A study at MD Anderson Cancer Center reveals that increased methylation of epidermal growth factor receptors (EGFR) leads to resistance to cetuximab antibody therapy, resulting in poorer clinical outcomes and higher recurrence rates. The study also found that expression of methylation-defective EGFR reduces tumor growth in mice.
Recent genome engineering and gene editing breakthroughs will significantly impact biological system engineering, enabling more efficient production of drugs and other important products. Dr. Ryan Gill discusses the future directions and funding needs in the field.
Scientists at the University of Tokyo have created an electrically-controllable valley current device that may pave the way to ultra-low-power computing devices. The device uses pure valley current, which is non-dissipative and does not produce heat, making it a promising alternative to traditional electronics.
Researchers at UCLA have found a new way to reduce painful ascites, a common condition in ovarian cancer patients. The experimental drug inhibits macrophages, immune cells that help cancer spread, making the abdominal cavity less conducive to tumor growth.
Researchers have designed a tunable filter that can be integrated onto a photonic chip, enabling flexible optical networks. The device has a record-breaking tuning span of 670 GHz, making it suitable for handling large data volumes and adapting to dynamic changes.
A team from ASU and UNC aims to resolve uncertainties in the nuclear fusion process that creates elements forged by stars. They will investigate the range of elements produced by a star, including calcium and carbon, to determine their variation in output.
Researchers developed software to detect cyber threats in near-real-time, increasing security capabilities. A new mass spectrometry technology collected more ions, enhancing accuracy in chemical analysis.
A University of Alberta study found that homeless people who felt disrespected during police interactions retained negative attitudes towards police for at least two years. The study suggests teaching empathic listening and communication skills to police can improve interactions with the homeless population.
A UK study found that each additional 10,000 people reassessed using the Work Capability Assessment was associated with an increase in suicides, self-reported mental health problems, and antidepressant prescribing rates. The most deprived areas experienced the greatest increases in these adverse outcomes, widening health inequalities.
Researchers at NC State University have developed a device that monitors a guide dog's breathing and heart rate, sharing the information with its handler to detect stress or anxiety. The technology aims to prevent early retirement of guide dogs by providing real-time health insights.
Researchers at UTA are exploring polyculture planting, which uses timesharing strategies to allow multiple species to coexist and grow together. This approach provides benefits such as increased oxygen production and diversity of insect species, leading to a more sustainable ecological environment.
Researchers discovered human brains exhibit greater plasticity and adaptability than chimpanzee brains. Human brain organization is less influenced by genetics compared to chimpanzees, suggesting a strong role for environmental factors in shaping the human cerebral structure.
Researchers identified a genetic variant in the endocannabinoid system that may protect individuals from marijuana dependence after experiencing childhood sexual abuse. The study found that a specific allele of the monoacylglycerol lipase gene, known as rs604300, was associated with an increased risk of cannabis dependence symptoms.
A new study found significant positive associations between breakfast consumption and educational attainment. Children who ate a better quality breakfast achieved higher academic outcomes, with the odds of achieving an above average performance up to twice as high for those who ate breakfast compared to those who did not.
The researchers built single-molecule submersibles powered by ultraviolet light, achieving speeds of less than 1 inch per second but exceeding expectations for molecular motion. The study shows an enhancement in diffusion of 26 percent, outperforming Brownian motion.
A systematic evidence review and meta-analysis found that peripheral thermometers have poor clinical accuracy and sensitivity compared to central thermometers. Central thermometers, such as rectal or bladder thermometers, are considered the gold standard for accurate temperature measurement.
Researchers discovered that the protein APP forms spherical structures in the nucleus, affecting gene activity and neurotransmitter modulation. This finding may lead to new therapies for Alzheimer's disease by inhibiting neurotransmitter activity.
Researchers at USC discover enzyme MMP-20 that can regrow tooth enamel, reducing lesions by up to 70%. The breakthrough could lead to a new treatment option for tooth decay and sensitivity.
A new study by Rice University and the University of North Carolina, Charlotte found that overweight men experience subtle yet statistically significant interpersonal discrimination in employment settings. This bias can impact their chances of getting hired or being treated fairly as customers.
Researchers found that therapeutic hypothermia increased survival rates by 2.8 times and neurologic recovery by 3.5 times in comatose cardiac arrest patients. Therapeutic hypothermia may benefit comatose cardiac arrest patients with non-shockable heart rhythms, increasing their chances of survival and better brain function.
Research by the University of Waterloo's ITC Project reveals China's slow progress in implementing strong FCTC policies, leading to high levels of second-hand smoke exposure and ongoing tobacco use threats. The country lags behind other countries in protecting its people against second-hand smoke.
Researchers have discovered a 'supergene' underlying genetic differences in sexual behaviour among male ruffs, with Satellite and Faeder males carrying a chromosomal inversion that has been maintained for about 4 million years. The study found an association between the 'supergene', testosterone levels, and altered behaviour.
San Francisco State University researchers developed a new method to analyze river rocks, revealing the impact of climate on sediment size. The study found that larger sediment sizes are produced on steeper, colder mountains, controlling canyon formation.
Research finds a 'serious' toll on mental health after introducing tougher disability benefit assessments in England. A higher reassessment rate was linked to more suicides, mental ill health issues, and antidepressant prescribing. The study suggests that the policy may be undermining the mental health of claimants.
A new analysis of the jaw of Haramiyavia clemmenseni clarifies the timeline of early mammalian evolution. The study found complex teeth and chewing motions adapted for an herbivorous diet, indicating diverse feeding adaptations evolved early among proto-mammal lineages.
Men with prostate cancer who undergo radiation therapy can benefit from yoga, which stabilizes fatigue, sexual health, and urinary incontinence. Yoga also improves general quality of life by reducing cancer-related fatigue and strengthening pelvic floor muscles.
A new high-resolution method allows precise identification and quantification of interactions between a receptor and two ligands. Scientists have developed a novel approach using atomic force microscopy, enabling the imaging of single membrane receptors while detecting their interactions with multiple ligands.
A study ranks six American cities on their preparedness for climate change, with Portland ranking number one. The research found that the political culture of a city plays a significant role in its ability to prepare for extreme weather events linked to climate change.
A recent study reveals that over 50% of tropical plant specimens are likely to be incorrectly named, raising concerns about the reliability of biodiversity data. Researchers estimate it takes £500 to revise a species, suggesting a feasible solution to address this issue.
Researchers found that cold, steep slopes produce coarser sediment than gentle slopes, suggesting variations in climate, topography, and weathering rates shape mountain landscapes. This discovery quantifies the relationship between sediment size and erosion rates, providing new insights into the interplay of climate and tectonics.
Researchers found that arguments based on a political opponent's moral principles have a better chance of success in winning them over. The study suggests using purity-based arguments can help bridge gaps between liberals and conservatives, increasing support for universal healthcare and same-sex marriage.
Researchers studied two plant species, Zaluzianskya natalensis and Z. microsiphon, finding that flowers pointing upwards were more attractive to hawkmoths than those pointing sideways.
A new study reveals that climate change is driving bird declines in the Western Cape, with factors such as changing fire and rainfall patterns playing a significant role. The research found striking similarities between bird population declines and increases in average temperature, highlighting the need for urgent conservation action.
A new study reveals that up to half of the world's natural history specimens may have incorrect names, which can hinder biologists' work in fields like evolution and conservation. The researchers suggest that digitalised specimens and DNA sequencing can improve naming accuracy when integrated with taxonomic projects.
A recent US study found that some adult smokers who quit within the last year used e-cigarettes as a quitting aid. The study analyzed data from the 2014 National Health Interview Survey and found that nearly half of daily cigarette smokers have ever tried e-cigarettes. Daily e-cigarette use was more common among adults over age 25 than...
A Kansas State University study found that the High Plains Aquifer's groundwater depletion peaked in 2006 and is expected to decrease by 50% over the next 100 years. Researchers analyzed data from over 14,000 wells and developed a logistic equation to project future water levels through 2110.
Researchers have made encouraging results using gene therapy to treat cystic fibrosis by inserting a healthy copy of the CFTR gene into affected cells. The approach restored chloride and fluid transport in both mouse models and human-derived cell cultures, suggesting a potential cure for the genetic disorder.
The diversity and number of foraminifera in Bellingham Bay and Bremerton areas have deteriorated significantly, despite a reduction in chemical pollutants. Researchers are investigating alternative environmental factors, including high acidity caused by decomposition of organic matter and industrial contaminants.
A new study from Oregon State University researcher Jonathan Garcia finds that safe spaces serve as surrogate homes, creating an environment with social support and reducing vulnerabilities like exposure to violence and lack of employment opportunities. The spaces help men feel secure, increasing their openness to HIV testing and treat...
Researchers have discovered a mouse-sized mammal fossil dating back to the Middle Jurassic, which belonged to a single species of 'stem therian' mammal. The new findings indicate that three previously recognized species are actually one, providing novel information about early mammal evolution.
Researchers found that low-dose atropine eye drops significantly slowed myopia progression in children, with a 50% reduction compared to untreated children. The medication is safe for use in children age 6-12 for up to five years and may be an effective treatment in the fight against global nearsightedness.
Students from high socioeconomic backgrounds use more college enhancement strategies, such as AP exams and extracurricular activities, to strengthen their college applications. These strategies may be contributing to socioeconomic stratification in college admissions, but overall high use of these strategies is an important factor.
The University of Washington team has made history by cooling water by about 36 degrees Fahrenheit using an infrared laser. This breakthrough technology has the potential to revolutionize various industries, including manufacturing, telecommunications, and defense.
Researchers identified a conserved set of gene expression patterns common to all individuals, providing key insights into the core genetic code that makes our brains human. These patterns include those associated with diseases like autism and Alzheimer's, offering new opportunities for therapeutic targeting.
Researchers discovered that disruptive camouflage evolved twice within the group, with the second origin occurring after a special leg lobe was re-evolved. The study analyzed 33 species and nearly 400 specimens, revealing similarities in developmental mechanisms controlling cryptic features.
Researchers discovered that bats' weighty wings enable a unique landing technique by utilizing inertial forces. By reorienting their bodies through wing mass and inertia, bats can land feet-first and quickly adjust for forward flight.
Scientists have created RNA-based drugs that can temporarily activate and inactivate the CRISPR/Cas9 gene editing system, providing more precise control over gene expression. This breakthrough enables researchers to correct and inactivate genes with increased efficiency and potential selectivity.
Scientists estimate nearly 23 million cubic kilometres of total groundwater, with most modern groundwater found in tropical and mountain regions. The study highlights the need to manage this precious resource sustainably due to increasing demand and climate change.
Researchers at Harvard University have demonstrated effective safeguarding mechanisms for gene drives and unveiled a method for reversing the changes they spread. This breakthrough enables the safe management of disease-transmitting organisms and paves the way for potential use in pest control and disease prevention.
A meta-analysis of 75 studies found that birds in urban areas are more tolerant of humans than those in rural areas, while larger birds are more tolerant than smaller ones. This challenges previous recommendations about large-bodied species being vulnerable to human presence.
Researchers at IRCM identified the mechanism of action for a new target in immune-oncology treatments, focusing on natural killer cells and DNAM-1 protein. The discovery could lead to improved therapies using antibodies against TIGIT receptor.
Researchers at the University of California, San Diego, have developed a simple way to send peptides into cells and tissues. The new method uses a densely packed brush to protect peptides from digestion and enhance their ability to enter cells without altering their biological function.
The NYU Langone team performed a groundbreaking face transplant on volunteer firefighter Patrick Hardison, restoring his sight and enabling him to perform daily tasks independently. The surgery involved the transplantation of the entire scalp, eyelids, and muscles, marking significant milestones in the field.
Researchers at University of Edinburgh discover key components in algae that enable efficient photosynthesis, leading to potential breeding of high-yield crops. By understanding and replicating these mechanisms, scientists aim to create more productive varieties of wheat, rice, and barley.
According to a study published in JAMA Pediatrics, children with Medicaid and the Children's Health Insurance Program (CHIP) were more likely to receive preventive medical and dental care compared to those with private insurance. The study analyzed data from over 80,000 children and found that 88% of Medicaid- and CHIP-covered kids had...
Researchers at the University of California, San Diego have made significant breakthroughs in understanding how fat cells metabolize nutrients to produce fatty acids. This discovery could lead to new insights into potential irregularities in fat cell metabolism and help identify better drug targets for treating diabetes and obesity.
Researchers identified how Salmonella infections trigger thrombosis through inflammation regulation and platelet activation. Thrombosis persisted even after bacteria were cleared from the blood, highlighting a previously unknown pathway involved in sepsis complications.
Researchers propose a two-phase model describing gene loss patterns after whole genome duplication in teleost fishes, the largest group of bony fishes. Approximately 80% of duplicate genes were lost within the first 60 million years, with slower gene loss occurring in subsequent phases.
Classifying high risk has become a disease in itself, undermining preventive medicine efforts. Doctors and patients often lack understanding of what constitutes high risk and the anticipated treatment benefit, leading to ineffective prevention strategies.
A genetic variant has been found to increase the risk of fatty liver disease in obese children and adolescents, despite lower total and LDL cholesterol levels. The variant affects the TM6SF2 protein, which regulates fat metabolism in the liver.