Researchers discovered that HSPCs preferentially anchor at venous capillary confluence points guided by VCAM-1+ macrophages. This interaction helps regulate HSPC retention and expansion, providing new insights into the homing process.
A neuroimaging study reveals that the medial prefrontal cortex (mPFC) shows increased activity when patients are shown drug cues, indicating a potential target for addiction treatment. The study aims to develop a novel non-invasive therapy using transcranial magnetic stimulation (TMS) to modulate neural networks.
Research from King's College London and UCL found that parents' feeding practices are shaped by their child's natural body weight, which is influenced by genes. Parents of children with a higher genetic predisposition to weight tend to be more restrictive, while those of children with a lower predisposition are more pressuring.
Researchers at the University of New Hampshire have developed a new, macroporous hydrogel that facilitates faster wound healing by allowing cells to migrate into the wound. The injectable formulation also enables slow release of protein drugs, such as platelet-derived growth factor, to aid in the healing process.
Researchers identified the protein BRD9 as essential for the survival of synovial sarcoma tumours. They developed a new drug that degrades this protein, which is also responsible for driving cancer development, and found it to be effective in blocking tumour progression.
Researchers at Ruhr-University Bochum used microscopic methods to observe the solvation process of a crystal in water. The team imaged individual molecules at extremely low temperatures, revealing the attachment of solvent molecules and the loss of molecular order.
Researchers develop new method for selectively binding proteins to nanoparticles using co-assembling points of contact, promising applications in diagnostics and medicine. The method has potential for treating diseases such as Alzheimer's by dissolving amyloid aggregates.
Scientists at UNC School of Medicine discovered that replacing the faulty UBE3A gene in children's brains can prevent seizures, but not in adults. The study suggests a window of opportunity for prevention between early childhood and adulthood.
The OARtrac radiation treatment monitoring system has been awarded a 2018 R&D 100 Award for its innovative application of scintillating fiber material. The system, developed by RadiaDyne and Jefferson Lab, allows clinicians to monitor and adjust radiation delivery to patients.
Researchers at Clemson University have discovered a key role for glucose in the parasite's life cycle, potentially leading to new treatments for African sleeping sickness. The study sheds light on how the parasite adapts to its environment and can inform strategies to defuse outbreaks.
A team of vulcanologists from ETH Zurich has found evidence suggesting the Phlegraean Fields are in the early stage of a new caldera cycle, which could lead to another massive eruption. The researchers used rock samples from previous eruptions to reconstruct the conditions in the crust and create a model of the cycle.
A study by Monash researchers has revealed the molecular mechanism behind Candida albicans' transformation into its deadly hyphal form. This process is crucial in understanding how to develop effective treatments for this fatal infection, which affects patients with weakened immune systems and has a high mortality rate.
A recent study by Earlham Institute sheds light on the genetic orchestra conductors behind domestication of dogs, cows, horses, pigs, and rabbits. By analyzing microRNAs in their brains, testicles, hearts, and kidneys, researchers discovered that some miRNAs have evolved more recently, playing a crucial role in emerging novel traits.
Researchers at Vanderbilt University Medical Center have isolated a human monoclonal antibody that can neutralize the West Nile virus, potentially preventing viral encephalitis in the US. The study found that a single dose of this antibody completely protected mice from an otherwise lethal West Nile infection.
A new study suggests that romantic crushes can evoke a desire for increasing variety in purchases, as people seek to reassert control. The findings have implications for marketers, who could target those with a crush with promotional campaigns involving high variety options.
Researchers have developed a painless and efficient alternative to current treatment methods for eye diseases, using biodegradable microneedles that deliver drugs into the eye. The patch has been shown to be 90% more effective than eye drops in alleviating corneal vascularisation.
A team of scientists at McGill University Health Centre identified three genes responsible for recurrent molar pregnancies, a rare complication that occurs when a non-viable pregnancy with no embryo implants in the uterus. They discovered MEI1, TOP6BL/C11orf80, and REC114 mutations linked to genetic causes of fetal loss and miscarriages.
Russian scientists developed a new surgical technique using drug-eluting balloon catheters to treat bifurcation lesions in coronary arteries. The method showed lower rates of repeated luminal occlusion and fewer long-term complications compared to traditional single-stent methods.
Tropical Depression Man-yi has formed over the Northwestern Pacific Ocean, triggering watches and warnings for several Pacific island nations. The storm is expected to intensify through Friday, possibly becoming a tropical storm, with maximum sustained winds of 30 mph.
A new study suggests that antioxidants can reduce cognitive impairments caused by low blood sugar in diabetic patients. The research found that stimulating antioxidant defenses with sulforaphane improved cognitive ability in mice, indicating potential benefits for humans.
Researchers have discovered a way to make paper supercapacitors that can bend, fold, flex and still hold electricity. These new supercapacitors have vast potential applications, including medical implants, wearable tech, and novel energy storage solutions.
Frogs from quiet ponds exhibit increased stress hormone levels and impaired immune function when exposed to traffic noise. In contrast, frogs from noisy ponds display a dampened stress response and altered immune profile, which reduces the negative effects of traffic noise.
A research team at Hokkaido University found that lower TRIM29 levels correlate with more mobile and invasive squamous cell carcinoma cells, leading to a worse prognosis. The TRIM-29/keratin interaction plays a crucial role in regulating cell shape and motility.
Researchers discovered how Staphylococcus aureus assembles a complex to anchor pores, which are then stabilized and used to destroy host cells. Blocking this complex's formation can prevent toxin pore assembly.
A new study from the University of Sydney suggests that low-protein, high-carbohydrate diets may be beneficial for brain health and longevity. The research found improvements in learning, memory, and overall health in mice fed an unrestricted low-protein, high-carbohydrate diet.
A Norwegian study of over 4400 children and parents found that moms' weight loss has a significant impact on their children's body mass index (BMI), particularly in families with higher education. In contrast, dads' lifestyle changes show little correlation with children's BMI.
Researchers used MRI brain scans to predict Alzheimer's disease, achieving 89% accuracy in identifying patients at risk. The study found that diffusion tensor imaging (DTI) identified quantifiable differences in the brains of those who developed the disease.
Researchers found that starving ticks have higher activity levels and increased questing behavior to find a meal. Their metabolism speeds up by 100% after three months without food, preparing them for an imminent meal.
Research reveals that a genetic mutation in Filamin A protein impairs cellular force transmission, leading to valvular heart disease. The study provides new insights into the molecular mechanisms of the disease and paves the way for developing new treatments.
Cancer cells exhibit sneaky movement patterns that allow them to invade adjacent tissue and spread throughout the body. Researchers have found a way to target these movements, using medicines to stop cancer cells in their tracks.
A study reveals that European waterbird species shift their wintering areas northeastwards with warmer winters and southwestwards with colder spells. Species preferring deep waters show the fastest long-term changes, while farmland birds like geese exhibit weak responses.
A recent study published in Nature Cell Biology suggests that epigenetic treatments can alter the accumulation of mutations in tumors, potentially leading to more aggressive tumor growth. The researchers warn that these treatments should be used with caution and further studied before being used in clinical practice.
A recent study analyzed data from over 5,900 US adults, revealing that nearly half are physically inactive and spend more than 8 hours daily sitting. The research also found that 1 in 4 adults sit for extended periods, highlighting the need for initiatives to promote physical activity and reduce sedentary behavior.
Scientists at Nagoya Institute of Technology create raspberry-shaped nanoparticle that converts toxic carbon monoxide into harmless carbon dioxide. The unique surface nanostructure improves low-temperature CO oxidation activity and holds promise for future applications in catalysis.
Researchers develop novel method to realistically simulate dressing tasks using machine learning techniques, incorporating sense of touch to overcome challenges in cloth simulation. The approach enables single dressing sequences and a character controller that can successfully dress under various conditions.
The Realizing Increased Photosynthetic Efficiency (RIPE) project has received an additional $13 million to accelerate its progress in redesigning photosynthesis. The funding will be used to test model predictions in key crops and translate yield-boosting technologies more quickly, aiming to achieve a 50 percent yield increase.
A groundbreaking study by LSU researchers found that the loss of local media leads to a decrease in split ticket voting by 1.9%, as voters turn to partisan national news for information. This shift results in voters making more party-based decisions rather than considering candidate platforms.
Researchers developed a model predicting animal viruses capable of spreading among humans, highlighting potential targets for disease surveillance. The study identified 47 viruses with high transmissibility potential, including Carnivore amdoparvovirus 1 and Simian Foamy virus.
Researchers at Chalmers University of Technology have made the surface of a gold object melt at room temperature, opening up new avenues in materials science. The discovery enables various novel practical applications, including sensors, catalysts, and transistors.
Plant root hairs grow long by suppressing lateral cell expansion due to PI(3,5)P2 regulation. This allows for increased surface area absorption of water and nutrients from the soil. The discovery sheds light on plant cell morphogenesis and could lead to the development of more efficient nutrient-absorbing plants.
The occurrence and progression of chronic kidney disease (CKD) in children are influenced by multiple factors, including preterm birth, genetic predisposition, HIV status, and access to kidney transplant. Clinicians must consider these competing issues when treating affected children.
Researchers found that live probiotics in SymproveTM successfully colonized the gut and modified immune response, leading to changes in gut flora and a positive anti-inflammatory effect. The addition of Symprove resulted in increased beneficial bacteria and reduced inflammatory markers.
A study of nearly all births in Vancouver found that air pollution exposure, particularly nitric oxide, was associated with an increased risk of autism spectrum disorder. The findings suggest environmental contaminants and air pollution may be potential risk factors for ASD.
Astronomers have found a rare gamma-ray burst candidate in the Milky Way's star system Apep, which could pose a threat to Earth. The system, featuring a pair of scorchingly luminous stars, is thought to be on the brink of a massive supernova explosion.
A study found that midlife and older women experiencing menopause are at risk for intimate partner violence, sexual assault, and posttraumatic stress disorder (PTSD). The research highlights the association between traumatic experiences and common symptoms related to menopause, including difficulty sleeping and vaginal symptoms.
A novel multisystem disorder has been identified due to bi-allelic variants in the CCDC47 gene, affecting individuals with symptoms such as woolly hair, liver dysfunction, and global developmental delay. The study demonstrates the importance of CCDC47 in normal development and highlights the need for further research into this condition.
Research found that individuals with diabetes who switched to high-deductible health plans experienced delays in seeking care for symptoms of blood vessel diseases, including cardiac chest pain and transient ischemic attacks. The study suggests that increased out-of-pocket costs lead to changes in healthcare behavior.
Associate Professor Klavs Martin Sorensen's research uses big data and machine learning to optimize food production, reducing waste of raw materials. His projects include reusing water in dairies and predicting cheese quality using near-infrared spectroscopy.
Researchers at NSLS-II have developed a TXM that can image samples in 3D faster than previously possible, reducing the time from over 10 minutes to just one minute. The new microscope enables scientists to visualize their samples much faster and collect more valuable data.
Researchers discovered vitamin D is essential for embryonic development and dormancy in fish, a trait conserved across species. This finding could lead to better understanding of dormancy mechanisms and their applications in human health.
Researchers have discovered a universal power law describing black carbon's light absorption, which could help climate scientists build more accurate models. The findings suggest that warming due to black carbon may have been underestimated by current climate models.
Researchers have generated a novel mouse model with a humanized cereblon receptor to study the effects of immunomodulatory drugs. The new mice respond to treatment with these drugs, revealing distinct therapeutic pathways for immunomodulation.
The study found that MDMA increases activity in brain regions linked to social processing, particularly when interacting with trustworthy players. This suggests that MDMA may be a valuable tool in treating psychiatric conditions like PTSD by enhancing cooperation and rebuilding relationships.
The nationwide average exposure to PM2.5 in China decreased significantly between 2005 and 2015, mainly attributed to declining household solid fuel use. Researchers estimate that replacing all remaining household solid fuels with clean energy sources could prevent an additional half-million premature deaths per year.
A recent study published in JAMA Neurology reveals that adults with Down syndrome are more likely to die from dementia, highlighting the importance of studying disease progression and potential treatments for this population. The study, which included 211 adults, found that 70% of those who died had dementia.
Researchers found a bright appearance on deltoid muscle ultrasounds is associated with type 2 diabetes, indicating earlier treatment may be warranted. The study suggests using shoulder ultrasound as a supplemental screening option to detect undiagnosed patients.
Researchers at Columbia University's Mailman School of Public Health found that teens increasingly choose pot over alcohol and cigarettes. The average school grade during which young people first tried alcohol and cigarettes has increased, with a significant drop in the proportion who used cigarettes before marijuana.
Researchers have discovered 16 novel giant viruses in a forest soil ecosystem, more than doubling the known giant virus diversity. These viruses were found using a non-standard approach that involved flow-sorting microbes into small pools, revealing a wealth of giant viruses previously overlooked.
Scientists at NRL have developed a chip-based beam steering technology that steers laser light in two dimensions without mechanical devices, offering improved steering capability and higher scan speed rates. The new technology has potential applications in chemical sensing, monitoring emissions, and other industrial facilities.
Researchers discovered that Sonora cactus pads undergo complex microscale, seasonal and age-related wettability changes. This unique characteristic is now being applied to develop smart materials for hazmat suits, which will preserve water while allowing vapor and heat transfer.