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Science News for February 15, 2011


Study finds racial disparities in hospital readmission rates

A study found that elderly Medicare black patients have higher 30-day hospital readmission rates for conditions like congestive heart failure and pneumonia compared to white patients. The disparities are related to hospitals that disproportionately care for black patients, suggesting a systemic issue with the healthcare system.

SourceJAMA Network·JournalJAMA·DateFeb 15, 2011

Safety of biologic treatment for arthritis depends on the drug

A systematic review found that biologic drugs used to treat arthritis may have rare but serious side effects, including increased risk of infections and cancer. The study analyzed data from 163 studies involving over 50,000 patients, highlighting the importance of comparative safety research.

SourceWiley·JournalCochrane Database of Systematic Reviews·DateFeb 15, 2011

Zinc reduces the burden of the common cold

A systematic review published in The Cochrane Library found that zinc supplements reduce the severity and duration of illness caused by the common cold. Zinc syrup, lozenges or tablets taken within a day of symptom onset reduced symptoms severity and length of illness.

SourceWiley·JournalCochrane Database of Systematic Reviews·DateFeb 15, 2011

Atomic model of tropomyosin bound to actin

The study provides the first detailed atomic model of tropomyosin bound to actin, significantly advancing our understanding of this key cellular protein. The researchers found that the interaction between tropomyosin and actin is weak enough that it can be readily perturbed by regulatory proteins, acting as a molecular switch.

SourceCell Press·JournalBiophysical Journal·DateFeb 15, 2011

Hearing loss and dementia linked in study

Seniors with hearing loss are more likely to develop dementia over time than those with normal hearing. The study found a significant link between the two conditions, with the risk of developing dementia increasing by twofold, threefold, and fivefold for individuals with mild, moderate, and severe hearing loss.

SourceJohns Hopkins Medicine·JournalArchives of Neurology·DateFeb 15, 2011

Method of DNA repair linked to higher likelihood of genetic mutation

A recent study published in PLOS Biology reveals that Break-induced Replication (BIR) is up to 2,800 times more likely to cause genetic mutations than normal DNA synthesis. The researchers found that this method of DNA repair can lead to sudden bursts of mutagenesis, increasing the risk of cancerous cell development.

SourcePLOS·JournalPLOS Biology·DateFeb 15, 2011

New study finds no cognitive impairment among ecstasy users

A large-scale study has found that ecstasy users show no signs of cognitive impairment attributable to drug use. The research, funded by $1.8 million from the National Institute on Drug Abuse, aimed to minimize methodological limitations of earlier studies and compared 52 ecstasy users with 59 non-users.

SourceWiley·JournalAddiction·DateFeb 15, 2011

'Healthy' patients at high risk of cardiac death identified

Researchers found that an abnormal response to early heartbeats can predict cardiac death in healthy-looking individuals. Those with no conventional markers of cardiovascular disease were eight times more likely to die from cardiac causes if they had abnormal heart rate turbulence.

SourceWashU Medicine·JournalJournal of Cardiovascular Electrophysiology·DateFeb 15, 2011

Jefferson researchers provide genetic evidence that antioxidants can help treat cancer

Researchers have found that antioxidants can help prevent and treat breast cancer by targeting mitochondrial oxidative stress. The study, published in Cancer Biology & Therapy, used a genetically tractable model to show that loss of the tumor suppressor protein Caveolin-1 leads to increased oxidative stress, which fuels cancer cell gro...

SourceThomas Jefferson University·JournalCancer Biology & Therapy·DateFeb 15, 2011

Designing new molecular tools to study the life and death of a cancer cell

Research team designed synthetic molecules to study proline residue's role in cancer cell apoptosis by XIAP protein. The results suggest that these tetrapeptide analogs can be further developed into new molecular tools to analyze protein-protein interactions and signal transduction pathways of XIAP in cancer cells.

SourceSociety for Experimental Biology and Medicine·JournalExperimental Biology and Medicine·DateFeb 15, 2011

Study compares balanced propofol sedation with conventional sedation for therapeutic GI endoscopic procedures

A study compared balanced propofol sedation with conventional sedation for therapeutic GI endoscopic procedures, finding higher health care provider satisfaction and better patient cooperation in the BPS group. The results show that BPS provided similar adverse event profiles to conventional sedation.

SourceAmerican Society for Gastrointestinal Endoscopy·JournalGastrointestinal Endoscopy·DateFeb 15, 2011

NYU Langone Department of Orthopaedic Surgery chosen to participate in joint replacement registry

The NYU Langone Department of Orthopaedic Surgery has been selected to participate in the American Joint Replacement Registry (AJRR), aiming to collect key joint replacement and revision data to monitor device performance and identify best practices. The registry's participation is expected to improve long-term outcomes, cost managemen...

2 in 1: Multi-tasking protein provides new approaches for anti-tuberculosis drugs

Scientists at EMBL identified a multi-tasking protein PriA from Mycobacterium tuberculosis that catalyzes reactions on two different molecules. This finding presents new opportunities for developing organism-specific drugs, targeting the pathogen but leaving other beneficial microorganisms untouched.

SourceEuropean Molecular Biology Laboratory·JournalProceedings of the National Academy of Sciences·DateFeb 15, 2011

How do women fend off domestic violence?

A Concordia University study finds that wealth is not a guaranteed escape from an abusive relationship, but rather one of many factors that can help a woman resist violence. The research also highlights the importance of women's negotiation tactics and challenging societal authority to create effective resistance.

SourceConcordia University·JournalReview of Radical Political Economics·DateFeb 15, 2011

Using chlorhexidine gluconate baths to reduce hospital-acquired infections

A new study from Rhode Island Hospital found a 64 percent decrease in the risk of acquiring an infection from MRSA or VRE when using two percent chlorhexidine gluconate cloths for daily bathing. The study suggests that CHG bathing may be a beneficial infection control intervention for patients outside of ICU settings.

SourceLifespan·JournalInfection Control and Hospital Epidemiology·DateFeb 15, 2011

Ion-exchange water softeners do not improve eczema in children

A study by Kim Thomas and colleagues found that ion-exchange water softeners do not improve eczema severity scores or symptoms, such as sleep loss and itchiness, in children with moderate to severe eczema. However, parents reported small health benefits and over 50% chose to install a water softener due to perceived improvements.

SourcePLOS·JournalPLOS Medicine·DateFeb 15, 2011

The lock shapes the key

Scientists at TUM have developed a novel method to observe hydrogen bond formation in protein binding processes. Their model system showed that protein recognition takes place via hydrophobic interaction of the S-protein with two spatially clearly defined areas of the unstructured S-peptide.

SourceTechnical University of Munich (TUM)·JournalProceedings of the National Academy of Sciences·DateFeb 15, 2011