Researchers have created a new CRISPR/Cas9 delivery system that reduces off-target effects and improves gene editing efficiency. The 'hit and run' approach delivers Cas9 activity transiently, allowing for highly efficient genome editing while minimizing unwanted results.
Researchers precisely dated Deccan Traps volcanic eruptions, finding four pulses that released toxic gases into the atmosphere. The findings suggest a possible link between volcanic activity and dinosaur extinction, but the exact cause remains uncertain.
Researchers from the Center for Genomic Regulation developed a method to predict and classify these tiny proteins using bioinformatics tools, discovering they account for 16% of bacterial genomes. The small proteins play a crucial role in antimicrobial responses, microbiota balance, and may be overlooked in complex organisms.
A team of researchers at the University of California, Riverside, has developed a method to reconstruct what a researcher is doing with a DNA synthesizer by recording its sounds. The technique uses machine learning algorithms to identify patterns in the sound signals and can detect the type of DNA being produced with high accuracy.
Researchers have identified the causes of gas pockets in 3D printing, which can lead to cracks and failures. The study used high-energy X-rays to predict when these pockets will form, enabling better control over the printing process.
Researchers at Michigan Technological University have developed a carbon dioxide scrubber that converts captured CO2 into oxalic acid, a naturally occurring chemical used in the processing of rare earth elements. The technology has shown promising results, reducing emissions to below two percent and demonstrating potential for US produ...
The study found that burnout decreased and satisfaction with work-life integration improved among US physicians between 2014 and 2017. However, levels of burnout remain higher than in other fields, affecting around 44% of physicians.
Researchers at Osaka University have found a correlation between T cell activity in lung tumors and blood, predicting the efficacy of immune system-targeting therapy. This breakthrough enables non-invasive diagnosis and personalized treatment planning for lung cancer patients.
Researchers at University of Cologne decipher mechanism by which intestinal microbiota amplifies inflammatory reactions in lungs. Candida albicans stimulates Th17 cells, leading to cross-reactivity and immune system imbalance.
Researchers create experimental device to mimic realistic chest impacts, testing its effect on bioengineered heart tissue. Contrary to previous studies, they found that even very rapid strains had no effect on the propagation of electrical impulses.
A study analyzing over 50,000 living rooms across six continents found that people tend to follow cultural trends when decorating their interiors. Americans, regardless of income level, also showed similar efforts in interior decoration.
The ancient people of Zhokhov Island in the High Arctic exchanged objects, including obsidian, through fairs. They practiced reindeer and polar bear hunting, with evidence suggesting a well-developed transport system that connected them to mainland territories.
In a study published in Communications Biology, viceroy butterflies living in northern Florida have evolved to produce a foul-tasting chemical, making them unpalatable to predators. This discovery challenges traditional mimicry theories and suggests a continuum between Batesian and Mullerian mimicry.
A new study found a link between Celebrex and heart valve calcification, contradicting previous findings that declared the drug safe. The study analyzed patient records at Vanderbilt University Medical Center and found a 20% increased prevalence of valve disease among those who took Celebrex.
The RESTORE Health initiative aims to develop advanced therapies for curative treatments, backed by an international and interdisciplinary community. The consortium plans to invest up to €1 billion in new research projects over the long term.
Typhoon Wutip's eye is located about 105 miles north of Faraulep and 230 miles south of Guam, moving northwest at 15 mph. Cloud top temperatures as cold as or colder than 70F/56.6C indicate heavy rainfall potential.
Researchers found that bee colonies are more successful collecting food without waggle dance, suggesting the environment plays a key role. Bees were more active and produced more honey when deprived of dance language.
Researchers found that most individuals misusing prescription opioids also use cigarettes, alcohol, marijuana or hard drugs. Those who misuse multiple substances have a greater risk of behavioral problems, mental health issues and treatment needs.
Researchers at Tokyo Institute of Technology demonstrate magnetization reversal in thin films of BFCO at room temperature, overcoming previous limitations. This breakthrough paves the way for low-power-consumption magnetic memory devices.
A new dynamic dependency framework, developed by Bar-Ilan University researchers, can capture interdependent and competitive interactions between dynamic systems. This framework provides a powerful tool for studying synchronization and spreading processes in multilayer networks with interacting layers.
A national survey of physicians found that burnout is improving, but the risk remains high, particularly due to electronic health record demands. Physicians report reduced emotional exhaustion and improved satisfaction with work-life integration, but more organizational change and research are needed to sustain this trajectory.
Scientists from Institute of Atmospheric Physics found a strong relationship between historical precipitation biases in South Asia and the western North Pacific and future Sahel precipitation projections. The study reveals a 109% increase in Sahel summer precipitation and a 119% increase in available water resources due to global warming.
The study found a substantial increase of 230% in colon cancer screenings among Medicaid patients post-ACA expansion. Additionally, data showed a 9.3% rise in early-stage colon cancer diagnosis and a 27% decrease in risk of death.
A new study found that marine wildlife near coral reefs respond differently to climate change events depending on their distance from the mainland. Surveys of fish and coral habitats showed an increase in herbivorous species in middle- and outer-shelf reefs after severe environmental disturbances, but not near the coast.
The study found that anthropogenic nitrogen discharge significantly increased DIN in US rivers due to fertilizer use, while European rivers were affected by point source pollution. The total anthropogenic impact on Pacific Ocean export has risen from 10% to 30% over the past 20 years.
Emerging research on topological structures and their potential applications in nanotechnology and nanoelectronics is reviewed in Nature Materials. Topological defects, such as domain walls, can exhibit intrinsic properties and significantly affect material properties.
Researchers at Medical University of South Carolina found that marijuana and tobacco co-users with a close link between their use were more dependent on tobacco and smoked more cigarettes per day. This study highlights the need for personalized cessation programs to address the unique challenges faced by co-users.
Researchers from Trinity College Dublin and St James's Hospital successfully measured vitamin D in human hair, a major step forward in assessing vitamin D status. This could provide a longer-term record of an individual's vitamin D levels, potentially allowing for better strategies to maintain stable concentrations.
Researchers used DNA methylation to estimate biologic age and found that women with older biologic ages had higher breast cancer risks. The study suggests that biologic age may be tied to environmental exposures, potentially serving as an indicator of disease risk.
Researchers found widespread allomaternal nursing behavior in golden snub-nosed monkeys, where most infants were nursed by one or two additional adult females. This behavior enhanced infant survivorship and supported kin selection and reciprocity hypotheses, expanding our understanding of allomaternal nursing in primates.
A nationwide study published in ESC Heart Failure has identified four major mutations causing hypertrophic cardiomyopathy in Finland. The study found that 40% of patients carried a specific or likely mutation, while 20% were carriers of a rare gene mutation with unknown role.
Researchers identified ELMO1 as a surprising contributor to rheumatoid arthritis, which may lead to a new treatment and blood test for early detection. The discovery also challenges the understanding of genes' roles in the body.
The 2019 American College of Cardiology/American Heart Association/Heart Rhythm Society Guidelines for the Management of Patients with Atrial Fibrillation provide updated management strategies for patients with AFib. The guidelines emphasize the use of new blood thinners and lifestyle modifications, such as weight loss and physical act...
A recent clinical trial found that pregnant mothers who consumed daily 600 milligrams of docosahexaenoic acid (DHA) had offspring with protected blood pressure levels despite excessive weight gain during early childhood. The study demonstrated a significant reduction in blood pressure increases associated with obesity.
Researchers found that split sleep schedules with short night duration but longer afternoon nap improved alertness, vigilance, working memory, and mood compared to continuous sleep. In contrast, continuous sleep schedules were better for glucose tolerance, but this doesn't necessarily mean a higher risk of diabetes later in life.
Researchers developed a cell model to investigate anti-inflammatory drug efficacy in both acute and resolving phases of chronic inflammation. The model reveals that conventional drugs can impair the resolution phase, leading to prolonged inflammation.
Nicholas Valerie receives a $50,000 prize for his thesis on NUDT5 and NUDT15 enzymes, demonstrating novel functions in oxidized nucleotide metabolism and their potential as therapeutic targets. The discovery could lead to the development of targeted inhibitors to potentiate cancer therapy.
Researchers engineered T cell receptors that can specifically stick to cells infected with cytomegalovirus, offering a new potential treatment option. These receptors could aid in developing CMV vaccines and target brain tumors.
Researchers at the University of Illinois have developed a technology platform that digitally counts growth factor binding in individual cells. This breakthrough allows for direct cause-and-effect relationships between growth factors and cell behavior, leading to a better understanding of cell signaling and resistance to cancer treatme...
New research from Carnegie Mellon University and Argonne National Laboratory has identified how and when gas pockets form in 3D printing, leading to cracks and failures. The study developed a methodology to predict gas pocket formation, which could improve the consistency of finished products.
MIT researchers have developed a new MRI-based detection method for intracellular calcium signaling, enabling precise measurements of neural activity. This breakthrough allows scientists to link neural activity with specific behaviors and could lead to further research on brain function and diagnostics.
A new study from the University of British Columbia found that neighbourhood income and education level are associated with an increased risk of disability progression in patients with multiple sclerosis. The research suggests that modifiable lifestyle factors, such as diet and exercise, could be involved in this relationship.
The Health Equity Network of the Americas (HENA) aims to address persistent health inequities in the region by fostering intersectoral partnerships. HENA's approach focuses on increasing knowledge of effective practices, promoting adoption of policies and programs, and ensuring successful implementation.
A new pilot study found that autistic adults showed real-life improvement after a virtual reality treatment combining graded exposure to fear and anxiety-producing experiences. The approach, which included cognitive behavioral therapy, aimed to minimize anxiety and promote functional improvement in individuals with autism.
Dogs' personalities change over time due to various factors, including age and environmental influences. Research found that older dogs are harder to train, while younger ones exhibit more excitable behavior. Owners with positive personality traits report more responsive dogs.
A new study found that doctor-affiliated PACs contribute more money to politicians who oppose evidence-based firearm safety policies than those who support them. The findings contradict the advocacy efforts of individual physicians and organizations, highlighting a disconnect between their public health goals and political contributions.
Researchers used biomechanical modeling to determine that the Leptarctus primus skull is most similar to an American badger's, indicating a primarily carnivorous diet but also potential for omnivory. The study uses CT scans and virtual modeling to reconstruct feeding habits in extinct animals.
The new WHO strategy aims to reduce the death and disability burden of snakebite by 50% by 2030 through delivering effective treatments and strengthening health systems. It also emphasizes empowering communities and building a global coalition to coordinate action and mobilize resources.
Elevation of blood sugar levels triggers muscle atrophy by increasing KLF15 protein abundance, slowing down its degradation via WWP1. This leads to diabetes-induced skeletal muscle mass decline.
Two Rice University faculty members, Mark Torres and Ming Yi, have been selected as 2019 Alfred P. Sloan Research Fellows for their work in ocean sciences and physics. The fellowships provide $70,000 in funding to support fundamental research by early-career scientists.
Researchers found patients born without a CCR5 gene recover better from mild stroke than those with the gene. Maraviroc, a drug blocking CCR5, accelerated recovery in mice and boosted motor skills, language, and sensory function.
Researchers found that Natura 2000 in Germany effectively protects all listed habitat types, but large-area and common ones are significantly underrepresented. This imbalance can be addressed by setting specific area targets for each habitat type.
A recent study published in the International Journal of Food Sciences and Nutrition has found a significant link between poor diet quality and mental illness in California adults. The research revealed that those who consumed more unhealthy food were more likely to report symptoms of moderate or severe psychological distress.
Researchers identified nine patients with leprosy treated at Mayo Clinic from 1994 to 2017, revealing common factors such as Micronesian lineage and extensive travel while immunosuppressed. The study highlights the importance of treatment and vigilance for immunosuppressed individuals traveling to areas with high rates of leprosy.
Researchers identified a genetic mutation in the PKD1L1 gene linked to Biliary atresia, a devastating condition that affects many children. The study found five patients with two copies of mutations and three additional patients with one mutation, providing new insights into the cause of the disease.
The Slide Hammer Seeder is a low-cost tool that allows precise planting of small-seeded species, including insectary plants and novel vegetables. It can significantly improve the efficiency and effectiveness of growing these crops, reducing the need for pesticides.
A new study suggests the Affordable Care Act's requirements on pre-existing conditions and age clauses had a significant impact on adults with diabetes. The percentage of people with private health insurance who had diabetes increased after the ACA provisions began, especially among those in their 50s.
The UK will create 1,000 new Ph.D.s in Artificial Intelligence (AI) with a £100m investment, driving transformation across industries, healthcare, and climate change. The program aims to ensure AI innovation has ethics at its core, training future leaders to work on complex tasks and generate novel large-scale open datasets.
Research by University of Sydney researchers reveals a significant association between diabetes and low back pain and neck pain. The study found people with diabetes have a higher risk of experiencing these conditions, warranting further investigation into the link.
A new study published in Scientific Reports found that brain areas responsible for movement and sensation alter their functional communication after a limb amputation. Researchers discovered that sensitive and motor areas of the brain exhibited abnormal patterns of communication among hemispheres, even in patients without phantom pain.