Cardiovascular complications, including myocarditis and pericarditis, have been identified in patients treated with immune checkpoint inhibitors. The study also found a link between vasculitis and visual impairment, highlighting the need for clinicians to monitor for these conditions.
A study by University of Edinburgh researchers found that pregnant women living in areas with high tobacco availability are 70% more likely to smoke. Limiting tobacco supply could help reduce smoking rates and tackle health inequalities.
A new study found that insufficient sleep duration is associated with unhealthy dietary habits, increased screen time, and obesity in children. The study suggests that promoting healthy sleeping patterns can help prevent these negative effects.
Hands-Only CPR training kiosks are effective in teaching life-saving skills in minutes, increasing bystander intervention and improving survival rates. The study found that kiosk sessions outperformed video-only sessions in raising awareness and teaching techniques.
The study found that performance coaching significantly increased rates of tobacco dependence treatment delivery among primary care clinicians. Clinicians who received coaching had higher rates of providing key elements of the 5As model and arranging follow-up support.
Researchers at the University of Wisconsin-Madison identified a fatty acid called butyrate as the mechanism behind certain protective effects of a high-fiber diet. Mice with Roseburia bacteria and a high-fiber diet had reduced inflammation and atherosclerosis.
A randomized clinical trial found that patellar mobilization therapy significantly reduces pain in patients with knee osteoarthritis. The technique can be easily performed in primary care practice, requiring only one hour to learn and practice.
Ancient DNA analysis reveals extinct Jamaican monkey Xenothrix, which diverged from Cheracebus monkeys around 11 million years ago. The study suggests that adaptation can shape species morphology in novel environments, supporting primate colonization of the Caribbean islands.
Patients with common heart failure are more likely to experience lethal heart rhythms, according to research from Cedars-Sinai Medical Center. The study found that those with heart failure with preserved ejection fraction (HFpEF) are twice as likely to suffer from pulseless electrical activity or asystole, which can be fatal.
A study on atmospheric microbes found consistent seasonal variations in diversity and composition. Microorganisms were closely related to specific biomes such as aquatic, cropland, and urban environments.
Researchers at Berkeley Lab and UC Berkeley create high-resolution images of individual atoms in synthetic polymers, revealing 35 arrangements of crystal structures. The discovery could inform polymer fabrication methods and lead to new designs for materials and devices.
Researchers found that failing DNA repair systems lead to chromosome fragmentation and defective assembly in cancer cells. This can be treated with PARP inhibitors, which block another critical DNA repair enzyme, causing genetic damage that kills the cell.
A recent study using computer vision technology reveals how diverse fish species make decisions when fleeing from predators. The researchers found that neural circuits previously identified in lab animals are also present in wild fish shoals, governing escape decision-making.
A large study found that people who experience major injuries requiring hospital admission are at substantially increased risk of being admitted for mental health disorders. The study also revealed a higher risk of suicide among these patients, with 70 suicides per 100,000 patients per year compared to the general population.
Researchers designed a quadrivalent fusion glycoprotein vaccine against human parainfluenza viruses, inducing up to 500-fold higher neutralizing immune responses. The shape-stabilized glycoproteins may offer a general class of vaccines against widespread parainfluenzas and related pathogens.
Lehigh University's Kelly Schultz and her team discovered that the structure of cross-linked polymeric gels is independent of concentration until a limit, called the overlap concentration. This characteristic could improve the tailoring of implantable scaffolds to regrow tissue.
A new computer tool has been developed to identify patients with chronic pulmonary embolism (PE) who can be safely treated at home. The tool uses a sensitive cardiac injury marker, troponin, to measure the severity of PE and predict patient outcomes.
A new study reveals a massive shortage of home-based medical care for frail seniors, particularly in rural areas. The researchers found that only 2-4% of rural Medicare recipients received home-based medical care, highlighting the need for increased access to telemedicine and improved payments for in-home care providers.
Researchers at MIT have developed a method to control magnetic properties of thin-film materials using hydrogen ions, enabling spintronics devices that consume less power and generate less heat. This breakthrough has the potential to overcome physical limitations in memory and logic devices.
Researchers at Ruhr-University Bochum developed a new fabrication process for transparent ultra-thin silver films, which may improve the efficiency of solar cells and light-emitting diodes. The process overcomes challenges associated with traditional chemical methods.
Regularly used forest trails have fewer bird species and lower numbers of birds compared to less-used areas, even with decades of human activity. This suggests that forest birds do not habituate to trail use, highlighting the need for protected areas and adherence to stay-on-trail rules.
A new study published by Insilico Medicine using artificial intelligence has identified potential FP2 blockers, which could lead to the development of new antimalarial drugs. The research provides insights into the properties of E64 approaches and their interaction with falcipain-2, a key target for malaria treatment.
Renewable energy cooperatives are a viable option for energy production and marketing, offering a democratic alternative to fossil fuels. Despite regulatory hurdles, the number of contracts exceeding 70,000 demonstrates their potential in Spain.
Researchers discovered that mitochondria deploy ROS to destroy invading MRSA bacteria by packaging and delivering these molecules to the phagosome, bypassing traditional immune mechanisms. This backup system helps immune cells fight off pathogens with increased effectiveness.
A study analyzes airway mucus properties contributing to ineffective coughing in respiratory disease. Strategies to reduce mucus hyperconcentration and viscosity are proposed as potential solutions.
Researchers have discovered a possible path forward in preventing cancers linked to the Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV), which cause infectious mononucleosis. By blocking the viruses' defense proteins, it may be possible to treat mono and prevent cancer development.
Researchers at Yale University have identified a new fluorescent protein, VARNAM, that allows for live neurons to glow red when activated, making it possible to monitor brain activity in a less invasive way. This breakthrough enables scientists to capture complex brain activity spikes in multiple systems.
Researchers have identified a heterogeneous pattern on liver ultrasounds as a predictor of advanced liver disease in cystic fibrosis patients. Children aged 10 years old are at the average age of diagnosis, and 25% develop advanced liver disease within four years.
Researchers found that a large percentage of violent injuries treated in emergency departments are from incidents unknown to law enforcement. Combining hospital and police data can provide a more complete picture of violence, highlighting the need for improved reporting and tracking.
Researchers developed a long-life metal-O2 battery using Li-Na eutectic alloy, exhibiting similar reaction activities to other alloys and suppressing dendrite growth. The study also introduced efficient O2 reduction/evolution catalysts to improve cycling life and rate capability.
A systematic review and meta-analysis of 17 studies involving over 700,000 patients with concussions or mild traumatic brain injury found a significant association between the two conditions and an increased risk of suicide. However, the absolute risk was small due to the low mortality rate among these patients.
A survey of primary care clinicians found that most are willing to provide routine care for transgender patients, with a decrease in willingness among older clinicians. Factors such as personal exposure and transphobia levels influenced clinicians' willingness to provide Pap tests to transgender men.
The American Academy of Pediatrics recommends light physical activity and allows electronic device use during concussion recovery. Young athletes should stop playing immediately after a suspected concussion but can engage in brisk walking and academic workloads with reduced intensity.
A study of over 10,000 participants found that gray matter volume in certain DMN subregions was associated with white matter microstructure changes. Variations in functional coupling patterns were also linked to connectivity changes between major brain networks.
Researchers are creating three-dimensional models of blood vessels using pig arteries and human endothelial cells to study fibroblast behavior. This could provide a powerful tool for diabetes basic research and drug screening systems.
A study published in Gerontology and Geriatric Medicine found that regular exercise among Japanese expatriates can reduce time spent sitting down and improve mental health. Compared to non-exercisers, those who exercised regularly spent 135 minutes less time sitting and had a higher quality of life score.
Johns Hopkins researchers discovered that blocking the activin receptor can suppress the growth and spread of retinoblastoma cells, halting the cancer's progression. The therapy showed promising results in both human cells and zebra fish, offering new hope for treating this deadly eye cancer in children.
A research team from Massachusetts Eye and Ear discovered a new mechanism by which the immune system protects itself against bacteria inhaled through the nose. The 'exosome swarm' process involves tiny fluid-filled sacs that directly attack bacteria and shuttle protective antimicrobial proteins along the airway to protect other cells.
A study by Universitat Autonoma de Barcelona and Pablo de Olavide University found that dynamic audiovisual editing increases attention by reducing blink rates and stimulating brain activity in the visual processing areas. In contrast, continuous editing stimulates cognitive processing activity in frontal lobe regions.
Researchers at the University of Montreal have discovered two proteins essential to the development of skeletal muscle. The study, published in Nature Communications, sheds light on the 'dance' of muscle cell movement and how cells fuse together to form a single large cell, leading to improved understanding of rare muscular diseases.
A recent study found that cancer stem cells rely on amino acids for energy, rather than glucose, and this difference makes them susceptible to targeting without harming healthy cells. Researchers have already shown promise with this approach in clinical trials against acute myeloid leukemia, with potential applications to other cancers.
Researchers at Karolinska Institutet discovered that oligodendrocytes, cells responsible for myelin production, may play a significant role in MS development. This finding could lead to new therapies targeting areas beyond the immune system.
Researchers found fecal microbiota transplantation (FMT) to be an effective treatment for severe colitis caused by immune checkpoint inhibitors. The study showed both patients experienced significant improvements in inflammation and ulcerations after FMT, with reduced resemblance to their own pre-treatment gut microbiome.
Researchers found genetic changes in Batwa and Andamanese populations that influenced growth factor binding pathways and cardiac muscle tissue development. This suggests a connection between short stature and cardiac problems in these populations.
A new study found that personalized medicine technique reduced treatment times by up to 6 weeks, with 21 patients remaining virus-free and no significant loss of efficacy. The results have the potential to save $10 billion annually in healthcare costs.
Researchers found that pneumolysin can interact with a special receptor in immune cells, triggering an anti-inflammatory response. This allows the bacteria to hide from further attack and grow, eventually giving rise to pneumonia. The study's findings may lead to new strategies for tackling pneumococcal infections.
A study on UK dairy farm medicines storage practices found most farmers store medicines appropriately, but with room for improvement. Inappropriate use and disposal of expired medicines are common, highlighting the need for open conversations between veterinarians and farmers.
Researchers have discovered previously unidentified mutations in the PfCoronin and PfKelch13 genes that confer artemisinin resistance in West African malaria strains. These findings provide potential insights into the molecular mechanisms of artemisinin resistance.
Research has found a strong link between adolescent weight and an increased risk of pancreatic cancer later in life. The study analyzed data from over 1.7 million Israeli adolescents and found that obesity was associated with a four-fold higher risk of pancreatic cancer, even among those who were not obese.
Researchers create a concentrator platform with micro- and nano-structured superhydrophilic traps to increase molecule concentration by up to a million times, enabling quick identification of substances in trace amounts. The technology cuts down analysis time from days to hours and potentially achieves single-molecule detection.
A new study found that pregnant women with Medicaid support urine testing to promote smoking cessation, but fear consequences such as clinician reaction and government involvement. Clinicians are concerned about the impact on patient relationships, but researchers call for consensual testing to improve public health outcomes.
A study of 1,448,952 Medicare beneficiaries found that higher primary care physician continuity was strongly correlated with lower healthcare expenditures and hospitalization rates. Continuity of care is a core tenet of primary care that should be incorporated into official primary care measures.
A study found that only 1.9% of COPD patients nationwide started a pulmonary rehabilitation program within six months of hospitalization, despite Medicare coverage and proven benefits. The low utilization rates were linked to barriers such as transportation and socioeconomic factors.
A recent study of peripheral pulse oximeters found that non-approved devices accurately measure oxygen saturation above 90%, potentially ruling out hypoxemia. However, below 90%, medical-grade pulse oximeter measurements are recommended for accurate patient management decisions.
Researchers found that part-time clinicians have longer appointment backlogs when available in clinic is reduced. Establishing clinician teams and non-clinician support can help improve access to appointments.
Researchers found that plants developed ant-friendly traits long after ants started relying on them for food and habitat. Plants use ants to spread seeds and act as bodyguards, while ants benefit from rich nectar and shelter in hollow thorns.
Researchers have found a potential Achilles' heel in micrometastasis that could be targeted with medications to reduce the risk of full-blown metastasis. Blocking calcium transfer through gap junctions and mTOR pathway results in cancer cell death or growth inhibition.
Research using 2011 Medicare claims data found a strong association between higher primary care physician continuity and lower healthcare costs, as well as decreased hospitalization rates. The study suggests that continuity of care is a valuable aspect of primary care that should be incorporated into quality measures.
Researchers have published the first estimates of antibiotic and pesticide planetary boundaries, revealing that Gram-negative bacteria are already beyond these limits. The study emphasizes the urgent need for new approaches to manage resistance, including promoting susceptibility to pesticides and antibiotics.
Researchers used Natatanuran frogs to study biogeographic exchanges between Laurasia and Gondwanan landmasses. They found two major stepping-stone dispersals via the Indian Plate: from Africa to Asia and from Asia to Madagascar, challenging traditional views of isolated biotic ferry.