Scientists have successfully mapped tens of thousands of molecular signaling events involved in DNA damage repair, shedding light on how cells communicate when their DNA is broken. This research will help develop new drugs with fewer side effects and better protect healthy cells during cancer treatment.
A new study suggests that people save only about half of their inherited wealth, with the remaining amount spent, donated, or lost. This decision has significant implications for families, financial markets, and the economy.
Astronomers using NASA's Hubble Space Telescope have found galaxies containing quasars that act as gravitational lenses, distorting images of aligned galaxies. Quasars are powered by supermassive black holes and help estimate the mass of host galaxies.
Researchers at UCLA have developed graphene-based electrochemical capacitors that store substantial amounts of charge, far surpassing traditional batteries. These devices exhibit ultrahigh energy density values while maintaining high power density and excellent cycle stability.
Researchers at Carnegie Mellon and Stanford are expanding the EteRNA project with a $1 million grant from the W.M. Keck Foundation, allowing them to test thousands of RNA designs each month. The online game has identified talented players who can generate important scientific insights.
Food-insecure mothers face increased weight gain due to skipping meals and eating cheaper, less nutritious foods to ensure their children are fed. This behavior is linked to metabolic responses that retain fat, exacerbating obesity risks.
A study by Columbia University's Mailman School of Public Health found a significant link between economic conditions and suicide rates in NYC. The monthly suicide rate was 29% higher at the economic low point in 1992 than at the peak in 2000, with white men under 45 being the most affected.
A seven-year antimicrobial stewardship program at a hospital eliminated $3 million from its annual budget for antimicrobials within three years. The program reduced antibiotic spending per-patient day nearly in half without compromising quality of patient care.
A study by Aaron R. Brough and Alexander Chernev found that consumers tend to perceive bundled products as 'moderately expensive', leading them to pay less. The authors suggest that managers should sell items from different price tiers separately to maximize revenue.
Researchers have created a new lithography strategy that allows for dynamic generation of various patterns on large areas of soft plastics or polymers. This enables rapid switching between different textures, such as smooth to rough and back again, with fast timescales of milliseconds.
A new study reveals a correlation between working memory capacity and mind wandering, suggesting that higher working memory resources may enable off-topic thoughts. Working memory capacity has previously been linked to intelligence measures, and the study suggests it plays a role in everyday planning and decision-making.
A Stanford researcher used an integrative 'omics' profile to discover and track his own type-2 diabetes onset, demonstrating the potential of personalized medicine. By analyzing his DNA, RNA, proteins, metabolites, and immune system responses, he was able to identify the disease early and make lifestyle changes to prevent further damage.
A new study found that using 'I don't' instead of 'I can't' when facing temptation can increase feelings of autonomy and empowerment, leading to positive behavioral change. The strategy was effective in promoting long-term adherence to healthy habits.
Researchers found that giant squids' large eyes are better suited for spotting large objects, like whales, rather than average prey. Their 10-inch eyes allow them to see predators from a distance despite the dim light of their underwater habitat.
A new study reveals that consumers make choices based on their mood and level of emotional arousal. People in a positive mood prefer products matching their state, while those in a low-energy state seek reversals. The study finds that consumers consistently choose products promoting pleasant moods.
The PCP genetic pathway has been found to act as a stop sign for cell growth, signaling organisms when to halt growth. Inhibition of this pathway results in excess growth of neural tissue, offering new potential strategies for regenerative medicine and birth defect treatment.
A study found that AD patients have difficulties transferring acquired knowledge to new contexts, despite being able to learn and acquire information. This transfer deficit may be related to deficits in declarative learning and dysfunction in the medial temporal lobe region of the brain.
Winifred Edgerton Merrill was the first woman to earn a PhD in mathematics in the United States. She overcame obstacles, including being forced to study harder by male classmates, to achieve her academic goal. Her pioneering work helped found Barnard College and inspired future generations of women in math and education.
A new policy report from Rice University's Baker Institute warns that India's economic slowdown is due to its failure to implement necessary reforms. The report highlights the need for fiscal discipline, tax reform, governance initiatives, and other measures to boost growth.
The EASL-EORTC joint Clinical Practice Guidelines (CPGs) on the management of hepatocellular carcinoma (HCC) provide best practice recommendations for surveillance, diagnosis, and therapeutic strategies. The guidelines aim to improve access to effective interventions for patients with HCC, an increasing global health burden.
A new study by Ohio State University suggests that adults who receive an inheritance spend roughly half of what they receive, while the rest is lost or spent. The study, which analyzed data from over 7,500 participants, found that nearly one-third of all inheritors saw a decline or no change in their wealth after getting an inheritance.
A recent study found that Asian breast cancer patients suffer from memory loss, decision-making difficulties, and speech problems after chemotherapy treatment. To cope with these changes, many turned to mind stimulation activities such as mahjong and qi gong.
The 2012 Arctic campaign measures changes in polar ice using a modified P-3 aircraft equipped with various instruments, including lasers and radar. The campaign also features international collaboration and educational activities.
Researchers found that sex-deprived fruit flies prefer alcohol to satisfy a physical reward, which could lead to understanding of human addiction causes. The study's findings could also inform the development of treatments for substance abuse in humans.
The Pancreatic Cancer Action Network and AACR have awarded $1.2 million in grants to two postdoctoral fellows, Stephanie K. Dougan and Oliver G. McDonald, to advance pancreatic cancer research through immunotherapy and epigenetic reprogramming studies.
Researchers have discovered a dramatic improvement in life span and motor function in mice with infantile Batten disease when treated with gene therapy and bone marrow transplants. The combination therapy created a striking synergy, with mice living nearly 18.5 months, more than double the lifespan of untreated mice.
Researchers at Thomas Jefferson University have discovered a powerful new strategy for personalized anti-cancer therapy by linking biomarker MCT4 to tumor metabolism. High levels of MCT4 are correlated with poorer overall survival and increased risk of recurrence in patients with triple negative breast cancer.
Researchers found that wild orangutans in north Borneo exhibit an immediate stress response to eco-tourist interactions, but levels return to baseline after the encounter. The study suggests that low levels of predictable disturbance may have a minimal impact on these endangered species.
ChronoZoom is a web-based software that enables users to visualize history and discover new connections. The project uses Microsoft Azure and HTML5 to allow for easy updates and expansion of content.
Researchers analyzed 100,000 molecular components from a patient's genome, revealing genetic risks and biomarkers for diseases. The study provides insights into the correlation between individual genetic profiles and environmental interactions in disease development.
A study by University of Alberta researcher Marianne Clark explores women's experiences of changing in public change rooms, finding that societal beauty standards and lack of privacy contribute to anxiety and self-consciousness. The research highlights the need for more inclusive and comfortable facilities for diverse body types.
A study published in Ecology Letters found that early snow melt in the Colorado Rocky Mountains leads to lower flower availability, negatively affecting the growth rate of the Mormon Fritillary butterfly. Reduced flower availability per butterfly explained most of the observed variation in population growth rate.
A new study explains why consumers agonize over minor decisions like toothbrushes and breakfast cereals. People assume difficult decisions are important, leading to increased time and effort spent on them.
Researchers at Stanford University have engineered piezoelectricity into a nanoscale material, known as graphene. By modifying the graphene lattice, they were able to achieve fine physical control and created piezoelectric levels comparable to traditional materials. This breakthrough brings new dimension to straintronics and has promis...
The Surface Ocean CO2 Atlas (SOCAT) provides a comprehensive dataset of 6.3 million global observations since 1968, documenting year-to-year and decadal changes in ocean carbon uptake. This will help assess the feedbacks between climate change and the ocean carbon cycle.
A new study found that planning doesn't aid self-control for those who perceive themselves as overweight, leading to unhealthy choices. Conversely, confident savers were less likely to spend their tax rebate after planning, highlighting the importance of a positive self-view in goal attainment.
A new study examines neural activation among individuals with and without a history of alcohol-induced fragmentary blackouts, suggesting individual differences in how alcohol impacts memory. The study found that some people are more likely to experience alcohol-induced blackouts due to unique patterns of blood flow and neural activity.
A study using integrative Personal Omics Profiling (iPOP) combines genome sequencing, disease risk analysis, and molecular measures to capture changes in human biology. The researchers observe tens of thousands of components over two years, revealing dynamic molecular-level changes that provide meaningful physiological information.
A more effective environmental governance system is needed to address increasing natural disasters, food and water security problems, and biodiversity loss. The article suggests creating a UN Sustainable Development Council and upgrading the UN Environment Programme to improve global governance.
Researchers found that giant squids' large eyes collect more light, improving their ability to detect small contrast differences and bioluminescence. The boost in detecting low-light differences is critical for spotting approaching sperm whales, but the squid's escape is not entirely dependent on its eye size.
Deaf individuals experience higher rates of mental health disorders due to communication barriers and lack of specialized services. Specialist training and sign language interpreters are crucial for improving access to mental health care for this population.
A new study from MIT neuroscientists found that sharing stories about one's life with members of the opposing group improves attitudes and reduces prejudice. The benefits were greatest for members of the less empowered group, who reported improved attitudes towards the other group after sharing their own perspectives.
Research reveals that BRG1 gene mutations render tumor cells unresponsive to hormones like retinoic acid and steroids, leading to continued growth and spreading.
A study at the Clark Park Farmers' Market in Philadelphia found that vendors can increase SNAP sales by 38% when using wireless point-of-sale terminals, but the costs may be out of reach for farmers. The study highlights the need for an equitable approach to subsidizing EBT fees at farmers' markets.
Researchers found pine beetles can breed twice a year, leading to up to 60 times more beetles attacking trees annually. Warmer temperatures also allow beetles to survive and attack trees with previously developed defenses.
Research presented at the American Heart Association's Scientific Sessions found that children living in a neighborhood with a specially-designed bike trail were three times more likely to engage in vigorous physical activity. The study compared two low-income neighborhoods in Chattanooga, Tenn., one with a wide trail/sidewalk for biki...
A recent study published in Journal of Thoracic Oncology suggests that CYFRA21-1 levels can reliably indicate patient response to chemotherapy for non-small cell lung cancer (NSCLC). Higher baseline concentrations were linked to poorer overall and failure-free survival. Further research is needed to confirm these findings.
American signal crayfish are gaining the upper hand in Britain's waterways, threatening native white-clawed crayfish populations. The invasive species' greater appetite for food and reduced susceptibility to parasites have significant implications for biodiversity.
A recent study published in the Journal of The National Cancer Institute suggests that estrogen alone may reduce breast cancer risk, whereas estrogen plus progestin can increase it. The findings are based on data from two randomized clinical trials conducted as part of the Women's Health Initiative.
Recent generations, including millennials, are less interested in community issues, politics, and environment. A 40-year study of young adults found a decline in political participation, concern for others, and interest in saving the environment.
Patients with kidney failure have relatively poor physical health. Frequent dialysis does not significantly improve their overall physical capacity compared to conventional dialysis, but it can provide improved quality of life.
Primary care physicians with unconscious racial biases tend to dominate conversations with African-American patients, making them feel less involved in decision-making. The study found that these biases can lead to reduced trust, disrespectful treatment, and lower likelihood of recommending the doctor.
A Chinese team has developed a theoretical model for multiple solitary optical waves, also known as dark photovoltaic spatial solitons, which induce waveguides and can reconfigure optical beams by splitting them. The findings confirm previous research on the behavior of these solitons in photorefractive crystals.
New research in epigenetics explores the impact of environmental factors on gene expression, shedding light on the relationship between diet, lifestyle, and disease. The study suggests that environmentally induced epigenetic changes may not persist across generations, challenging the idea of an 'epigenetic designer baby'.
Researchers have created a genetic map of recombination in chimpanzees, showing that hotspots differ significantly from those in humans. The study reveals the complex evolution of this process, which drives genetic diversity and adaptation.
A new study suggests that stem cells could potentially restore muscle coordination deficits in patients with Huntington's disease. Researchers successfully integrated human embryonic stem cells into mouse brains, reestablishing the broken communication network and restoring motor function.
Research from Rice University found that bilingual immigrants experience improved physical and mental well-being compared to unilingual immigrants. The study, which analyzed over 4,649 U.S. immigrants, suggests that maintaining native-language fluency alongside English proficiency contributes to better health outcomes.
Researchers at Winship Cancer Institute developed a technique to remove cancer cells' defenses against radiation by disabling their ability to repair DNA. The experimental method uses RNA molecules that shut down genes needed for DNA repair, making brain and lung cancer cells more sensitive to X-ray radiation.
A group of specialists explored options for searching and reporting incidental genetic findings in clinical genome sequencing. The study found that while there was no perfect agreement among experts, the majority agreed that many incidental findings should be reported to clinicians. Specialists also differed on whether to disclose cert...
A recent study published in Cancer Research suggests that dietary cadmium may be associated with an increased risk of breast cancer. Women who consumed higher amounts of whole grain and vegetables had a lower risk of breast cancer compared to those exposed through other foods.