Scientists have discovered a protein involved in drug resistance in breast cancer, which could be targeted for new treatments. Blocking the production of this protein in human cells made them more responsive to anti-oestrogen drugs.
Mainz University's Gutenberg Research College awards fellowship to Stuart Parkin, renowned experimental physicist and IBM Fellow. The award enhances postgraduate research in spintronics, a key area of focus for both institutions.
Astrocytes, the most common cell in the human nervous system, have been cultivated in a lab dish using embryonic and induced human stem cells. This breakthrough allows researchers to better understand their functions and develop new therapies for neurological disorders such as dementia and Parkinson's disease.
Recent meta-analyses show telemedical monitoring can improve overall survival by 17-47% in CHF patients. Two trials presented at the Heart Failure Congress 2011 found benefits in specific subgroups, including those with prior decompensation and no depression.
Researchers from IDIBAPS have conducted a study on HIV-infected patients with undetectable viral load, finding that they can induce a broad and strong humoral immune response. The percentage of treated and untreated patients generating broad-spectrum neutralizing antibodies was very similar, suggesting a potential preventive vaccine ba...
Researchers found that episodic tremors can reverse direction and travel back through fault lines much faster than the original rupture. The event was observed in the Pacific Northwest region, particularly in Washington state, and released as much energy as a magnitude 6.8 earthquake.
Researchers at Stanford University School of Medicine used undifferentiated induced pluripotent stem cells to study dyskeratosis congenita, a rare genetic disease. They found that the activity of telomerase, an enzyme critical to aging and cell renewal, is correlated with the severity of symptoms.
A UBC-led team has developed an automated microfluidic cell culture platform to study hundreds of hematopoietic stem cells at the single cell level. The new tool provides insights into HSC survival and growth factor requirements, with applications in drug development, clone selection, and culture optimization.
A new computer model simulates how Gulf currents enabled marine microorganisms to degrade oil spills more quickly. The 'dynamic auto-inoculation' process activated microbes, increasing bacterial populations and degrading hydrocarbons.
A study found that infection with the bacteria Helicobacter pylori can lead to Parkinson's disease symptoms in mice, and researchers suggest that this may be due to a modified cholesterol produced by the bacteria. The findings could have implications for understanding the development of neurodegenerative disorders.
A recent study published in Nature Immunology has discovered a novel mechanism by which tumor necrosis factor (TNF) suppresses inflammatory responses. The researchers found that TNF activates the glycogen synthase kinase 3-alpha protein and upregulates the A20 gene, leading to reduced inflammation.
A genome-wide association study found a novel risk variant on chromosome 17q21 that is common in African American men but rare in other populations. This discovery builds on previous research identifying a risk region on chromosome 8q24, suggesting a genetic contribution to racial disparities in prostate cancer risk.
Researchers used whole genome sequencing and social network analysis to track a tuberculosis outbreak in British Columbia, identifying key individuals as superspreaders and behaviors contributing to the outbreak. The technique allowed public health officials to reconstruct outbreaks and understand how pathogens move through populations.
Patients with mild to moderate dyssynchrony and preserved contractile function benefit most from CRT-D, according to the latest MADIT-CRT trial analysis. The study found that improvements in synchrony and contractile function are associated with reduced death and heart failure events.
Researchers identified the Lrp5 gene's crucial role in bone growth and density, providing a new strategy for treating diseases like osteoporosis. The study also found that targeting mature bone cells might increase bone mass and treat conditions like osteogenesis imperfecta.
Researchers at Queensland University of Technology found a mushroom compound, polysaccharopeptide (PSP), to be 100% effective in suppressing prostate tumor development in mice. PSP targets prostate cancer stem cells and prevents tumour formation without causing side effects.
A sub-analysis of the EMPHASIS-HF trial found eplerenone significantly reduced new onset atrial fibrillation and flutter in patients with class 2 heart failure. The benefits of eplerenone were similar in patients with and without atrial fibrillation at baseline.
Scientists at Harvard School of Public Health discovered that cells exert forces on their neighbors, leading to a cooperative yet chaotic migration. The study found that collective cellular migration is not a smooth process, but rather an 'organized chaos' with pushing and pulling in all directions.