A revolutionary new scientific method developed at the University of Leeds uses 'promiscuous reactions' to improve the diversity of biologically active molecules, such as antibiotics and anti-cancer agents. The approach has successfully identified three biologically active molecules with potential applications in cancer treatment.
A new study reveals that neurons in the brain's inferotemporal cortex fire strongly and selectively when exposed to familiar images, especially those seen many times before. This finding suggests that the brain uses this mechanism to track a rapidly changing visual environment and may lead to improvements in perception and cognition.
Researchers found that apolipoprotein E-derived therapeutic peptide improved synaptic stability and learning and memory performance after diffuse brain injury. The peptide also protected against brain injury by reducing oxidative stress, suppressing the ERK1/2-Bax mitochondrial apoptotic pathway, and decreasing neuronal death.
A recent study reveals that genetic selection has imprinted its signature on the genomes of poplars, a finding that could improve predictive climate change models and tree breeding programs. By analyzing over 1,100 wild poplar trees, researchers identified 397 genomic regions contributing to adaptive traits.
Researchers found that carbon-reduction policies can lead to significant health savings, with benefits ranging from 26% to 10.5 times the cost of implementation. A transportation policy was the most expensive option, costing over $1 trillion in 2006 dollars, while a clean energy standard fell between the costs of other policies.
A new study published in Neurobiology of Aging found that exercising improves cardiovascular strength, which may protect against cognitive impairment as we age. The researchers tested 31 young people and 54 older adults, finding that those with better aortic elasticity and aerobic fitness performed better on cognitive tests.
The LSU Health New Orleans School of Nursing received a $700,000 Advanced Education Nursing Traineeship grant to increase access to advanced nursing education and patient care. The program will provide funding for up to 50 PCFNP students from disadvantaged groups.
The FASEB MARC Program has announced travel awards for postdoctorates and research scientists from underrepresented groups to attend a grant writing seminar and practical exercises workshop. This year, 11 awards totaling $20,350 were conferred.
Thomson Reuters has included five UC Riverside researchers in its list of highly cited individuals, citing their impact on various scientific fields. The researchers, Roya Bahreini, Julia Bailey-Serres, Robert Haddon, Wei Ren and Yadong Yin, were identified through citation data analysis over 11 years.
Tropical Storm Lowell poses a threat to Baja California with strong ocean swells and life-threatening surf conditions. The storm's size and weakening trend indicate it may become a post-tropical cyclone by the weekend.
Researchers found high concordance (94%) between EGFR mutations in plasma-derived ctDNA and tumor tissue in NSCLC patients. This suggests that a single plasma sample may be sufficient for mutation status assessment when tumor tissue is unavailable.
Tropical Storm Karina intensified on August 22 with moderate rainfall and towering thunderstorms, dropping rain at a rate of near 25 mm/1 inch per hour. The storm is moving to the northeast near 3 mph (6 kph) and is expected to weaken in two days as it enters cooler waters and stable dry air.
Researchers have successfully imaged gold nanoparticles at atomic resolution using high-resolution electron microscopy, revealing a crystalline structure with 68 gold atoms. The breakthrough opens the way for understanding and practical applications of nanoparticle structures.
Scientists have found that punicalagin, a polyphenol in pomegranate, can inhibit neuro-inflammation in brain cells. The compound may help slow the development of diseases like Alzheimer's and Parkinson's by reducing inflammation.
A large-scale study by Uppsala University researchers reveals that genetics and lifestyle factors play a crucial role in protein levels, enabling the use of more effective biomarkers. The study analyzed 92 protein biomarkers in 1,000 healthy individuals, finding that hereditary factors contribute to over 75% of proteins.
Researchers at the University of Alberta have developed a compound that targets a specific enzyme overexpressed in certain cancers. The enzyme inhibitor shows promise in turning glioblastoma cancer stem cells into normal cells and stopping their growth.
Researchers at Hera Therapeutics have developed a therapy that blocks replication of high-risk HPV types, including HPV-16 and HPV-18, which cause 70% of cervical cancer. The company is developing a topical approach to treat HPV infection, offering hope to millions of women infected with these high-risk strains.
A new study found that women with severe disabilities are screened for breast cancer less often, at 61%, compared to those with moderate disabilities, who were screened more frequently. This disparity highlights the persistence of health disparities in breast cancer screening, particularly among vulnerable populations.
A study by Wayne State University researchers found that cognitive-behavioral coping skills training significantly improved RA patients' pain and mood for at least a year. In contrast, written emotional disclosure had only short-term benefits on joints and functioning. The combination of both therapies showed no unique benefits.
Researchers at Karolinska Institutet find that the striatum integrates sensory input from touch, vision, and sound to guide movements. The study provides insight into the brain's processing of external input and its role in motor function and disease.
A volunteer group, known as 'vigías', has been instrumental in safeguarding communities around the Tungurahua volcano in Ecuador. The network enables citizens to continue living and working in hazardous areas by enhancing their capacity to respond quickly to escalating threats.
Researchers found calcium involved in chemical signaling throughout the double fertilization process, guiding sperm release and fusion with the egg cell. This discovery sheds light on the complex process of flowering plant fertilization.
Researchers at HZB's BESSY II have discovered a new class of materials using protein crystalline frameworks, which can achieve high stability and be intricately interconnected. The discovery allows for controllable interpenetration and variability, opening up potential applications.
The Penn Medicine team found that targeted automated alerts in electronic health records significantly reduced urinary tract infections in hospital patients with urinary catheters. Simplifying the alert design increased the rate of catheter removals, leading to a dramatic decrease in infections.
Researchers found BIM deletion independently predicts overall and progression-free survival in advanced NSCLC patients, particularly in those treated with EGFR TKIs or chemotherapy. The study suggests considering BIM deletion as a clinical trial stratification factor for Asian NSCLC patients.
New research reveals that one out of four acutely admitted medical patients leave the hospital without a diagnosis. The study found that many patients were not adequately examined during their hospitalization, increasing the risk of deterioration and re-hospitalization.
Researchers at Iowa State University found that using a rule of thumb to control pouring reduces overconsumption. Men who poured wine with a general guideline poured significantly less than those without one, regardless of their body mass index. This study suggests using a drinking rule can help prevent overdrinking.
A new Kessler Foundation study reveals that people with multiple sclerosis (MS) can enhance their self-awareness through hands-on task experiences. Researchers found improved metacognitive knowledge and online awareness in participants, suggesting potential benefits for cognitive rehabilitation.
A recent study from the University of Waterloo monitored smokers switching to cigarettes with reduced nicotine levels, finding no change in puffing behavior or toxic chemical exposure. This suggests that reducing nicotine levels may not lead to an increase in cigarette consumption or nicotine intake.
Scientists at Stanford University have developed a low-cost, emissions-free device that uses an ordinary AAA battery to produce hydrogen by water electrolysis. The battery sends an electric current through two electrodes that split liquid water into hydrogen and oxygen gas.
A recent study by NYU researchers found that NYU nurses deployed to other hospitals after Hurricane Sandy experienced significant stress and uncertainty. The mixed-methods study identified several psychosocial and practice-based challenges, including limited orientation time, legal concerns, and issues with patient assignments.
Recent studies have shown that microglia-conditioned culture medium supports OPCs' survival and enhances their differentiation. The role of microglia in remyelination is complex and varies depending on the timing of disease progression. Microglia/macrophage activation can lead to poor remyelination in MS plaques lacking microglia.
A team led by Arun Sharma has developed a system to protect against inflammatory reactions that can hinder tissue growth and function. Using self-assembling peptide amphiphiles, they demonstrated superior bladder function in a urinary bladder augmentation model.
The European Society for Medical Oncology (ESMO) recognizes the contributions of three outstanding individuals in cancer research and treatment. Carsten Bokemeyer receives the ESMO Award for his work on malignant germ cell tumours, while Peter Boyle wins the Lifetime Achievement Award for his long-standing contribution to cancer epidem...
Researchers estimated the risk of premature menopause in women treated for Hodgkin lymphoma, providing precise estimates based on treatment types and ages. The study found that certain treatments, such as ovarian radiotherapy and chemotherapy, significantly increased the risk of early menopause.
Researchers discover that a key cow milk allergen is more potent when bound with iron complexes, triggering an immune response in people with a milk allergy. This finding has significant implications for diagnosis and treatment of the condition.
Researchers at Champalimaud Foundation establish the effect of serotonin on sensitivity to pain, revealing a significant decrease in pain perception when serotonin is released. This breakthrough provides new insights into chronic pain treatment.
A new study has found a wide range of epigenetic changes in children with Crohn's disease, which may be related to key environmental exposures. The research suggests that these changes could have early implications for clinical management of the disease.
Researchers identify RET M918T mutation in SCLC tumors, which drives increased ERK signaling and MYC expression. The mutation makes cells sensitive to tyrosine kinase inhibitors ponatinib and vandetanib.
Tropical Storm Marie rapidly formed off Mexico's coast, with powerful thunderstorms stretching towards the troposphere. The storm is expected to intensify rapidly due to warm sea surface temperatures, potentially becoming a hurricane by Monday, August 25. Rapid intensification is predicted due to favorable environmental conditions.
Renal artery stenting may benefit patients with kidney artery blockages who were excluded from clinical trials. Expert panel recommendations suggest patients with cardiac disturbance or severe high blood pressure are good candidates for the procedure, while others may not be suitable due to mild or moderate blockages.
Percutaneous stereotaxic rhizotomy (PSR) provides good pain relief at a much lower cost than other surgical treatments, but is underutilized due to limited data and complications. The study found PSR to be eight times more cost-effective than microvascular decompression and 13 times more cost-effective than stereotactic radiosurgery.
Researchers analyzed 500 patients with diabetes mellitus and found altered nerve conduction in the early asymptomatic stage of diabetic peripheral neuropathy. The amplitude of sensory nerve action potential was the most sensitive measure of this condition, revealing varying degrees of nerve conduction changes.
Researchers found that geniposide, a component of the Chinese herbal formula Tongluojiunao, protects hippocampal neurons from Aβ1-mediated cell death via a non-classical estrogen signaling pathway. This study suggests a new potential therapeutic approach for Alzheimer's disease.
Hurricane Lowell strengthened into a Category One hurricane with sustained winds of 75 mph after being observed by NASA satellites. The storms' cloud top temperatures exceeded -63F, indicating high thunderstorms with potential heavy rainfall.
Scientists have developed a genetically engineered mouse line that allows them to study calcium levels in living brain cells, enabling new research on epilepsy, Alzheimer's, and other neurological diseases. This breakthrough opens up possibilities for new treatments and a deeper understanding of the immune system's role in brain function.
Researchers successfully constructed an adenovirus that induces DHCR24 specifically in neuronal cells, demonstrating its neuroprotective effects against amyloid beta-induced apoptosis. This breakthrough paves the way for further studies on DHCR24 gene therapy and neuronal functional research.
A new study found that overweight individuals with type 2 diabetes who lose weight through dieting and physical activity can reduce their healthcare costs by an average of over $500 per year. Those in the intensive lifestyle intervention group had fewer hospitalizations, shorter hospital stays, and used fewer prescription medications.
The University of Wisconsin-Madison has been selected to participate in the National Science Foundation-funded CloudLab project, which aims to develop cloud infrastructure and support high-level research. The $2.3 million grant will enable researchers to evaluate novel cloud technologies in a realistic environment.
A newly discovered species of ant, Mycocepurus castrator, has been found to support the theory of sympatric speciation, where a new species develops within a single colony. The research team found that the parasitic ants were genetically close to their host, but no longer reproductively compatible and had stopped reproducing together 3...
Researchers found that elasticity, free oil, moisture, water activity, and transition temperature influence color uniformity of cheeses. Mozzarella can be combined with less burnt cheeses like Gruyere or provolone to create a gourmet pizza.
Researchers found that negative emotions like anger can be used as a force for good when motivated by moral standards, while excessive positivity can lead to complacency and superficiality. In some team situations, negativity can actually enhance discussion and effectiveness.
Reconstruction of sea ice changes in the Fram Strait reveals that Arctic sea ice cover decline led to significant weakening of the Gulf Stream. This change had a direct impact on European climate, with cooling occurring twice in the past 30,000 years.
Researchers detected quantum vortices in nanodroplets of liquid helium, forming a densely packed lattice. The droplets rotated at up to 14 million times per second, defying classical physics.
A Canadian team outlines possible coping mechanisms for lost or stolen mobile devices, highlighting the importance of user awareness and organization security measures. The researchers found that many users are either unaware or unwilling to use security countermeasures, leaving them vulnerable to data loss risks.
Researchers develop theoretical framework to generate coherent radiations in the water window range, enabling high-contrast imaging of biological samples. The study extends previous work on hydrogen and applies it to argon atoms, paving the way for improved spectroscopy techniques.
Using Extracorporeal Membrane Oxygenation (ECMO) has increased the number of organs available for transplant after circulatory death by 20%. This technology improves organ viability, particularly for kidneys, livers, and pancreases, making more life-saving organs available for patients waiting for transplants.
A new study projects a continued decline in US edentulism prevalence through 2050, with high-income households experiencing the steepest reduction. However, tooth loss remains disproportionately prevalent among low-income populations, highlighting a need for targeted public health measures to address this issue.
A University of New Hampshire and NASA study suggests that high-energy particles from solar storms can charge the moon's polar soil, creating sparking and potentially altering its composition. This process could have significant implications for our understanding of planetary surfaces in extremely cold regions.
Researchers from Louisiana State University have confirmed the existence of microbial life in a subglacial lake beneath the West Antarctic ice sheet. The discovery sheds new light on the potential for life in other extreme environments and has implications for our understanding of the planet's biosphere.