Scientists at VIB and Ghent University identified a new protein, ERF115 transcription factor, which regulates quiescent center cells. This discovery explains why plants can live for hundreds of years while animals typically do not.
Researchers at EMBL have determined the 3D structure of RNA polymerase I, revealing a unique 'Swiss-army knife' strategy that allows it to produce RNA molecules faster than its counterpart, RNA polymerase II. The protein's larger size and efficiency are due to its built-in modules, which prevent the need for external recruitment.
African lions in Uganda have decreased by over 30% in the past decade due to poisoning and human-related conflicts. The species' decline poses a significant threat to the country's tourism industry and ecosystem balance.
A new study published in Cell suggests that the latent reservoir of HIV-infected patients is significantly larger than previously estimated, making it a major barrier to cure. The findings highlight limitations of current treatment strategies and could lead to the development of more effective interventions.
Researchers at Howard Hughes Medical Institute discovered that the pool of inactive HIV viruses in a patient's body is larger than expected, with some retaining the ability to become active even after treatment. This finding suggests that targeting the inactive viruses, known as proviruses, is crucial for achieving a complete cure.
Researchers found that eastern coyotes and coyote × wolf hybrids in central Ontario have killed adult moose, challenging the long-held notion of their inability to tackle such prey. The study also discovered that younger and older adult moose are more vulnerable due to inexperience and deteriorating body condition.
A new study finds that an experimental drug called 3K3A-APC reduces brain damage and eliminates brain hemorrhaging in stroke-afflicted mice and rats. The drug extends the therapeutic window of FDA-approved clot-busting therapy tPA, counteracting its tendency to induce bleeding.
A study by the American Society of Hematology found that bone marrow transplant is linked to diminished sexual health in both men and women. Chronic graft-versus-host disease and total body irradiation are particularly damaging, with men experiencing a decline in libido and dysfunction.
Researchers replicate formation of first silicate dust and find matching oxygen isotopes in stony meteorites, solving long-standing solar system formation puzzle. The discovery suggests a simple physical chemistry principle governed the early solar system.
The study will focus on three leading Philadelphia arts organizations: the Chamber Orchestra of Philadelphia, Opera Philadelphia, and the Pennsylvania Ballet. The research aims to understand how these organizations cope with changing landscapes and explore best practices for other institutions.
A new study found a significant gene-diet interaction between processed meat consumption and genetic variants associated with reduced risk of colorectal cancer. The study suggests that understanding these interactions may lead to targeted prevention strategies for individuals at higher risk.
A systematic review found that early spinal decompression surgery following traumatic spinal cord injury is associated with significantly greater motor and neurological improvement. However, the evidence supporting early spinal surgery lacks robustness due to various sources of bias.
Research finds obesity may significantly increase the risk of C. difficile infection, particularly in those with no prior healthcare exposure. Additionally, patients with inflammatory bowel disease are also at higher risk, highlighting the need for improved clinical surveillance and monitoring.
Researchers at Washington University in St. Louis are developing an early warning system using machine learning algorithms to identify hospitalized patients at risk of deterioration or life-threatening events. The system aims to reduce readmissions and improve patient outcomes by providing real-time alerts to physicians.
Researchers at UC Davis and Stanford University have identified a key step in assembling hydrogen-generating catalysts, which are based on precisely organized clusters of iron and sulfur atoms. This study reveals how bacteria naturally build these catalysts and could pave the way for more efficient production of clean energy.
Researchers found a 60-fold increase in dormant HIV proviruses, potentially making it harder to find a cure. The latent reservoir is thought to contain functional proviruses that can reactivate and resume infection if antiretroviral therapy is stopped or interrupted.
Researchers identified a link between rare RINT1 gene variants and increased risk of early onset breast cancer. The study found that these variants may also predispose individuals to other types of tumors, highlighting the potential for RINT1 to play a broader role in cancer susceptibility.
Physicists at Rice University have deciphered the operating principles of a genetic switch that cancer cells use to decide when to metastasize and invade other parts of the body. The research found a three-way genetic switch that explains previously confusing experimental results, opening new avenues for cancer treatment.
Researchers found that the fungus can survive on various carbon sources and grow in a wide pH range, making it hard to stop its spread. It can also tolerate sulfur compounds and calcium, but struggles to absorb water from dry surfaces.
The OPTIMISTIC study, a healthcare initiative from Indiana University and the Regenstrief Institute, is underway in 19 Central Indiana nursing facilities. The program focuses on improving care coordination, palliative care, and chronic disease management to reduce avoidable hospitalizations.
In a plant cell model system, the katanin enzyme carefully cuts misaligned microtubules at crossovers to form parallel bands. This activity organizes and maintains the cytoskeleton's pattern, essential for its functions in shape and molecular transport.
A new study from the Norwegian Institute of Public Health found that maternal anxiety and depression can lead to increased risk of emotional and disruptive problem behaviors in children as early as 18 months old. The study also highlights the importance of early prevention and intervention, particularly for mothers with high levels of ...
A mindfulness-based professional development program, CARE for Teachers, improves teachers' well-being, efficacy, and classroom environments. The program combines emotion skills instruction, mindful awareness practices, and compassion-building activities to reduce stress and improve social-emotional learning.
Two student-developed mobile apps, FoodFeed and FL•U, have been created to combat health threats. FoodFeed provides alerts on food recalls, illness outbreaks and health code violations, while FL•U allows users to share flu-like symptoms and view localized outbreak maps.
A new study finds that women are more sensitive to mobile phone use during business meetings than men, with significant regional and age differences. The research highlights the importance of understanding social expectations around polite smartphone behavior in the workplace.
A UMass Amherst researcher conducted the largest-ever scientific study on video ad effectiveness, analyzing over 257 million ads and 367 million videos. The study found that viewers who return to a site have higher completion rates for all ad categories, while ads inserted in long-form content are more likely to be watched to completion.
The Endocrine Society publishes a Clinical Practice Guideline for diagnosing and treating polycystic ovary syndrome (PCOS), a leading cause of infertility in women. The guideline provides clear criteria for diagnosis and treatment recommendations, aiming to address the complexities of this hormone disorder.
Researchers at Princeton University discovered nearly straight paths in quantum control landscapes, allowing for more efficient manipulation of atoms and molecules. This breakthrough could lead to improved measurements and design of quantum systems, including quantum computers.
A mid-level solar flare, classified as an M9.4 event, was observed by NASA's Solar Dynamics Observatory (SDO) on October 23, 2013. This flare had a significant impact on Earth's atmosphere, causing disruptions to radio signals and potentially affecting GPS communications.
Researchers have discovered coral animals produce dimethylsulphoniopropionate (DMSP), a molecule that helps protect them against heat stress and influences cloud formation. This finding could be crucial for regulating local climate and mitigating the effects of rising seawater temperatures.
A team of researchers from Berkeley Lab and the Scripps Research Institute used a new technique to study the role of MutS in DNA's mismatch repair system, providing new insight into genome integrity. The study validated the 'beads-on-a-string' model of DNA repair and revealed details about MutS that could be valuable for drug design an...
A UCSB anthropologist examines the enduring practice of hazing, finding a connection between its persistence across cultures and our shared evolved psychology. He suggests that group benefits may be a key factor in hazing behavior, as individuals with automatic benefits are more likely to haze.
Researchers have discovered how αA-crystallin and αB-crystallin proteins prevent protein clumping in the ocular lens, paving the way for new treatment approaches. The molecular switch mechanism triggers protein activation when cells are stressed, such as under heat or stress.
Researchers at NIST developed a novel method for measuring laser power by reflecting light off a mirrored scale, simplifying calibration and enabling on-site measurements. The technique enables accurate and fast measurement of high-power lasers with reduced costs.
A simple blood test detecting epigenetic alterations may reveal the earliest signs of pancreatic cancer, a disease with nearly always fatal outcomes. The test's sensitivity and specificity are 97% and 85%, respectively, offering a promising step towards reducing mortality from this cancer.
Researchers at Penn Medicine found that focusing on factors like hope, randomization, and altruism can increase patient willingness to participate in clinical trials for malignant pleural mesothelioma. The study showed a significant increase in participation rates when physicians spent more time discussing these factors with patients.
The Johns Hopkins Berman Institute of Bioethics has launched a new two-year postdoctoral fellowship program in bioethics, funded by the Hecht-Levi Foundation. The program aims to support at least 10 promising young scholars in their research and career development.
Kaiser Permanente's Complete Care model has shown steady improvement in quality scores, with an average increase of 13% compared to the national average. The program uses Proactive Office Encounters to address patient needs, promoting preventive care and improving chronic condition management.
NASA's Terra satellite captured visible and infrared data on Lekima, revealing its 20 nautical mile-wide eye with intense thunderstorms. The storm's powerful winds were near 140 knots, extending 55 nautical miles from the center.
A national study led by the University of Miami's Miller School found that brief patient-centered counseling before rapid HIV testing has no significant impact on subsequent STD acquisition. Instead, resources should be devoted to universal testing that can detect more HIV cases earlier and link newly infected individuals to treatment.
Researchers have developed a new Trojan-horse approach using stealth nanoparticles to sneak into tumor cells, lower their defenses and attack them with drugs. The nanoparticles showed significantly enhanced therapeutic effects and shrunk tumors by 8-fold in mice, offering a potential strategy to treat aggressive breast cancer.
Plants have a 24-hour circadian rhythm that allows them to measure time and adjust their biology accordingly. Researchers found that sugar production plays a key role in regulating this internal clock.
Researchers found that emotionally intelligent individuals are more likely to manipulate others' decisions based on their own intentions. They can either facilitate or hinder retaliation, depending on their own goals.
Research reveals that regional differences in rainfall timing and resulting vegetation patterns help maintain genetic diversity among giraffe species. Annual climate cycles may play a key role in this process, with each species tied to its local seasonal cycle of greening.
A study by MU researchers discovered that older siblings' cells can be passed from a female dog to her puppies while they are still in the womb. This finding will help further investigate the health effects of microchimerism in dogs and humans.
Researchers from Imperial College London have discovered how Mycobacterium tuberculosis tricks the immune system to establish persistent infections. They hope to develop small molecule drugs that can block or destroy the bacteria by targeting these sugar molecules.
Researchers found metformin as an effective radiosensitizer for treating stage III non-small cell lung cancer, improving local control and overall survival. The study suggests combining metformin with chemotherapy and radiation therapy may be a promising treatment approach.
Stroke cases among young and middle-aged people have increased by 25% over the last 20 years, with the total number projected to double by 2030. The global burden of stroke is expected to more than double worldwide due to rising disability and premature death.
A new algorithm based on the Parsons code successfully identifies individual dolphin whistles, reducing time and errors in classification. This innovation enables researchers to study dolphin social behavior and develop a better understanding of their communication.
Researchers use TopoChip platform to test thousands of surface patterns and catalog cellular responses, revealing the 'Braille code' of cells. The approach has potential applications in improving medical device performance and reducing negative reactions to artificial implants.
Researchers at North Carolina State University and Laser Zentrum Hannover have discovered a natural compound, riboflavin, that can be used to create non-toxic polymers for 3D printing medical implants. This breakthrough opens up new possibilities for customized implant designs.
Researchers at Scripps Research Institute have developed a promising technique for treating human eye disease by targeting microRNAs, which can stop abnormal blood vessel growth. The approach shows promise in preventing blindness in diseases like neovascular macular degeneration and diabetic retinopathy.
Researchers at Linköping University have identified six proteins in spinal fluid that can be used as markers for the illness, offering a potential step towards early diagnosis. The study found that these proteins are associated with the breakdown of brain cells and toxic accumulations of beta amyloid protein.
A study led by a CU School of Medicine researcher has confirmed the Gene Expression Classifier (GEC) test can accurately identify benign thyroid nodules, significantly reducing the need for unnecessary surgeries. The test was found to have a very high negative predictive value, with only one nodule out of 71 identified as cancerous.
Researchers at UAlberta have discovered a potential new treatment for colitis by using a leukemia drug to reverse symptoms in lab tests. The discovery suggests that inhibiting inflammation can reduce the likelihood of patients with ulcerative colitis developing colorectal cancer later in life.
A new study published in Pediatrics found that patients with cystic fibrosis experience no rapid decline in pulmonary function or other significant health-related changes when transitioning from pediatric to adult care. The study's results contradict previous reports on negative health outcomes after transition for other chronic childh...
Researchers are developing novel systems to accurately redefine the kilogram using vacuum technology, promising a more precise and reliable measurement. The current kilogram definition relies on the International Prototype Kilogram, which has increasing discrepancies with national prototypes every 100 years.
A USC study reveals Google has expanded its search infrastructure to serve clients from over 1400 locations worldwide, reducing warming up lag time and packet loss for faster searches. This shift allows Google to deliver content quickly while keeping operational costs low for ISPs.
Researchers have discovered a new breed of materials with properties unlike those of their parent compounds, including conductive interfaces and topological insulators. These interfacial materials offer potential applications in tiny devices that consume less power.
A new, inexpensive paper-based device has been developed to detect disease markers in patients' blood, offering a potential solution for medical testing in remote regions. The device uses simple materials and no electronics, allowing it to be easily operated by users with limited resources.