For-Robin's monoclonal antibody JAA-F11 successfully targets and kills human breast cancer cells in human tumors grafted into mice, effectively treating triple-negative breast cancer. The company is now focusing on fundraising and preparing for human clinical trials to bring its product from the bench to the bedside.
A recent study published by researchers at the University of Pittsburgh found that many women after weight-loss surgery do not follow recommended contraceptive practices. The findings highlight the need for more frequent referral to counseling for contraception guidance throughout the bariatric surgery process.
A new study by the University of Bonn has identified a way to enhance the impact of killer T cells in fighting cancer. By blocking a protein called IKKβ, researchers were able to increase the effectiveness of killer T cells against tumor cells.
A study by Iowa State University researchers found that collective intelligence theory does not apply to real-world teams due to factors like leadership and communication skills. The research contradicts previous findings supporting the concept, which has been widely adopted in business and management.
The partnership aims to improve food security crops with enhanced native traits, disease resistance, nutritional value, and biotic stress resilience. Gene editing is being employed to increase understanding of crop plants and deliver benefits to African farmers.
A study published in JAMA found that the semaglutide pill resulted in better glycemic control than placebo over 26 weeks, with significant reductions in HbA1c levels. The oral formulation of semaglutide also showed comparable safety and weight loss benefits compared to the injectable form.
A community-based intervention called c-CARE improved cancer literacy and reduced disparate lung cancer outcomes among minority communities. The study found that participants showed increased knowledge and self-efficacy for lung cancer screening, but not perceived susceptibility.
Scientists at NIST have developed a new way to test high-performance fibers used in body armor, revealing critical damage mechanisms that lead to degradation. The technique uses positron beam analysis to characterize fiber structure, enabling the creation of more comfortable and effective vests.
Scientists have discovered a new method to generate terahertz frequencies, long considered challenging to source, using an infrared frequency comb. The innovative system produces extremely pure terahertz tones, opening up new applications for wireless communications and high-speed digital communication.
Researchers investigated optimal fertilizer rates and soilless growing substrates to grow cannabis plants with higher medicinal components and greater yield. The study, published in HortScience, is the first of a series investigating ideal horticultural practices for indoor cannabis production.
Researchers at the University of Würzburg have uncovered key details of how Myc proteins work inside tumor cells, revealing their crucial role in cancer development. The study found that an enzyme called polymerase-associated factor 1 (PAF1) plays a significant role in amplifying Myc protein activity.
A study published in JAMA found that receiving a red blood cell transfusion from an ever-pregnant female donor was associated with an increased risk of death among male recipients compared to male donors. In contrast, mortality rates were similar for female recipients of transfusions from pregnant or non-pregnant female donors.
Astronomers conclude that Saturn's seven moons - Pan, Atlas, Prometheus, Pandora, Epimetheus, Mimas, and Janus - work together to contain the A ring. The moon's gravitational influence slows down the spreading ring's momentum, creating an edge.
A Canadian study found that transgender patients seeking gender-affirming surgical care face complex pathways and long wait times, with many traveling hours to access publicly funded surgeries. The research highlights the need for improved access and training for healthcare providers to support these patients.
A French and Japanese research group developed a new way to turn AFM measurements into clear color images, enabling observation of materials and substances like alloys, semiconductors, and chemical compounds. The newly developed method holds promise for becoming widely used in the research and development of surfaces and devices.
A study published in Cell Research found that intermittent fasting can be beneficial for the metabolism, reducing fat build-up and stabilizing glucose and insulin systems. After sixteen weeks of on-and-off fasting, mice weighed less and had lower body fat compared to control groups.
A study published by Johns Hopkins University researchers found that a specific brain-training method, dual n-back, significantly improved working memory and attention in young adults. This exercise resulted in more substantial changes in brain activity, particularly in the prefrontal cortex region responsible for higher learning.
Researchers at MIT have found a low-temperature electrochemical process to convert methane into valuable derivatives, potentially leading to lower-cost methane conversion and reduced flaring. This technology could provide an alternative to high-temperature industrial processes and pave the way for widespread adoption.
A study published in Frontiers in Neuroanatomy found that HIV-positive children who started antiretroviral treatment by 18 months old have ongoing disruptions in white matter development at age 7, even with viral suppression. Uninfected children also show changes in brain development, suggesting long-term effects of HIV exposure
The UMass Amherst TickReport service is expanding its public health mission with a recent NIH grant and collaboration with L2 Diagnostics to study Borrelia miyamotoi, a tick-transmitted bacterium causing infection and disease in the US, Europe, and Asia. Researchers will conduct human testing on people who submitted B. miyamotoi-positi...
A new pilot study using data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) found that 10 out of 14 geriatric-specific variables can predict morbidity and mortality outcomes in older surgical patients. The study identified risk factors such as cognitive impairment, surrogate consent, and...
Researchers developed state-dependent detection theory, which considers multiple connected decisions and energy reserves. The new model finds that as predation risk increases, animals become more tolerant of danger signals, prioritizing short-term survival over long-term reproductive success.
A new study suggests that many pelvic tumors in women may have a common origin in the fallopian tubes, which could lead to new strategies for preventing and early detecting ovarian cancer. The research found that ovarian cancer cells share genetic similarities with cells covering the tips of fallopian tubes.
A recent study has reshaped the understanding of climate change's impact on early societies, focusing on ancient Egypt. The research, published in Nature Communications, explores how large volcanic eruptions affected Nile river flow, reducing summer flood heights and causing social stress that could trigger unrest.
Researchers found a strong correlation between waste disposal in catchment areas and plastic loads in rivers. Large river systems contribute significantly to ocean pollution due to higher concentrations of plastic particles per cubic meter of water.
A new curriculum has been developed to provide standardized training for healthcare providers in teleneurology. The curriculum covers key areas such as technology, licensure, and patient relationships, aiming to improve the quality of remote neurology care.
Researchers studied exposure to high-magnitude head impacts in young athletes during football games and practice drills, finding that players in 'Back' positions sustained more head impacts than others. High-magnitude head impacts occurred more often in open field areas during games than in line of scrimmage.
Researchers propose swapping atoms to demonstrate exotic properties. The process involves swapping two identical atoms without distinguishing them, leading to questions about individuality and connection in the quantum realm. This phenomenon has philosophical implications, as it challenges traditional notions of identity and connection.
A new origami lattice prototype can potentially reduce acoustic noise on roadways by selectively dampening noise at various frequencies. The technique allows researchers to adjust the distance between noise-diffusing elements, reducing noise levels by up to 90%.
Scientists from RUDN University have developed a new way to synthesize 1,2,4-oxadiazole derivatives, including the active ingredient of genetic disorder treatment drugs. The new method simplifies production while reducing costs and enabling high-yield synthesis without expensive reagents.
Researchers propose active sieving to fine-tune filtration systems for improved separation abilities. The technology could also filter molecules based on movement dynamics, opening a new avenue in membrane science.
A new study examining occupational licensing contradicts decades of research, finding that licensure may rigidify reward structures and enhance entry for historically disadvantaged groups. The study reveals that licenses do not limit competition or increase wages, but rather stagnate quality and widen wage inequality.
Digital archivists from UT Austin collaborate with classicists to improve database preservation methods, enabling long-term accessibility of texts. The new approach preserves data and interactive applications separately, allowing for reuse in different contexts.
Researchers at Binghamton University developed a micro-scale biological solar cell that generates high power density and long operational capability, making it suitable for lab-on-a-chip applications in remote regions. The device harnesses microbial photosynthetic and respiratory activities to provide a clean and renewable power source.
The study reveals that bismuth doping in PbSnSe films causes a ferroelectric phase transition, changing the allowable energy levels of electrons. This effect enables the development of new functionality, including lossless conduction of electricity.
A team of researchers is working on a computer software that can deliver better therapies for patients with life-threatening heart failure. The computer model will take MRI or genetic data of a patient and build a multiscale simulation of their heart, leading to more personalized treatment plans.
Researchers discovered a possible reason for Ptolemy III's sudden return home: massive volcanic eruptions. These events cooled the planet's atmosphere, disrupting the Nile River's flow and leading to food shortages and heightened tensions. The study links eruptions to violent uprisings and other upheavals in ancient Egypt.
Researchers have identified two species of diving beetles in European streams, challenging long-held assumptions about a single common species. The new species, Meladema lepidoptera, is found only in Corsica and Sardinia, with genetic data suggesting it diverged from the other species around 1.5 million years ago.
Researchers found a potential bridge between Martian geology and atmospheric models, suggesting peak daily temperatures above freezing could cause melting at glacier edges. This meltwater could have carved the features observed on Mars today, supporting the formation of water-carved valleys and lakebeds.
Researchers have identified key pathways and mechanisms underlying viruses and infections, opening new avenues for treatment. The studies found that targeting the Hedgehog pathway may reduce severity of flu symptoms and could lead to effective treatments for anthrax infection.
A large international study found that schizophrenia affects the entire brain's communication system, with frayed white matter wiring evident throughout. The study's findings could lead to the identification of biomarkers for treatment and a better understanding of the disease's causes.
Researchers found that high genetic diversity can prime new mutations causing drug resistance in yeast cells, with varying degrees of impact. The study highlights the importance of understanding genetic diversity's role in evolving drug resistance, with potential implications for treating antimicrobial and anticancer diseases.
Researchers identified 'speed neurons' and 'direction neurons' in the bee brain that work together to create a memory for navigation. This ability is crucial for bees, as they rely on it to return to their hive after foraging trips.
Scientists from Scripps Research Institute have shown that a novel compound effectively suppresses HIV virus production in chronically infected cells and prevents viral rebound. The 'block-and-lock' approach blocks reactivation of the virus in cells and locks it into a durable state of latency.
A UH-led research found that Hispanic middle school students who worked with high school health mentors, called compañeros, lost significantly more weight and kept it off longer. After six months, 80% of students with compañeros decreased or maintained their BMI, compared to 64% without.
The CAMI challenge ranked metagenome interpretation tools to provide a roadmap for biologists. Biologists face challenges due to the high number of tools and limited accuracy assessments.
A new study reveals that Amazonian communities with access to healthy fish stocks and large areas of intact forest do not empty their forests through sustainable subsistence hunting. However, large-bodied species and those forming large groups are depleted near communities, highlighting the importance of conservation efforts.
A new synthetic compound, E260, has been developed to target the energy generation system of cancer cells, inhibiting an enzyme that supports their survival and dissemination. This approach has shown promising results in treating mice with metastatic cancer, completely curing them with no toxic effects.
Researchers at North Carolina State University have developed new software and hardware designs to improve the performance and reliability of non-volatile memory systems. The 'Proteus' system uses a flexible and fast approach to logging, reducing the need for additional code and preserving long-term memory reliability.
A Northwestern University research team found a conserved mechanism for nociception in planarian flatworms, fruit flies, and humans. The discovery could lead to new strategies for treating acute pain in humans by designing analgesic drugs targeting the transient receptor potential ankyrin 1 (TRPA1) receptor.
The Los Alamos team used supercomputers to analyze gravitational wave data from a neutron star merger, confirming the formation of heavy elements beyond iron. The observation also provided the first direct detection of gravitational waves in gamma rays, confirming Einstein's prediction.
Researchers have developed a flexible sensor 'skin' that mimics human physiology, allowing robots and prosthetics to accurately sense vibrations and shear forces. This breakthrough enables advanced robotic capabilities, including delicate tasks such as handling eggs or dismantling explosive devices.
A new Cleveland Clinic study emphasizes the significance of prompt treatment in stage I melanoma, with patients treated within 30 days showing better survival rates. Delayed treatment beyond 90 days led to significantly worse outcomes, especially among older patients and those with comorbidities.
Researchers identified effective treatments for patients with rare cancers through genomic analysis, resulting in stabilization, shrinkage, or remission for half the patients. Precision medicine offers new hope for managing these uncommon but significant cancers.
Researchers found that arsenic trioxide can be a powerful therapy for glioblastoma multiforme, extending patient survival by three to four times. The treatment targets specific genomic signatures of brain tumor cells, allowing for precision medicine and matching the right drug to the right patient.
Researchers at MIPT have conducted precise measurements of ultrathin gold films, which are key components of modern micro- and nanoscale optical and optoelectronic devices. The findings reveal that the properties of thin gold films are heavily dependent on their structure and average grain size.
A research team led by Eva Dyer has imaged brains at a mesoscale using the most powerful X-ray beams in the country, revealing capillary grids interlacing brain tissues. The technique could open new windows onto how brain signaling networks work and potentially lead to better understanding of neurological diseases.
Researchers found that mechanically thinning and prescribed burns can reduce fire-severity by up to 60% when used optimally. The study's findings have implications for forest management teams across the US, highlighting the importance of fire in ecosystem restoration.
Dr. Michael Keidar, a George Washington University professor, received the award for his groundbreaking research on cold plasma application in cancer therapy. His work demonstrated progress in creating cold plasmas and their applications to cancer therapy procedures.
Researchers identify regulatory T cells containing replication-competent virus in lymph nodes and gut, providing a strong rationale for targeting CTLA4. The discovery could help design immunotherapies to purge the viral reservoir and induce a stronger antiviral immune response.