A four-year grant will explore nanoparticle-mediated manipulation of pro- and anti-inflammatory factors to limit intestinal inflammation and promote wound healing in IBD patients.
Researchers discovered dozens of new genes involved in resistance to immunotherapy treatments for cancer patients. The study used a novel CRISPR technique to examine genetic mutations in cancer cells and their interactions with the immune system.
A study by the University of Manchester found that a pharmacy service, launched in 2011, improves patient medicine adherence and translates to increased health gain at reduced overall cost. The New Medicine Service has saved NHS England £517.6m in its first five years.
A study published in the Journal of Clinical Investigation reveals that genetic abnormalities contribute to thiazide-induced hyponatremia, a condition causing low sodium levels. Researchers identified patients with this side effect who exhibited persistent subtle differences in blood and urine tests even after medication was stopped.
A new portable platform enables sensitive and rapid diagnostic testing in resource-limited settings, detecting telltale markers of disease as accurately as the most sensitive tests on the market. The D4 assay can identify a disease biomarker in as few as 15 minutes.
The Treehouse Childhood Cancer Initiative has made a comprehensive tumor database available for researchers to use in the fight against childhood cancer. The database contains RNA-Seq gene expression data and demographic information, covering over 11,000 cases of pediatric cancer.
A 30-year-old woman had a dental brace wire removed from her bowel after 10 years, revealing a twisted intestine. The wire was surgically removed without complications, and the woman made a full recovery.
Researchers found that paclitaxel, a breast cancer treatment, can fuel the spread of disease to lungs by creating an environment hospitable to cancer cells. The study identified a gene called Atf3 as key to this process, which helps distribute 'seeds' (cancer cells) and fertilize the 'soil' (lungs).
A clinical trial at the University of Cincinnati is investigating a drug combination therapy using sirolimus and resveratrol to induce disease remission in patients with lymphangioleiomyomatosis (LAM). The study aims to identify a regimen that will eliminate LAM cells, which currently only suppress growth.
Researchers studied lizard venom to discover novel compounds with potential in treating stroke and deep-vein thrombosis. The study identified selective action on fibrinogen chains, a targeted approach successful for snake venom treatments.
Researchers have accurately measured the Sun's core rotation rate, discovering it takes just one week for the core to complete a full rotation. This groundbreaking finding has the potential to refine models of the Sun's birth, evolution, and structure, shedding new light on its internal dynamics.
A Tel Aviv University study finds that pre- and post-surgery administration of beta blockers and anti-inflammatory medication significantly reduces metastatic cancer recurrence. The treatment improves long-term survival rates and is safe, inexpensive, and easily administered.
Researchers found that age and tumor type are key factors in initial denial, with cancers outside brain/spine denied 4.5 times more frequently. Despite this, 97% of cases were overturned on appeal, highlighting the need to streamline the appeals process.
Researchers mapped an acquired mutation altering DNA make-up in 50% of patient tumor samples, identifying a new target for therapy. The discovery highlights the power of mutations to influence epigenetics in cancer cells.
Researchers at Northwestern University have developed a range of bioactive tissue papers made from materials derived from organs, which can potentially be used to support natural hormone production in young cancer patients and aid wound healing. The new biomaterials are thin, flexible, and pliable enough to fold into origami structures.
The region is grappling with a growing number of non-communicable diseases and mental health conditions, particularly depression and anxiety disorders. Mental health practitioners are scarce, exacerbating the issue, as countries such as Libya, Sudan, and Yemen have ratios of only 0.5 psychiatrists per 100,000 people.
Researchers found that self-distancing language, such as using third-person pronouns, can lead to greater challenge and confidence in stressful situations. This approach was shown to promote a more confident and challenging mindset, rather than reducing anxiety or effort.
A 2002 extreme melt season triggered long-term ecological changes in Antarctica's McMurdo Dry Valleys, altering the trajectory of an ecosystem over several years. The study highlights the importance of decadal data records in understanding how organisms respond to abrupt climate events.
A large NIH-funded study found that middle-aged Americans with vascular health risk factors such as diabetes and high blood pressure are more likely to develop dementia later in life. The study analyzed data from 15,744 participants over 25 years and found a strong link between midlife vascular health and the risk of developing dementia.
NASA's Aqua satellite captured an image of extra-tropical storm Nalgae near the Kuril Islands, indicating a transition from tropical to non-tropical characteristics. The storm was moving north-northwest at 20 mph with maximum sustained winds down to 28.7 mph.
Research reveals a stark North-South divide in middle-aged adult mortality rates, with 49% more deaths among 35-44 year olds in the North in 2015. The study attributes this to economic and social factors, highlighting the need for rebalanced investment and devolved powers to tackle health inequalities.
Researchers from the University of Miami used Interferometric Synthetic Aperture Radar (InSAR) to detect ground inflation along one flank of Cotopaxi volcano before its eruption in 2015. The study's results, supported by ground-based GPS instruments, show that similar or greater ground inflation is expected for future eruptions.
A new study has found a correlation between depressed people's Instagram photos and characteristics such as bluer tones, fewer faces, and a preference for filters that drain color. The algorithm's detection rate of 70% surpasses the success rate of general-practice doctors diagnosing depression in-person.
A new study from UT Dallas found that the loss of trust in investment advisory services after the Madoff scandal led to changes in investors' behavior, with $363 billion pulled from advisors and many firms closing. The researchers also identified the spread of distrust through social networks and local media.
Tropical Storm Franklin formed in the Caribbean Sea on August 6 and is expected to make landfall in Mexico. The storm's maximum sustained winds are near 60 mph with higher gusts, and it could reach hurricane strength before landfall.
Researchers used baker's yeast to test natural compounds from soil-based bacteria, discovering diverse agents affecting various cell processes. These compounds may be used to treat conditions like Alzheimer's, Parkinson's, and cancer.
Researchers found that defects in primary cilium structure impaired brain development, resembling those seen in autism and schizophrenia. Restoring signaling through primary cilia resolved wiring defects in the brain.
A recent study found that media portrayals of pregnant women and new moms are often unrealistic, leading to negative emotions such as self-consciousness and depression. Women reported feeling pressure to lose weight quickly after childbirth and being influenced by social media, which can foster competition and guilt.
A new study found that installing 'cool roofs' in Southern California could lead to small increases in ozone and fine particulate pollution levels. The predicted increase can be minimized by requiring more comprehensive performance standards for cool-roofing materials.
A new NCI study identifies more than 100 genes necessary for cancer cells to respond to T cell-mediated killing, shedding light on resistance to immunotherapies. The findings offer a blueprint for studying tumor resistance and developing new therapeutics.
A recent study published in Nature Communications found that all contemporary dogs have a common origin and emerged through a single domestication process of wolves. The research team analyzed the DNA of two prehistoric dogs from Germany and found that their genomes were the probable ancestors of modern European dogs.
NASA's Satellite Servicing Projects Division tested three rendezvous and proximity operations sensors in a simulated environment. The testing confirmed improved performance for light intensity and range measurements, and will help build flight cameras and Lidar systems for satellite servicing.
Researchers found that puppies raised by doting mothers were less likely to succeed in a training program to become guide dogs. The study suggests that guide-dog-training organizations can better identify dogs who are more likely to succeed by understanding the impact of maternal style on offspring behavior.
A study in The FASEB Journal found that mothers who were malnourished in utero tend to have smaller babies, while fathers' malnutrition affects their offspring's weight by age 2. This intergenerational influence suggests it may take several generations to eliminate growth failure and stunting.
A team of scientists at UC San Diego has found that lysosomes can travel to distant parts of neurons' dendrites and branch-like areas, playing a key role in remodeling and plasticity. This discovery may provide new insights into the development of neurodegenerative diseases.
Ludwig-Maximilians-Universität München researchers have developed a method for producing semi-conducting nanocrystals with controlled size, enabling the creation of color-tuned LEDs. The new method uses perovskite-based nanocrystals and allows for high color fidelity and industrial-scale production.
A new mobile program significantly improved adherence to recommended safe sleep habits for infants, including back sleeping and room-sharing without bed-sharing. The program's rates were higher than those achieved by interventions tested in previous research.
Researchers emphasize the importance of primary prevention for Type 2 Diabetes patients to reduce heart disease risk, highlighting the need for evidence-based guidelines and lifestyle management strategies. Proven medical therapies and lifestyle interventions can significantly reduce cardiovascular burden among these patients.
Headwater streams, often overlooked due to their small size, have a significant impact on river ecosystems. Research highlights the importance of improved mapping, understanding resistance and resilience, and assessing impacts from human alterations to land use and climate.
A new study refines death certificate data to provide more accurate estimates of opioid and heroin fatalities, resulting in significant shifts in state-by-state mortality rates. The corrected rates show a 24% higher national growth rate for opioids and a 22% higher rate for heroin.
Using marine reserves can allow fishermen to catch more of the profitable fish they want while protecting weaker fish that can be caught inadvertently by fishing gear. This approach could also help sustainably manage global fisheries and rebuild depleted species.
The University of Pennsylvania is launching a new training program for state and local governments to develop integrated data systems, enabling more effective policy analysis. The program will assist 10 jurisdictions in developing governance processes, legal frameworks, and data plans.
Researchers manipulate brain connections to enhance or impair cognitive functions, offering potential therapeutic applications for psychiatric disorders and learning disabilities.
A University of Utah-led team analyzed archaic DNA to reconstruct the early history of humans, revealing an evolutionary story that challenges traditional views. The study found that Neanderthals and Denisovans nearly went extinct after separating from modern humans, but later diverged and grew into tens of thousands of individuals.
A systematic review and meta-analysis found that both bisphosphonates and denosumab improve bone mineral density in men with nonmetastatic prostate cancer receiving androgen deprivation therapy. Further trials are needed to confirm fracture reduction outcomes.
A new inorganic adhesive method was developed to overcome the challenges of using organic adhesive in cryogenic adsorption pumps. The method involves combining membranes of metals with good compatibility, creating a strong adhesive force. The new pump achieved seven times larger pumping speed compared to previous models.
Researchers hope IBM's Watson will help people with cancer by providing detailed information on genetic mutations and targeted therapies. With Watson, pathologists can analyze multiple genes simultaneously, including those that are not currently tested, to provide more personalized care to patients.
Researchers have discovered a new biomarker associated with mucopolysaccharidoses (MPS), a group of rare genetic disorders. Elevated CSF spermine levels were linked to CNS symptoms in patients, providing a potential diagnostic tool and target for novel therapeutics.
A study of age and crime statistics from Taiwan suggests that cultural factors, such as collectivist societies and parental supervision, may influence the age-crime relationship. The findings challenge the long-held assumption that biology drives teen criminal behavior, instead highlighting the importance of cultural influences.
A dedicated transport system has been characterized that delivers specific mRNAs to active synapses, allowing for the modulation of synaptic junctions and enabling learning and memory. The key factor involved in this transport binds specifically to regions of its mRNA cargo lacking protein-coding information.
A study by RTI International found that low Medicaid payment rates discourage residential care providers from serving Medicaid beneficiaries, limiting access to community-based care. This results in a reliance on nursing homes, which can be more expensive for taxpayers.
Two studies led by Harvard Medical School researchers found that few people actually use price shopping tools to choose lower-cost healthcare options, despite growing interest in the idea. The research suggests that consumerism may not be as effective as believed in driving down healthcare costs.
A study by Cathy Bradley found that small cash incentives and interactions with health program coordinators can increase primary care visits among low-income individuals, reducing emergency department use and improving patient care. The study showed a significant reduction in costs overall.
Researchers discovered gold nanoparticles can boost lung cancer treatment effects and reduce side effects by precisely targeting diseased cells. A tiny device containing these particles could potentially be used in humans to activate chemotherapy directly in tumors.
A systematic review found that lifestyle-modification programs have no significant impact on body weight in Arab countries, highlighting the need for adapted treatment programs. The studies cited methodological flaws, including linguistic and socioeconomic context neglect, and sociocultural obstacles to female participation.
Researchers developed Tissue Nanotransfection (TNT) technology to generate any cell type for treatment within the patient's own body. The technology can repair injured tissue and restore organ function in aging tissues, including organs, blood vessels, and nerve cells.
The five sunshield layers of NASA's James Webb Space Telescope have been fully installed, providing precise temperature control for the telescope's infrared sensors. The layers work together to reduce temperatures by approximately 570 degrees Fahrenheit, ensuring optimal performance for observing distant objects in the universe.
Health insurance coverage in China rebounded from 32.3% in 1991 to nearly universal coverage of 94.7% in 2011. The study found that increasing health insurance rates led to higher treatment-seeking for chronic conditions such as diabetes and hypertension.
Rodeo Therapeutics aims to develop drugs that promote tissue repair using 15-PGDH inhibitors, which have shown promise in animal models for treating inflammatory diseases and bone marrow transplants. The company plans to focus on increasing prostaglandin E2 levels to support tissue stem cell production.
A new computer program correctly identifies depressed individuals from their social media photos 70% of the time, according to a study. The program uses features such as photo color, comments, and face presence to predict depression. Future research aims to refine the model and address data privacy concerns.