Researchers found that patients with obstructive sleep apnea who responded to mandibular advancement splint treatment had a larger tongue volume for their oral cavity size, suggesting this ratio as a predictor of response. The study included 49 patients and assessed the association between anatomical factors and treatment outcome.
A new study found that pediatric patients are at high risk for sleep-related breathing disorders (SRBD), with 18% of children in the study at-risk. The study did not find any associations between demographic or craniofacial characteristics and SRBD risk, making detection difficult.
A study by OHSU Emergency Department found that Oregon's law prohibiting the sale of pseudoephedrine products led to a significant decrease in methamphetamine-related emergency room visits. The number of such visits dropped by 35% over a one-year period, from an average of 18 per week to 11.3.
A study found that oral appliance therapy remained effective in reducing sleep apnea symptoms, with significant improvements in respiratory disturbance index, daytime sleepiness, fatigue severity, and quality of life. Patients showed high compliance with wearing their appliances at night.
A phase III clinical trial found that ipilimumab, a monoclonal antibody, significantly extended the lives of patients with metastatic melanoma. The therapy showed a 67% increase in survival time compared to those receiving gp100 alone, demonstrating its promise as an alternative treatment for cancer patients.
Researchers found that adding sorafenib to chemotherapy regimens does not improve patient survival in advanced melanoma patients. The study, sponsored by ECOG, enrolled 823 patients and did not confirm promising results from previous phase II studies.
The TARGIT-A trial found that targeted intraoperative radiotherapy (TARGIT) is non-inferior to whole breast external beam radiotherapy in reducing local recurrences. Patients who underwent TARGIT had similar recurrence rates to those receiving conventional radiotherapy, with lower rates of radiotherapy toxicity.
A new study suggests that nasendoscopy can help dentists predict which sleep apnea patients are most likely to benefit from oral appliance therapy. The procedure involves examining the velopharynx and oro-/hypopharynx, and results show that patients who exhibit this widening respond more effectively to treatment.
The study enrolled 237 patients with recurrent GBM and found that NovoTTF was as effective as the best available chemotherapies without the toxicity. Patients treated with NovoTTF lived longer and experienced fewer infections compared to chemotherapy.
A decade-long Phase III clinical trial found that selenium has no benefit in reducing the risk of developing lung cancer, either a recurrence or second primary malignancy. The study involved 1,522 Stage I non-small cell lung cancer patients and showed that selenium had minimal side effects but failed to demonstrate any protective effect.
Two new CML treatments, nilotinib and dasatinib, demonstrate improved efficacy over existing medications in treating drug-resistant chronic myeloid leukemia. Clinical trials showed significant increases in complete cytogenetic response and major molecular response rates compared to standard treatment.
A new study reveals that female jumping spiders fight with different rules than males, skipping preliminaries and engaging in all-out battles. The researchers found that the motivation behind a female's fighting behavior is her proximity to reproductive age and desire to protect her nest.
Researchers evaluated two pediatric SDB questionnaires in children undergoing orthodontic treatment, finding that 20% of subjects reported snoring and suggesting that family dentists may use simple questionnaires to identify preliminary risks of sleep-disordered breathing. Craniofacial abnormalities are a common cause of SDB in children.
A Phase III clinical study found that dasatanib provides quicker responses and better outcomes compared to imatinib for newly diagnosed CML patients. The study reported higher rates of confirmed complete cytogenic response and major molecular response in the dasatanib arm.
A man and his two Great Pyrenees embark on a 2,000-mile walk to raise awareness about cancer in dogs while collecting DNA samples for a new $5.3 million canine cancer project. The TGen-VARI program aims to discover the causes of cancer in dogs and potentially translate findings to humans.
A survey of 58 US dental schools found that students spend an average of just 2.9 hours studying sleep disorders, despite a growing epidemic of obstructive sleep apnea (OSA) affecting 18 million Americans.
A new chemotherapy delivery method has shown promising results in treating advanced melanoma patients with liver metastasis. The phase III trial demonstrated a significant increase in progression-free survival rates and controlled tumors in the liver.