A study comparing buprenorphine/naloxone and extended release naltrexone found similar outcomes among patients who initiated medication. However, initiating treatment with naltrexone was more challenging due to detoxification hurdles.
Scientists have found a key to unlock blocked differentiation in microRNA-deficient embryonic stem cells, enabling neural cell differentiation without p53 expression. This breakthrough supports the goal of using stem cells in therapy and could lead to innovative treatments for various diseases.
A study of 62,070 hospitalized heart patients found that only 30.1% were on statins three years after discharge, highlighting a significant treatment gap. Reasons for non-adherence included cost, lack of follow-up screenings, and prior diagnosis before starting the medication.
Induction of labor at 40 weeks is associated with a lower risk of in-hospital perinatal death and meconium aspiration syndrome in nulliparous women over 35. The study analyzed data from 77,327 mothers giving birth between 2009 and 2014.
Research presented at the American Heart Association's Scientific Sessions 2017 found that traumatic lifetime events and recent negative life experiences increase a woman's likelihood of being obese. Women who experienced four or more negative events in the past five years had a 36% higher risk of obesity compared to those with no such...
Researchers found a strong connection between psoriasis severity and the risk of developing type 2 diabetes. Patients with more severe psoriasis are 64% more likely to develop diabetes than those without the condition.
A study found that Medicaid coverage for methadone maintenance therapy increases planned use of opioid agonists among pregnant women with opioid use disorder. The rate of planned OAT use was about 61% in states with Medicaid coverage compared to 28% in states without coverage.
Researchers found a strong link between low vitamin D concentrations and lower live birth rates after ART compared to those with sufficient levels. Women with adequate vitamin D were 34% more likely to have a positive pregnancy test and 46% more likely to achieve a clinical pregnancy.
A special issue in the Harvard Review of Psychiatry explores the intersection of neuroscience and law, highlighting key areas such as addiction, dementia, chronic pain, and behavioral genetics. The research has significant implications for legal proceedings and mental health treatment.
A study of 2,908 participants found no change in glycemic control among people with diabetes in the US between 1998-2010 and 2007-2014. Despite an increase in awareness and testing for HbA1c levels, there was no significant improvement in glycemic control during this period.
A team of researchers has created the first atlas of the healthy human heart's protein composition, which will aid in identifying differences between healthy and diseased hearts. The study found that despite functional differences between the right and left halves of the heart, they share similar protein compositions.
Researchers found pregnant Asian women with pregnancy-related hypertension at highest risk for heart failure hospitalization. White and Hispanic/Latina women fell between the two groups, while Black women had lowest likelihood of heart failure hospitalization.
A new study from McGill University Health Centre found that women with gestational diabetes and high blood pressure are 15-37 times more likely to develop type 2 diabetes and hypertension, respectively. The risk also affects fathers, particularly when they share similar lifestyle habits with their partners.
Researchers found that scab-resistant apple cultivars, such as GoldRush and CrimsonCrisp, retain their quality and nutritional value after storage, rivaling traditional varieties like Golden Delicious. The new apples also show promise for long-term storage using 1-MCP gas.
The study reveals wide inequalities in life expectancy between states, with some experiencing significant improvements while others lag behind. Non-communicable diseases, including heart disease and stroke, claim a disproportionate number of lives across many states.
Researchers found that poison-ivy can co-exist with knotweed, supporting native understory plant species and tree seedlings. This unexpected partnership could help restore degraded forest ecosystems threatened by knotweed invasion.
A new study from Cedars-Sinai Medical Center found that the risk of sudden cardiac arrest during or after sex is exceedingly small. The study analyzed over 4,500 cases and found that only 34 cases occurred during or within an hour of engaging in sex, with nearly 20% of these patients surviving.
Researchers analyzed 1.3 million tweets from users with self-reported ADHD diagnoses to understand their online behavior. The study found that people with ADHD tend to post messages related to lack of focus and mental exhaustion, often using words like 'hate' and 'sad'. This could help clinicians develop condition-specific apps that of...
A recent study by La Jolla Institute for Allergy and Immunology reveals that dengue immunity can confer protection against Zika virus. Cytotoxic T-cells have been identified as crucial in defending against both viruses, suggesting that vaccines targeting either dengue or Zika could be effective.
A new study by Dr Nikos Skoutaris suggests that the EU has mechanisms to accommodate Scotland and Northern Ireland's differing aspirations. Two options are explored: achieving Scottish independence through democratic referendums or remaining in the EU and/or single market without leaving the UK.
A low-cost rapid blood test can accurately rule out heart attack risk in nearly half of all patients with chest pain, saving millions from further tests and reducing healthcare costs. The test, which measures troponin levels in the blood, can identify a threshold level below which patients are unlikely to have had a heart attack.
A recent study at Berkeley Lab's Advanced Light Source used X-ray-based imaging to investigate the effects of temperature and moisture on fuel-cell performance. The research found that even slight saturation produces nearly double thermal conductivity, while water evaporation increases dramatically at 120 degrees Fahrenheit.
Dr. Walter J. Koch, a renowned researcher at Temple University Health System, has been awarded the American Heart Association's Basic Research Prize for his groundbreaking work on molecular signaling of cardiac injury and repair. His research has identified novel molecular targets for treating heart failure.
The JEDIS Alliance aims to promote North American-German cooperation in biophotonics, a growing field using light-based technologies to address medical issues. The partnership will focus on cancer diagnostics and develop new tools for tumor margin detection and staging.
Research on opioid addiction has made significant progress in understanding its impact on brain development, fear, anxiety, and memory. Studies have found that opioids can influence these processes, potentially contributing to substance use disorders and dependence.
A large registry study found that older adults with inflammatory bowel disease are more likely to consume healthcare services and undergo surgery than younger patients. The study also revealed a significant difference in medication between age groups, with younger patients receiving modern immunomodulating drugs and TNF inhibitors.
Researchers developed a bone-targeted nanoparticle that delivers chemotherapy directly to bone lesions, reducing tumor size and pain. The targeted nanoparticles showed a strong burst release of cabazitaxel and increased binding to bone compared to non-targeted nanoparticles.
The lab aims to create bonds of trust and emotion between humans and robots, improving quality of life for older adults. A recent study found a significant drop in depression and increase in human-robot social engagement after three weeks of interactions with a robot using Shakespearean sonnets.
A team of researchers has found an efficient way to produce neurons from pluripotent stem cells by knocking down a single gene. This approach enables 100% efficient neuron production and could facilitate the study of neurodegenerative diseases.
A study of firearms-related eye trauma in the US found significant racial disparities, with African Americans making up 35% of patients and suffering greater odds of being assaulted on the street. Whites were more likely to suffer self-inflicted injuries at home, while most common injury locations were the home and the street
Scientists at Duke-NUS and National Heart Centre Singapore have made a major breakthrough discovering that interleukin 11 is responsible for fibrosis and causes widespread organ damage. This finding has the potential to transform treatment of millions worldwide, as inhibiting IL11 can prevent heart and kidney fibrosis.
New research reveals stress's negative effects on brain function, including gene expression alterations, anxiety responses, and mental illness symptoms. Potential paths for relief include astrocyte signaling control, microbiome regulation, and newborn neuron development.
Evolocumab reduced risk of major cardiovascular events and major adverse limb events among patients with peripheral artery disease. The PCSK9 inhibitor also lowered the number needed to treat to prevent adverse events, making it a promising treatment option for this high-risk population.
The University of Pittsburgh Graduate School of Public Health shares a training protocol for community health center leaders and staff on using big data for informed decision-making. The protocol provides access to over 100 training programs, webinars, and tools to address specific needs in health informatics.
A study presented at the American Heart Association's Scientific Sessions 2017 found that fast eaters were more likely to develop metabolic syndrome, a cluster of heart disease, diabetes, and stroke risk factors. Eating slowly was also associated with lower weight gain, higher blood glucose regulation, and a smaller waistline.
A new study estimates that seals and birds consume about 100,000 tons of fish per year, primarily herring and cod. While their consumption has a significant impact on some fish stocks, such as eel, it is estimated to be lower than human fishing activities.
The Environmental Data and Governance Initiative (EDGI) aims to preserve environmental justice data and monitor federal landscape changes. EDGI proposes a forward-looking research agenda to advance public access to environmental data, supported by an online infrastructure.
A recent study reveals that continental rift zones release large amounts of CO2 from depth, influencing global climate change. The East African Rift and Eger Rift are examples of such systems, which contribute a significant fraction of the anthropogenic carbon release today.
Researchers found that California birds are breeding five to 12 days earlier than a century ago, producing eggs and young at lower temperatures. This adaptation allows birds to avoid the negative effects of climate warming.
The report reveals that global CO2 emissions from all human activities reached 41 billion tonnes in 2017, following a projected rise in burning fossil fuels. This delay is attributed mainly to China's growing coal use, reversing previous decreases since 2013.
A new study supports the view that increased lifetime exposure to estrogen is linked to a reduced risk of developing glaucoma. Women who took estrogen-only hormone replacement therapy after ovary removal had a lower risk of developing glaucoma.
A study by Florida State University researchers, led by Benjamin Schneer, demonstrates that the news media causes Americans to take public stands on issues and join national policy conversations. The research found a 62.7% increase in social media discussion about a major topic when just three outlets reported on it.
A breastfeeding program was associated with reduced atopic eczema risk in adolescents, but no protective effect on lung function or asthma. The study involved over 13,500 children born to mothers participating in a breastfeeding promotion trial.
The World Scientists' Warning to Humanity has been updated 25 years after its initial issuance, warning of catastrophic biodiversity loss and widespread human misery if urgent steps are not taken. The authors highlight areas where reined-in human behaviors can move the Earth's systems toward sustainability.
Researchers develop a novel method for folding and protecting recombinant proteins using a protein-in-a-protein technology. This innovation improves functional protein yields and protects against various denaturants, offering potential applications in the biologics and pharmaceutical industries.
A recent study published in the Journal of Allergy and Clinical Immunology found that breastfeeding may increase the risk of developing hay fever and eczema, while not having a clear effect on asthma. Lifestyle factors such as socioeconomic status and body mass index also played a role in the study.
Researchers have created a molecule that harnesses the power of unpaired electrons to create permanent magnetism. The 'messenger electron' plays a crucial role in controlling the spins of these electrons, resulting in added strength and durability.
Researchers discovered a novel form of crosstalk among tumor cells and immune cells that inhibits the effectiveness of immunotherapeutic strategies. Combining CSF-1R inhibitors with selective CXCR2 inhibitors shows significant anti-tumor effects, suggesting new approaches to enhance therapeutic efficacy.
Researchers discovered chemical evidence of grape wine in Georgia as early as 5400-5000 BC, and radiocarbon age determinations confirm Neolithic hunter-gatherers innovated viniculture around 5800-6000 BC. The study also found abundant grapes in the region during this period, highlighting deep historical roots of Georgian wine culture.
Scientists have identified a novel biological pathway in beige fat cells that burns excess blood glucose to produce heat, suggesting a new strategy for treating metabolic disorders. This discovery could lead to the development of anti-obesity drugs.
A new tool, the Ottawa Subarachnoid Hemorrhage Rule, helps identify high-risk patients with potentially fatal brain aneurysms, reducing wait times and unnecessary testing. The rule has been validated in over 1153 patients, showing it can improve survival rates and save lives.
Researchers found that hair cortisol levels in pregnant women who developed postpartum depression were higher throughout pregnancy than those who didn't. The study suggests that detecting these differences can help anticipate the psychological state of new mothers and prevent potential negative effects on their babies.
A systematic review and meta-analysis published in JAMA Internal Medicine found that intensive blood pressure lowering treatment does not reduce death or cardiovascular disease in healthy individuals with a systolic blood pressure below 140mmHg. Treatment's beneficial effect is limited to trials in people with coronary heart disease.
Researchers developed a new optogenetic technique that enables precise stimulation of individual neurons, allowing for the study of how cells generate specific behaviors. By targeting single neurons, scientists can map connections among neurons that underlie behavior and analyze how those connections change in real-time.
Researchers developed a novel rare earth recovery process that recovered over 80% of the elements present in coal sources and produced more than 80% total rare earth elements on a dry whole mass basis. The concentrates contained critical elements like neodymium and yttrium, representing over 45% of the total concentrate.
NASA-NOAA's Suomi NPP satellite passed over Tropical Depression Haikui on Nov. 12 as it was fading, capturing a visible image of the storm as a weak swirl of clouds in the South China Sea. The depression had maximum sustained winds near 25 knots and was waning under strong vertical wind shear conditions.
Researchers at the University of Bergen found no negative effects from annual influenza vaccination on developing natural immunity. Annual vaccination actually provides a better first line defence against infection, without preventing natural immunity.
Researchers at Lobachevsky University are developing a neural network prototype based on memristors that can analyze and classify living cell culture dynamics. The project aims to create compact electronic devices that function as part of bio-like neural networks in conjunction with living biological cultures.
A study published in the Journal of the American College of Cardiology found that eating regular variety of nuts, including peanuts and walnuts, was associated with a lower risk of cardiovascular disease. Participants who consumed five or more servings of nuts per week had a significant reduction in cardiovascular disease risk.
Research found that 15% of heart attack and stroke patients, and 9% of CABG patients, were uninsured during 2008-2012. Hospital bills exceeded 40% of annual income for 85% of heart attack patients, 75% of stroke patients, and 83% of CABG patients.