sulforaphane inhibit cell proliferation and kill precancerous cells, similar to anticancer drugs. This finding suggests that consuming cruciferous vegetables like broccoli may help prevent breast cancer.
The Krumlauf Lab has discovered that protein coding regions can modulate gene expression in the developing brain. This finding has important implications for understanding the regulation of brain development and designing tests for large-scale analyses of gene regulation.
A survey of US academic emergency physicians found nearly all believed police use excessive force during arrests and detentions. Doctors frequently treated patients with blunt trauma and handcuff injuries sustained by police officers.
Researchers at UC Davis Cancer Center have identified three compounds that can help make chemotherapy for kidney cancer more effective by blocking the repair mechanism of a key cancer gene. These findings offer hope for patients who currently face limited treatment options and many side effects.
In a rat model of depression, fluoxetine inhibited mast cell ultrastructural alterations and de-regulated rMCP-1 expression. Treatment with fluoxetine suggested that SSRIs are an effective therapeutic agent for some gastroduodenal diseases caused by psychological factors.
Researchers have developed a new method to boost the efficiency of solar cells by using nanoparticles. By scattering light and improving color-specific capture, this approach could significantly improve sunlight conversion rates.
A study led by Nina Luning Prak found a lower level of antibody editing in mice and human blood samples from patients with lupus and type 1 diabetes. This suggests that not all autoimmunity is caused by errors in editing, requiring a targeted approach for treatment.
The Rockefeller University Center for Clinical and Translational Science has awarded grants to university investigators to conduct early studies in translational science. These studies may lead to improvements in human health if successful.
SUNY Downstate researchers discovered that the PKMzeta molecule stores complex memories while leaving other brain functions intact. This finding suggests that targeting specific debilitating memories with PKMzeta erasure could be effective in treating conditions like depression, anxiety, and addictions.
Engineers have achieved a new record in efficiency of blue organic light-emitting diodes (OLEDs), which can produce high-quality white light similar to standard incandescent bulbs. The breakthrough paves the way for more efficient and affordable lighting solutions.
A new report suggests that routine dental cleanings and periodontal scaling can lower medical care costs for people with diabetes. The study found significant reductions in medical expenses, with costs decreasing by an average of 11-12% per month.
In eastern Burma, over 88% of women had home deliveries, with displaced women facing up to 5 times less antenatal care. Human rights violations, including displacement and forced labor, exacerbate poor health outcomes. The study highlights the need for increased access to maternal healthcare services in conflict-affected regions.
A study found that participants who slept an hour longer per night had a lower incidence of coronary artery calcification, a predictor of future heart disease. The association was similar to established coronary risk factors and held true even after adjusting for potential confounders.
Researchers at Harvard University discovered that many fungal species produce spores with aerodynamically optimized shapes, allowing them to minimize air resistance and maximize travel distance. In contrast, spores transported by animals lack these drag-minimizing features.
A study found that psychiatric patients in Medicare plans with equal cost sharing for mental health services had higher use of those services compared to those in plans with greater cost sharing. Individuals in full-parity plans were more likely to visit a mental health practitioner within 7 and 30 days after a hospitalization.
Researchers discovered that bone marrow-derived dendritic cells (BM-DCs) pulsed with tumor lysates can stimulate T cells to attack and kill gastric cancer cells. This finding suggests a potential new approach for treating advanced gastric cancer.
Researchers found that honey bees on cocaine exaggerate their dances, regardless of food quality or hive status. The study supports the idea that insects have a reward system motivated by feelings of pleasure.
A systematic review found that homeless people in the US, UK, mainland Europe, and Australia have higher rates of mental health problems than the general population. The editorial argues that 'imaginative and collaborative solutions' are needed to address these complex needs.
Researchers have developed a genetic modification that modifies the connections in lignin, making it easier to break down and access cellulose for ethanol production. The modified plants show increased sugar yields without compromising plant strength or lignin content.
Scientists used live animal imaging to study chronic Listeria infection harbored in bone marrow, finding persistent patches of bacteria. The researchers also explored attenuated strains of Listeria for cancer treatment, but it's unclear if bacterial persistence affects therapeutic effects.
A systematic review of carbon nanotubes' cytotoxicity found that various factors affect CNTs' toxicity, including species, impurities, lengths, and assaying methods. The study emphasizes the need for more complete characterization and determination of cell viability to ensure safe application of CNTs.
A new study found that British American Tobacco used a multi-pronged strategy to undermine China's secondhand smoke policy. BAT funded the Beijing Liver Foundation and promoted ineffective ventilation systems, diverting attention from SHS issues. Researchers call for policymakers and media to be aware of these tactics.
Researchers have redesigned factor VIII to increase its ability to drive blood clotting, which could lead to more effective and less burdensome hemophilia treatment. The new design improves the stability of the protein, allowing it to withstand manufacturing processes and exposure to the human bloodstream.
Maura Borrego, a Virginia Tech assistant professor, received the Presidential Early Career Award for her development of methods to prepare faculty and students for interdisciplinary research. Her award marks the first one given to an engineer in this area.
Researchers found that overweight and obese women who thought they weighed less than they actually did at the start of pregnancy had seven times the odds of gaining excessive weight during their pregnancy. In contrast, normal weight women who thought they weighed more than they actually did had twice the odds of gaining excessive weight.
Researchers have determined the atomic-level structure of botulinum neurotoxin subtype E, revealing a unique arrangement that may help explain its faster-acting properties. This finding could lead to the development of faster-acting vaccines and therapeutic agents.
A Princeton-led team discovered a new mechanism for making electronic materials emit laser beams, potentially leading to more efficient lasers with applications in environmental monitoring and medical diagnostics. The new laser phenomenon has some interesting features, including reduced photon absorption and improved performance.
A Stanford researcher has quantified the enormous size jumps of life on Earth, finding two major leaps: one 1.6 billion years ago and another 600 million years ago. These increases were triggered by significant boosts in atmospheric oxygen levels, which enabled eukaryotic cells to develop and multi-cellularity to emerge.
A Michigan State University researcher found that specific genes may influence social consequences of behaviors, including popularity among peers. Male college students with a rule-breaking gene were rated most popular by unacquainted peers.
Research at UCL found premature infants who required intensive care or surgery have reduced sensitivity to temperature and pain later in life. This study, published in the journal Pain, suggests that early medical interventions may alter how children respond to painful stimuli.
Researchers found that leptin enlists the sympathetic nervous system to prevent bone-making cells from releasing osteocalcin, which stimulates insulin release. This back-door route could lead to a new treatment for diabetes using osteocalcin.
Researchers at Harvard Medical School discovered a natural product, surfactin, that causes bacteria to form social networks. Biofilm formation is triggered by potassium leakage and subsequent gene activity, leading to the creation of complex communities.
Research found that gene expression and alternative splicing vary significantly between blood and brain tissues, with potential implications for understanding diseases such as epilepsy and Alzheimer's. The study suggests that genetic variation affecting splicing may be more relevant to disease than variations in overall gene expression.
Researchers found that honeybees reduce plant damage by 60-70% when present, even without pollination, due to the caterpillars' inability to distinguish between bees and predators. This discovery highlights the importance of indirect effects in food webs and may lead to a new biological control method for sustainable agriculture.
A trial conducted in northwest Thailand found that artemisinin combination therapy (ACT) is safe for pregnant women with malaria, but its efficacy is inferior to single-drug artesunate treatment. The study suggests that longer regimens of ACT may be more effective in treating pregnant women.
A recent study found that nearly 90% of women in eastern Burma gave birth at home without a skilled attendant present, while only a third had any antenatal or postnatal care. The research also revealed high rates of anemia, malaria, and poor nutrition among the population.
Research identified common variants in ABCB1 and ABCC1 genes that increase lung cancer risk. Variants were found more often in patients than controls, particularly in women and younger individuals. These findings may help prevent tobacco-related cancers.
Only 3% of fast-food kids' meals met federal dietary guidelines, with fruit as a side dish and milk being common, while most exceeded sodium and added sugar limits. Researchers call on the industry to develop nutritious options and parents to make informed choices.
Researchers demonstrate a blind man's ability to navigate an obstacle course without visual awareness, utilizing alternative brain routes. The study reveals the importance of these hidden pathways in everyday navigation and function.
The Lunar Reconnaissance Orbiter has successfully completed thermal vacuum testing at NASA's Goddard Space Flight Center, simulating extreme hot and cold conditions of space. The orbiter will carry seven instruments to provide detailed maps of the lunar surface and increase understanding of its topography and natural resources.
Researchers found that people from the same racial group as participants are more sensitive to signs of anxiety, such as fidgeting and vocal tension, in interracial interactions. This 'in-group advantage' makes it difficult for those outside the same racial group to detect changes in anxiety levels.
Researchers have discovered that people naturally produce salicylic acid (SA) in their bodies, which is also found in fruits and vegetables. This finding suggests SA may play a role as an animal bioregulator in fighting inflammation and disease.
Researchers at Saint Louis University discovered genetic patterns that can predict which patients are likely to respond to hepatitis C treatment. The study identified 'covariance networks' in the genes of patients who responded and resisted therapy, revealing a complex web of amino acid interactions.
Researchers found that activating Nrf2 can prevent emphysema in mice by reducing oxidative stress and improving lung function. The study suggests targeting Nrf2 could be a novel strategy for preventing chronic obstructive pulmonary disease (COPD).
Scientists identify a common vulnerability in rotaviruses, enabling the development of a broad-spectrum treatment for severe diarrheal diseases. This breakthrough could lead to improved vaccines and medications to prevent or treat rotavirus infections.
Researchers at Northwestern University have developed a new method to produce and sort out double-walled carbon nanotubes, overcoming the challenge of sorting valuable tubes from other types. This breakthrough discovery has significant implications for advanced solar panels, sensors, and other renewable energy technologies.
A new study finds that hospice services are restricted by eligibility criteria that reduce usage among patients who need it most, particularly African Americans. The researchers suggest revising the criteria to prioritize those with greater needs for specific services like pain management.
Artificial human bone marrow can replicate blood stem cells and produce B cells, key immune cells, in a test tube. This development could lead to simpler drug testing and a continuous supply of blood for transfusions.
Researchers found that high-risk drivers are less likely to drink and drive if they perceive a probability of being stopped or arrested by law enforcement. The study suggests that public safety education, media efforts, and high-visibility enforcement campaigns can effectively deter drunk driving behavior.
Researchers used repeating microearthquakes to estimate the deep slip rate of the Lijiang-Ninglang fault, yielding a value of 5 mm/yr at 23 km depth. This discovery provides a new method for inferring slip rates along active faults and sheds light on earthquake recurrence.
A new prototype cell phone uses holographic lens-free imaging to accurately identify smaller particles such as E. coli in saliva or blood samples, enabling rapid diagnosis of diseases like HIV and malaria. The technology also has potential for monitoring water quality and detecting hazardous microparticles in disaster situations.
Researchers employed intravital two-photon microscopy to study immune cells in mice with viral meningitis. They found that T-cells didn't attack infected cells but instead recruited monocytes and neutrophils, which caused fatal seizures.
Researchers found that CD4+ T cells play a significant role in Parkinson's disease progression. Infiltration of these immune cells in the brain contributes to neurodegeneration. Targeting the immune system might offer a new therapeutic approach.
Researchers studied odorant octanal and its shape-changing properties to understand how our sense of smell works. They found that conformationally constrained odorants can alter fragrance mixture odors by muting flexible odorant activity or activating smaller subsets of olfactory sensory neurons.
Researchers at Memorial Sloan Kettering Cancer Center developed a new generation of microscopic particles, called C dots, that are biologically safe and stable. These particles can be customized to target specific molecules on tumor surfaces, enabling earlier detection and more personalized treatment options.
Researchers found that adjusting warfarin doses only when the international normalized ratio is between 1.7 and 3.3 improves patient outcomes. The study used a model to predict optimal dose changes based on clinic visits and anticoagulation control, revealing that patients deviating from predicted changes had worse control.
Researchers created a simple model to predict patients at high risk for chronic kidney disease, using an eight-point risk factor checklist. The model accurately stratifies middle-aged and older patients and has been validated across different cohorts.