Researchers found that narciclasine, a natural compound in daffodil bulbs, markedly reduces cancer cell proliferation and migration. The study suggests that narciclasine selectively inhibits the growth of very aggressive cancer cells while avoiding adverse effects on normal cells.
A new study reveals that social and genetic effects are both crucial for female dolphins' reproductive success. Female dolphins who have help from their friends and relatives tend to be more successful mothers than those without such support.
A recent review reveals that antibiotics can alter normal gut bacteria composition and leave resistance genes present for extended periods. This increases the risk of pathogenic bacteria survival and multi-drug resistance.
A study published in Psychological Science found that associating an object with anger motivates people to want it, similar to how positive emotions motivate us. This surprising result suggests that anger has some positive features and can even drive motivation.
Excess nitrogen in groundwater and water bodies harms aquatic life; new denitrifying bioreactors can treat agricultural runoff and urban wastewater at a lower cost. Research confirms successful operation in various settings, including agricultural fields and small townships.
A recent study published in Archives of Pediatrics & Adolescent Medicine found that non-medical prescription drug use is more prevalent among rural teens compared to urban peers. The study analyzed data from 17,872 adolescents and found that 13% of rural teens reported ever using prescription drugs for non-medical purposes, compared to...
New data from Phase 3 studies demonstrated telaprevir-based combination therapy achieved higher viral cure rates (75%) compared to current therapies, with significant improvements in response to treatment across various patient groups. African Americans and those with advanced liver fibrosis or cirrhosis also showed improved SVR rates.
A study from Rhode Island Hospital found that 33 individuals were responsible for 305 cases of medical intervention to remove intentionally swallowed foreign bodies, resulting in estimated hospital costs of over $2 million. The most common items ingested were pens, batteries, knives, and razor blades.
A team of ASU professors will evaluate novel 'soft law' mechanisms for oversight of nanotechnology using the grant. They aim to bring cutting-edge analysis of innovative governance mechanisms to the rapidly-developing technology, focusing on industry groups, non-governmental organizations, and voluntary norms.
Researchers found the PHQ-9 screening test to be effective in detecting major depression in teenagers with a sensitivity of 89.5% and specificity of 77.5%. The team concluded that the PHQ-9 is an excellent choice for primary care clinicians seeking to screen for depression in teens.
Researchers identify five flirting styles: physical, traditional, polite, sincere and playful. Self-awareness can help individuals avoid past dating mistakes and succeed in courtship. The study's results have value beyond research, highlighting the importance of early relationship development.
The University of Rochester Medical Center has been awarded a $1 million contract to launch an initiative that aims to accelerate the identification of improved pain treatments. The partnership, known as Analgesic Clinical Trial Innovations, Opportunities, and Networks (ACTION), will analyze clinical trials to identify problems in tria...
A new survey conducted by researchers at UCSF and UC Merced found that half of teens who have oral sex during the ninth grade will have intercourse by the end of the 11th grade. The study also suggests that oral sex can influence the onset of riskier sexual behavior, highlighting the need for comprehensive sex education programs.
Researchers developed a new animal model that uniquely identifies genes associated with increased resistance to disease in high-runners, which could help explore mechanisms underlying complex diseases and develop effective diagnostics and therapies.
Two compounds, called PITs (non-phosphoinositide PIP3 inhibitors), show promise in halting cancer growth by inducing cell death and limiting tumor growth in mice. These compounds interfere with cell signaling pathways, positioning them as a promising new approach to cancer treatment.
A study of 70 babies' brain scans found that their brains already have adult-equivalent networks at birth, including the default mode network involved in introspection. The research suggests that conscious introspection may be more complex than previously thought, with other factors also playing a role.
Using x-ray crystallography, researchers at Saint Louis University have revealed the molecular structure of the zymogen form of thrombin, a precursor to the active enzyme involved in blood clotting. This discovery provides crucial information about the activation mechanism and opens new opportunities for therapeutic intervention.
Virginia Tech computer scientist Daphne Yao and her student Deian Stefan have designed a software framework called Telling Human and Bot Apart (TUBA) to combat 'spoofing attacks' that hack into user identities. Their system uses keystroke-dynamics information to authenticate users and detect anomalous activities on personal computers.
A new study by the US Forest Service found that certain types of city trees can reduce property and violent crime rates. Large street trees were associated with lower crime rates, while numerous small yard trees may increase crime by blocking views.
The LSU Health Sciences Center New Orleans Department of Psychiatry was recognized for its successful integration of mental health services into the school system, youth leadership, and community outreach after Hurricane Katrina. A study found that 72.3% of students had recovered or demonstrated resilience five years post-Katrina.
Scientists imaged individual neurons in zebrafish optic tectum, finding that strong activation leads to chasing motion, while weak activation results in no action. Inhibitory neurons play a key role in filtering out irrelevant signals.
Researchers at Bell Laboratories have created braided anyons that can withstand disturbances and store quantum information, potentially dispending with error prevention methods. The findings suggest that two-dimensional braids could lead to more robust quantum computing schemes.
Researchers have solved some of the mysteries of the zebrafish's neural circuit that underlies its vision. By analyzing the brain activity of retinal cells, they found that large visual stimuli are filtered out to prevent overreacting, while small moving objects activate the output neurons efficiently.
Researchers found that younger women (under 35) are more likely to have cancer invade lymph nodes, while a posterior axillary boost reduces regional recurrence rates. The study suggests patients at higher risk may benefit from additional radiation therapy under the armpit.
A recent study has found that elderly women are at higher risk of receiving unnecessary urinary catheters in emergency departments. The study revealed that nearly half of female patients over 80 years old did not meet institutional guidelines for urinary catheter placement.
A new study reveals that the protein T-cadherin is necessary for adiponectin's cardioprotective functions. Adiponectin activates AMPK, which regulates energy usage in the cell. The absence of T-cadherin leads to impaired AMPK activity and increased cardiac damage.
Research by Imperial College London and UCSF suggests that anti-inflammatory drugs could help prevent cognitive problems after surgery. The study found that a specific inflammatory response in the brain triggers memory loss, and targeting this response with TNF inhibitors may be an effective treatment approach.
A new study shows that using a more expensive but accurate tool to test for glaucoma can reduce unnecessary referrals by nearly two thirds. This could alleviate pressure on hospitals and lower costs for patients.
A study by the American College of Radiology found that nearly all US community facilities performing breast MRI exams meet ACRIN and EUSOBI technical requirements. The Breast Cancer Surveillance Consortium data revealed excellent adherence to equipment recommendations, with 94% of scanners using a dedicated breast coil.
A team of UCLA chemists and engineers has developed a new method for coating large surfaces with nanofiber thin films that are both transparent and electrically conductive. The technique, published in the Proceedings of National Academy of Sciences, uses a solution-based approach and can be applied to virtually any surface.
A railroad bypassed the first black-founded town in the United States, New Philadelphia, Illinois, to avoid expensive iron rails. The town's location proved more favorable for a straight route, but a shallow creek required a curved detour that increased construction costs.
A study by the University of Wisconsin-Madison and other institutions reveals that expanding croplands in the tropics releases nearly twice as much carbon per unit of food produced compared to temperate regions. The findings highlight a pressing need to balance agricultural production with carbon sequestration.
Researchers found a tight coupling between intention and action in skilled typists, suggesting conscious control is not an illusion. Typists' fingers slowed down only when they made errors, regardless of whether the error was corrected or not.
Researchers at UC discover that rabbit food can effectively reduce estrogen levels in wastewater, with a potential impact on the environment and wildlife. The study found that the rabbit food reduced estrogen hormone levels by more than 80%, making it a promising alternative for treatment.
A new study using positron emission tomography (PET) and magnetic resonance imaging (MRI) found that traumatic brain injuries lead to widespread decreases in brain functioning, particularly in the hippocampus. The research suggests a time window during which intervention could mitigate long-term neurological consequences.
A study by Saleem Alhabash and colleagues found that individuals conditioned to reject racial stereotypes showed increased attention to commercials with black actors, while those in the affirmation condition decreased their attention. This paradigm demonstrates the power of media training in shaping audience responses.
Researchers at Henry Ford Hospital found that African American patients are more likely to have a recurrence of uterine cancer after undergoing a total hysterectomy or radiation therapy. The study, which analyzed 750 patients, also identified higher tumor grade and cancer stage as risk factors for recurrence.
Researchers at NYU's Courant Institute of Mathematical Sciences developed an algebraic model to predict DNA hybridization, enabling the monitoring of cell gene expression and genome characterization. The study provides a new tool for understanding biological systems and enhancing cancer and genetics research.
A new study from the University of Michigan suggests that Helicobacter pylori infection in the stomach may reduce the severity of colitis caused by Salmonella. The research found that H. pylori infection alters the immunological environment of the lower gastrointestinal tract, leading to reduced inflammation.
Researchers have linked anti-inflammatory arthritis drugs to preventing cognitive decline after surgery by targeting a specific inflammatory response in the brain. The findings suggest that these therapies could lead to human clinical trials within 12 months.
A Brown University-led study reveals significant geographic disparities in lead poisoning rates across Rhode Island, with some areas experiencing rates as high as 48.6% among young children. The analysis highlights the need for targeted cleanup efforts to address these disparities and mitigate the long-term effects of lead poisoning.
A study of depressed adolescents found that nearly all recovered from their depression after treatment, but nearly half relapsed within five years. Females were at significantly higher risk of another major episode than males.
A study has characterized a crucial chemical reaction that affects ground-level ozone formation in urban areas. The research, funded by NSF and NASA, reveals that current computer models may underestimate ozone levels in urban areas by up to 10%.
Researchers identified a novel negative regulator called eye transformer that controls the flow of information from chemical signals to genes in the cell nucleus. When this regulator is turned off, the JAK/STAT pathway hyper-activates, leading to conditions such as cancer, severe immune deficiencies, and autoimmune diseases.
Researchers tested three MRI contrast agents on different stem cell populations and found changes in stem cell proliferation depending on the agent used. The study revealed varying labeling efficiencies with each agent, but no significant alterations in cell phenotypes or differentiation.
A new study published in the New England Journal of Medicine found that crizotinib caused tumors to stop growing, shrink or disappear in 57-33 percent of patients with a specific genetic mutation. This represents a significant improvement over the current standard treatment, which has a response rate of around 15 percent.
Researchers found that plugged females mated just as often and were more attractive than unplugged ones. Plugging improved female fitness by increasing egg production, suggesting a male's act may be beneficial to its partner. The study reveals new insights into the reproductive behavior of nematode worms.
New 3D modeling of Anomalocaris' mouth parts reveals they were flexible, not hard like teeth. This challenges the long-held idea that it preyed on trilobites with hard shells. The investigation also found no signs of wear on the mouth parts, which further supports a soft-food diet.
A grant-funded program has helped increase the number of underrepresented minority surgeons in academia, with 86% of graduates acquiring fellowship training. The Diverse Surgeons Initiative addresses healthcare disparities by providing advanced minimally invasive surgery skills to qualified candidates.
A team of Rutgers and Chilean astrophysicists has discovered 10 new massive galaxy clusters, shedding light on the universe's birth and evolution. The breakthrough technique uses 'cosmic shadows' to reveal these previously unseen clusters.
A study found that adding monounsaturated fats to a low-cholesterol diet increased HDL by 12.5% and lowered LDL levels by 35%. The Mediterranean diet is an effective approach to cholesterol control. Increasing dietary monounsaturated fat may enhance the cardioprotective effect of cholesterol-lowering diets.
Researchers at IRCM identified a mechanism regulating activation-induced deaminase, which could lead to new therapies for some types of lymphoma and leukemia. The discovery found that Hsp90 inhibition destabilizes AID, preventing uncontrolled gene mutation and accelerating disease progression.
Researchers at Oregon State University have developed a new method to produce nanoparticles 500 times faster than traditional methods, using an arrayed microchannel reactor and laminated architecture. This breakthrough could make nanotechnology products more commercially practical and environmentally friendly.
The scarcity of new energy minerals will lead to a significant increase in trade tensions between nations. China's growing reliance on wind power to meet its renewable energy targets is exacerbating the issue, as the country needs rare earth elements like neodymium and selenium for high-strength magnets.
Research from Tel Aviv University reveals that cloud seeding with materials like silver iodide and frozen carbon dioxide does not produce rain. Instead, changes in weather patterns are responsible for increased rainfall.
Research finds that mandatory limits on processed food salt content could reduce cardiovascular disease by 18% compared to voluntary curbs. Voluntary industry restrictions are cost-effective but would only cut ill health from cardiovascular disease by 1%.
A new method for extracting and archiving CT radiation dose information enables providers to track estimated radiation doses, make informed health care decisions, and improve patient safety. The automated extraction pipeline can process both retrospective and prospective studies.
A new scale of drug harm assesses both individual and social harms, ranking alcohol as the most harmful, with heroin and crack in second and third place. The analysis suggests that a classification system based on overall harm scores could be more effective than current systems.
Researchers found that deep sleep strengthens new memories by transferring information from the hippocampus to the neocortex. Volunteers who experienced more sleep spindles overnight were more successful in connecting new words to existing knowledge.
A new mutation in the B cell activating factor receptor (BAFF-R) has been identified as a potential contributor to non-Hodgkin's lymphoma. The mutation amplifies BAFF signaling, leading to increased B cell function and cancer progression.