A combination of ipilimumab and nivolumab demonstrated clinical benefit among patients with high-grade neuroendocrine carcinoma in a phase II clinical trial. The therapy showed an overall response rate of 24% and improved progression-free survival, offering new hope for this patient population.
A study found that excess body weight before age 50 is strongly associated with an increased risk of dying from pancreatic cancer. The research, which analyzed data from over 963,000 adults, suggests that excess weight measured earlier in adulthood may be more closely linked to pancreatic cancer risk than previously thought.
A mesothelin-targeted CAR T-cell therapy demonstrated antitumor activity and acceptable toxicity in a phase I clinical trial for patients with malignant pleural disease. The therapy showed significant tumor regression and reduced mesothelin-related peptide levels in the blood.
Adding savolitinib to osimertinib yields clinical responses in patients with EGFR-mutant non-small cell lung cancer and MET-driven acquired resistance. The combination therapy demonstrates efficacy in a patient population for whom chemotherapy is the current primary treatment option.
Researchers have identified bacteria with promising antibiotic activity against known pathogens in the protective mucus that coats young fish. The study found five bacterial extracts strongly inhibited methicillin-resistant S. aureus and three inhibited Candida albicans, a fungus pathogenic to humans.
Researchers developed liquid crystal technology that can block a wide range of laser wavelengths, including red, blue, and green. The system uses a voltage-controlled phase change to scatter light and block laser beams.
A new combination of immunotherapy and chemotherapy has caused tumors to shrink in 83% of patients with metastatic pancreatic cancer. The treatment, involving a CD40 antibody, checkpoint inhibitor, and standard-of-care chemotherapy, showed manageable side effects, suggesting a durable response.
Researchers create covalent nanoparticles to deliver naloxone for 24-hour protection against morphine and fentanyl's effects. The nanoparticle system shows promise in treating fentanyl overdoses and could potentially replace short-acting naloxone as an antidote of choice.
Researchers have identified key compounds responsible for the flavor and aroma of Tennessee whiskey. By studying the effects of the Lincoln County Process, distilleries can optimize their production to achieve the desired flavor profile.
A new experimental glioblastoma vaccine developed by Jefferson and Imvax has shown promising results in a phase Ib clinical trial. The treatment was found to slow tumor recurrence and prolong patient survival in patients with newly diagnosed glioblastoma multiforme.
A phase I clinical trial found that a combination of chemotherapy and HER2-targeted CAR T cells is safe and effective in treating advanced sarcoma, with some patients experiencing complete responses. The therapy showed promising antitumor activity and minimal treatment-related toxicities.
A combination of ipilimumab and nivolumab has been shown to shrink tumors in patients with high-grade neuroendocrine carcinoma by 42 percent, while all low-grade patients did not see a response.
Researchers have discovered a correlation between estrogen byproducts and survival rates for women with breast cancer, with higher levels of the "good" metabolite associated with reduced mortality. The study suggests that measuring these byproducts may help predict prognosis after breast cancer diagnosis.
A study from the European Society of Cardiology reveals that nighttime trips to the bathroom may be a sign of high blood pressure or excess fluid in the body. The researchers suggest that individuals experiencing nocturia should consult their doctor about their blood pressure and salt intake to address potential hypertension.
Researchers found that obesity at older ages is linked to worse outcomes, with higher tumor growth in obese mice compared to lean mice. They also discovered a connection between leptin, a biological signal released by fat tissue, and increased numbers of tumor-initiating cells.
Researchers have developed a new way to visualize nano objects using superlenses and titanium oxynitride films, achieving spatial resolutions of 8 nm and 80 nm. This breakthrough enables non-destructive analysis and 3D visualization without the need for fluorescent labels.
A Columbia University study found that adversity-induced disruptions in gut microbes are associated with changes in brain function in young children. The research linked gastrointestinal symptoms in childhood to potential emotional health issues later in life.
Researchers evaluated the safety and effectiveness of uterine artery embolization (UAE) in patients with various autoimmune diseases. UAE was technically and clinically successful in all patients, with no significant difference in volume reduction rates between groups.
Researchers at Rice University discovered that PTFE stir bars react with chemicals in an unexpected way, affecting the modification of nanotubes. This discovery highlights the importance of choosing inert materials in laboratory settings.
Researchers designed proteins that can assemble into complex structures using supercomputers and artificial charges. The stacked octamer structure consists of 16 proteins, resembling a braided ring with highly ordered and specific interactions.
Physicians at the University of Vienna have developed a novel method to cool nanoparticles using quantum optics, enabling unprecedented control over particle motion in ultra-high vacuum. The approach, inspired by atomic physics, harnesses scattered light from an optical tweezer to effectively cool particles' kinetic energy.
A new CU Anschutz study found that physical activity is essential for maintaining substantial weight loss, rather than diet. Successful weight-loss maintainers engage in high levels of physical activity to prevent weight regain.
Researchers create green fluorescent protein-based biosensors to probe energy metabolism in living cells, enabling multicolor imaging and visualization of multiple molecules. The sensors achieve up to a seven-fold increase in fluorescent brightness in response to glucose concentrations.
A team at the University of Delaware has engineered a silicon-graphene device that can transmit radiofrequency waves in less than a picosecond, enabling faster communications. The device combines the benefits of silicon and graphene, with improved carrier mobility and electrical properties.
Scientists at University of Freiburg create three-dimensional hollow structures in quartz glass using Glassomer process. This breakthrough enables the production of optical waveguides and microfluidic channels, previously difficult to manufacture due to glass's chemical resistance.
A recent study published in The FASEB Journal found that low oxygen levels during fetal development can lead to premature ovarian ageing and reduced egg availability. Researchers exposed pregnant rats to chronic hypoxia, leading to accelerated ageing of the ovaries and fewer eggs available for future reproduction.
Researchers have developed a new methodology that allows solid state lighting to measure and self-adjust its spectral power distribution based on environmental conditions. This enables the system to maintain consistency and stability over time, making it suitable for applications requiring precise light spectra.
Researchers use metal nanoparticles to detect single target molecules in paper-based tests, overcoming limitations of conventional dyes. The results enable ultra-sensitive diagnostics with limitless applications in medicine, forensics, and environmental safety.
Genome editing enables crop development with resistance to pests, diseases, drought, and heat, reducing losses and chemical pesticide sprays. However, regulatory hurdles in Europe may hinder the adoption of these technologies, posing a risk to developing countries.
Researchers warn that increased tariffs on US soya bean exports to China could trigger extensive tree-felling in Brazil's Amazon rainforest. The study suggests measures to reduce deforestation, including removing trade tariffs and improving environmental protection schemes.
Astronomers estimate that Messier 11 formed 220 million years ago and will disperse in a few million years as its stars are ejected by stronger gravitational forces.
Paleontologists uncover part of a skull from the Liscomb Bonebed, revealing the presence of lambeosaurines in the Arctic during the Late Cretaceous. The discovery suggests that hadrosaurines and lambeosaurines may have had different habitat preferences.
Researchers from Rochester Institute of Technology and Georgia Tech developed a new approach to simulate the heart's electrophysiology in real-time, allowing doctors to better discuss life-threatening heart conditions with patients. This method uses WebGL code to repurpose graphics cards for faster scientific computing applications.
A nationwide survey analysis found that more Americans view e-cigarettes as harmful as, or more so than, traditional cigarettes. The shift in perception may have led to fewer smokers switching to e-cigarettes, highlighting the need for accurate risk communication.
Tropical Cyclone Joaninha's maximum sustained winds dropped to 65 knots on March 29, 2019, after being pushed away from its center. The storm was expected to weaken further due to increasing wind shear and cooler sea surface temperatures.
A team of researchers found that people differ substantially in how they perceive roughness, with different relationships between skin vibrations, friction, and grain size. The study aims to understand individual differences in tactile sensation and develop an estimation model for perceptual roughness ratings.
Researchers at LSTM and University of Buea developed new Loa loa infection models to assess the safety of anti-filarial drugs. These models have enabled the prioritization of drug candidates for preclinical development, targeting onchocerciasis while avoiding loiasis adverse reactions.
A study by QUT researchers found that women caring for children experience a negative impact on their research output, visibility, and ability to network. Institutions should adjust publication and citation benchmarks to cater for women who have cared for children to ensure fair career advancement and funding opportunities.
Researchers discovered high concentrations of toxic heavy metals in blood samples from Great white sharks in South Africa. The study found no adverse effects on the sharks' immune system despite the presence of these toxins.
A team of researchers found that cilia's most efficient beating occurs at a natural length of 10-12 microns, but surprisingly lacks synchronization. The study provides insight into human cilia and defects leading to diseases such as primary ciliary dyskinesia.
Polygenic scores developed using European data are more accurate for people of European ancestry than those of African or East Asian ancestry. Researchers recommend increasing minority population representation and making data accessible to improve healthcare outcomes.
Scientists create vaccine that strengthens immune defences by multiplying cancer-repelling T cells, promising treatment for individualized cancer immunotherapy and potential application in autoimmune diseases. Laboratory tests conducted on tumours in mice show effectiveness of approach.
University of Arizona immunobiologist Michael Johnson is using a $1.9 million grant to explore copper's potential as an antibiotic. He hopes to create therapeutics that target the copper-sensing protein CopY, which helps bacteria fight off copper stress.
Two new genes, ENAM and ACP4, have been identified as causative variants in canine enamel development defects. The study reveals that these genes are also associated with human enamel development disorders.
Breast cancer cells exploit the FGFR4 receptor to regulate growth and prevent programmed cell death. Targeting this vulnerability with combination therapies shows promise for improving treatment outcomes.
A study published in EClinicalMedicine found that preterm babies born without the haptoglobin protein have a higher risk of brain bleeding, cerebral palsy, and death. The absence of the protein may serve as a potential biomarker for increased monitoring or preventive interventions.
Researchers at UC used LIDAR technology to discover ancient farm fields in Mexico's Yucatan Peninsula, indicating surplus crop production. The discovery supports the idea of a complex market economy among the ancient Maya civilization.
Experts have developed a model to identify suitable locations for the reintroduction of Eurasian lynx in Scotland, suggesting that the Kintyre Peninsula is the most suitable site. The study found that Scotland possesses sufficient habitat for population establishment and spread, with the Central Belt acting as a barrier to colonization.
Two rare genetic variants, NOTCH3 and TREM2, linked to Alzheimer's disease have been discovered. The NOTCH3 variant is more frequent in Ashkenazi Jews and may lead to a diagnostic test for AD in this population.
Researchers found that tiny Brazilian frogs, called pumpkin toadlets, have fluorescent patterns on their backs and heads when exposed to UV light. These patterns are created by bony plates beneath a thin layer of skin, allowing the frog's skeleton to glow under UV illumination.
Researchers successfully connected two nanofiber cavity-QED systems over a distance of up to two meters, enabling reversible interaction between atoms and delocalized photons. The breakthrough paves the way for distributed quantum computing and quantum networks.
A review explores how two cell populations respond to organ failure, with one type relying on endoreplication and the other on cell regeneration. This cooperative response allows organs to recover from failure, but also presents tradeoffs that can impact long-term health.
The UTA Research Institute and Neuro Rehab VR are developing a robotic glove that will aid in rehabilitating stroke patients through virtual reality gaming. The device aims to provide fine motor training and increase patient compliance, saving money on rehabilitation. Clinical testing is expected to begin after development.
A study by Rod Duclos and Mansur Khamitov found that individuals who receive cash are more likely to opt for immediate gratification, leading to lower savings rates. Activating a mindset focused on long-term goals can increase patience and tolerance for parting with cash.
The CARD System, an evidence-based approach, reduces vaccine-associated pain, fear, and fainting in school-based clinics. Implementing this system in Ontario schools improved student symptoms and increased use of the tools.
Researchers identified six age-related subgroups of acute erythroid leukemia with distinct mutations and patterns of gene expression. These findings suggest that genomic alterations can predict treatment outcomes, offering new insights into the diagnosis and treatment of this aggressive cancer.
Scientists have discovered a unique fossil site in North Dakota that preserves the remains of hundreds of fish and other organisms killed instantly by a massive asteroid impact 66 million years ago. The site, dubbed Tanis, provides conclusive evidence of the impact's devastating effects on Earth's ecosystems.
Researchers presented studies on the clinical utility of liquid biopsy powered by ddPCR technology to measure blood-based tumor biomarkers in a reproducible way. Studies demonstrated correlations between ctDNA mutations and response to abemaciclib in breast cancer patients and found potential as a predictor for surgery success in malig...
Researchers at UC San Diego identified unique bacterial features in the stool of people with nonalcoholic fatty liver disease and their twins, allowing for 92% accurate diagnosis of liver cirrhosis. The test also showed promise in detecting previously undiagnosed cases with 87% accuracy.
Konstanz researchers Dina Dechmann, Alex Jordan, and Ariana Strandburg-Peshkin receive HFSP grants to study seasonal brain change in shrews, coordination in animal groups, and network design inspired by plant societies. The projects aim to uncover new approaches to fundamental biology problems.