A new study links elevated levels of FAK to the survival of cancer stem cells and DNA repair in ovarian cancer tumors, making them resistant to platinum chemotherapy. Researchers found that FAK inhibition can improve treatment response in mice with chemo-resistant tumors.
Frontera, the fastest academic supercomputer in the world, is set to revolutionize scientific research in the US. With its leadership-class computing capability, Frontera will support complex science applications in fields like black hole physics, climate modeling, and drug design.
Researchers from Osaka University have identified a gene, GREB1, as a key player in the development of hepatoblastoma. The study found that suppressing GREB1 production using antisense oligonucleotides significantly reduced tumor formation and cell proliferation in mouse liver cancer models.
NutraMaize will develop improved varieties of orange corn to deliver better nutrition on a population-wide scale. The startup aims to address vitamin A deficiencies and improve vision health through its orange corn products.
A new PSU study estimates that snowfall frequency will decline across the Pacific Northwest by 2100, with low- and mid-elevation sites like the Cascades experiencing the largest declines. Global efforts to mitigate greenhouse gas emissions can slow this rate of decline.
A biodegradable microrobot has been developed to perform hyperthermia treatment and control drug release, enhancing the efficacy of cancer treatment. The microrobot can carry out precise transport of drugs through wireless control using an external magnetic field.
A recent study found that exercising while using antibacterial mouthwash can significantly reduce the benefits of exercise on lowering blood pressure. The researchers discovered that oral bacteria play a crucial role in the production of nitrite, a molecule that enhances nitric oxide production and helps maintain widened blood vessels....
According to the PURE study, cancer is now the leading cause of death globally, accounting for 26% of all deaths. Cardiovascular disease (CVD) remains a significant cause of mortality, particularly in high-income countries where its burden has decreased.
Researchers develop algorithm that can predict complex chemical reactions and provide a 'chemical map' to desired products, reducing time in preclinical drug discovery and materials science. The model achieves high accuracy by distilling patterns of reactivity from millions of published chemical reactions.
Juha Muhonen's research group aims to solve a key issue in creating large-scale quantum platforms in silicon. The new quantum hybrid platform combines quantum elements with nano-optomechanical elements to enable practical applications of silicon quantum technologies.
A new study by Thanh Nguyen and Rakesh Vohra proposes a solution that balances parental choice with diversity goals, using school choice programs to assign students to their preferred schools. This approach aims to close the opportunity gap while allowing parents to have a say in where their child attends school.
Researchers discovered a potential new treatment for preventing sepsis in burn patients by using the secretions of probiotic bacteria Lactobacillus gasseri to combat antibiotic-resistant Pseudomonas aeruginosa. The study found that applying these secretions to the wound inhibited bacterial growth and prevented biofilm development.
A large-scale study found no evidence that testosterone reduces cognitive empathy, challenging the 'extreme male brain' hypothesis of autism. The study, involving nearly 650 men, used randomized controlled trials and behavioral tasks to measure cognitive empathy.
A new study found that medical imaging rates have continued to increase in the US and Ontario, Canada, despite a campaign to reduce their use. The study analyzed over 135 million imaging exams and found that CT and MRI use have grown in most age groups, with a notable decline in children.
Researchers found that resistance to ghrelin hormone is linked to cognitive impairments and memory loss in Alzheimer's disease. Activating both ghrelin and dopamine receptors simultaneously may help restore brain function and reduce lesions.
A new study found that schizophrenia's neurobiological mechanisms vary between males and females, with many genes related to the illness expressed differently in each. This suggests that sex-specific treatments may be necessary to address the different underlying causes of schizophrenia in males and females.
A systematic review suggests that cannabinoids in cannabis may help reduce nightmares and improve sleep for people with PTSD. However, more research is needed to confirm the effectiveness of these treatments and ensure their safety.
Researchers investigated how radiation damages DNA in cancer cells treated with 5-fluorouracil, identifying new fragment ions and their formation thresholds. The study could lead to new ways of protecting normal tissues from radiation damage caused by radiotherapy.
Researchers found a modified Mediterranean-ketogenic diet altered gut microbiome and reduced Alzheimer's markers in participants with mild cognitive impairment. The study suggests that specific gut bacteria changes may impact dementia development.
The book explores the social and ethical implications of gene editing on human germline cells, including its impact on relationships between parents and children, health, normalcy, and well-being. Leading thinkers weigh in on the potential risks and benefits of this revolutionary technology.
A multidisciplinary team from NYU Tandon School of Engineering is conducting foundational research to understand the impact of AI on expert work in healthcare. The project aims to redesign technology, workflow, and interactions to improve the effective use of healthcare technologies and human capabilities.
A new study led by Flinders University Professor Derek Chew has shown that up to 70% of patients presenting to Australian emergency departments with chest pain can be safely discharged in less time under a new protocol. The trial involved over 3000 patients and found that those receiving rapid troponin testing spent an average of one h...
A study of 691 patients found that starting statins late did not increase mortality risk, but rather reducing dosage did. Patients who took high-dose statins throughout the study had the lowest mortality rate, while those with reduced dosages had the highest death rate.
Dawid Kielak, a Bielefeld mathematician, has been awarded an ERC Starting Grant for his research on geometric group theory. He aims to apply a similar trick used in understanding four-dimensional space-time to higher dimensions.
Typhoon Lingling strengthened quickly in the Northwestern Pacific Ocean, fueled by powerful thunderstorms. NASA's MODIS instrument used infrared data to analyze storm strength and reveal coldest cloud top temperatures at minus 80 degrees Fahrenheit.
Researchers found that 'humanizing' produce can change consumer attitudes toward fresh fruits and vegetables showing signs of age. Depicting imperfect-looking produce with human characteristics enhances its appeal, leading consumers to evaluate it more favorably.
A study of ICD patients found that nearly one-third resumed driving during banned periods, with men, older adults, and single drivers more likely to do so. Improved education and support are necessary to address nonadherence, as it poses risks for patients and others on the road.
Four researchers from Istituto Italiano di Tecnologia have been awarded ERC Starting grants to develop collaborative robotics and biotechnologies. Their projects aim to improve human-robot interactions, create new solar energy storage methods, and enhance immunotherapies using genetically modified T cells.
A study by Karolinska Institutet shows that a mobile phone-based treatment adjustment algorithm can improve symptoms and medication adherence in uncontrolled asthma sufferers. The digital tool, AsthmaTuner, analyzes lung function and symptoms to provide personalized feedback and treatment recommendations.
In a feasibility study, PrEP was successfully integrated into family planning clinics in Kenya, with 114 women out of 278 initiating PrEP experiencing no HIV infections. The study indicates that integration of screening for HIV risk and preventive treatment among young women in a family planning clinic setting is feasible.
A new study reveals that adults fetching water is associated with an increased risk of child death and children collecting water with increased odds of childhood diarrheal disease. Improving access to clean drinking water and sanitation reduces maternal and child health risks, including lower child mortality rates.
Researchers investigated melatonin's role in preventing bone loss during space flight using cultured goldfish scales. They found that melatonin suppresses bone resorption by stimulating osteoblasts to produce CALCITONIN. This suggests melatonin could serve as a prophylactic drug to prevent bone loss of astronauts.
The Lake Ohrid drilling project has provided a unique window into the region's climate history, revealing significant increases in winter precipitation and shedding light on the causes of rain phases. The findings offer valuable data for assessing the effects of climate change and comparing with models.
Researchers at U of M Medical School have discovered a new mechanism that could help treat obesity. The team found critical mutations in molecules implicated in obesity and diabetes, suggesting a possible therapeutic approach to human disease.
Researchers at KIT develop innovative accelerator technologies with €3 million funding, enabling new discoveries in biology, medicine, and materials science. The project focuses on developing special magnets, radiation diagnosis systems, and plasma accelerators for cutting-edge research applications.
A new beaked whale species, Berardius minimus, has been discovered and confirmed in the waters off Hokkaido. The species exhibits distinct physical characteristics, including a smaller body size, shorter beak, and darker color compared to known species.
Researchers developed a 'fat fingerprint' using machine learning to identify inflammation, scarring, and changes to blood vessels. The new biomarker can predict heart attacks with higher accuracy than current tools.
A meta-analysis of 58 studies found that brachytherapy and Mohs surgery have better cosmetic outcomes than conventional excision and external beam radiation therapy. These treatments offer effective alternatives to surgery for patients, particularly those who may not be suitable for surgical options.
Schistosomiasis, a parasitic disease affecting 200 million people worldwide, can't be cured with current approaches due to poverty's role. Researchers found that mass drug administration programs fail to eradicate the disease, as treated individuals re-expose themselves to contamination.
A study using a blood marker of inflammation found an association between late adolescence inflammation and death among Swedish men up to age 57. The results suggest that chronic inflammation in young adulthood may increase the risk of mortality decades later.
Rhabdoid tumors are aggressive brain and kidney cancers with poor prognosis, requiring innovative treatments. The ERC grant aims to understand the disease's underlying mechanisms through unique models and lineage tracing techniques.
Researchers developed a novel liquid process to fabricate an affordable multiferroic nanocomposite film, exhibiting a strong correlation between its electric and magnetic properties. This breakthrough enables the production of materials for various applications such as large-volume memory, spatial light modulators, and unique sensors.
Scientists discovered that viruses alter host plant immunity to deter non-vector insect herbivores, facilitating disease transmission. Geminivirus infection redistributes plant metabolites, inhibiting herbivore growth and production.
Researchers at University of Göttingen developed a new method using graphene to measure the distance of single molecules from the sheet, allowing for high accuracy in optical resolution. The technique enabled the measurement of single lipid bilayers with nanometre resolution, advancing super-resolution microscopy.
Patellofemoral pain affects one in four of the general population every year, with women reporting PFP twice as often as men. Exercise therapy, particularly hip and knee strengthening treatments prescribed by a physical therapist, is found to be the most effective recovery approach for individuals with patellofemoral pain.
The NASA IMERG algorithm provides near-realtime precipitation estimates for Hurricane Dorian, showing storm-total rain accumulation exceeding 24 inches over the Grand Bahama and Abaco Islands. The hurricane's trajectory is expected to bring it dangerously close to the Florida east coast late today through Wednesday evening.
A recent study by the University of Leeds found that high-tech air mattresses provide only minimal gains in preventing pressure ulcers compared to specialist foam mattresses. The study involved over 2000 patients and showed that the benefits were mostly limited to those who were completely immobile, confused, or had nutritional deficits.
A study published in Acta Neuropathologica has identified an epigenetic lesion called NSUN5 that can predict good clinical course in 15% of patients with gliomas, a type of brain cancer. The researchers found that this alteration allows the tumor to grow slowly and enables patients to survive longer.
Researchers at UTA developed a system to track repairs and data on potentially problematic slopes, reducing repair time from four months to one to two weeks and costs by 20%. The project was recognized as one of AASHTO's top projects in 2019.
A new study by researchers at the Institute for Transformative Sustainability Research (IASS) in Potsdam shows that many regions and municipalities in Europe can meet their electricity demand using renewable energy systems. However, achieving complete self-sufficiency would require large shares of land to be assigned to electricity gen...
Researchers at Osaka University used X-ray imaging to visualize Lewy bodies in post-mortem brains and found α-synuclein aggregates with cross-β structure. This discovery supports the idea that Parkinson's disease is a systemic amyloidosis, with implications for diagnosis and treatment.
Researchers at Kyoto University discovered that fruit flies can thrive on various diets due to their flexible response to carbohydrates. In contrast, genetic cousins of the fruit fly are 'nutritional specialists' and can only grow on specific plants. The study sheds light on how organisms adapt to different nutritional environments.
A new special collection of articles analyzes the impact of 11 articles from the American Journal of Medical Quality (AJMQ) on improving healthcare safety. Despite progress, the country has only made modest strides towards zero harm, emphasizing the need for continued efforts.
The University of Minnesota Medical School has been awarded a $945K grant to advance its cell-based therapy for Duchenne muscular dystrophy. Researchers aim to replace diseased muscle tissue with healthy muscle cells using human induced pluripotent stem cells.
A new study reveals a shift in obesity-associated cancers towards younger individuals, with significant increases in certain types of cancers among non-Hispanic Black and Hispanic women and men. The study found that the number of cases of these cancers increased by 25% to 400% in specific populations between 2000 and 2016.
Two University of Konstanz researchers, Dr. Damien Farine and Professor George Walkden, have been awarded European Research Council (ERC) Starting Grants to conduct pioneering research on group-living birds and the impact of language contact on grammar. The grants will fund their innovative projects over a five-year period.
Researchers at King Abdullah University of Science & Technology found that corals use organic carbon to recycle waste ammonium, revealing new insights into coral-algae symbiosis. This process allows corals to control algal growth by regulating nitrogen flow.
Researchers found agrivoltaics significantly impacted air temperatures, direct sunlight and atmospheric demand for water, leading to improved crop growth and reduced water loss. The system also increased energy production efficiency by cooling solar panels with crops underneath.
Researchers have confirmed genetic ties among three individuals buried together after a 13th-century massacre by the Mongol army, shedding new light on the tragic event. The DNA analysis reveals a grandmother, daughter, and grandson were part of the same family.
The USPSTF recommends medications like tamoxifen, raloxifene, or aromatase inhibitors to reduce breast cancer risk in asymptomatic women over 35 with increased risk but low adverse effects risk. The Task Force advises against routine use for women not at high breast cancer risk.