Researchers at Emerald BioStructures have developed new allosteric small molecule modulators of phosphodiesterase-4 (PDE4) with improved safety and efficacy. These discoveries validate the company's structure-based drug design capabilities for addressing previously undruggable targets in inflammatory diseases and cognitive impairments.
Researchers created stimulus-specific sustained activity patterns in brain circuits maintained in vitro, revealing the possibility of storing information in isolated brain tissue. The study found that semilunar granule cells played a critical role in this process.
Using disinfectants can promote the growth of antibiotic-resistant bacteria, such as Pseudomonas aeruginosa. This adaptation enables the bacteria to survive and infect patients even without exposure to antibiotics.
Researchers at Helmholtz Munich identified genetic variants associated with disturbances in lipid metabolism, which may contribute to the development of diabetes. The study provides a new approach for early diagnosis and therapy of metabolic diseases.