Researchers identified PUMA, NOXA, and TRB3 as executors of glutamine-starved cells in Myc-mutant cells. The team showed that drugs targeting these proteins induced cell death in assays using neuroblastoma cells and inhibited tumor growth in transgenic mice.
A new study by Dana-Farber Cancer Institute researchers found that patients who discussed end-of-life care several months before their death were less likely to receive aggressive therapy and more likely to enter hospice care. These conversations enabled patients to think through their options more carefully, leading to better quality ...
Researchers found that stress-related problem drinking is linked to a specific combination of neural circuit functioning, including highly reactive reward circuits and hypo-reactive threat circuits. This imbalance can lead to excessive drinking in response to stress, as the brain struggles with opposing drives for pleasure and fear.
Experts in PLOS Medicine recommend new signal functions to track the quality of routine and emergency newborn care. The new methods aim to improve maternal and newborn care in low- and middle-income countries, helping to meet Millennium Development Goals 4 and 5.
A new health-economic model shows that increasing dairy food consumption can prevent osteoporotic fractures and reduce healthcare costs. The study found that France, Sweden, and the Netherlands could potentially save millions of euros in healthcare costs by boosting dietary calcium intake.
In a study, MIT physicists found that cooperative yeast members outperform cheaters when competing with bacteria in an experimental setup. This is because cooperators have easier access to sugars and can spread less due to population density constraints.
A new study reveals that metalloacid-coated surfaces exhibit strong antimicrobial activity against various microorganisms, including those resistant to multiple antibiotics. The coating's ability to produce acidic pH through oxonium ions significantly limits the survival of microbes on coated surfaces.
A recent study published in the American Journal of Obstetrics and Gynecology challenges the benefits of planned home birth, citing higher rates of unexpected complications, emergency transports, and perinatal mortality. The authors argue that a hospital-based approach can provide a safer and more satisfying experience for patients.
Sanford-Burnham researchers found that different brain tumor cell types respond to distinct treatments due to varying growth factor regulation. This discovery offers potential for more effective and less harmful treatments tailored to individual tumors.
A study at the University of Texas Health Science Center at Houston aims to enhance ER care by reducing information overload and improving communication among healthcare teams. The researchers will test new electronic health record systems and communication prototypes to help doctors make informed decisions.
The 2012 Collegiate Inventors Competition awarded over $100,000 to students for their groundbreaking inventions in medical devices, cancer therapies, and more. Inanc Ortac's Nano-Wiffle-Balls for Cancer Therapy and Leslie Myint's FastStitch suturing device were among the top winners.
A recent study found that consumers tend to favor warranties expressed in standard units, such as years. When presented with alternative units, like days, consumers' evaluations of cell phone warranties were negatively impacted. This shift in perception occurred mainly when individual products were shown in isolation.
Researchers at the University of Innsbruck propose a novel method for powering lasers through heat, which could provide internal cooling and revolutionize microchip technology. The concept involves using temperature gradients to separate cold and warm areas in the laser, allowing for efficient energy transfer.
Aerobic exercise can help relieve fatigue associated with cancer and treatment, balancing rest with physical activity may reduce fatigue. The new review adds 28 studies, including those in breast cancer patients, showing that aerobic exercise benefits those with solid tumours during and after treatment.
When conflicts end, in-group solidarity in alliances rapidly disappears as former comrades fight over spoils. Economist experiments demonstrate that alliance members expend less effort when anticipating future distributional conflicts, highlighting the collective action problem faced by alliances.
A network of marine zones in the Pacific Ocean could significantly improve numbers of heavily overfished bigeye tuna and local economies. The study found that restricting longline fishing in tuna-spawning areas and managing fish-aggregating devices are key measures to effectively conserve Pacific bigeye tuna.
Researchers at the Max Planck Institute have discovered how external signals regulate vascular remodelling through G protein-mediated signalling pathways. These pathways work together in other contexts but act as antagonists in blood vessel remodelling, balancing cell growth and regression.
A study on young children's use of British Sign Language found that iconic signs were comprehended and produced more by younger children, with the benefit increasing for older children. This suggests that iconicity may play an important role in language acquisition, providing a mechanism for early sign learning.
Research found that people with diabetes who have adequate vitamin D are less likely to develop clogged arteries. In contrast, insufficient vitamin D leads to immune cells binding to blood vessels and trapping cholesterol.
Researchers explored the benefits of adding radionuclide therapy to cancer treatment regimens for patients with advanced disease. Studies found improved tumor control rates and longer patient survival without significant side effects, suggesting a potential paradigm shift in cancer control.
Researchers have developed a new artificial lens that mimics the natural lens of the human eye, enabling incremental refraction control. This breakthrough could improve performance in implantable lenses and consumer vision products, as well as enhance ground and aerial surveillance technology.
UT Southwestern Medical Center is one of only two academic medical centers in the US to receive a Patient Voice Award and a Summit Award for outstanding patient satisfaction scores. The hospital achieved high levels of excellence in patient care, with recognition for its communication, responsiveness, and pain management.
Researchers at Aalto University have developed a cost-effective and environmentally friendly process for producing lithium batteries. By replacing the hazardous methylpyrrolidone solvent with water, they reduced production costs by up to 5%.
A UT research team will investigate the effects of education on lifelong health, employment, and mortality outcomes in a three-year study of over 14,800 individuals born between 1964-65. The grant aims to provide insights into public policy areas like healthcare, economics, and education reform.
Researchers have developed a low-energy defibrillation scheme that significantly reduces the energy needed to re-establish a normal rhythm in the heart's main chambers. This novel electrotherapy could be less painful than existing implantable defibrillators and may even fall beneath the threshold at which patients begin to perceive pain.
A new study published in the Journal of Happiness Studies found that disease disrupts daily functioning is associated with reduced happiness. The study used a direct measure of disability and found a three-percent reduction in unhappiness for every one-point increase in freedom-from-debility score.
A study by Temple University found that fast food menus have doubled in size, but calorie counts have changed little between 1997 and 2010. The average calorie content of foods offered by major U.S. fast food restaurants remained stable, while entree salads and sweetened teas became increasingly popular additions to the menus.
A study found that plus-sized consumers create a collective identity as 'fatshionistas' and mobilize for greater inclusion by identifying influential designers and retailers. The authors identify institutional entrepreneurs like Beth Ditto who inspire the movement.
A study led by University of Washington researchers identifies unusual weather patterns that contributed to the 2010 India flood, which killed 193 people. The findings suggest that organized clouds in high mountains can tap into additional moisture from nearby bodies of water, leading to severe flash flooding.
A team of researchers used advanced soil analysis to uncover evidence of ancient Maya maize production in lowland areas, but also found signs of erosion in steeper soils. This study demonstrates the power of modern soil science in understanding past civilizations' treatment of the land and its impact on food security.
A Johns Hopkins doctor argues that comprehensive guidelines for physicians on disclosing conflicts of interest on social media are lacking. Electronic tags and online profiles could help address this issue, DeCamp says, as physicians' posts can be re-tweeted and potentially biased by financial conflicts.
Joint BioEnergy Institute researchers identify a gene in rice plants that improves extraction of xylan and release of sugars needed for biofuels by over 60%. This breakthrough could lead to more efficient production of advanced biofuels.
A study by Jay Teachman found that veteran populations are becoming more concentrated in rural areas surrounding military bases. This has led to a decrease in contact between veteran and non-veteran populations, with the proportion of veterans in America declining by an average of 15.54% since 2000.
The UT Arlington physics team has developed a novel thermoelectric generator using copper sulfide nanoparticles and single-walled carbon nanotubes. The technology, which can convert both light and thermal energy into electrical current, shows increases of up to 80% in light absorption compared to earlier methods.
Researchers have found that targeting human endogenous retroviruses (HERVs) can effectively eliminate HIV-infected cells using immune responses. This discovery could lead to the development of novel HIV vaccines by leveraging HERV-targeted T-cells.
Researchers identified 70 genetic mutations in Burkitt lymphoma tumors, including a new mutation that accelerates tumor growth. The findings could lead to the development of new treatments or targeted therapies for cancer patients.
Researchers identified a genetic variant on chromosome X that predicts high-risk men who drink heavily are at risk for developing chronic pancreatitis. The discovery enables doctors to identify patients with early signs of pancreatitis or acute attacks, allowing them to take preventative action and give the pancreas a chance to heal.
A novel approach to cataract surgery using binaural beats audio therapy significantly reduces patients' anxiety, with consistent results in heart rate and blood pressure. The study highlights the potential for this simple, inexpensive method to improve patient outcomes and satisfaction.
A new approach to hysterectomy allows for essentially scar-free surgery using robotic arms in a thin incision. The technique provides improved access for surgeons, enabling clearer views of anatomy and reducing the risk of injury to vital structures.
Researchers at Ghent University have developed a simplified model to measure the absolute density of OH radicals in plasma, improving the accuracy of radical treatment for medical applications. This breakthrough could stimulate tissue regeneration and induce targeted antiseptic effects without harming neighboring tissues.
A new study from the University of Michigan found that physicians who commit suicide often have known mental health problems but fail to seek treatment due to stigma and lack of confidentiality. The study highlights the need for greater effort to address job stress, under-diagnosis, and treatment of depression among physicians.
Scientists propose using ultraprecise atomic clocks to directly measure the Earth's true physical form, the geoid, which is currently determined indirectly through satellite tracking. This method has the potential to map the interior of the Earth to great depths, enabling more accurate exploration and discovery of subsurface structures.
A study found that 8-week meditation training can alter brain function even outside of meditation. Different forms of meditation may have distinct effects on the amygdala, a key structure for emotion processing.
A new study found that adding Gemtuzumab Ozogamicin to chemotherapy treatment improved the effectiveness of cancer treatment without increasing side effects in older AML patients. The results show a 22% lower risk of relapse and a 13% lower mortality rate compared to standard treatment.
The US will need 52,000 additional primary care physicians by 2025 due to population growth and aging, with a projected 25% increase in the workforce. Researchers also examine the benefits of starting prostate cancer screening at age 40 versus 50 and argue that guidelines should be evidence-based to prioritize proven services.
A new $3 million study will investigate biological markers measuring treatment efficacy for Chagas disease. The research seeks to develop a robust test to expand treatment options and accelerate clinical trials for this potentially fatal neglected tropical disease.
A new study reveals that cilia play a dynamic role in guiding neuronal migration during brain development. In mice with deleted Arl13b gene, interneurons fail to migrate properly due to abnormal cilia function.
A study published in the Journal of Neuroscience identified two brain regions involved in making rapid judgments about potential partners. The paracingulate cortex and rostromedial prefrontal cortex are active when people consider physical attractiveness and individual compatibility, respectively.
The University of Southampton is leading a €11.6 million EU-funded research project to develop new crops that can withstand drought, addressing the impact of climate change on crop productivity. The project aims to characterise DNA variation in under-utilised crops and harness this knowledge to produce better crops.
A team of researchers has made a groundbreaking discovery that challenges long-standing theories on marine methane oxidation. They found that a single microorganism, an archaeon, can perform both methane oxidation and sulfate respiration without the need for bacterial collaboration.
A new study found that black patients with kidney cancer have a survival disadvantage compared to white patients, even when diagnosed at early stages or receiving less aggressive treatment. The study analyzed nearly 40,000 renal cell carcinoma patients and confirmed poorer survival rates for blacks.
The ICTS will focus on translating genetic and genomic research into patient care, developing new therapeutics, and disseminating research findings. The grant supports Washington University's strengths in genetic and genomic research and its efforts to advance clinical and translational research.
Two studies estimate the cost of delivering HPV vaccines to girls in Tanzania, finding costs substantially higher than existing infant immunization schedules. However, integration with existing health systems may improve affordability and effectiveness of HPV vaccination programs, especially in low- and middle-income countries.
A dance intervention program improved the self-rated health of Swedish girls with internalizing problems, such as stress and psychosomatic symptoms. The study found that 91% of girls rated the dance intervention as a positive experience.
A new study by the University of Cambridge reveals substantial inequalities in cancer stage at diagnosis, which can impact survival. The research highlights the importance of awareness campaigns to improve early diagnosis for specific patient groups, including those living in poorer neighborhoods or with different tumour sub-types.
A new statistical image analysis method can assist in grading breast cancer by automatically segmenting tumour regions and detecting dividing cells. The method, developed at the University of Warwick, promises to bring objectivity and automation to the cancer grading process.
Researchers found that inhibiting PI3-kinase can convert BRCA-proficient triple-negative breast cancers into BRCA-deficient ones, making them sensitive to PARP inhibitors. This combination treatment showed promising results in preclinical studies and is now being tested in a clinical trial.
Researchers found that intravaginal immunization significantly increased immune cells in the vaginal mucosa, enhancing local immune response. This site-specific vaccination technique may be useful in developing effective STD vaccines.
A study from the University of Gothenburg found that quality of life is highest among couples who adopted, followed by those with children through IVF. The study suggests considering adoption as a fertility option for couples seeking medical help.
Researchers at MIT developed a microfluidic device that captures circulating tumor cells using DNA 'tentacles' inspired by jellyfish. The device increases flow rates 10 times higher than existing ones, enabling rapid processing of blood samples and potential monitoring of cancer patients.