Researchers have identified a critical component, Jarid2, of the delicate balancing act between stem cell specialization and cellular chaos. The study reveals how Jarid2 recruits PRC2 to genes important in differentiation and modulates its activity to keep it poised for action.
Researchers have identified a molecular scaffold that bridges the two rare inherited disorders, revealing how cells repair damaged DNA. The study suggests that disruption of this interaction leads to similar chromosomal repair defects in both Fanconi anemia and Bloom's syndrome.
Researchers at the Salk Institute discovered that CtIP plays a crucial role in converting DNA damage signals into repair responses. By understanding how CtIP works, scientists hope to develop new cancer treatments and uncover the secrets of DNA repair.
Researchers discovered a molecular switch that prevents Huntington's disease from developing in mice, providing new hope for treating the genetic disorder. The study suggests that phosphorylation of specific amino acids near the huntingtin protein can prevent the onset of symptoms.
Researchers found that injecting triamcinolone into the eye may slow proliferative diabetic retinopathy progression, but not macular edema. Steroid treatments reduced the risk of retinopathy progression without significantly improving vision outcomes.
Researchers identified a link between Sec24b and Vangl2 genes in mouse spinal cord development, which may lead to new research on all spinal defects. The discovery opens doors for investigating the root of spinal cord defects in humans.
Scientists discovered that locusts, like mammals, rely on vision rather than touch to navigate ladders. This finding highlights the complexity of insect behavior and challenges the notion that larger brains are necessary for sophisticated motor control.
A new study reveals that self-seeding allows circulating tumor cells to return to their primary tumor and promote local growth while increasing potential for distant metastases. The research identifies key genes responsible for this process, which may lead to targeted therapies to slow or prevent tumor progression.
A new study shows that locusts rely on visual input from a single eye to control their legs while walking, achieving similar results to vertebrates like humans or cats. This discovery emphasizes how insects can use simpler mechanisms to achieve complex behaviors with fewer neurons.
Researchers found that vitamin C accelerates gene expression changes and promotes efficient iPSC generation. The study suggests a simple way to improve iPSC production, which can be considered a reversal of the aging process at the cellular level.
A recent study by researchers at the Salk Institute found that the superior colliculus plays a key role in controlling attention, particularly in covert attention. This discovery may shed light on neurological disorders such as neglect syndrome and autism.
Two studies found that small changes to a protein's chemistry can eliminate signs of Huntington's disease in mice. Researchers identified two amino acids critical for regulating the toxic protein, suggesting potential targets for drug therapy.