Researchers found that PFASs, such as PFOS and PFNA, have high binding affinities to Baikal seal PPARα, suggesting a role in toxicity. In vitro and in silico approaches revealed interspecies differences in the binding of PFASs to PPARα.
Fossils found in North Dakota's Tanis site reveal creatures killed suddenly by the Chicxulub impact's aftereffects, with some fish inhaling tiny spherules ejected from the impact. The rapid 'bloody nose' effect caused devastation worldwide before other aftermath could reach affected areas.
Researchers found that species with high adaptability tend to have longer lifespans, as they can better cope with environmental changes. The study also discovered that reversible phenotypic plasticity, where individuals can switch between different traits, is key to survival in changing environments.
A new study found that using an electronic dashboard linked to patients' medical records increased the prescription of preventive therapy by 18% among cardiac patients. The study suggests that education alone is not enough and that technology-assisted nudge approaches can be effective in improving prescribing rates.
Researchers developed a wireless, battery-free sheath that can be laid on the skin and gently peeled off when needed. The patch gathers medical data and processes it locally to reduce information sent wirelessly. Since deployment at two hospitals, 90 babies have used the patches, validating them as a feasible alternative to current tec...
A recent study found that nearly a quarter of small and medium-sized enterprises (SMEs) in the UK view Brexit as a major obstacle to their success, with investment and exporting being significantly affected. SMEs are disproportionately impacted by uncertainty and have lower resilience to unexpected shocks.
A six-month study of children with asthma found that higher omega-3 fatty acid intake was associated with lower odds of daytime asthma symptoms in response to indoor air pollution. Conversely, higher omega-6 intake was linked to more severe asthma and increased inflammation. The study suggests that dietary recommendations can help prot...
Scientists have created nanocubes that can form stable cubes at specific temperatures, then scramble back into individual components when heated or cooled. This self-assembly ability mimics life's chemical processes, enabling the creation of complex systems.
A study found that lumbar spine MRI reports were written at a readability level significantly above the average reading ability of US adults, with only one report meeting basic education standards. The high complexity of these reports may limit patient understanding and access to their health information.
Researchers at The University of Queensland have created a new animal model of schizophrenia that specifically targets elevated dopamine levels in the dorsal striatum. This model enables scientists to test potential therapeutics and explore the basic changes in brain circuitry that contribute to the disease.
A team of scientists led by Paula McSteen identified a new gene called barren stalk2 (ba2) that affects the development of axillary meristems in corn plants. The ba2 gene interacts with another gene, barren stalk1 (ba1), to regulate ear formation.
A phase I clinical trial has found a new combination therapy to be well-tolerated in patients with recurrent high-grade gliomas, a disease historically under-funded. The treatment combines ADI-PEG20, pemetrexed and cisplatin, showing encouraging efficacy and paving the way for further research.
A recent study by the University of Kentucky has identified a potential cellular mechanism that connects smoking during pregnancy with an increased risk of offspring obesity later in life. The research found that expectant mothers who smoke cigarettes during pregnancy induce distinct changes in chemerin gene expression in their offspring.
Research suggests that omega-3 fatty acids can modify asthma severity and response to indoor air pollution in children, while higher levels of omega-6 may exacerbate the condition. The study found a correlation between increased neutrophils in response to particulate pollution and higher levels of omega-6 in the diet.
Researchers have made significant breakthroughs in understanding snake genomes, including the evolution of venom genes, dosage compensation mechanisms, and sex determination systems. The study provides a comprehensive genomic context for these complex biological processes, offering new insights into the unique adaptations of snakes.
A new census using the IUCN A.P.E.S. database estimates that 52,800 western chimpanzees live in western Africa, primarily outside protected areas. The study highlights the need for conservation efforts to reduce habitat loss and connectivity due to development corridors.
Michigan State University has landed a $1.8 million National Institutes of Health R01 grant to develop new brain implants that decipher complex chemical and electrical input and output for treating Alzheimer's, Parkinson's, depression, and traumatic injuries.
A study found that contrast-enhanced MRI significantly benefited patient care by successfully triaging patients with discordant benign biopsy results to surgical or nonsurgical management. The test showed high sensitivity and specificity in detecting malignancies, with a false-positive rate of 6.7%.
A new study reveals that chronic kidney disease of undetermined causes (CKDu) is present in rural India, particularly in Southern areas, and shares similar risk factors as in Central America and Sri Lanka. The disease affects mainly working-age populations and has a faster clinical evolution compared to traditional CKD.
A new study found that patient factors, including distance from hospital, age, and health insurance status, significantly impact follow-up imaging rates. The study also showed disparities in follow-up rates among different age groups, with younger and older patients having lower completion rates.
A study led by Queen Mary University of London found that shorter stature is associated with higher risk of heart disease, primarily due to impaired lung function. The researchers suggest assessing lung function alongside height to better predict heart disease risk.
A new study from Uppsala University reveals that Scandinavian wolves originated from the Nordic region or adjacent parts of Northern Europe, rather than from hybridization with dogs. Genetic analysis shows that patrilines in Scandinavian wolves are unique and not found in dogs.
Researchers from Lancaster University found that April Fools hoaxes share similarities with fake news stories, including simpler language, longer sentences, and less formal tone. The study provides new insights into detecting disinformation and may aid in identifying 'fake news' articles.
A study of over 1 million participants from China, Japan, South Korea, Singapore, Taiwan, and India found that smoking was associated with 144,366 deaths during a 12-year follow-up period. Tobacco use accounted for 56.6% of lung cancer deaths and 21.1% of total deaths among men born in the 1920s.
The first total-body PET/CT scanner has shown promising results in enhancing image quality, reducing scan time, and lowering dose. Clinical trials have demonstrated improved diagnostic capabilities with minimal impact on patient exposure.
Researchers at UNIGE and UNIL discover clofazimine's efficacy in stopping triple negative breast cancer progression by blocking Wnt cell signaling pathway. The study highlights the need to re-examine existing drugs for potential targeted therapy.
The study reveals that increases in soil biodiversity follow plant cover increases in less productive ecosystems, while acidification leads to declines in more productive ecosystems. These patterns differ from those observed in other communities.
A recent study found that individuals who prioritize making the best choices in their relationships, known as maximizers, tend to be more satisfied in their marriages. Maximizing men with attractive wives reported higher satisfaction, while maximizing women with high-status husbands experienced less decline in satisfaction over time.
Researchers found that consumers' pre-determined beliefs about nutrients and their relationship with health outcomes drive how they interpret and understand claims. Consumers may upgrade nutrition claims to health claims based on familiarity and personal relevance.
Researchers at Tufts University have successfully grown and maintained olfactory stem cells in culture, which can then be used to restore tissue in the nose. The discovery raises hope that future therapies could be developed to restore the sense of smell in individuals where it has been damaged by injury or degeneration.
Brazil is expected to increase its soybean production by up to 39% to satisfy China's increased demand, which could lead to dramatic deforestation in the Amazon rainforest. Global meat consumption must be reduced to sustainably cope with this problem, and ecological consequential costs need to be included in food costs.
Researchers have successfully targeted the tumor biomarker EpCAM with chimeric antigen receptor-modified T cells, significantly delaying tumor growth in mice. The study suggests that EpCAM could be a promising target for cancer immunotherapy in various tumor types.
The Slide-seq technique generates detailed three-dimensional maps of tissues, revealing the location and activity of cell types and genes. This platform offers unparalleled views of tissue function, allowing researchers to study cellular relationships, gene expression, and responses to perturbations.
Breast cancer cells are inherently changeable, morphing from one cell type to another at the molecular level. This feature may promote resistance to certain therapies. The research provides new insights into how cancer cells develop and evolve within tumours.
A study published in The Lancet found that caesarean sections in low- and middle-income countries lead to significantly higher maternal and infant mortality rates. The analysis of 12 million pregnancies revealed that women undergoing emergency caesarean sections were twice more likely to die than those delivering by elective means.
Researchers at the University of Science and Technology of China have developed a simple, efficient, and non-metallic anionic composite photocatalytic system to free trapped radicals from carboxyl groups. This breakthrough simplifies photocatalytic systems, reduces costs, and promotes industrialization in organic synthesis.
Researchers discovered how specific fungal prostaglandins deactivate immune cells, allowing fungi to grow and increase infection. This finding provides insight into the interaction between fungal pathogens and the human immune system.
A new study published in Ecology found that rusty crayfish populations declined in lakes with mucky and sandy bottoms, while those with rocky substrates remained stable or increased. The research suggests that the invasive species sabotages its own success by using aquatic plants as shelters to avoid predators.
Researchers at KAUST's Clean Combustion Research Center investigate pre-ignition, a major bottleneck to engine downsizing. By analyzing engine parameters, they identify conditions that trigger pre-ignition, including high exhaust back-pressure and oil-fuel droplet interactions.
Researchers found a way to exploit Striga's Achilles' heel by using artificial plant hormones called strigolactones. The treatment reduces Striga plants by over half, making it a game-changer for farmers in sub-Saharan Africa where the weed threatens up to 40% of staple crops.
A team of researchers has shown that a single population of stem cells in mice generates new neurons throughout their lifetime, contributing to embryonic, early postnatal, and adult neurogenesis in the hippocampus. This finding suggests that the brain has the capacity for continuous improvement and adaptation.
Researchers at Helmholtz-Zentrum Dresden-Rossendorf have developed a new procedure to optimize water usage in mineral beneficiation technology. By using process simulation, the team was able to significantly reduce water consumption, from 4,000 litres per tonne of ore to below 1,000 litres per tonne. This innovation has the potential t...
A novel refrigerator design using a loop thermosyphon has shown promising results in reducing energy consumption, with an estimated 30% saving. This sustainable energy technology could lead to a significant decrease in household energy costs and greenhouse gas emissions.
Researchers at UMSOM have discovered a crucial receptor called mGlu2 that is critical to the mechanism of fast-acting antidepressants like ketamine. The discovery could lead to better treatments for depression by understanding how the brain reacts to Ketamine.
Researchers found that severe flu cases reshape the lungs by triggering the growth of 'tuft cells', which may help protect lung function. The discovery may provide insight into preventing long-term respiratory damage after a severe flu infection.
The US FDA has approved the use of a rhesus macaque model to support the development of remdesivir, an investigational antiviral agent for treating Ebola virus infections. The study provides a framework for developing Ebola therapeutics under animal rule.
The Pancreatic Cancer Collective has awarded two million-dollar grants to AI teams developing tools to identify high-risk individuals with pancreatic cancer. One team will focus on rare gene variants and the other on machine learning analysis of clinical records and images.
A team of biomedical engineers has developed a stem cell cardiac patch made with tissue engineered with tiny blood vessels to mimic real heart muscle. The patch can connect to native vasculature, bringing nutrients and oxygen, making it potentially effective for treating myocardial infarction.
A new study has found that increased human activity along the boundaries of the Serengeti-Mara ecosystem is having a detrimental impact on plants, animals, and soils. The study reveals how population growth and livestock in buffer zones are reducing available migration routes for wildebeest, zebras, and gazelles.
A new residential wood ash program aims to replenish Muskoka's declining calcium levels, essential for forest growth and life. The program could also improve crayfish stock, water quality, and maple syrup production.
A multidisciplinary team from Johns Hopkins Medicine has completed the first living donor HIV-to-HIV kidney transplant in the US. Nina Martinez, a 35-year-old living with HIV, donated her kidney to an anonymous recipient after undergoing rigorous evaluation and testing.
Researchers at Osaka University have developed a glue-free bimorph deformable mirror that can be used in vacuum chambers. The new technology uses inorganic silver nanoparticles to bond PZT actuators to a mirror substrate, allowing for precise shape modification and high-precision optics.
A study found that sexual satisfaction among older people is influenced by factors beyond just health, including communication with partners, relationship quality, and lifestyle. The research highlights the importance of a holistic approach for healthcare professionals when discussing sexual problems with older adults.
The MIT-led Center of Excellence in Energy will support research collaborations with Egyptian universities to develop innovative solutions for the country's energy challenges. The center will focus on renewable energy, biomass conversion, and sustainable projects.
Researchers discovered that the electric field component of a terahertz pulse plays a key role in large magnetization modulation of ferromagnetic nanoparticles. This allows for ultrafast coherent magnetization reversal within a picosecond, essential for ultrahigh-speed spintronics.
Researchers from Marshall University found that consuming two ounces of walnuts daily for two weeks changes gene expression in confirmed breast cancers, slowing growth and reducing survival risk. The study involved 10 women with breast lumps, who were randomized to walnut or control groups.
Researchers at Far Eastern Federal University are studying the properties of quark-gluon plasma using a combination of lattice quantum chromodynamics and neural networks. The goal is to understand how this substance modifies with temperature and density changes.
A new study by University of Alberta biologists reveals that feather mites may be beneficial to birds, helping remove bacteria and fungi from their feathers. The researchers found that vane-dwelling feather mites feed mainly on fungi and bacteria, rather than bird feathers.
Tropical Cyclone Joaninha maintains its eye due to low wind shear and warm sea surface temperatures. The cyclone is expected to weaken as it moves into an unfavorable area with increasing westerly vertical wind shear.
A team of researchers has revealed the molecular structure of membranes used in reverse osmosis, a leading method of purifying brackish water into drinking water. The study found that the perpendicular packing motif is better correlated with optimal filtration properties and may be related to how water pathways are oriented.