A redesigned microchip-based device, HB-Chip, captures more than 90% of cancer cells from blood samples, improving upon the original CTC-Chip. The new device also identifies previously unseen clusters of tumor cells, providing valuable insights into metastasis and targeted cancer therapies.
Researchers used corals as a proxy to study the shift in the ocean's thermocline, finding it has risen since the mid-1970s. The findings support climate model predictions and suggest a potential impact on global climate and oceanography.
Researchers at Fox Chase Cancer Center found that the loss of protein Nedd9 initially slows cancer formation but then makes tumors more aggressive. A class of drugs already used in clinics can make these aggressive tumors more sensitive to treatment.
Researchers are investigating a theory that 'friendly bacteria' can kill bone cancer cells in osteosarcoma. Modifying Salmonella typhimurium to produce molecules that target cancer-causing molecules could lead to a more effective treatment for bone cancer.
Researchers have identified a preclinical candidate that may slow the natural decline in memory associated with ageing. The new synthetic compound selectively blocks an enzyme involved in high levels of 'stress' steroid hormones, which are linked to memory loss.
A 12-week study of 86 overweight participants found that all three groups lost weight when consuming five to seven servings of potatoes per week. The results suggest that potatoes, when prepared in a healthy manner, do not contribute to weight gain and can be part of a weight loss program.
A Phase 3 trial showed patients receiving Probuphine had significantly less illicit opioid use and fewer withdrawal symptoms compared to placebo. The innovative implant formulation provided a steady, round-the-clock low dose of buprenorphine over six months.
A new mobile phone game, OrderUP!, has been shown to change health behaviors after just three weeks of play. Players are tasked with making healthy food choices for virtual customers, leading to discussions about nutrition and changes in eating habits.
Two social scientists are studying the pathways to commercialize graphene, examining strategies for research and development and fostering commercialization through external partnerships. The project aims to provide real-time insights into how nanotechnology research moves into early applications, addressing barriers and concerns.
A restrictive use of blood transfusions during cardiac surgery was associated with similar death and severe illness rates as a liberal approach, according to a study published in JAMA. The researchers found that limiting red blood cell transfusions did not increase the risk of complications or death at 30 days.
A clinical trial is underway at Cincinnati Children's Hospital Medical Center to test a genetically reprogrammed herpes simplex virus (HSV1716) as a treatment for rare and aggressive forms of childhood cancer. The Phase I trial aims to assess the safety of the agent in young patients with solid tumors.
A mobile outreach program staffed by current and former sex workers is associated with increased entry to detoxification and residential drug treatment among women in street-based sex work. The program provides a safe space for sex workers to rest and have access to health, support, and addiction treatment services.
Hospitalizations for ATV injuries among US youth increased by 150% over a nine-year period, with significant increases seen in the South and Midwest. The study found that females ages 15 to 17 experienced the sharpest rise in ATV hospitalizations, despite males having the highest rate.
Researchers are conducting a national study to assess whether a targeted rehabilitation approach can aid stroke patients in leaving their homes more confidently. The study will compare outcomes of volunteer patients receiving the intervention with those not receiving it, aiming to improve physical capabilities and boost confidence.
Researchers at the University of Utah Health used MRI to identify areas where the left and right hemispheres of the brains of people with autism do not properly communicate. The study found functional connectivity abnormalities in the entire brain, adding to the understanding of this disorder.
Researchers detected a massive star's supernova in 2007, which appeared as a hot dust cloud instead of the typical explosion. The astronomers suspect this was more common early in the universe and may be related to the brightest star system in our galaxy.
A study of postmenopausal women found that engaging in a healthy lifestyle reduces breast cancer risk for those with and without a family history. Women who adhered to regular physical activity, maintained a healthy weight, and drank less alcohol had lower rates of invasive breast cancer.
A significant proportion of patients with advanced cancer receive common cancer screenings, despite the limited benefit. Screening rates are higher among those with a recent history of screening and in those with higher socioeconomic status and married status.
The program aims to cultivate public awareness of aging issues through diverse reporters. The fellows will develop a major aging-focused story or series, exploring topics such as grandparents raising grandchildren, elder-friendly housing, and seniors' use of new technology.
Research suggests that women who develop cardio-metabolic risk factors before pregnancy are more likely to have a subsequent pregnancy with gestational diabetes. The study recommends pre-conception screening for metabolic abnormalities to prevent this condition and its lasting health effects on children.
Scientists use rock hyrax urine to study long-term climate change, providing unique terrestrial records. Biomarkers in the urine reveal insights into ancient environments and potential climate drivers.
Research reveals that a pregnant woman's immune response to viral infections may induce subtle neurological changes in the unborn child, increasing the risk of neurodevelopmental disorders. The study suggests potential strategies for reducing this risk by targeting specific immune proteins.
Researchers studied peptide hormones in planarian flatworms to understand their reproductive output and potential link to parasitic diseases. The study found that disrupting neuropeptide processing in sexually reproducing planaria causes reproductive organs to regress.
Researchers recreated a miniature event at the universe's origins using Einstein's E=mc2 equation and the Large Hadron Collider. Dr. Andreas Warburton and his team are searching for exotic new particles, which could help complete or contradict the Standard Model of Particle Physics.
Research consensus establishes DBS as a treatment option for patients with severe Parkinson's symptoms, including tremors and motor fluctuations. The study provides guidelines for patient selection and surgical approach, emphasizing the importance of experienced teams and neurosurgeons.
Research by Prof. Eshel Ben-Jacob suggests that bacteria can effectively control 'noise' in their environment and make decisions that benefit the entire colony. Bacteria's group decision-making processes can inform human decision-making, particularly in situations with multiple stakeholders.
Physicists at the University of California, Berkeley and the Max Planck Institute of Quantum Optics successfully observed an electron being ejected from an atom using ultrafast laser pulses. The experiment enabled the capture and photography of valence electrons for the first time, paving the way for better control over high-speed elec...
A Concordia University professor argues that nurses can advocate for better healthcare and services for teenagers who are LGBTIQ, reducing transmission of sexually transmitted infections by discussing safe sex practices. Nurses should be nonjudgmental, tolerant and supportive of LGBTIQ individuals in the clinic and community.
A study of 102,470 patients found that transfusion rates for red blood cells, plasma, and platelets varied greatly between hospitals, ranging from 0% to 92.8%. Researchers did not find a link between patient mortality rates and hospital transfusion practices.
The National Science Foundation has renewed two centers for nanotechnology in society, investing $12.5 million to study the ethical, legal, economic, and policy implications of emerging technologies. The centers will focus on developing a strategic vision for anticipatory governance and ensuring responsible development.
Spinal osteoporotic fractures often go undiagnosed and untreated, leading to severe repercussions such as stooped back, acute pain, loss of height, and premature death. The IOF campaign aims to raise awareness and promote prevention, diagnosis, and early treatment.
The US Department of Defense has awarded a $1.5 million grant to develop and test nanoemulsion technology against a wide range of wound infections, including drug-resistant forms. The project aims to create a broadly effective treatment that can prevent infection, increase survival and enable rapid healing in wounded military personnel.
The Journal of Molecular Diagnostics is published on behalf of the Association for Molecular Pathology (AMP) and the American Society for Investigative Pathology (ASIP). The journal publishes high-quality original papers on scientific advances in molecular diagnostics.
Researchers have created a novel anaerobic digestion reactor that can generate electricity comparable to 25 wind turbines. Additionally, scientists have isolated a bacterium capable of decontaminating groundwater contaminated with chlorinated alkanes.
An observational study found that prenatal treatment of congenital toxoplasmosis with antibiotics significantly reduced the proportion of infected fetuses developing serious neurological sequelae. The study estimated that treating three fetuses could prevent one case of brain damage, suggesting a potential preventive strategy.
Researchers argue that genomic risk prediction for population-level preventive healthcare is not yet supported by evidence. A cost-effective approach would require interventions for those at risk, but such an approach has yet to be demonstrated. The authors caution against widescale implementation of genetic screening for disease risk.
African American women with higher vegetable intake have a lower risk of developing estrogen receptor-negative breast cancer. High cruciferous and carrot consumption may play a role in reducing breast cancer risk through their effects on estrogen metabolism and antioxidant properties.
A study found that buprenorphine implants significantly reduced opioid use over 16 weeks, with 65.7% of patients remaining in the study for 24 weeks and fewer withdrawal symptoms. The implants also showed promise in decreasing non-medical opioid use.
Research suggests a potential viral link between HCMV and intestinal cancer in mice, where infected cells develop tumors. Meanwhile, scientists identify a key protein regulating breathing in mice and explore survivin as an anticancer target.
A Phase IIb/III trial shows afatinib benefits patients with lung adenocarcinoma whose cancer progressed after chemotherapy and erlotinib or gefitinib. Patients receiving afatinib experienced delayed disease progression and greater tumor shrinkage, but no significant difference in overall survival.
Growing plants with red flowers or striped blooms can significantly increase the number of visits from bumblebees, according to a study by Norwich BioScience Institutes. The research found that stripes following the veins of flowers provide a visual guide for pollinators, directing them to nectar and pollen.
Researchers have found that Labidolemur kayi shares similarities in bone features with other mammals, indicating its living relatives are rodents, rabbits, flying lemurs, tree shrews and primates. The study provides valuable information for understanding the origin of primates.
A Phase II study of the new-generation lung cancer drug PF-299 has shown impressive results in preventing disease progression when administered as a first-line treatment in patients with advanced disease. The study found that 85% of patients with EGFR mutations remained progression-free for at least nine months.
Researchers at Woods Hole Oceanographic Institution found that ocean acidification would only affect whale hearing by a negligible 2 decibels by 2100. The impact on marine animals relies heavily on natural noise levels, not human-made noise from ships.
A recent study found that women with epilepsy are more likely to experience infertility compared to the general population, particularly those taking multiple epilepsy drugs. The study also revealed that older women and those with less than 10 years of education were more likely to experience infertility.
A recent study found that cancer patients taking targeted therapies have significantly decreased levels of sexual function and satisfaction. The researchers surveyed 51 patients and found that men's erectile function scores were just 53% of the maximum, while women's desire and arousal scores were also affected.
Scientists compare ocean microbe genomes to understand environmental adaptations and evolutionary changes. The study found significant differences in phosphorus-related genes between Atlantic and Pacific populations, revealing a strong selective force driving these adaptations.
Researchers found that mice exposed to dim light at night gained about 50% more body mass than those in a standard light-dark cycle. The study suggests that timing of eating is critical to weight gain and may be contributing to the obesity epidemic in Western countries.
A Phase-II trial investigating pazopanib for relapsed/refractory urothelial cancer has generated promising results, with four patients experiencing tumor shrinkage and twelve seeing their metastases die due to 'necrotic evolution'. Researchers are eager to translate this activity into a survival advantage.
The study found that stricter limitations on land development lead to higher rental and purchase prices, while people saving for a house in markets with limited land availability need larger down payments and buy houses later in life. The research also suggests that relaxing borrowing constraints increases home ownership rates
A new Ohio University-led study suggests that combining preventive medication and behavioral changes offers significant relief from frequent, disabling migraines. The research found that the combination of these interventions resulted in a 77% reduction in migraine frequency, days with migraine, and improved quality of life.
A nationwide clinical trial is underway to test the effectiveness of ranolazine in treating ventricular arrhythmias. The study aims to determine if ranolazine decreases death and cardiac arrhythmias, as well as hospitalizations from cardiac causes.
Researchers have discovered that specialized bacterial filaments, known as nanowires, can conduct electricity, allowing microbial colonies to thrive. The findings suggest a new way for bacteria to transfer electrons and support each other, potentially leading to breakthroughs in biofilm resistance and sustainable energy.
Researchers found that cancer patients across all stages exhibit a high burden of somatic symptoms, including fatigue, pain, and insomnia. These symptoms significantly impair daily functioning and overall well-being, highlighting the need for comprehensive symptom management strategies.
Scientists have developed a microchip technology that rapidly tests potential drugs on tiny worms, identifying promising chemicals for regenerating nerve cells. The technique has already found one class of neuronal regenerators and holds promise for treating Alzheimer's, Parkinson's, and ALS.
A new study found that a slowing of population growth could contribute to reducing greenhouse gas emissions, with slower growth paths by 2050 accounting for 16-29% of necessary emissions reductions. Urbanization and aging also play significant roles in shaping future emissions.
A study published in Archives of Internal Medicine found that hormone therapy after menopause increases the risk of developing kidney stones by approximately 20 percent. The research calls into question the long-held belief that estrogen protects women from the disease, and clinicians need to consider the risks and benefits of hormone ...
Research by Sergio Lira at Mount Sinai School of Medicine found that HCMV-infected mice develop intestinal tumors as they age, with increased tumor growth compared to normal mice. The study suggests a potential viral link to intestinal cancer in humans, although further work is needed to confirm the association.
Using large-scale computer simulations, researchers at Georgia Tech have identified hydrodynamic interactions as a dominant factor in intracellular diffusion, accounting for much of the reduction in molecular movement. This finding has significant implications for understanding disease states and developing therapeutic drugs.
A new study by the University of Bristol has found that dogs with separation-related behaviors tend to make more pessimistic judgments, suggesting a cognitive bias. The research provides insight into animal emotions and highlights the importance of addressing underlying negative emotional states in dogs.