Researchers at McGill University are targeting a small organelle called glycosome to develop new treatments for Leishmania parasite. The goal is to create less toxic drugs with fewer side effects. A potential breakthrough could help combat devastating diseases like African Sleeping Sickness and Chagas' Disease.
A new statistical model, developed by researchers at the Seattle Cancer Care Alliance, uses three key characteristics to predict malignancy in breast lesions. The model identifies patients and lesions that are highly likely to be benign, allowing for reduced unnecessary biopsies.
Biologists have discovered a sexual cycle in the deadly fungus Aspergillus fumigatus, revealing its ability to adapt to new environments and evade antifungal drugs. This breakthrough could lead to new treatments for patients infected with the fungus, which causes severe asthma and immune deficiency-related deaths.
Researchers found seven different receptors on T cells that can tamp down immune responses, leading to exhaustion. Blocking multiple inhibitory receptors, such as PD-1 and LAG-3, improved T cell responses and viral control.
Researchers found that combining PI3K and MEK inhibitors led to significant tumor shrinkage in mice with lung cancer driven by K-Ras mutations. The combination treatment eradicated the tumors with minimal toxicity, providing a strong rationale for testing this therapy in human trials.
UK scientists claim ancient Earth never froze completely during the Cryogenian Period due to carbon dioxide's insulating effect. This contradicts the Snowball Earth hypothesis, which suggests a fully frozen planet.
A study funded by the Economic and Social Research Council found that NHS hospitals' risk management standards are linked to lower MRSA infection rates. Hospitals that meet certain targets receive discounts on their liability insurance premiums, leading to a reduction in infections.
A study published in the Journal of Consulting and Clinical Psychology shows that Mindfulness Based Cognitive Therapy (MBCT) is as effective as anti-depressant medication in preventing relapse and enhancing quality of life for people with long-term depression. The study found that MBCT provides a cost-effective alternative to prescript...
Researchers question the long-held free radical theory of ageing, suggesting that oxidative stress is not a major cause of ageing. The study found no significant impact on lifespan when controlling superoxide levels in nematode worms.
Researchers at Stanford University School of Medicine have shown that distinct groups of proteins each control one of four simple activities involved in the cells' collective migration. The study overturns an assumption common in genomics and provides a powerful tool for developing new therapeutics.