A global task force of 180 scientists has identified high-priority molecular targets for improved patient outcomes in most cancers. The team recommends low-toxicity approaches using non-toxic chemicals, including those found in plants and foods, to reach a broad-spectrum of priority targets.
Researchers at UC Santa Barbara have developed an insulin pill using novel drug delivery technology that shows early promise as a form of diabetes therapy. The pill's oral delivery system could circumvent the discomfort associated with injections, leading to improved patient compliance and potentially more effective treatment.
Despite improvements in antidote availability, many UK hospitals still lack essential stocks for treating poisoned patients. The study found that only 20 out of 22 category A and B antidotes were stocked within the recommended time in over 78% of hospitals.
The International Society of Neurogastronomy Symposium brought together scientists, chefs, and patients to explore ways to improve quality of life for those with altered taste or smell. Chefs and neuroscientists collaborated on the 'Applied Neurogastronomy Challenge' to create dishes that appealed to cancer patients.
A NYU study found that a classroom program improves teacher emotional support, student engagement, and classroom organization in kindergarten and first-grade classes. INSIGHTS, a social-emotional learning intervention, supports responsive teaching strategies and enhances children's ability to regulate classroom behaviors.
A new study reveals that certain 3D printed parts are highly toxic to zebrafish embryos, causing lower survival rates and malformations. Treating the parts with UV light may reduce some side effects, emphasizing the need for safe disposal strategies.
Researchers sequenced acorn worm genomes to find similarities with human genes, establishing a distant connection. The study identified 8,600 shared gene families across deuterostomes, including humans, starfish, and frogs, suggesting a common ancestor that lived half a billion years ago.
A recent study published in Cancer Epidemiology, Biomarkers & Prevention found that U.S. adults who used only smokeless tobacco products had higher levels of biomarkers for nicotine and cancer-causing toxins. This increased exposure puts smokeless tobacco users at risk for adverse health effects, including cancer.
The European Menopause and Andropause Society (EMAS) has published a position statement on testosterone replacement therapy in the aging male, highlighting the importance of lifestyle modifications before considering TRT. The statement emphasizes the need for careful risk versus benefit estimation and individual evaluation of co-morbid...
A new study found that pigeons can accurately distinguish between benign and malignant breast cancer slides, similar to human observers. With some training, pigeons performed just as well as humans in categorizing digitized microscope slides and mammograms of normal vs. cancerous breast tissue.
The TATORT-NSTEMI trial found no significant difference in major adverse cardiac events at 12 months between thrombectomy and standard PCI in NSTEMI patients. Thrombus aspiration also did not affect quality of life or functional class.
Researchers at Brigham and Women's Hospital have developed a new approach to predict which tumors will be most responsive to therapeutic nanoparticles. They use an FDA-approved magnetic nanoparticle and MRI to identify tumors with high or low EPR, a physiological condition that allows nanoparticles to accumulate faster.
A new supplement published by the NIH details a research strategy to tackle global brain disorders, which affect millions worldwide. The initiative aims to improve diagnosis, treatment, and prevention of conditions such as depression, dementia, and substance abuse in low- and middle-income countries.
Researchers at the University of Queensland discovered that mantis shrimp use circular polarised patterns as a means to covertly advertise their presence to aggressive competitors. This new form of light communication has potential applications in satellite remote sensing, biomedical imaging, and computer data storage. The study also f...
A new study suggests that Antarctic ice sheet collapse will contribute to a significant but lower-than-expected 10-30 cm sea-level rise over the next two hundred years. The research uses an ice-sheet model to predict the consequences of unstable retreat of the ice, which recent studies suggest has begun in West Antarctica.
A study found that socioeconomic factors like race, ethnicity, insurance status, and geographic location affect the likelihood of undergoing surgery for early-stage pancreatic cancer. Patients who underwent resection had improved disease-specific survival compared to those who did not, with regional differences in survival rates observed.
Hui Shen, a Van Andel Research Institute Assistant Professor, has received an Ovarian Cancer Research Fund award to investigate cell types that may be used to pinpoint ovarian cancer's cells of origin. Her research aims to identify epigenetic fingerprints of specific genomic regions of ovarian cancer cells and normal cells.
Astronomer Evan Kirby measures high concentration of dark matter in small dwarf galaxy Triangulum II, potentially making it a leading candidate for direct detection. The galaxy's unique characteristics and minimal background noise make it an ideal location to search for gamma-ray signals from colliding dark matter particles.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that weekday sleep changes may raise the risk of developing metabolic problems such as diabetes and heart disease. Researchers discovered a link between social jetlag, which refers to the mismatch between an individual's biological...
Researchers tracked whale sharks in the Gulf of Mexico, revealing they use both near-surface and deeper waters for feeding, with some staying at depth greater than 50 meters continuously for over three days. The study found complex patterns of habitat utilization likely driven by shifting ocean conditions and prey distribution.
MIT neuroscientists have discovered a new way that the brain strengthens connections between neurons. The presynaptic neuron plays a crucial role in this process, releasing neurotransmitters to stimulate growth of new connections and enhancing synaptic function.
Researchers at San Diego State University have discovered a new phenomenon in materials science using puffed rice cereal. They found that highly porous, brittle materials can deform differently depending on compaction velocity, with three distinct deformation patterns emerging at low, medium, and high velocities.
A study found that Chukchi Sea polar bears spent more time on land during summer sea ice loss, with minimal access to preferred prey. The increased land use may lead to increased nutritional stress and human-polar bear interactions.
The National Institute of Allergy and Infectious Diseases (NIAID) has launched a major initiative to advance novel approaches to treat and prevent HIV infections using broadly neutralizing antibodies. Researchers will work with GlaxoSmithKline to develop long-acting agents for preventing and treating HIV.
Scientists from Osaka University have observed the electron partitioning process in graphene for the first time, a world-first discovery that could lead to the development of electron interferometer devices. The study found that electron partitioning took place in the p-n junction of graphene in the Quantum Hall regime.
Mirabbos Hojamberdiev, a senior researcher from Uzbekistan, has won the 2015 Atta-ur-Rahman Prize for his innovative work on producing hydrogen from water using inorganic crystals under visible light. His research aims to develop sustainable energy sources and reduce greenhouse gas emissions.
A Dartmouth study shows that the brain processes motion differently for animate and inanimate objects, interacting between two visual pathways. This discovery has potential applications in improving motion recognition algorithms for public security systems and treating motion blindness and object agnosia.
Researchers analyzed genomic data from 1,120 pediatric cancer patients and found that 8.5% had pathogenic germline mutations in cancer predisposition genes. This study suggests that comprehensive genomic screening may be necessary for all pediatric cancer patients, not just those with a family history of cancer.
University of Toronto Rotman School professor András Tilcsik won the Financial Times/McKinsey Award for Young Business Writers for his book proposal on managing catastrophic failure risk. The proposal, 'Rethinking the Unthinkable,' aims to help managers rethink existing organizational practices and build more robust systems.
A new study found that gamma interferon, an FDA-approved drug, completely protects mice from death when given either before or up to 24 hours after exposure to Ebola. The treatment targets macrophages and blocks the infection of those initial cell targets, preventing a second round of infection.
A study found a strong association between obesity and an increased need for surgery, longer hospital stays, and higher treatment costs in orthopaedic trauma patients. Patients with obesity were more likely to be discharged to a care facility rather than home.
A new study reveals that ethnic minority populations face significant barriers to receiving quality end-of-life care, with financial resources and insurance being the biggest obstacle. The researchers emphasize the need for education, training, and support to improve end-of-life care among diverse patient populations.
A study at Georgetown University Medical Center found that HIV+ individuals over 50 years old showed cognitive impairments, even if they scored 'cognitively normal' in standard tests. Brain scans revealed deficits in the dorsal anterior cingulate cortex region, a key executive area.
Researchers at Brigham Young University create a system to speed up vaccine production by storing the biological machinery in a freeze-dried state. This allows labs to rapidly produce vaccines with just the addition of water, reducing the time from months to days.
A UBC study published in JAMA Psychiatry found that light therapy can effectively treat non-seasonal depression and improve the overall wellbeing of people suffering from the disease. The research, which followed 122 patients, showed that light therapy was most beneficial when used with antidepressants.
A new study has pinpointed the symptoms of rare myotonic dystrophy type 2 (DM2) that are most important to patients. The research, published in Neurology, found that fatigue and pain were key concerns for DM2 patients.
A study published in Injury Prevention found that gunshot wound patients in urban areas with high crime rates were more likely to die within five years, mainly due to homicide. The research tracked patients after discharge from hospital and showed a significant risk of early death among these survivors.
Researchers propose a novel way to create robust electron waves by exploiting magnetic ions to bind together electron's direction of movement and its spin. This could drive advances in data- and energy-storage technologies.
A Vanderbilt study found that sildenafil improves insulin sensitivity in people at risk for diabetes, potentially reducing the risk of developing type 2 diabetes. The researchers discovered that sildenafil inhibits an enzyme called phosphodiesterase 5, resulting in relaxation of smooth muscle and increased blood flow.
Researchers at Mass Eye and Ear found that chronic conductive hearing loss can lead to permanent hearing impairment if left untreated. The study, published in PLOS ONE, showed dramatic changes in the inner ear after a year of sound deprivation.
A new study finds a link between abrupt ocean warming and low-oxygen conditions that led to vast marine dead zones in the North Pacific. The researchers discovered a clear connection between two prehistoric intervals of abrupt ocean warming that ended the last ice age, resulting in an increase in diatom production and subsequent hypoxia.
A large national survey found nearly 10% of Americans have lifetime drug use disorder diagnoses, resulting in significant impairment and comorbidities. The study also highlights the importance of treatment, with only 24.6% of those with lifetime diagnoses receiving treatment.
A robotic prosthetic control strategy based on human reflexes has shown promise in simulation and laboratory testing, producing stable walking gaits over uneven terrain and improved balance recovery from trips. The technology will be further developed and tested using volunteers with above-the-knee amputations over the next three years.
Researchers from Osaka University developed a technology that projects images onto moving objects, aligning them with the object's movement. The technology uses visual markers and radiometric compensation to achieve accurate registration.
While parents' fears about teens' digital habits are often overstated, there are valid concerns about cyberbullying and sleep disruption. Teens' online lives mirror their offline experiences, but excessive screen time can lead to negative effects for vulnerable adolescents.
Researchers have identified mutations in the STAT3 protein that can block its ability to act as a transcription factor, suggesting a basis for new cancer treatments. The discovery reinforces the importance of targeting transcription factors like STAT3 in fighting cancer.
The Power Over Wi-Fi system can wirelessly power low-power devices, such as cameras and wearable trackers. The technology attracts attention for its potential to enable Internet of Things development.
Researchers analyzed competitors before the Ultraman competition and found that body fat percentage dropped significantly, but weight remained unchanged due to fluid retention. The study also revealed signs of muscle damage, elevated cortisol levels, and reduced insulin sensitivity.
Researchers at UMass Medical School have developed a new CRISPR/Cas9 technology that improves gene editing accuracy by nearly 100 fold. The system combines the CRISPR/Cas9 complex with a programmable DNA-binding domain to verify an additional genetic feature before cutting the genome, reducing off-target changes.
Researchers from the University of Sydney and other institutions have directly observed a planet in formation for the first time. The planet, located 450 light years away, is surrounded by a vast disc of dust and gas, and its presence has been confirmed through images and spectral fingerprint analysis.
Researchers at the Institute of Molecular Biology in Mainz have identified a key gene that drives brain cell development, revealing a complex regulatory mechanism. The discovery has significant implications for understanding neurodegenerative disorders and developing new treatments.
A recent study by Woods Hole Oceanographic Institution researchers reveals that long-term ocean warming significantly increased the risk of devastating floods in northeast Australia during the 2010/2011 event. The study found that warmer sea surface temperatures contributed to record-breaking rainfall and extreme weather conditions.
Women with neuromyelitis optica spectrum disorder have a higher risk of miscarriage, particularly within three years before or after disease onset. Preeclampsia is also more common among women with the condition, especially those with multiple autoimmune disorders or previous miscarriages.
Typhoon In-fa intensified into a typhoon near Micronesia, prompting warnings and advisories for the region. The storm is expected to continue intensifying as it moves west-northwest through Micronesia and the Marianas, bringing stronger winds and heavier showers.
A study by the American Psychological Association found that older adults who take college courses show significant increases in cognitive capacity compared to those who don't. The research suggests that mentally stimulating activities like college studies can enhance cognitive reserve and potentially reduce dementia risk.
Smaller geomagnetic storms cause fluctuations in wholesale electricity prices in equatorial regions due to the amplified effects of the electrojet. The research highlights the need for scientists to investigate the infrastructure and economic implications on countries near the equator.
A recent study found that high concentrations of carbon dioxide deter even small invasive carp from entering areas with elevated CO2 levels. The gas causes stress and avoidance behavior in fish as young as eight days old, providing a non-physical barrier against the species.
A new study from Harvard University found that children globally quickly reject unequal distributions of rewards, but in three countries (U.S., Canada, and Uganda), they also accept deals that favor themselves. This suggests that fairness behaviors may vary across cultures.
Researchers analyzed data from 6039 Hodgkin's lymphoma survivors, finding a higher risk of cardiovascular disease associated with specific dose levels of radiation and anthracycline exposure.
A study investigates how to control noise in quantum dot LEDs by modulating bias current, leading to stabilized light sources suitable for optical telecommunications. The researchers found that spiking competition of quantum dots enhances self-feedback and affects noise perturbation.