A study found that most UK women (85%) would back the idea of more frequent breast screening if they are at higher genetic risk of developing breast cancer. Women at lower genetic risk were less supportive, but still willing to participate in screening with proper information and support.
The University of Texas MD Anderson Cancer Center has received over $22 million in CPRIT research grants to study breast, skin, prostate, and lung cancers, as well as leukemia and brain cancer. The funding will also support prevention and early detection efforts.
Research from the University of Warwick suggests delaying school entry for pre-term and full-term children may lead to poorer academic performance as they get older. The study found that missing one year of learning opportunities was associated with poorer average performance in standardised tests at 8 years of age.
Researchers found that fruit flies can remember and crave sweeter, energy-rich foods. A growth factor controlling brain vessel formation also stimulates mouse and human neural stem cells to produce new brain cells.
Scientists at Karolinska Institutet have created a detailed map of cortical cell types and the genes active within them using single-cell sequencing. They identified 47 different kinds of cells, including hitherto unknown types, which can help shed more light on diseases like multiple sclerosis.
A new study by UW researchers suggests that sensor technology can help identify deep tissue lesions during clinical breast exams. The study found that using a palpable force between 12-17 newtons improves the probability of detecting deeper lesions.
Researchers found that glyphosate-resistant kochia has duplicated several EPSPS copies on a single chromosome, enabling it to survive higher doses of the herbicide. This increase in gene copies has created a nonsustainable way of controlling kochia with glyphosate-only programs.
Research reveals that DNA sequences in 'gene deserts' can regulate gene activity elsewhere by forming DNA loops, increasing cancer risk through wormhole-like effects. The study provides new insights into the role of long-range genetic regulation in cancer development.
A recent study analyzed two large surveys to gauge the use of approved and unapproved hormone therapy among US women at menopause. Women taking compounded hormones often lack understanding about the risks associated with these treatments, which are not tested in clinical trials before dispensing.
A mobile app with decision support features significantly increased diagnosis rates for tobacco use, adult and pediatric depression, and obesity among registered nurses. The app prompted clinicians to follow evidence-based guidelines and encouraged detailed conversations with patients about their health.
Researchers found a possible link between maternal age and abnormal chromosome numbers, which can cause birth defects like Down syndrome. The study used genetic data from over 4,000 families and found that the shuffling process of parental chromosomes becomes less regulated with age.
A large-scale study found a 0.22% incidence of uterine sarcoma in women after hysterectomy, with most cases being unexpected endometrial cancer. Researchers emphasized the need to balance minimally-invasive procedures with cautious preoperative planning.
Chronic pain in patients with chronic kidney disease is common and associated with improper use of pain medications. An estimated 26 million people in the US have CKD, making it a significant concern for patient safety.
Researchers at UNIGE reconcile two dominant endocytosis theories, proposing a balanced interplay between clathrin proteins and other adaptors. The study suggests that clathrins do not dominate the process, but rather contribute to a subtle energy-based deformation of the membrane.
The study finds that the Dinner Creek Tuff Eruptive Center was a common source for mafic and silicic magmatism, linking the GRB eruptions and providing evidence for the location of Columbia River Basalt storage sites. This suggests that shallow crustal rhyolitic reservoirs played a key role in controlling the timing and place of eruption.
A new test, PLA test, evaluates the effectiveness of cancer vaccines by detecting tumor antigens presented on MHC molecules. The test has shown promising results in identifying glioma tumors and melanoma cells with specific antigens.
A new study published in Diabetologia found that lack of sleep can lead to elevated levels of free fatty acids in the blood, causing temporary pre-diabetic conditions in healthy young men. Insufficient sleep also results in increased insulin resistance, a hallmark of pre-diabetes, that persists for nearly five hours.
Cell division relies on a collective process rather than a single molecular architect. The cleavage furrow's formation is driven by chemical signaling and mechanical processes, not just one key protein.
Researchers led by Johns Hopkins Medicine discovered that three drugs, Eylea, Avastin, and Lucentis, are effective in treating diabetic macular edema. Eylea performed better than the other two drugs when vision loss was moderate to severe.
A study confirmed artemisinin-resistant malaria parasites in Homalin, Sagaing Region, Myanmar, just 25km from the Indian border. This finding poses a significant threat to global control and eradication of malaria, as drug resistance spreads from Asia to Africa and potentially emerges independently.
INRS has received significant funding to develop new fibre laser systems, electrocatalysts for CO2 reduction, and terahertz technologies. These collaborations aim to enhance broadband communication and energy efficiency, while addressing greenhouse gas conversion and chemical detection needs.
Researchers from INSERM have demonstrated gallopamil's clinical efficacy in treating severe asthma by reducing bronchial smooth muscle mass and airway obstruction. The study involved 31 patients with severe asthma, who showed significant improvements in BSM thickness and asthma attacks after treatment.
A nationwide clinical trial found that Eylea performed better for those with moderate or worse vision loss, while Lucentis and Avastin performed similarly for people with mild DME. The study recruited 660 participants across the US, showing improved visual outcomes for patients treated with Eylea.
A study led by Tokyo Medical University researcher Toshihiro Nakajima found that an anti-inflammatory drug can counteract obesity in mice by regulating mitochondrial biogenesis and fatty acid breakdown. The drug, LS-102, inhibits the Synoviolin gene, leading to increased energy control pathways.
Researchers at the University of Cambridge and Animal & Plant Health Agency highlight the importance of specificity in new diagnostic tests for bovine tuberculosis (bovine TB) vaccination. For vaccination to be economically viable, the number of false positives must be below 15 out of every 10,000 cattle tested.
A study published by Hasbro Children's Hospital found that while high schools in the state followed mandated concussion laws, recommended protocols were poorly implemented. The researchers emphasize the importance of stricter enforcement to protect young athletes from prolonged symptoms and devastating injuries.
Researchers create an ultra-thin, completely flat optical component made of glass substrate and silicon antennas that compensates for wavelength differences. This allows for consistent effects like deflecting beams of different colors by the same angle or focusing those colors on a single spot.
A new study from the University of New Hampshire has found that flame retardants can cause metabolic and liver problems in laboratory rats, leading to insulin resistance. The researchers discovered that fat cells in these rats became more sensitive to hormones, similar to those experienced by people who are overweight.
A study found that even with health impact assessments, political agendas often override HiAP considerations in decision-making. Funding for HiAP initiatives can be split between government departments, creating challenges to its success.
A new study combines lab tests and ultrasounds to diagnose appendicitis in children, significantly improving clinical value and risk profiles. The approach can be adapted to individual settings, providing better care for patients with suspected appendicitis.
A researcher at IUPUI is studying how glaucoma develops in stem cells created from skin cells genetically predisposed to the disease. The goal is to identify the cause of damage and develop customized strategies to fix it, potentially leading to repairing existing cells and restoring vision.
Pollinator decline threatens European food security and ecosystem diversity. The STEP project has mapped the climatic risk of European bumblebees, revealing that many species are at high risk under climate change scenarios.
Scientists at Washington State University have discovered a probiotic toxin that can combat Coldwater Disease in rainbow trout, killing the bacteria with a toxic protein. The probiotics could be a game-changer for the global salmonid aquaculture industry, reducing disease losses and improving animal welfare.
Researchers propose a new model showing the sun's magnetic field controls the shape of the heliosphere by accelerating solar wind into two jets. This understanding could have implications for future space travel and help us comprehend the filter protecting the solar system from galactic cosmic rays.
Researchers at MD Anderson Cancer Center found that targeting pericytes and angiopoietin-2 signaling may reduce breast cancer tumor growth and metastasis. The study suggests a potential new therapeutic approach for metastatic breast cancer.
UV radiation damages skin cells' DNA, even when sun is no longer present, according to a study published in Science. Melanin offers both protection and harm to skin cells.
Men with favorable intermediate-risk prostate cancer may be candidates for active surveillance, with no significantly increased risk of death compared to those with low-risk PC. The study found that the absolute estimates of PC-specific mortality were less than one percent in men with both low-risk and favorable intermediate-risk PC.
Researchers used a new computational method to predict the interactions between small molecules and thousands of proteins, revealing that many chemical probes are not selective but instead interact with multiple proteins. This study highlights the importance of understanding protein functions to develop more efficient and safer medicines.
Researchers detected a nearly spherical stream of highly ionized gas streaming out of the quasar PDS 456, measuring the strength of ultra-fast black hole winds. The discovery reveals that these powerful winds can transfer energy back to their host galaxies and affect star formation.
A comprehensive assessment of cellulose nanocrystal environmental toxicity is crucial for their industrial applications. The latest evidence highlights potential adverse health effects through various types of exposure.
Research published in BMC Public Health found that shisha pipes remove only a minimal amount of heavy metals from tobacco smoke. The study analyzed four popular brands of shisha tobacco and found that the levels of heavy metals in smoke were significantly higher than in water, with uranium being the most abundant metal present.
A study found that both fruit flies and mice exhibit similar cellular and genetic features during ovulation, including the degradation of follicle cells and the role of Matrix metalloproteinase (Mmp) enzymes. These similarities suggest a conserved basic mechanism in ovulation across animals.
Women with multiple sclerosis may have lower levels of important antioxidant and anti-inflammatory nutrients like folate from food and vitamin E compared to healthy people. The study found that women with MS had lower average intake of these nutrients and a lower percentage of calories from fat.
To make bovine TB vaccination viable, researchers recommend diagnostic tests must achieve high specificity to avoid increasing restrictions and financial burden. Achieving a specificity of greater than 99.85% is necessary to see benefits of vaccination.
Abl and Src proteins have distinct evolutionary paths, allowing Brandeis researchers to pinpoint specificity for Gleevec. Their findings pave the way for rational drug design in various cancers.
A nationwide study found that a new transfusion technique significantly improved survival rates among trauma patients with major bleeding. The equal-ratio blood transfusion reduced mortality within the first 24 hours and stopped bleeding in 86% of patients, compared to 78% in the unequal-ratio group.
Dasgupta, a renowned chemist and educator at the University of Texas at Arlington, has received the prestigious J. Calvin Giddings Award for his commitment to teaching and research excellence. The award recognizes his efforts to enhance analytical chemistry students' professional development and publish influential textbooks on teaching.
A comprehensive study found nearly 700 species of marine animals have encountered man-made debris, with plastic accounting for 92% of cases. The study highlights the widespread harm caused by debris on threatened or near-threatened species.
Researchers found that pigs can tolerate up to 0.38% sulfur in their diet without negative effects on carcass quality or growth performance. Excess sulfur is excreted in the urine, not accumulated in tissues, allowing pigs to regulate sulfur retention and excretion.
The editorial highlights the need for bold action to improve end-of-life care in nursing homes, focusing on symptom control, advance care planning, and high-quality palliative care. Nursing home providers are urged to prioritize training staff in these areas to ensure better support for patients and their families near the end of life.
Researchers found that flash-heating experiments using NASA's Curiosity Rover instrument can destroy organic compounds if jarosite is present. This could impact the search for signs of life on Mars. The team is exploring ways to compensate for this effect, which has implications for future missions like ExoMars 2018.
A new semiconductor compound is bringing fresh momentum to the field of spintronics, an emerging breed of computing device that may lead to smaller, faster, less power-hungry electronics. The compound's unique low-symmetry crystal structure offers much greater flexibility, enabling precise control over conductivity and magnetism.
Researchers suggest that human dispersal into southern Asia via Arabia was linked to changing climate and environmental conditions, with increased rainfall supporting populations. The Al Sibetah alluvial fan sequence provides a unique record of landscape change in southeast Arabia, revealing multiple humid episodes during glacial periods.
Researchers found a key difference in human and chimpanzee DNA that boosts brain size in mouse embryos. This discovery sheds light on the genetic basis of human brain evolution and may help explain why humans have unique capabilities compared to chimps.
A pilot study by NC State University finds that 25% of homeless children in the US are in need of mental health services. The study highlights the critical need for more screening and support for these vulnerable children.
University of Pennsylvania researchers have made an advance in manufacturing molybdenum disulphide, allowing for easier control over its size, thickness, and location. The new technique enables the creation of transistors that turn on and off, as well as devices that emit light.
A clinical trial found that all three anti-VEGF drugs were effective in improving vision and preventing vision loss in patients with diabetic macular edema. Aflibercept showed more significant visual gains in patients with worse vision at the start of the trial, providing robust data for clinicians to guide treatment decisions.
A recent study finds that climate change will lead to a significant decrease in wheat production, with yields projected to drop by 6% for each degree Celsius temperature rise. The resulting loss of nearly one-quarter of current wheat production could severely impact global food supplies.
A new type of self-healing hydrogel has been developed by MIT chemical engineers that can carry one or two drugs at a time. The gel consists of a mesh network made of nanoparticles and polymers that can be injected through a syringe and released over several days, targeting specific tissues and allowing for long-term drug delivery.
Researchers have identified a new gene, TBK1, associated with sporadic ALS, highlighting the importance of inflammation and autophagy pathways. The study also found that OPTN may be a major player in the disease, interacting physically and functionally with TBK1.