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Science News for May 31, 2008


Genetics of ALS progression

ALS researchers have identified a molecular pathway where mutated SOD1 leads to accumulation of malformed proteins in motor neurons, causing ER stress and cell death. Inactivating key factors in this pathway may mitigate neurodegeneration and prolong survival in mouse models.

SourceCold Spring Harbor Laboratory·JournalGenes & Development·DateMay 31, 2008