Researchers from University of Warwick modelled effects of high blood glucose on human endothelial cells, revealing a key mechanism in blood vessel damage. The study identifies increased hexokinase-2 activity and methylglyoxal formation as drivers of metabolic dysfunction and inflammation.
A new study found significant issues with non-medical use of alprazolam in the UK, particularly among younger adults. The estimated national prevalence of lifetime and recent use was 0.32% and 1.30%, respectively.
Researchers at MIT have developed a new latching mechanism for autonomous boats, allowing them to form 'pop-up' structures such as bridges and stages. This innovation enables more efficient use of Amsterdam's canals for transportation, waste collection, and other purposes.
Researchers have found that anle138b can reduce alpha-synuclein clumps, restore dopamine levels and stop the progression of Parkinson's. Early treatment may be crucial in stopping the condition in its tracks.
Hepatitis C virus (HCV) suppresses the immune response by triggering SOCS regulators, dulling the normal immune response to viral infection. This allows HCV to survive, replicate and infect other cells, making it undiagnosed for months after initial infection.
Drinking unsalted tomato juice lowered blood pressure and LDL cholesterol in Japanese adults at risk of cardiovascular disease. The study found significant drops in systolic and diastolic blood pressure and LDL cholesterol levels over a year.
A new microgrid system designed by American and Chinese researchers promises improved stability, safety, and resilience in delivering energy. The system aligns several energy sources in parallel and uses a decentralized control algorithm to overcome the burdens of system overload and shutdown.
Researchers now believe that beauty preferences are partly an effect of a rudimentary cognitive process. The perception of attractiveness has fluctuated over time, influenced by both physical features and environmental factors.
Scientists have created a skin patch with tiny needles to collect interstitial fluid, containing biomarkers of disease. The device uses surface-enhanced Raman scattering to analyze the collected fluid and detect biomarkers more efficiently than traditional methods.
A 12-year study of older adults with prediabetes found that most reverted to normal blood sugar levels, while obesity accelerated its progression to diabetes. Effective weight management and blood pressure control can help reverse prediabetes in older age.
Researchers have developed DNA nanorobots that recognize and bind to HER2 on breast cancer cells, targeting them for destruction. The nanorobots, consisting of a tetrahedral framework nucleic acid with an attached aptamer, persist in the bloodstream longer than free aptamers and selectively kill only HER2-positive cell lines.
A team of researchers, led by Princeton's Rob Pringle, studied the effects of invading predators on prey species in the Bahamas. The study found that when prey can respond rapidly to the presence of a predator, predators might reduce the ability of prey species to coexist.
A new study found that humans can only burn calories at 2.5 times their resting metabolic rate before the body starts breaking down tissues to make up for the caloric deficit. This limit is linked to the digestive process and applies to various endurance activities, including marathons, ultra-marathons, and pregnancy.
Researchers discovered cytochrome P450 enzymes in giant ocean viruses, which may help develop treatments for life-threatening illnesses. The findings, published in Proceedings of the National Academy of Sciences, could also shed light on the biology and origin of these viruses.
Researchers found that dynamic contact angle is crucial in predicting splashing behavior, contradicting previous static droplet angle method. The study enables creation of splash-free coatings by pre-treating surfaces to increase wettability.
A low-pressure system in the Gulf of Campeche brought heavy rainfall to southeast Texas and southern Louisiana, with flash flooding reported throughout the Houston area. The National Weather Service predicts a high risk for flash flooding across parts of the region, with rainfall totals expected to reach 3-7 inches.
Researchers have created a new type of hydrogel that can grow new tissue to heal wounds, eliminating the need for external growth factors. The hydrogels are made with biomolecules anchored in crosslinkers and can be mixed at room temperature.
A researcher is using a $2.3 million grant to study the mechanisms by which bacteria in the colon may trigger cancer development. The goal is to develop prevention strategies, such as probiotics, to stop the triggering of the immune response.
Researchers developed a fast and efficient way to engineer metabolic pathways using cell-free protein synthesis and SAMDI mass spectrometry. This enables the creation of thousands of potential mixtures to be tested in a single day, providing new insights for synthetic biologists.
Researchers estimate that Americans consume between 74,000 to 113,000 microplastic particles annually, depending on age and sex. This analysis suggests significant exposure to microplastics through food consumption, especially bottled water versus tap water.
A recent study found that nearly all newborns had bacteria in their first poop, contradicting the long-held assumption of a sterile womb. The researchers collected amniotic fluid samples from 50 healthy women undergoing planned caesarean deliveries and discovered bacterial DNA in almost all viable samples.
A new clinical guide aims to empower physicians to recognize patients' risk of firearm injury or death and discuss safe firearm practices. The guide, published in Annals of Internal Medicine, provides practical tools for screening, counseling, and interventions.
Researchers at Friedrich Schiller University Jena have successfully created plasma using nanowires and long-wavelength ultrashort pulse lasers. The new method achieves higher temperatures than previously thought possible in a laboratory setting, opening up new avenues for studying plasma and its properties.
Research reveals that excessive Internet use can lead to changes in brain structure and function, impacting cognitive processes like attention and memory. The study also highlights the need for balance between online activities and social interactions, emphasizing the importance of 'Internet hygiene' techniques.
Researchers found that cardinalfish, thought to be monogamous, engage in complex mating behaviors including infidelity and cannibalism. The study suggests that males can offset the energy costs of brooding eggs by eating them or accepting eggs from other females.
A research team from Osaka University has developed a novel gene therapy approach that targets α-synuclein, a protein associated with Parkinson's disease. By using amido-bridged nucleic acid-modified antisense oligonucleotides, the treatment effectively decreases α-synuclein production and reduces disease severity in mice models.
A study of 50 APECED patients found that 40% developed pneumonitis, a condition often misdiagnosed or missed. Targeting T and B cells resolved symptoms and improved lung function in five treated patients.
Researchers created an AI algorithm, VarCoPP, to identify genetic combinations causing rare diseases. The algorithm provides confidence intervals for predicting pathogenicity, aiding doctors in diagnoses.
Researchers at Stanford University discovered an aquatic highway that lets nutrients from Earth's belly reach surface waters off Antarctica, stimulating explosive growth of microscopic ocean algae. Hydrothermal vents may affect life near the ocean's surface and global carbon cycle more than previously thought.
A new study suggests that abnormal chemical changes in specific brain areas may cause functional motor symptoms, which can be treated with medications modulating glutamatergic activity. The study found increased levels of glutamate and glutamine in the limbic areas of people with these symptoms.
Researchers at Imperial College London have developed affordable and biodegradable sensors that can detect spoilage gases in meat and fish products, reducing food waste and plastic pollution. The sensors, called PEGS, can be read on smartphones and are cheaper to produce than existing sensors.
Researchers believe a zone of preferential heating surrounds the sun's surface, with temperatures rising and individual elements heated to different levels. The Parker Solar Probe will test this theory by entering the zone in 2021, providing direct measurements of processes behind solar wind acceleration.
Researchers analyzed over 400,000 sets of questions and answers on Stack Exchange to discover a 'politeness bias' where users prefer respectful responses, even when content isn't the most useful. The study's findings suggest that Q&A platforms should display more votes and consider renaming the 'best answer' feature to reduce bias.
A Rutgers study has found that facial bones in black adults maintain higher mineral density as they age, resulting in fewer changes to their facial structure. This difference can affect how plastic surgeons approach facial rejuvenation, with black individuals seeking cosmetic procedures double the amount of whites.
Researchers discovered that widowed men are 11% more likely to die from a heart attack compared to widows, while divorced men with atrial fibrillation have a 14% higher risk. Single women actually have a 13% lower risk of death from heart failure than single men.
Zebrafish have been found to have a type of pigment cell that can transform into another cell type during normal development, challenging the long-held dogma that once a cell has completed its development, it stays that way. This discovery sheds light on how cells differentiate and may hold implications for regenerative medicine.
The Enabling FAIR Data project calls on all scientific disciplines to adopt a set of principles ensuring data is findable, accessible, interoperable, and reusable. This shift in research culture could increase opportunities for new research outcomes, enabling scientists to spend more time on research.
ActiveVision enables transportation agencies to autonomously detect and report traffic condition changes using machine learning algorithms. The tool integrates with existing cameras and infrastructure, providing actionable data for enhanced intelligent transportation systems.
A new study published in Nature Digital Medicine found that smartphone-based relaxation technique RELAXaHEAD can reduce migraine headache days by four per month. The app's success rate increased from 51% to 29% after three months, suggesting its potential as a treatment option.
Researchers developed a psychological model to understand readiness for professional development in defectologists, highlighting three key components: adaptability, self-respect, and motivation. Motivation was found to be the most critical factor, followed by self-respect and adaptability.
Researchers developed an alternative method to evaluate local magnetization switching efficacy in ultrathin ruthenium-cobalt-ruthenium films with a wolfram layer added. The study revealed that adjusting the materials' layers thickness can change magnetic parameters, increasing spin switching efficacy.
Experts from 10 European Countries and 16 Research Institutions aim to drill for and recover ice from up to 1.5 Million years ago in Antarctica to study greenhouse gases during the Middle Pleistocene Transition. The project, led by Carlo Barbante, will take 6 years and cost around €11 million.
A new review finds that agriculture and food systems must undergo significant changes to limit warming to 2 degrees C. Efforts should focus on reducing emissions from agriculture, food loss and waste, and meat and dairy production, while supporting smallholder farmers through climate-smart agriculture and social safety nets.
A recent study published in Scientific Reports found a negative combination between neonicotinoid insecticides and the Varroa mite, weakening honeybee colonies. The researchers observed a synergistic effect on body mass and survival rates, particularly in winter bees, compromising colony survivorship.
Researchers found that only 35% of probiotic products were supported by clinical evidence, highlighting the need for clearer labeling. Products with fewer strains and lower cost were more likely to be backed by evidence, but consumers must still do their own legwork to find trustworthy products.
Research shows that heart attack patients with prolonged depression or anxiety are at a higher risk of death. Patients who experienced chronic emotional distress were more likely to die from cardiovascular and non-cardiovascular causes during follow-up.
The superconducting quantum refrigerator utilizes the principles of superconductivity to create an environment conducive to generating unique properties that defy classical physics. Researchers successfully demonstrate a practical way to use the device, paving the way for advancements in quantum technologies and ultrafast computing.
Plan Universal proposes funding organizations require preprint posting for supported researchers. This would increase accessibility and speed up research by allowing experts to build on others' work quickly.
A mouse model of autism has shown that exercise eliminates excess connections between neurons characteristic of ASD. After one month of voluntary running, behavioral differences disappeared and structural brain differences were reduced.
A new study by immunologists at the Babraham Institute has shown that fecal transplants from young mice can replenish and boost the gut microbiome of older mice, rejuvenating their immune system. The research suggests that targeting the gut microbiome could be a way to treat age-related symptoms and facilitate healthy aging.
Researchers discovered a molecular mechanism that allows cancer cells to regenerate and evade therapy, but found treatments that can target these cells. The study provides a new logic for identifying therapies that can kill hard-to-kill cancer cells.
A new study has identified several potential approaches for improving medication adherence among Latinos with diabetes, including simple measures like pillboxes and family member education. The study also highlights specific challenges faced by underserved Latino communities, such as difficulty understanding medications and managing mu...
Researchers found that gravitational forces of an unseen moon outside the rings could cause gaps in the ring structure, but the effect is unlikely to be caused by a currently unseen moon.
A new alliance of six German research institutions is investigating the nanostructure and microstructure of polymer gels to understand their capabilities. The group aims to create polymer networks with controllable structures to control the selective transport of active substances.
A new Dartmouth-led study reveals how ACOs are using home visits to improve care management and identify patient needs while reducing hospital use. The majority of ACOs reported using home visits within 72 hours of post-discharge, often conducted by a care management team member.
Scientists are using the laws of physics and predictive computer modeling to improve bioprinting techniques, which can create living tissues like muscle and bone. The new approaches aim to overcome trial-and-error methods and achieve more controlled printing processes.
A Phase II clinical trial conducted at MD Anderson Cancer Center revealed an 84.6% overall response rate and 38.5% complete response rate when combination targeted therapy was given prior to chemotherapy for newly diagnosed patients with a specific type of diffuse large B-cell lymphoma. The findings suggest that patients who respond to...
Researchers at Columbia University have developed a new technique using reinforcement learning to train a neural network model to plan synthetic routes to any target molecule. This approach is more successful than existing strategies and can optimize user-specified objectives such as cost, time, and sustainability.
Researchers at Université de Montrêal discovered a molecular indicator for cancer progression, enabling precision medicine. They found that SRC kinases chemically modify SOCS1, leading to uncontrolled cell proliferation in cancers.
Researchers discover that cell cannibalism contributes to the concentration of harmful substances, leading to a 'double-whammy' for cell health. This process can perpetuate disease transmission and exacerbate conditions like atherosclerosis.