A new study published in ecancermedicalscience suggests that turmeric's curcumin can quell the activity of human papillomavirus (HPV) in oral cancer cells, potentially providing a means of future control for the virus-related cancers.
Researchers create robust platform to investigate hundreds of mutations in a single experiment, allowing for the mapping of gene expression networks and understanding how genetic variations contribute to human diseases. The tool helps identify disruptions in gene regulation, leading to disease.
A new study found that long-term exposure to air pollution is associated with smaller brain structure and covert brain infarcts in middle-aged and older adults. Exposure to PM2.5 particles was linked to increased risk of silent strokes and dementia.
Researchers identified 200 previously unknown compact elliptical galaxies using public archives of data from the Sloan Digital Sky Survey and the GALEX satellite. Of these, 11 isolated compact galaxies were found moving faster than their cluster counterparts
A new study finds that niclosamide, a drug used to treat tapeworms, suppresses the growth of MRSA cultures and preserves the lives of infected nematode worms. Oxyclozanide, another salicylanilide anthelmintic, proves more effective in killing MRSA.
Researchers at Duke-NUS Medical School have discovered a long non-coding RNA that regulates brown fat development in mice. This finding holds promise for developing new therapeutic strategies to prevent and treat obesity.
Researchers have made significant strides in measuring preferential flow, a crucial factor in soil's physical, chemical, and biological functions. The study reveals unique water patterns depending on landform units, soil types, initial moisture, and precipitation features.
The study found that a key enzyme produced by fat tissue regulates brain function and energy levels, suggesting an optimal amount of body fat for maximizing health and longevity. Mice with low NAMPT in fat tissue had impaired energy levels and physical activity, while those with high NAMPT exhibited increased physical activity.
Researchers at the University of Edinburgh have discovered that Shetland ponies' immune response to insect bites can prevent allergic reactions, similar to what happens in people with allergies. The study found that two different responses occur in horses, one triggering allergy symptoms and the other preventing allergic reactions.
The daclatasvir-sofosbuvir combination was highly effective and well-tolerated in treating hepatitis C virus (HCV) patients with HIV co-infection. Across genotypes 1-4, the treatment resulted in a sustained virologic response rate of 97% at 12 weeks post-treatment.
Researchers investigated parents' attitudes towards illness and decisions on sending children to daycare with respiratory tract infections. The study found that parents often view coughs and colds as less serious and contagious than other illnesses.
A recent slowdown in global average temperatures is having no effect on the planet's projected warming by 2100. The study found that long-term temperature outcomes are unaffected by short-term variability, with greenhouse gases expected to overwhelm natural fluctuations and lead to dangerous levels of warming.
Researchers have updated the TRANSP program to better simulate interactions between energetic particles and instabilities in plasma, which can affect fusion reactions. The updated code will provide a more accurate way to compute particle transport and improve simulations for future fusion facilities like ITER.
A study published by the European Association for the Study of the Liver found that silymarin, derived from milk thistle, can resolve non-alcoholic steatohepatitis (NASH) and improve fibrosis in patients. The results suggest a potential new treatment option for this condition.
Researchers have imaged the continuous volcanic plumbing system under Yellowstone, revealing a reservoir of hot, partly molten rock 12-28 miles beneath the surface. The new discovery is 4.4 times larger than the previously known magma chamber.
A new study published in Nature Climate Change finds that high mountain regions are warming at a rate faster than lower elevations, posing significant risks to alpine flora and fauna. The research team calls for improved observations, satellite-based remote sensing, and climate model simulations to better understand this phenomenon.
A new survey found that nearly half of people with viral hepatitis have suffered some kind of discrimination, affecting their daily lives. The study highlights the devastating impact of stigma and discrimination on quality of life, particularly in family relationships and workplaces.
A new study finds that photosynthesis imparts a distinct biosignature on oxygen molecules, allowing scientists to trace biological processes. This discovery has the potential to measure productivity in the open ocean and assess the health of oceans.
A study reveals that an unfavorable bacterial network configuration in the gut can cause inflammation similar to Crohn's disease. Researchers found that transplanting 'healthy' bacteria into patients' intestines may provide a conventional treatment option.
A new study reveals a direct correlation between seasonal allergens and dry eye cases, with both conditions peaking in April. Dry eye can significantly impact quality of life, affecting millions in the US annually.
The study analyzed ancient mammoth genomes to understand population dynamics and genetic diversity. The results showed low genetic variation and inbreeding, indicating a small population size. The research provides insight into the woolly mammoth's evolutionary history and potential reasons for their extinction.
A recent study found that thawing permafrost in Siberia is releasing ancient carbon into the atmosphere, which is then consumed by microbes and released as carbon dioxide. This process accelerates global warming and creates a runaway effect. Scientists are now studying the impact of this phenomenon on climate change.
Researchers found that more resilient teens were less likely to suffer negative consequences from extreme online exposure, regardless of their level of internet usage. The study emphasizes the importance of empowering teens with coping strategies to manage online risks rather than relying solely on abstinence.
Researchers have identified a second possible specimen of the rare 'pocket shark,' measuring just 5.5 inches long, with distinct physiological features and an unhealed umbilical scar.
Researchers at ORNL have developed a technique that uses quantum correlated beams of light to overcome the fundamental detection limit of microcantilever-based sensors. This results in a 60% error reduction, enabling higher contrast imaging and detection of lower concentrations of particles.
A large cohort study found that long-term use of entecavir (ETV) or tenofovir (TDF) results in excellent 5-year survival for Caucasian patients with chronic hepatitis B (CHB), with a significant proportion of deaths coming from liver-unrelated causes. The development of hepatocellular carcinoma plays a major role in mortality.
A new study uses fossil data to predict that most rodent species will evolve continuously growing molar teeth over the next 50 million years. The researchers found evidence that many species possess the potential for acquiring dental stem cells, which are required for continuous tooth growth.
Preliminary results show that Civacir effectively prevents hepatitis C virus (HCV) recurrence in liver transplant patients who received antiviral therapy before their operation. The study found that Civacir provides a prophylactic efficacy in preventing HCV-reinfection, reducing the risk of graft loss.
Researchers found a way to predict protein structures by breaking them into smaller fragments and analyzing their distributions in nature. This discovery could lead to understanding how certain mutations cause disease and developing new treatments.
A study of antibiotic shortages from 2001 to 2013 found that 148 antibiotics were affected, with an upward trend starting in 2007. Many involved gold-standard therapies for life-threatening infections with limited alternative treatment options, raising concerns about patient care.
A six-year, $40 million trial aims to investigate the effectiveness of statin therapy in reducing HIV-associated cardiovascular risk. The REPRIEVE study is the largest clinical trial to focus on cardiovascular disease in HIV patients, targeting those with no known heart disease and low traditional risk factors.
TG1050 has been shown to reach the clinical goals considered a cure for CHB, including elimination of HBsAg and seroconversion. The study achieved these goals in 30% of TG1050-injected mice, supporting the move to a first-in-man study.
Scientists have discovered a protein called SARM1 that triggers axon degeneration after an injury, leading to a rapid decline in energy supply within axons. Supplementing neurons with a precursor to NAD, nicotinamide riboside, can block axon degeneration and neuron cell death.
Women with uterine fibroids have several treatment options, including medical and interventional therapies. Alternative treatment options include tranexamic acid, levonorgestrel-releasing IUDs, hysteroscopic myomectomy, endometrial ablation, gonadotropin-releasing hormone agonists, and more.
Researchers present key factors contributing to suicidal risk and new assessment and treatment approaches for adolescents. Studies investigate predictors of acute risk, relationship between suicide attempts and impulsive-aggressive responsiveness.
A new study presented at The International Liver Congress 2015 shows that significant weight loss through lifestyle changes can improve histological features of non-alcoholic steatohepatitis (NASH). Over 10% weight loss is necessary to induce complete resolution of steatohepatitis, fibrosis, and portal inflammation.
Researchers used a new computer model to simulate the formation of high-lying valleys in the southeastern Tibetan plateau. They found that these valleys developed in place, not as remnants of former lowlands, and were shaped by river disruption due to tectonic movement.
A new study reveals that tinnitus is represented differently in the brain compared to normal sounds, and that it may not be just a 'gap' left by hearing damage. The discovery could inform treatments such as neurofeedback and electromagnetic brain stimulation.
Many European countries lack national strategies to manage chronic viral hepatitis disease surveillance, burden assessment, and intervention impact. Governments need support for developing plans, estimating the national burden, and improving surveillance systems.
A new study by RAND Corporation reveals that California residents experiencing psychological distress face high levels of perceived stigma and discrimination, discouraging help-seeking. The survey found nearly 9 in 10 reported discrimination based on their mental health problem, with most experiencing it in intimate social relationships.
Researchers found that teens are more likely to make risky decisions when driving alone, but with a mother present, they become less likely to take risks. The brain regions responsible for this behavior include the ventral striatum and prefrontal cortex.
Two legal experts argue that the proposed Medicaid block grant in the Patient CARE Act would be unconstitutional as it violates the Tenth Amendment. The block grant's fixed sum allocation and limited growth rate would coerce states into accepting a reduced financing structure, similar to the 2012 NFIB v. Sebelius ruling.
Researchers developed a topical gene regulation technology that uses spherical nucleic acids (SNAs) to silence the gene that interferes with wound healing in diabetic animals. The treatment improved healing and blood circulation at the wound site, reducing recovery time by 50%.
Scientists have developed a method to extract rubber from guayule, a desert shrub native to the southwestern US, which could bolster the world's supply of natural rubber. The discovery may help reduce reliance on Southeast Asian plantations and diversify the global market.
Researchers at MIT and Case Western Reserve University will collaborate to advance understanding of Down syndrome, aiming to improve quality of life for those born with it. The collaboration will focus on developing personalized human stem cell models and testing potential therapeutic treatments.
Researchers at the University of Notre Dame investigate the clinical potential of microvesicles, shedding light on their role in promoting tumor invasion and metastasis. The study identifies key proteins that guide the formation of these vesicles and suggests a potential link to biomarker development.
High entropy alloys consist of four or more metals in equal amounts, exhibiting remarkable properties such as hardness and tensile strength at low temperatures. Researchers found that chromium and its spin play key roles in ordering the alloy's composition.
High mountain regions are warming at a faster rate than previously thought, according to an international research team. This accelerated warming can lead to dramatic changes in ecosystems, including glacial melt and vegetation shifts, posing significant social and economic risks.
Scientists have isolated dental stem cell lines and identified a natural mechanism for repairing tooth lesions. The study reveals that dopamine and serotonin play a crucial role in recruiting stem cells, which then repair the tooth. This breakthrough discovery opens up new therapeutic strategies to mobilize resident dental stem cells.
The team aims to create scalable nano-manufacturing processes for functional metamaterials, revolutionizing computing, communication, sensing, and imaging. By manipulating light in ways not possible in natural materials, they seek to overcome current roadblocks towards integrated photonics.
Bhutan is partnering with Internet2 to bring ultra-high-speed network access to its research and education community. The country's IT professionals will attend the Global Summit to connect with global leaders and gain resources for advancing their goals.
A large-scale study of Ebola survivors found persistent health effects, including vision loss, hearing impairment, and cognitive decline. The study highlights the need for strategies to address the long-term health needs of survivors.
Researchers at Université catholique de Louvain develop a new therapeutic agent that stimulates the immune system to target cancer cells by blocking immunosuppressive T-lymphocytes. This approach could lead to improved treatment efficiency for cancer patients and potentially treat other diseases with insufficient immunity.
The article highlights the importance of clinical phenotyping in precision medicine, with Penn researcher Garret FitzGerald advocating for translational med hubs to be equipped with the necessary resources. The NIH's Clinical and Translational Science Awards (CTSAs) program is seen as a key driver of this effort.
Researchers found a bacterium, Trichodesmium, with a unique genome that contradicts the understanding of free-living microbial genome architectures. The DNA sequence contains only about 63% expressed protein, breaking the mold for oligotrophs and challenging current knowledge.
Scientists Russell Hemley and Ivan Naumov found that certain metals transition from being metallic to insulating under pressure, and vice versa. They identified the physics framework underlying these transformations, which involves specific electron configurations and asymmetry.
Researchers used cosmic rays to measure electric fields in thunderclouds, revealing strengths of up to 50 kV/m. This new method provides a better understanding of lightning activity and contributes to more accurate predictions.
The Alana Foundation has awarded $1.7 million to Case Western Reserve University and MIT to advance research on new chemical compounds for treating Down syndrome. The study will test the effects of these compounds on cells involved in cognitive function, aiming to improve cognitive abilities in individuals with the condition.
Two new papers by St. Michael's Hospital researchers identified effective treatments for diabetic ulcers and pressure ulcers, as well as cost-effective interventions for complex wounds. The studies analyzed high-quality systematic reviews and cost-effectiveness analyses to provide clinicians and decision-makers with a guide towards tai...
A new study by researchers at the University of Missouri-Columbia found that MLB teams with more original content on their Twitter accounts gained more followers and increased engagement. The study also showed that trends such as winning streaks and frequent national television appearances led to significant increases in followers. By ...