A new study identifies brain processes in mice that may help explain how weak sensory inputs are interpreted differently in the same brain. Activity in higher-level perception areas of the brain is shaped by lower-level sensory input, adding a cellular layer to our understanding of perception.
Researchers found a 15-20% reduction in hospitalization risk for heart failure or death among patients with cardiac resynchronization therapy compared to those with implantable cardioverter defibrillators. The treatment is associated with improved outcomes, but further studies are needed.
Researchers found that winter temperatures drive synchrony in aphid flight timings, affecting commercial crops like alfalfa and wheat. Climate change influences spatial synchrony in many species, with implications for public health and commercial endeavors.
Recent research reveals that all dividing human skin cells have the potential to switch between two modes of cell division, one for maintenance and another for wound repair. This finding explains how skin grafts work and may lead to new treatments for wound healing and cancer.
A phase 1 clinical trial found that enzalutamide is active and well-tolerated alone and with fulvestrant in patients with advanced breast cancer. The study supports a larger trial of the combination, building on promising preclinical data and targeting androgen receptors in breast cancer.
Cavitation bubbles, formed by ultrasonic pressure waves, can cause severe damage to nearby cells. Duke researchers used high-speed cameras to study the effects of these powerful little bubbles on individual cells, finding that membranes can withstand higher strains than previously thought and reseal allowing target cells to fully recover.
Researchers discovered that ancient Puebloans used trees from the Zuni and Chuska Mountains to build massive structures in Chaco Canyon. The switch to Chuska Mountain trees coincides with significant cultural developments in Chacoan culture, including changes in masonry style and construction volume.
University of Oregon scientists have identified a molecular change in aging stem cells that stops them from making tumors. The discovery, detailed in the journal Current Biology, focuses on the larval stage of fruit fly development and reveals that a protein called Eyeless plays a crucial role in regulating Notch signaling.
Researchers have developed a new system to track nanometer-sized viruses at sub-millisecond time scales, shedding light on the spontaneous self-assembly of viruses. This breakthrough could help design drugs that prevent viruses from forming in the first place.
The American Epilepsy Society awarded Dr. Christian E. Elger the William G. Lennox Award for expanding his department into a leading program in epilepsy surgery and human brain research. Elger's pioneering work includes studying seizure prediction and developing pre-surgical cognitive outcomes.
A Stanford University study has found that men treated with androgen deprivation therapy for prostate cancer are nearly twice as likely to be diagnosed with Alzheimer's disease. The researchers analyzed electronic medical records of thousands of patients, revealing a significant increase in cognitive decline among those receiving ADT.
Researchers at the University at Buffalo have developed a method to convert skin cells into functional dopamine neurons by manipulating the expression of p53 and Tet1 enzymes. This breakthrough enables the efficient generation of patient-specific neurons that can be transplanted into the brain to repair faulty dopamine neurons.
Researchers found that hippos consume meat, challenging their dietary status as herbivores, and increasing their susceptibility to anthrax outbreaks. This behavior may be linked to the unique characteristics of antelope carcasses infected with anthrax.
A UCI study found that high doses of green tea polyphenols can cause developmental delays, reduced offspring output, and reproductive abnormalities in fruit fly larvae. The researchers recommend moderate consumption to avoid potential health risks.
Researchers presented landmark studies on newly diagnosed multiple myeloma, revealing key biological processes and disease mechanisms. Two combination therapy strategies showed high response rates in patients with difficult-to-treat myeloma.
A new model predicts that climate change impacts will worsen income growth for the poor, leading to a more unequal distribution of wealth. The researchers recommend lenient or sharp increases in carbon prices to mitigate these effects and protect vulnerable populations.
Research at Columbia University's Mailman School of Public Health found that young men with detectable HIV are more likely to engage in risky sexual behavior, particularly anal intercourse without condoms. This disproportionately affects vulnerable groups, such as those aged 13-29 and experiencing substance use issues.
Researchers discovered strikingly huge organs in tiny cave snails, including enormous kidneys and three-pointed teeth. These adaptations enable the snails to tolerate extreme conditions and survive in environments where others would perish.
Researchers at University at Buffalo find that motivational interviewing significantly reduces the risk of opioid misuse and abuse among older adults with chronic pain. The intervention increases motivation, self-efficacy, and confidence in changing behavior, while also decreasing depression and anxiety.
Researchers have invented a technique to dramatically accelerate protein evolution, allowing them to test millions of variants in hours or days. The technology, called µSCALE, enables the identification of promising variants and their DNA sequences, paving the way for breakthroughs in medicine, industry, and biosensors.
The Canadian Medical Association Journal recommends that the new Minister of Health enact a national pharmacare program, letting science guide health policy decisions. The editors also emphasize the importance of defending the Canada Health Act and focusing on social determinants of health.
Patients who discontinued ibrutinib or idelalisib due to side effects experienced durable responses after switching to another kinase inhibitor, with a 50% objective response rate and 11.9-month median progression-free survival.
Researchers found elevated levels of polycyclic aromatic hydrocarbons (PAHs) in NYC community garden soils, a concern due to air emissions. However, cultivating vegetables in beds may lower PAH concentrations, suggesting potential for reduction through gardening practices.
Hitachi and Tohoku University's Advanced Institute for Materials Research have developed a basic technology to reduce internal resistance in all-solid-state lithium-ion batteries, allowing them to operate at temperatures up to 150°C. This breakthrough enables the thermally durable battery to be used in various applications, such as lar...
Entomologists from the University of California, Riverside, discovered a new genus of plant bug, Restiophylus, and four new species from Australia. The new species are closely associated with Australian restiid clade (Poales). Detailed information on the insects is provided in the Annals of the Entomological Society of America.
Trees draw on stored carbon reserves when springtime sap begins to flow, integrating sugars from multiple growing seasons. This finding suggests that maple syrup production depends on long-term nutrient storage rather than just the last season.
Researchers found that losing CD73 enzyme promotes tumor growth and progression in endometrial cancer by disrupting adenosine signaling, which normally regulates tissue function. The study provides new insights into the role of CD73 in cancer development.
Kevin Staley, M.D., has made significant contributions to understanding neonatal seizures through his work on 'neuronal plumbing' and GABA receptors. His research will benefit patients with epilepsy for years to come.
Researchers at University of California, San Diego School of Medicine have discovered that the existing compound KD3010 offers hope for slowing Huntington's disease and its symptoms. The study found that KD3010 improved motor function, reduced neurodegeneration, and increased survival in a mouse model of HD.
A study by the University of Georgia found a correlation between certain patterns of connections on Facebook and drug and alcohol use among female students. Students with a history of childhood physical abuse were more likely to be part of densely interconnected groups, associated with higher risk for alcohol use. In contrast, those wi...
Researchers deciphered the atomic-scale structure of a botulism toxin-bound protein, revealing how it stays intact in acidic conditions and disassembles in neutral pH environments. This knowledge may help develop new vaccines or treatments targeting the deadly neurotoxin.
The Scripps Research Institute (TSRI) team has discovered a unique anti-diabetes compound that activates the GLP-1 receptor's G-protein pathway, potentially leading to a new type of diabetes treatment. The novel molecule P5 shows promise in boosting glucose tolerance with minimal insulin stimulation.
A study published in PLOS ONE found that treating ear mites in Santa Catalina Island foxes reduced ear tumor prevalence by 99% and inflammation by 90%. The success story highlights the impact of preventative treatments on wildlife populations, with improved conditions for foxes' ear canals and a notable decline in tumors.
Researchers have identified genes linked to epilepsy using innovative technologies such as gene editing and next-generation sequencing. These findings suggest a spectrum of conditions beyond Infantile Spasms or Lennox-Gastaut syndrome, prompting the exploration of personalized medicine for genetic forms of epilepsy.
Three studies explore SCN8A gene mutations linked to early infantile epileptic encephalopathy and other neurological conditions. The findings provide new data on the spectrum of SCN8A-related epilepsies, including familial and sporadic cases.
Researchers at La Jolla Institute for Allergy and Immunology identified the matchmaker that brings critical calcium channel components together, allowing calcium to rush into cytosol. This finding provides a potential target for developing drugs to modulate T cell activation status.
A recent study published in the New England Journal of Medicine found that ibrutinib, a targeted drug, was superior to chlorambucil in treating chronic lymphocytic leukemia (CLL) patients. The study showed improved progression-free survival, overall response rate, and overall survival rates for patients taking ibrutinib.
Researchers report improvements in four children treated with gene therapy for Wiskott-Aldrich syndrome, including reduced bleeding events and improved immunologic symptoms. The treatment's long-term safety and efficacy remain to be assessed as the children are monitored for 15 years.
Yale researchers developed a high-dose flu vaccine strategy that lowered infection rates by 64% among patients with immune system cancers. The novel dosing schedule improved protection against all flu strains in 66% of patients, offering promising results for cancer patient populations.
Children with childhood leukemia benefit from prophylactic antibiotics, reducing serious bacterial infections during the first month of treatment by approximately 60 percent. The use of antibacterial prophylaxis appears to have made a profound difference for patients.
A new study by King's College London found that reduced antibiotic prescribing is associated with lower GP satisfaction scores. The study, which analyzed records from 7,800 general practices, found a 25% lower rate of antibiotic prescribing corresponded to a 5-6 point reduction in GP satisfaction rankings.
A multi-center study found ibrutinib to be more effective than chlorambucil in treating CLL, with a 97.8% overall survival rate after two years compared to 85.3%. Ibrutinib also improves hemoglobin and platelet levels.
The IOF Young Investigator Research Award is offered to researchers aged 40 years or younger. The award includes a grant of 1000 USD and the opportunity to present at a special oral session during the Meeting.
Researchers unveil innovative studies on seizure detection and management, including electrodermal biofeedback and machine learning algorithms. These non-invasive methods offer accessible treatment options for patients with drug-resistant epilepsy.
Researchers detected radio absorption by gas clouds in front of bright radio sources, revealing the composition and conditions of diffuse gas in the Milky Way galaxy. The discovery of three new absorption systems and confirmation of one previously known system provides insight into tenuous gas clouds and their role in the universe.
Researchers identified 13 hotspot CNVs associated with JME and found that drug resistance enriches a clinical cohort for common CNVs. This study provides new insights into the genetic basis of JME and highlights the need for further molecular biology studies.
A study of 87 CLL patients found 12 genetic mutations that can be targeted by therapies already available for other cancers, including PARP and BRAF inhibitors. These mutations were detected through next-generation sequencing and may offer new treatment options for patients who fail current therapies.
A University of Sydney study found that 'no-drill' dentistry can stop and reverse tooth decay without traditional fillings. The Caries Management System (CMS) reduces decay risk and need for fillings by 30-50%, partnering patients with dentists for successful treatment.
Researchers found that door holders who made a high effort were more likely to receive reciprocation, with recipients saying "thank you" more often. The study also showed that small favors can inspire reciprocal acts, but verbal thanking and helping are not inherently correlated.
A study of 1,280 patients with myelodysplastic syndrome (MDS) found comparable survival rates at 100 days and two years for those aged 65 and older compared to younger patients. Age was not a determining factor in HCT outcomes, with marrow blasts, cytogenetics, and Sorror co-morbidity scores being independently associated with results.
Researchers successfully tested gene therapy combined with low-dose chemotherapy in five patients aged 7-24 with worsening immune systems due to SCID-X1. The therapy showed substantial improvements in immunity and clinical status, particularly in the first two patients who received treatment.
Scientists have found that maximum observed earthquake magnitudes on transform faults generally scale with offset across the faults, but for some earthquakes, a larger coseismic stress drop occurs. This study contributes to developing refined building codes and risk mitigation concepts along major transform faults.
Dr. Story Landis is honored with the AES's highest award for her exceptional service and contributions to epilepsy research. Her leadership at NINDS has supported $1.6 billion in annual research funding, driving progress in understanding synapse formation and neurological disorders.
Page B. Pennell, M.D., is recognized for her extensive service to the American Epilepsy Society (AES), including leadership roles on its Board of Directors and committees. She has made significant contributions to understanding and treating women with epilepsy through her research.
Studies investigate biological factors behind memory decline in people with epilepsy, particularly those with temporal lobe epilepsy. Loss of neurons from the hippocampus is a common cause of impaired memory. Researchers also explore effects of seizures on signaling pathways and brain activity.
Scientists create virtual tumors to test drug treatments, achieving an 85-86% correlation with lab results. The goal is a patient-specific workflow for early diagnosis and effective treatment identification.
Researchers at UT-Arlington developed a novel cancer cell detection method based on real-time cell behavior tracking, leveraging the unique dancing behavior of cancer cells on engineered surfaces. This technology has potential to serve as an additional modality for identifying tumor cells from blood samples or biopsy specimens.
A SWOG trial shows that adding bortezomib to lenalidomide and dexamethasone therapy in early treatment improves remission time and life expectancy for myeloma patients by about a year, compared to the standard two-drug regime.
Studies reveal that children with epilepsy show global differences in cognitive network development, but hubs of these networks are functionally similar to those of healthy peers. Graph analysis also suggests that neural networks linking cognitive skills are not well integrated in children with epilepsy.
Research from St. Jude Children's Research Hospital found genetic variations associated with an 8-to-15-fold increased risk for osteonecrosis in young ALL patients. These variants were more common in patients who developed osteonecrosis, particularly near the BMP7 gene important for bone development.