Researchers at UC San Diego School of Medicine developed a new approach to understand how master regulators read the genome and turn genes on and off. By analyzing DNA sequence differences affecting these proteins, they found that mutations impact neighboring transcription factors needed to make functional enhancers.
A large-scale genome-wide association study identified four genetic variants associated with an increased risk of esophageal cancer and its precursor, Barrett's esophagus. The study pooled data from over 8,000 participants and found that the genetic variants were more strongly linked to early stages of disease development.
Researchers at Monash University have combined computer modelling with pharmacology to gain new insights into how the body interacts with novel drug treatments. The study reveals alternative drug recognition sites on G protein-coupled receptors, which play a role in virtually every biological process and most diseases.
Researchers at CNIO have sequenced the exome of 17 patients with non-infiltrating bladder cancer, revealing new genetic pathways and genes involved in the disease. These findings provide a first step towards understanding the biology of bladder cancer and improving patient management.
Researchers at McMaster University have developed a novel approach to find new antibiotics by targeting the processes that bacteria use to produce essential vitamins and amino acids. The study identifies chemical compounds that block these processes, potentially providing much-needed therapies to address antibiotic drug resistance.
Researchers at Georgetown University Medical Center have discovered a genetic mutation, STAG2, linked to low-risk bladder cancer. The study found that 36% of low-risk bladder cancers had mutated STAG2, suggesting that testing the gene could help guide clinical care.
Researchers created a massive online database that matches thousands of genes linked to cancer and other diseases with drugs that target those genes. The database includes over 14,000 drug-gene interactions and is publicly available for research purposes.
The EU's total cancer cost was estimated to be €126 billion in 2009, with health care systems accounting for two-fifths of the expenditure. Lung cancer had the highest overall cost, while breast cancer was responsible for the largest share of spending on drugs.
A new study published in Diabetologia found associations between lifestyle factors and mortality risk differ less between individuals with and without diabetes. Those with diabetes may benefit more from healthy diet but recommendations are likely to be similar