A study found that oxcarbazepine, a commonly prescribed anti-seizure medication, is associated with a higher risk of fractures in children with epilepsy. The research team examined the effects of levetiracetam and oxcarbazepine on bone fragility in children between the ages of four and 13.
A Rice University professor has received a $2.4 million grant from the NIH to develop open-source software for designing personalized treatments for movement impairments using computational modeling and simulation. The software will create customized computer models of individual patients, optimizing treatment solutions.
A research group employed ultra-small testing technologies to measure the interfacial bonding strength of coated materials. The study successfully measured the shear strength of a tungsten coating on ferritic steel, contributing to the safe application of multi-material technology in industrial components.
A new study from Brigham and Women's Hospital identifies asthma, history of smoking, and chronic sinusitis as key risk factors for early COPD among US Hispanics/Latinos. The prevalence of early COPD was found to be 7.6 percent in this population, suggesting younger individuals are also susceptible to the disease.
Scientists have developed a method to produce strigolactones, a group of plant hormones that prevent excessive budding and branching. By combining yeast and bacteria, researchers can synthesize these hormones from microbes, providing a promising alternative to traditional methods.
A study analyzed SARS-CoV-2 vaccination distribution in Massachusetts, finding lower vaccine coverage and infection risk in communities with increased socioeconomic vulnerability. The analysis also revealed larger proportions of Black and Latinx individuals in these areas, highlighting disparities in COVID-19 vaccination access.
MIT researchers have found that vaccinating against certain cancer proteins can boost the overall T cell response and help to shrink tumors in mice. The study identifies specific neoantigens that, when targeted with a vaccine, can reawaken dormant T cell populations and lead to tumor regression.
A study published by Ruhr-University Bochum's Department of Neurophysiology found that the olfactory system works closely with the brain's reward and aversion systems to form and retrieve memories. Non-olfactory brain regions, such as the limbic cortex, play a crucial role in categorizing scents as pleasant or unpleasant.
Scientists discovered a fossil bird with elaborate tail feathers, showing how natural and sexual selection influenced bird evolution. The discovery sheds light on the balance between traits that aid survival and those used for display.
Novice participants in a three-week online meditation course showed improved emotional wellbeing, concentration, and motivation. Effects were strongest among those with high levels of self-control and motivation, highlighting the importance of individual differences in response to mindfulness interventions.
A study published in Anesthesiology found that anesthesia for total knee replacement surgery generates substantial CO2 emissions, with an average of 14.9-18.5 kg for general, spinal, and combined anesthesia approaches respectively, contributing to a carbon footprint of approximately 42 miles driven by a US car.
Research by the University of Kent and University of Reading reveals that a healthy lifestyle can increase happiness. The study found that consuming more fruit and vegetables and exercising can improve life satisfaction, with delayed gratification playing a key role.
Researchers at the University of Basel have discovered a novel combination therapy approach that combines inhibiting JAK2 with targeting the MAPK signaling pathway. This dual targeting strategy has shown promising results in improving leukemia treatment outcomes by reducing blood cell production and altering disease course.
A recent study found that colexification, where multiple meanings share one word, reduces language complexity. The study also suggests that communicative needs drive lexical choices in languages, with some languages preferring separate words for similar concepts depending on climate.
A UCLA-led team develops a breakthrough in microbial fuel cells by adding silver nanoparticles to bacteria, boosting electron transport efficiency and generating more electricity. The innovation could lead to practical applications of renewable energy from wastewater treatment.
A survey of 5,589 cancer patients found widespread unawareness about immunotherapy's mechanism, efficacy, and cost. Non-oncology doctors also face challenges in keeping up with the latest developments in oncology.
A study found that treating wounds with mesenchymal stromal cell secretions significantly reduced MRSA viability and stimulated the surrounding skin cells to build a defense. The treatment has potential as an alternative to antibiotics, reducing antibiotic resistance in both veterinary and human medicine.
A study analyzing mass shootings in the US found a significant increase during the COVID-19 pandemic, suggesting that extreme violence may be influenced by social and economic factors. The research revealed consistent patterns, implying that mass shootings are not solely driven by mental health issues or individual motivations.
The discovery of bone tools in Contrebandiers Cave, Morocco, dating back to 120,000-90,000 years ago, provides strong evidence for the manufacture of clothing during this period. The tools, which showed signs of skinning for furs and pelts, are similar to leather working tools found in other archaeological records.
Researchers found that coating Shewanella bacteria with silver nanoparticles improves electron transfer efficiency, leading to higher current and power densities in microbial fuel cells. The resulting MFCs have a maximum current density of 3.85 milliamperes per square centimeter and a coulombic efficiency of 81%.
Research investigated changes in myopia development among Chinese schoolchildren during digital learning and limited outdoor activities. The study found that the COVID-19 outbreak led to a significant increase in myopia prevalence among schoolchildren in China.
A Dartmouth research team has been selected to present their abstract on a new advancement in Cherenkov imaging at the ASTRO Annual Meeting. The work, which involves designing a color-sensitive camera to image Cherenkov emission from patients, allows for more accurate quantification of radiation delivery and safe treatment.
A new study from Edith Cowan University has identified over 2,500 proteins in lupin seeds using a novel testing regime. The research aims to develop value-added high protein ingredients while complying with food-labelling regulations, transforming lupins from feed to superfood.
A study published in Blood Advances found that hydroxyurea therapy can improve or even reverse cardiac complications in individuals living with sickle cell anemia. The longer duration of treatment was associated with better cardiac outcomes, suggesting the need for early screening and treatment initiation for this patient population.
Researchers at Boston Medical Center have identified six stages of engagement in ADHD treatment, highlighting the importance of breaking down barriers for racial and ethnic minority families. The study provides a comprehensive framework that can help healthcare systems better match the needs of children with ADHD and their families.
Researchers discover that tumor suppressor genes can prevent the immune system from spotting and destroying malignant cells in mice. The study reveals a surprising new action for many of these defective genes, which trigger mechanisms that prevent the immune system's T-cells from targeting tumors.
A team of researchers from Harvard and MIT observed hydrodynamic electron flow in three-dimensional tungsten ditelluride for the first time using a new imaging technique. The findings provide a promising avenue for exploring non-classical fluid behavior in hydrodynamic electron flow, such as steady-state vortices.
Researchers develop crowd-assisted deep learning system to analyze disasters, integrating human intelligence with AI models for better results. The project aims to improve AI's interpretability and accuracy in disaster assessment applications.
A research team identified H3 acetylation as a crucial factor in human brain development, leading to the unique neocortex structure. This finding could pave the way for new treatments for neurodegenerative diseases by manipulating basal progenitor cell proliferation.
Adults in the child welfare system with substance misuse issues have higher scores on a trauma questionnaire than previously estimated for other adults and the general population. Children in these families also experience more trauma, with trauma scores 27% higher than those in the juvenile justice system.
The Primary Care 2.0 model demonstrates increased team development, linked to improved staff wellness, but not sufficient in preventing burnout. Labor costs decrease over time with the new model.
A national study from the University of New Hampshire found that children who witness abuse of a brother or sister by a parent experience similar levels of trauma as those witnessing violence against another parent. This exposure is linked to mental health issues such as depression, anxiety, and anger.
Researchers have created a flexible polymer composite microneedle array that can effectively pierce biofilm in chronic wounds, delivering oxygen and bactericidal agents simultaneously. This innovation has the potential to improve treatment outcomes for millions suffering from diabetic foot ulcers.
Scientists developed a surface that directs different liquids to flow in opposite directions, inspired by the unique liquid transport behavior on Araucaria leaves. This approach could be used in practical applications such as microfluidics and water desalination, with high-flow velocity and self-propulsion exhibited.
A team of researchers has discovered a new species of giant penguin, named Kairuku waewaeroa, in the North Island of New Zealand. The fossil, estimated to be between 27.3 and 34.6 million years old, was found by school children on a fossil hunting field trip in 2006.
A new gene delivery system promotes healing in rat models by preventing inflammation and bone degradation after tooth replantation. The study found that teeth treated with the system showed significantly greater dental root thickness and fewer osteoclasts, leading to improved success rates.
A new study found that restoring peatlands now would provide significant economic benefits to society, including a reduction of greenhouse gas emissions and improved wildlife habitat. In Scotland, restoration could generate £191m in annual societal benefits if done by 2027, rather than later.
Researchers from University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine found that combining long-term injectable medications with psychosocial intervention improves adherence and symptoms in patients with bipolar disorder. The study enrolled 30 people with bipolar disorder who had adherenc...
Coral reefs will experience substantial declines in productivity and survival due to rising sea temperatures and ocean acidification, with some attributes responding similarly to heat stress with or without acidification
A study by Cincinnati Children's Hospital Medical Center has identified a common biological response platform that could help alleviate allergic inflammation. The research suggests that inhibiting this pathway may provide a unique opportunity to counteract type 2 immunity and reduce allergic reactions.
Researchers assessed diagnostic value of physical symptoms for urinary tract infections in children, finding only circumcision and diaper rash useful for ruling out UTI. They advise against restricting urine sampling to children with unexplained fever or specific features.
A new study from Cornell University has found that the antimicrobial properties of certain stem cell proteins can effectively reduce the viability of methicillin-resistant Staphylococcus aureus (MRSA) in skin wounds. The treatment also stimulates the surrounding skin cells to build up a defense against the bacterial invader.
Researchers found that validating accuracy of in vitro diagnostic tests carried costs and had higher true limits of detection than reported. The study suggests mechanisms for expanded regulatory oversight by the FDA, including technology certification to assess performance of complex diagnostic tests.
A collaboration led by Oregon State University aims to increase universities' societal impacts and inclusivity. The Promotion and Tenure, Innovation and Entrepreneurship (PTIE) Coalition recommends recognizing innovation and entrepreneurial achievements among university promotion and tenure criteria.
A study published in Psychological Medicine confirms that childhood maltreatment disrupts HPA-axis activity, leading to altered stress regulation and increased risk of mental disorders. The study found a dose-response relationship between the severity of maltreatment experiences and HPA-axis dysfunction.
Researchers at Kanazawa University have identified a new vaccine platform that targets liver cells to induce anti-malaria immunity. The AAV8 vaccine platform was found to be more effective in eliciting a T cell-mediated response in the liver, providing sterile protection against malaria in a murine model.
Researchers at Arizona State University have discovered a worked bone assemblage found near the Atlantic Coast of Morocco dating back to 120,000 years ago, suggesting the manufacture of clothing during this period. The find provides strong evidence for the emergence of complex culture and specialized tool manufacture in early humans.
Researchers at UT Southwestern Medical Center have discovered that LRP1 is the vehicle by which retinol enters myeloid cells, suggesting a potential target for treating inflammatory diseases such as Crohn's disease. The study also found that inhibiting this process could boost immune activity, making oral vaccines more effective.
Researchers have discovered a new technique to locate the diffusion wake's signal in the quark-gluon plasma, a subatomic soup that flowed like a friction-free fluid after the Big Bang. This breakthrough may help scientists understand how matter emerged from this perfect fluid.
The study uses the Relativistic Heavy Ion Collider to recreate Big Bang conditions, observing a significant enhancement of Ds±/D0 yield ratio compared to PYTHIA simulations. This confirms the role of quark-gluon plasma in open-charm hadron production.
A study compared four voice assistants - Alexa, Siri, Google Assistant, and Cortana - to assess their accuracy in providing information on cancer screening. The top three assistants provided consistent information with USPSTF guidelines roughly 70% of the time.
A new study by University of Bath psychologists suggests that Spice, a synthetic drug, is more harmful than cannabis and causes more severe withdrawal symptoms. Participants who tried to quit Spice reported experiencing sleep issues, irritability, and low mood, among other symptoms.
Researchers at the University of Central Florida have identified food products that can alter a person's saliva to reduce the transmission potential of airborne pathogens. By adding ingredients like ginger, cornstarch, and xanthan gum to food products, people may be able to make masks more effective or even reduce their need for them.
Researchers developed DamageMap, an AI system that uses machine learning to identify building damage from post-wildfire images, achieving 92% accuracy. The system can analyze satellite and aerial photos to pinpoint damaged buildings, providing immediate results for first responders and fire victims.
Scientists have developed a new therapy that combines bacteriophages with antibiotics to treat antibiotic-resistant infections, specifically targeting Mycobacterium abscessus. The treatment, using the bacteriophage 'Muddy', showed significant improvement in survival rates and severity of infections when paired with rifabutin, demonstra...
A recent study found that women with higher levels of PFAS in their system are 20% more likely to stop breastfeeding early. This is significant because almost every human on the planet is exposed to these endocrine-disrupting chemicals, which can have detrimental effects on reproductive health.
Researchers developed a new material that can form nanoscale thickness water-resistant coatings with self-healing properties. The coating is robust enough to survive scratches and has potential applications in various industries.
A recent review of international studies found that persistent symptoms after COVID-19 infection were most common among children with pre-existing health conditions. However, symptoms rarely lasted beyond 12 weeks in young people, suggesting long COVID may be less concerning than in adults.
A Japanese research team has improved an optical tissue clearing method to diagnose cancer, enabling 3D visualization of tumor tissues in just a week. The new approach uses zwitterionic hydrogels to rapidly remove fats from tissues, reducing processing time and improving diagnosis accuracy.
A new study predicts that climate change will cause a sudden shift in algae distribution pole-wards over the next 100 years, affecting marine ecosystems. The UK is among the areas most likely to be severely impacted due to its warm waters, with changes potentially occurring before previously thought.