A study found that isosorbide mononitrate, a common medication for heart failure with preserved ejection fraction (HFpEF), did not improve exercise tolerance or daily activity levels in patients. The drug actually decreased daily activity by 18 minutes per day at the highest dose.
Researchers found that reminders helped young children control impulsive behavior, while waiting didn't make a difference. The study suggests that training individuals to look for tangible cues can help improve inhibitory control. Effective reminder-based interventions could involve setting up situations where cues are always present.
According to a study of 16,415 U.S. Hispanic/Latino adults, only one-third to one-half are eligible for and receiving statin therapy, highlighting a significant undertreatment gap.
Researchers at Duke University have developed a technology that brings true color to infrared imaging systems, capturing specific wavelengths from the visible to the infrared spectrum. This allows advanced thermal imaging systems to be produced faster and cheaper, with higher sensitivity.
A new study found that the thickness of the cortex in the fusiform face area (FFA) can predict a person's ability to recognize faces and objects. The researchers discovered an inverse relationship between FFA cortical thickness and visual expertise, with thicker FFA cortex linked to better non-face recognition.
A new class of type 2 diabetes drugs, SGLT2 inhibitors, have been shown to significantly reduce hospitalizations and deaths from heart failure. The EMPA-REG trial found that patients treated with the drug experienced significant reductions in blood sugar, blood pressure, weight loss, and major hospitalizations for heart failure.
A study of over 1,900 young adults found that increases in self-weighing were associated with increased weight concern, depression, decreased body satisfaction, and lower self-esteem among females. This behavior may be a predictor of eating disorders, highlighting the need for obesity prevention programs to consider its impact.
Researchers at Vanderbilt University have developed an open-source hardware/software development kit for customizing medical capsule robots. This allows research groups to design and prototype capsules more efficiently, reducing the need for extensive redesign from scratch.
Researchers developed a new method to study metal-organic frameworks (MOFs) storing gases, revealing cooperative gas-gas interactions and superlattice structures. The discovery holds promise for designing more efficient MOFs for carbon capture and hydrogen fuels.
Recent SPRINT trial results suggest lowering systolic blood pressure below 120 may be associated with a lower incidence of cardiovascular disease and reduced mortality by 25%. The study's findings, published in the New England Journal of Medicine, may lead to a reevaluation of blood pressure goals for non-diabetic individuals over 50
A new study using state-of-the-art computer models finds that most aerosol species will increase under climate change associated with greenhouse-gas-induced warming. This could lead to reduced air quality and increased atmospheric aerosols, outweighing the decrease in precipitation in certain regions.
A new study published in JAMA Neurology found that loss of consciousness is a common presenting symptom in patients after subarachnoid hemorrhage due to brain aneurysm. The researchers suggest that loss of consciousness may be an indicator of severe bleeding and therefore predict death or poor functional outcome one year later.
The Indian star tortoise is being poached on a massive scale, with at least 55,000 individuals seized in a single year from one trade hub in India. The tortoises are sold to consumers for exotic pets or spiritual purposes, often for low prices, threatening their conservation and welfare.
Scientists at Brown University have successfully cultured cells to produce extracellular matrix with strength comparable to natural tissues. By using specialized molds to guide cell growth and alignment, the researchers created ECMs with specific mechanical properties, such as collagen fibers aligned along a tendon-like structure.
Researchers developed a new method that identifies more proteins and peptides in mass spectrometry data, analyzing pairs of overlapping peptide spectra. The method improves performance by up to four-fold, overcoming the bottleneck created by vast amounts of raw data.
A study published in Environmental Health found that short-lived environmental factors, such as common infections and atmospheric pollution, may be involved in the development of neuroblastic tumours in children. The research identified temporal clustering of cases in northern England over a 43-year period.
Researchers identified Irx genes' role in protecting joint cartilage cells, promoting flexibility by repressing stiffening genes. The study suggests harnessing these genes to encourage stem cell differentiation into new joint cartilage.
A study by NIH researchers found no increase in stillbirths after implementing a policy to delay elective deliveries before 39 weeks. The analysis of national infant birth and death statistics over several years showed that efforts to prevent elective deliveries were not linked to an increase in stillbirths on a national level.
Lung researcher Dr. Marie-Liesse Asselin-Labat has received a competitive $1.225 million Viertel Fellowship to investigate lung development and cancer. The funding will support her work on developing better treatments for premature babies with underdeveloped lungs and those with lung disease, including cancer.
Researchers analyzed millions of articles and patents to find that scientific research is often conservative, with scientists prioritizing established knowledge over risk-taking. However, they identified more efficient approaches that could unleash innovation, including a focus on exploring new connections and taking greater risks.
A gene, Lr67, has been identified to prevent important wheat diseases such as rust and powdery mildew. The discovery holds potential to save over $1.5 billion annually in Australian wheat production.
Researchers have achieved the most extreme entanglement between photon pairs, pushing quantum physics to its limit. The result bolsters confidence in schemes for quantum cryptography and computing.
Scientists have identified the 3D structure of iridoid synthase, an enzyme crucial for producing anticancer and antimalarial compounds from plant natural products. The discovery provides insights into the biosynthesis process, shedding light on the unique mechanism used by this enzyme to generate core iridoid structures.
A study found an association between early probiotic use and reduced islet autoimmunity among children at high genetic risk for type 1 diabetes. Probiotics were most prevalent in Finland and Germany during the first year of life, with a 60% decrease in islet autoimmunity risk observed in children with the highest-risk HLA genotype DR3/4.
Lunar rocks are depleted in volatile elements like potassium, sodium, and zinc. The Moon formed from an Earth-orbiting disk of vapor and molten matter, with the inner disk melt being preferentially deposited onto the Earth rather than the growing Moon.
A recent study found that nearly a third of adults with severe mental illness were not screened for diabetes, highlighting the need for improved integration of behavioral health and primary care. The study suggests that addressing barriers to screening in vulnerable populations is crucial.
A new study of 1,472 healthy men found that testosterone supplementation did not increase the risk of heart attack, stroke, or death. Testosterone therapy was shown to reduce these risks compared to non-supplemented individuals.
A study found that group therapy significantly improves cardiovascular health by promoting healthy behaviors, including smoking cessation and increased physical activity. The intervention improved cardiovascular risk factors in 67% of participants compared to 56% in the control group.
Researchers at USC and Sangamo BioSciences have developed a more efficient method for editing genes in blood-forming stem cells (HSPCs), which could potentially treat diseases such as HIV and other blood disorders. By combining two delivery methods, the team achieved unprecedented efficiency rates ranging from 15 to 40 percent.
A new study published in Food Research International found that eating vanilla yoghurt can make people feel happy due to the pleasant surprise of tasting a different flavor. Researchers discovered that yoghurts with lower fat content also elicit stronger positive emotional responses.
A first-of-its-kind study of puberty timing in men reveals a strong genetic correlation with females, showing that the same genetic factors influence both sexes. The study found five new genetic variants associated with puberty timing, some acting through known hormone pathways.
Researchers at ORNL developed a unique electron microscopy technique to sculpt 3D structures with precise control, enabling the creation of functional nanoscale devices. The method uses scanning transmission electron microscopes to precision-control shapes as small as one to two billionths of a meter.
Tropical Storm Kate forms in Atlantic Ocean near Bahamas, with NASA tracking its development and movement. The storm is expected to strengthen over the next two days, bringing potential heavy rain to the region.
Researchers have developed a novel protein from a bacterium that allows them to see early-developing cancer cells deeper in tissue using photoacoustic tomography. This technology provides a new tool for high-resolution imaging of cancer with genetic specificity, promising future studies and drug screening.
A group-therapy intervention program achieves significant improvements in cardiovascular risk factors, including blood pressure, exercise, weight, diet, and tobacco smoking. The program also encourages participants to adopt healthy habits and increase physical activity.
A meta-analysis of 33 studies involving over 20 million patients found a statistically significant increased risk of sudden cardiac death and ventricular tachyarrhythmias associated with macrolide antibiotics. Macrolides were also linked to an increased risk of cardiovascular death, especially with clarithromycin.
The study found a 64% decrease in rarely appropriate angioplasty procedures performed on patients with non-acute conditions. Hospitals with the highest initial rates of rarely appropriate procedures showed varying degrees of improvement, highlighting the need for ongoing quality improvement initiatives.
Researchers developed a technique using nanobodies to selectively manipulate and analyze the morphogen Dpp in wing development, influencing growth in the center but not periphery. The method holds promise for future studies on organ development and may uncover causes of malformation.
A study by UC Santa Barbara demographer Shelly Lundberg and economist Robert Pollak finds that marriage rates have declined among those with lower education levels, while college-educated couples marry earlier and their marriages are more stable. High-income parents invest more time and resources in children, making long-term commitmen...
A new review found scant scientific evidence supporting cannabinoid use in rheumatic diseases, citing only four small studies with limited information. Rheumatologists cannot recommend cannabinoids as a therapeutic option due to high side effects and limited long-term efficacy data.
Researchers study past abrupt climatic changes in North Atlantic and find global impacts, highlighting ocean and atmosphere coupling. They confirm 'bipolar ocean seesaw' concept and warn of climate instability triggered by forcing the climate system into a different state.
Researchers are developing new technologies to analyze pancreatic tumor super-enhancers and testing therapies targeting these signals in clinical trials. The goal is to reprogram cancer cells or create vulnerabilities that can be exploited with combination drug therapies.
A study published in the New England Journal of Medicine found that lowering systolic blood pressure to less than 120 mmHg significantly reduced the risk of heart attack, stroke, and death in adults, especially those over 75. However, intensive treatment also increased the risk of hypotension, fainting, and acute kidney abnormalities.
A team led by TSRI researchers identifies Piezo2 as the long-sought protein sensor for proprioception, allowing scientists to better understand this essential sense. The discovery may also lead to a deeper understanding of human diseases related to proprioception.
Barbara Riegel, PhD, FAHA, FAAN, was named a 2015 Distinguished Scientist by the American Heart Association for her groundbreaking research on self-care in adults with heart failure. Her work has shown that poor medication adherence is a primary contributor to hospitalization in these patients.
Researchers have identified 'sweet points' in dental cement where it regains elasticity before hardening, allowing for longer-lasting fillings. This breakthrough could lead to better applications of fillings and easier treatment options for patients.
Patients undergoing atrial septal defect closure experienced fewer migraines with dual antiplatelet therapy, showing a lower incidence of attacks and less severe symptoms. Researchers observed no significant increase in adverse events between dual and single antiplatelet therapy.
Tropical Cyclone Megh formed in Arabian Sea, moving west past Horn of Africa and into the Gulf of Aden. The storm is expected to make landfall in southeastern Yemen on November 10 with maximum sustained winds near 75 knots.
The study maps gene expression during early development of mice and common marmosets, pinpointing changes that regulate pluripotency. The complex network of gene regulation supporting pluripotency is analyzed, with implications for cell reprogramming and assisted conception.
Researchers found that white coat and masked hypertension are associated with increased rates of heart attacks, strokes, and heart failure. These conditions were also linked to aortic stiffness and kidney damage.
Engineers at MIT developed a synthetic hydrogel that is 90 percent water and has a toughness comparable to the bond between tendon and cartilage on bone. The hydrogel can adhere to surfaces like glass, silicon, and metal with high durability, making it suitable for protective coatings and biomedical devices.
Researchers are developing a simple, inexpensive blood test that can detect the risk of Alzheimer's disease in individuals with Down syndrome. The test aims to identify people who will develop the disease before cognitive symptoms appear.
Researchers found that ambulances deployed at temporary locations during peak traffic hours had a 2-minute shorter response time and lower mortality rates compared to permanent stations. The study, conducted in Shiraz, Iran, and replicated in Sweden, suggests that risk analysis and statistics-based deployment can improve emergency care.
A NYU research team led by Dr. Rodrigo Lacruz has discovered the mechanism of calcium transport essential for dental enamel formation. The study found that CRAC channels play a critical role in controlling calcium uptake, which is necessary for enamel crystal growth.
Researchers have discovered a potential link between Parkinson's treatment and protection against age-related macular degeneration (AMD), the most common form of blindness. The study suggests that patients taking L-DOPA as Parkinson's treatment may be less likely to develop AMD, with delayed or prevented disease progression.
Researchers tested intensive multifaceted interventions to reduce Potentially Inappropriate Prescribing (PIP) in older patients, finding significant reductions in PIP. A systematic review also found transitional care interventions for congestive heart failure patients reduced readmission and emergency department visits. Additionally, m...
A new technology developed by Carnegie Mellon University and Disney Research enables smartwatches to automatically recognize what objects users are touching. The technique, called EM-Sense, takes advantage of the body's natural electrical conductivity to detect and identify objects, creating opportunities for context-aware apps.
Scientists at UNC and UCSF developed a general tool to find homes for 'orphan' cell-surface receptors, illuminating their roles in behavior. The creation of the research tool allows researchers to learn how orphan receptors interact with molecules inside the body or with drugs.
Researchers at Boyce Thompson Institute have discovered a gene in wild tomato species that imparts resistance to the bacteria causing speck, a devastating disease affecting NY tomato crops. The gene, qRph1, has been mapped and is being used to develop resistant varieties of cultivated tomatoes.
A large study found that low-income patients on Medicaid are rarely screened for diabetes, despite being at high risk. Integrated health care would make it easier for patients to get screening and treatment.