A new mathematical model predicts prostate cancer tumor growth and invasiveness based on stromal ecology, revealing that highly reactive stroma drives aggressive tumors. The model was validated in animal models and patients, suggesting improved prognosis with ecological metrics.
A study found increased cancer risks in two regions of Switzerland, particularly brain tumors, due to localized factors. The research suggests a need for intensified search for environmental risk factors and separate consideration of different brain tumor subgroups.
Researchers surveyed patients with diabetes on their understanding of sharing medical data, finding they prefer a digital consent application that offers empowerment and control. The Dovetail Digital consent application, using blockchain infrastructure, received favorable responses for its transparency and traceability.
A recent survey found that cardiothoracic surgeons are highly satisfied with their jobs, despite external pressures, and are eager to attract new talent to the specialty. The demand for cardiothoracic surgery is expected to increase due to an aging workforce and growing patient needs.
A recent NIH-funded project explores how the fear of cancer recurrence affects the well-being and relationships of breast cancer patients and their spouses. The research team, led by Jean-Philippe Laurenceau, will focus on three main health behaviors that can be influenced by recurrence fears.
Scientists have observed long-lived plasmons in a new class of conducting transition metal dichalcogenide (TMD) called quasi 2D crystals. The study reveals that these plasmons could enhance light intensity by more than 10 million times, opening the door for renewable chemistry and electronic materials controlled by light.
Researchers found that longer alfalfa harvest intervals in the southeastern US result in positive outcomes, with harvesting at 42-day intervals producing maximum productivity. Growing alfalfa in mixtures with tall fescue also yields greatest forage mass and nutritive value.
High DPP3 blood concentrations are linked to circulatory failure, cardiac depression, and acute kidney injury in burn patients. Decreasing DPP3 levels indicate a reduced risk of mortality.
A small study found that anakinra improved respiratory function and reduced signs of immune system overactivation in severe COVID-19 patients with sHLH. The therapy did not prevent deaths on ventilators, but may improve outcomes for these patients.
Researchers used molecular imaging to track DNA damage in neuroendocrine tumors treated with 177Lu-DOTATATE. The technique enabled visualization of γH2AX foci just days after treatment, providing insights into therapeutic outcomes and potential dose adjustments.
Researchers developed an AI algorithm that can detect and identify different types of brain lesions on CT scans, with clinical validation showing high accuracy. The tool has the potential to improve patient outcomes by providing more personalized treatments for head injuries.
The COVID-19 pandemic has highlighted the need for clear international laws governing the sharing of pathogen samples and genetic sequence data. Despite critical importance to global public health efforts, there is currently no legal obligation for countries to share such information, impeding scientific progress.
A clinical trial led by Mount Sinai researchers showed that combining chemotherapy and immunotherapy can significantly delay the progression of metastatic bladder cancer. The trial also found that immunotherapy alone may be an option for patients with high PD-L1 protein expression in their tumors.
Researchers identify critical components for finding environmentally sustainable solutions to food security in the face of climate change. A better representation of physiological responses and crop management are essential for simulating crop growth under stressed conditions accurately.
A new study launched by Clínica Universidad de Navarra and the Barcelona Institute for Global Health aims to determine if ivermectin can reduce viral replication in patients with mild COVID-19. The trial, which will be conducted at home, will monitor symptoms and nasal swabs over a month-long period.
The Society for Cardiovascular Angiography and Interventions (SCAI) has released a position statement on optimal percutaneous interventional therapy for complex coronary artery disease. The guidelines address the challenges of treating patients with advanced age, frailty, comorbidities, and compromised hemodynamic status.
The COVID-19 pandemic has worsened health inequalities in hospitals due to restricted clinical services and emergency department attendances. Marginalized groups, including homeless people and migrants, are disproportionately affected by these changes.
Researchers found that miniature kirigami-based devices can be repeatedly compressed without damage, even with defects. This discovery has implications for the longevity of wearable electronics and other technologies incorporating such devices.
The Society for Cardiovascular Angiography and Interventions (SCAI) has issued a position statement on the performance of percutaneous coronary intervention (PCI) in ambulatory surgical centers (ASCs). The guidelines recommend diagnostic procedures, procedural standards, and operator standards for ASCs, emphasizing patient suitability ...
NASA-NOAA satellites track Typhoon Vongfong's landfall in the Philippines, revealing signs of a mature tropical system. The storm is weakening as it moves northward over Visayas and Luzon regions.
The study found that a specific strain, Sm6, is widely distributed worldwide and carries key virulence genes and resistance genes. This suggests a possible mechanism for the spread of different S. maltophilia subtypes in hospital settings.
A new study by UMass Amherst and NC State biologists found that flower strips benefit common Eastern bumblebees despite some plants increasing pathogen infection rates. The researchers created three conditions with canola plants and different types of flower strips, showing that bees reproduce more with flower strips than without.
Researchers at Indiana University School of Medicine tracked COVID-19 spread in a pediatric dialysis unit using antibody testing on patients, staff, and healthcare workers. The study found a high occurrence of COVID-19 antibodies among individuals interacting in the unit, suggesting that more healthcare workers may be antibody-positive.
The American Geriatrics Society (AGS) has released a high-priority question guide for the 2020 elections, addressing eight policy issues important to older adults. The guide focuses on increasing access to geriatric health professionals, expanding Title VII training programs, and prioritizing aging research to address chronic diseases.
A team of scientists developed an innovative method to study eye movements in mice, revealing two types of eye movement coupled to head movement: 'head tilt compensation' and 'saccade and fixate'. These findings validate using mice to study human brain disorders, including schizophrenia, Alzheimer's disease, and stroke.
A new study from the University of Sheffield reveals that bird species' development time is influenced by their lifestyle, environment, and evolutionary history. The research found that 'live fast die young' strategies allow birds to maximize offspring production in short periods.
Researchers have identified a new breast cancer gene, RBBP8, that may explain why some young women develop the disease. The study found that mutations in this gene can lead to cancer by damaging DNA and increasing the risk of genetic variants.
Researchers at the University of Sheffield have discovered ways to reduce DNA damage and mutations in pluripotent stem cells, a crucial step for regenerative medicine. The findings may allow for safer use of these cells in patients and significantly reduce the risk of genetic mutations.
Research found that malaria parasites have an inherent clock that drives their activity, resulting in cyclical fevers in humans. The parasite's gene expression patterns remained consistent despite changes in lighting conditions and host circadian rhythms.
A new study from Scripps Research reveals that the protein YAP plays a dual role in regulating cell growth, both promoting and inhibiting proliferation. This finding has significant implications for understanding cancer behavior and developing targeted therapies.
A recent study analyzed publicly available data on COVID-19 and seasonal influenza deaths, comparing mortality rates between the two. The research found that while both viruses cause significant morbidity, seasonal influenza was associated with a higher number of deaths compared to COVID-19.
At 1.1 million years ago, early human inhabitants of the Nihewan Basin developed novel technological innovations to cope with strengthened aridification and changing environmental conditions. These advancements provided benefits to early hominin populations in China, highlighting their adaptability.
The Gidget sea otter genome is now publicly available, revealing low genetic diversity and potentially harmful variation within genes. This provides valuable insights into the evolutionary history and conservation of this threatened species.
Researchers developed an expandable resin that can be used to print large objects with an inexpensive, commercially available 3D printer. The material expands upon heating, creating a porous, polystyrene foam-like material up to 40 times larger in volume than the original printed object.
Researchers have developed a new imaging tool that detects widespread synaptic loss throughout the brain in early stages of Alzheimer's disease. This breakthrough enables scientists to identify areas of specific damage and monitor disease progression.
The trial found that reduced postoperative radiation therapy in intermediate-risk patients with HPV+ oropharynx squamous cell carcinoma is safe and effective, with very good oncologic outcomes. Patients at low risk had favorable two-year progression-free survival without postoperative therapy.
A study found that an optimal minimum legal age of 19 for non-medical cannabis use balances the risk of adverse outcomes with the potential benefits. This age limit is lower than previously recommended ages, but higher than the current age of 18 in Canada.
A recent study using lidar technology reveals that mosquitoes are most active during morning and evening hours in Tanzania, with males being 87 times more active than usual. This finding suggests that light levels affect mosquito behavior, creating opportunities for developing light-based measures to prevent malaria.
Researchers have identified a non-protein coding 'dark matter' region of the genome that affects immune responses, revealing a key genetic switch that helps keep the immune system in check. This study provides insight into complex autoimmune and allergic diseases such as inflammatory bowel disease and asthma.
New research from Indiana University Kelley School of Business finds that scarcity decreases consumers' tendency to use price to judge product quality. Consumers are less likely to view lower-priced products as having better quality when faced with scarcity, according to the study.
Researchers have successfully developed heat-resistant coral by bolstering the heat tolerance of its microalgal symbionts, potentially reducing the impact of reef bleaching from marine heat waves. The breakthrough provides a novel tool to increase coral tolerance and is a great win for Australian science.
Researchers at Stevens Institute of Technology have developed an atomically thin magnetic semiconductor that enables faster processing speed, less energy consumption and increased storage capacity. The material works at room temperature and can be integrated with existing semiconductor technology.
The American Journal of Preventive Medicine emphasizes the importance of addressing risks in correctional facilities and marginalized communities. Researchers outline guidelines to mitigate transmission and protect workers and prisoners, as well as caution about existing health disparities and potential exacerbation of stigma.
A team of investigators from McLean Hospital and Massachusetts General Hospital have successfully reprogrammed a patient's skin cells to replace lost brain cells in Parkinson's disease. The patient has shown significant improvements in daily activities and quality of life after receiving the treatment, which involves transplanting repl...
A team of scientists discovered that plants reset their epigenetic memory by removing the H3K27me3 histone mark from sperm, allowing seeds to remember only their mother's environment. This process is crucial for seed development and ensures proper flowering times.
Researchers used magnetic resonance imaging to detect fetal brain impairments in rhesus macaques exposed to alcohol during pregnancy. The study suggests that early detection of fetal-alcohol syndrome could lead to timely therapy and improved outcomes.
Researchers have discovered that trefoil factors, a type of protein, bind to mucin glycoproteins in the lungs, making mucus thicker and more viscous. This knowledge could lead to new therapeutics for treating chronic respiratory diseases such as asthma, cystic fibrosis, and COPD.
A comprehensive review of 57 studies involving 7,000 participants found that programs can effectively enhance the social, emotional, and spiritual aspects of wisdom. The study suggests that interventions targeting these areas can lead to improved mental health outcomes.
A study published in the New England Journal of Medicine found that cats can become infected with SARS-CoV-2 and shed the virus, potentially transmitting it to other cats. The virus was not lethal and all cats ultimately cleared the virus.
A clinical trial found that anti-clotting drugs alone are as effective as graduated compression stockings in preventing blood clots. The study suggests that current guidelines should be revised for patients undergoing elective surgery who are at moderate or high risk of VTE.
Researchers have designed a π-conjugated small-molecule HTL material BDT-TPA-sTh, which improves hole-mobility and wettability with the perovskite precursor solution. This enhances the efficiency of p-i-n planar pero-SCs for large-area modular devices.
New research highlights the importance of legally protecting large indigenous territories in Brazil to preserve biodiversity, traditional livelihoods, and cultural heritage. Almost 90% of indigenous territories retain higher native vegetation cover than their surroundings, safeguarding over 100 million hectares of forests and savannahs.
A comprehensive epigenetic study on human tumor organoids reveals their potential as a reliable model for cancer research. The findings validate the use of these samples in biomedical research and pharmaceutical development, opening up new avenues for discovering anti-cancer treatments.
A team of researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg has developed a computer-based model to explain chronic tinnitus. The model is based on stochastic resonance, which amplifies white noise in the brain to compensate for hearing loss and increased nerve cell activity.
Researchers provide guidance on resuming intense exercise training after COVID-19 infection, emphasizing the importance of gradual progression and medical clearance. Athletes and highly active individuals can follow these recommendations to minimize risk of cardiac complications and return to sports safely.
Researchers at Yale University have discovered a molecular explanation for how HIV hides in immune system cells, allowing it to remain dormant and re-emerge. By understanding this process, scientists may develop new ways to control HIV infection.
People with ACL injuries can lose up to 40% of muscle strength due to muscle atrophy. A new University of Michigan study found that adding eccentric exercises to physical therapy can increase muscle volume and improve outcomes.
Researchers have found microplastics in air, drinking water, and table salt, highlighting the need for better understanding of their potential hazards to human health. Microplastics can be ingested through indoor air, especially from household plastic products, and may reach the lungs and digestive system.
Research finds giant T. rex relied on low-energy walking due to their massive size, contrary to previous focus on running speeds for theropod dinosaurs. The study analyzed limb proportions, body mass, and gaits of over 70 species, suggesting a trade-off between speed and efficiency in theropods.
Researchers discovered mathematical relationships describing gut microbiome dynamics, including Taylor's power law and drift rates. These principles help identify abnormal bacterial behavior and predict how dietary changes affect microbiomes.