Researchers at TIBI developed a minimally invasive method for targeted delivery of immunotherapeutic treatments, resulting in slower tumor growth and higher activation of T-cells. The injectable gelatin biomaterial containing silicate nanoplatelets showed sustained drug release and controlled ICI delivery.
The Cognitive and Neurobiological Approaches to Plasticity Center (CNAP) at Kansas State University will continue its neuroscience research, thanks to a $11.2 million NIH grant. The funding will support junior faculty development and infrastructure upgrades for neuroplasticity research.
New research finds junk food advertising restrictions have prevented 94,867 fewer obesity cases, 2,857 fewer diabetes cases, and 1,915 fewer cardiovascular disease cases. The policy is estimated to save the NHS £218 million over its lifetime.
Researchers used magnetoencephalography to study age-related changes in gamma-band oscillations in the auditory cortex of typically developing children. The results showed that power increased with age and cortical localization changed, indicating an age-related shift in the balance between excitation and inhibition.
Researchers have discovered that reactive oxygen species (ROS) can serve as a communication signal to indicate plant stress, which is critical for crop survival and can significantly decrease with multiple stressors. By monitoring ROS levels, farmers can identify plants under stress and take corrective measures to prevent crop loss.
The article highlights six strategies for addressing climate-related health inequities, including adopting standards for sociopolitical constructs and centering marginalized community voices. Researchers emphasize the importance of dismantling structural racism, environmental justice efforts, and effective communication strategies.
Researchers developed a novel composite material of COF and graphene that shows high and rapid adsorption capacity for organic pollutants. The material, consisting of a nanoporous, ultrathin covalent organic framework (COF) anchored on graphene, can filter out organic dyes from water efficiently.
Leukemia cells exploit metabolic pathways to evade programmed cell death, but researchers identified a weak spot in acute lymphoblastic leukemia that can be targeted with experimental drugs. Inhibiting glutathione metabolism induces ferroptosis, leading to the death of malignant lymphocytes.
Researchers argue that using tools to estimate racial and ethnic information can identify algorithmic bias and combat disparities in healthcare. This approach can lead to more equitable pay-for-performance schemes and better clinical decision-making.
Researchers found that ancestral SARS-CoV-2 replicates less efficiently in pediatric nasal epithelial cells, with a heightened antiviral response. This protection is not observed with the Omicron variant, highlighting the need for further study on emerging variants.
Molnupiravir's efficacy is affected by SARS-CoV-2 variant type and biological sex of patients, according to the study. The drug showed variable results in dwarf hamsters infected with omicron, but was more effective in males than females.
Researchers developed VegSense, an open-source application that uses a Microsoft HoloLens to quantify mature trees in the wild. The device excels at detecting relatively healthy forests by capturing vegetation patterns with a holograph-like grid pattern.
The Magnet4Europe project, a 4 million Euro initiative, aims to transform hospital work environments to improve clinician and patient wellbeing. The randomized trial in 130 hospitals across 7 countries found that burnout is an individual manifestation of organizational flaws, which can be addressed through evidence-based interventions.
Research suggests that chemicals produced by gut microbes after eating red meat may contribute to cardiovascular disease. The study found a 22% higher risk of atherosclerotic cardiovascular disease associated with increased red meat consumption, which was partly attributed to elevated levels of TMAO and related metabolites in the blood.
Researchers developed a new printing technique that applies a 19th-century color photography method to modern holographic materials, producing large-scale images on elastic materials with structural color. The team's results enable the creation of pressure-monitoring bandages, shade-shifting fabrics, or touch-sensing robots.
Researchers at Vienna University of Technology have measured the binding state of light and matter for the first time, creating an attractive force between ultracold atoms. This effect can be used to control and manipulate extreme temperatures and may also play a role in the formation of molecules in space.
Researchers from the University of Tsukuba discovered that changes in the extracellular environment during metamorphosis and body growth enable newt muscle fibers to dedifferentiate and contribute to limb regeneration. This process is crucial for newts' ability to regenerate limbs throughout their life cycle.
Virginia Tech scientists have developed a novel 3D tissue-engineered model of the glioblastoma tumor microenvironment to learn why tumors return and what treatments will be most effective. The model accounts for cell types, fluid flow, and other aspects of the actual tumor environment, allowing for easy testing of drug therapies.
Researchers at ORNL developed a theory that thylakoids help plants tolerate harsh conditions, while a digital platform informs on hydropower development. AI-powered neutron scattering can also accelerate experiments, and e-waste recycling is being explored.
Researchers at the University of Birmingham have developed a new method to boost biocatalytic activity using synthetic polymers that stimulate biofilm formation. The study found that hydrophobic polymers outperform mildly cationic polymers, increasing biomass and biocatalytic activity in E. coli.
A new study from the University of South Australia identifies five key approaches for parents and caregivers to discuss everyday pain with young children. Teaching children that they can control their pain and empowering them to actively engage in pain management can promote lifelong helpful pain behaviors and encourage recovery. By he...
Researchers at the University of Maryland School of Medicine found that cells lining the heart direct cardiac muscle growth and outlined a complex mechanism regulating this process. The discovery may help develop better techniques for regenerating heart tissue and prevent congenital heart defects.
University of Washington researchers have created a flexible, wearable thermoelectric device that converts body heat into electricity. The device's stretchable and efficient properties enable seamless integration into wearables and soft robotics.
COVID-19's impact on Native Americans led to a significant decline in life expectancy, with mortality rates surging due to chronic diseases and limited access to healthcare. The pandemic exacerbated existing social and economic inequities, further hindering the population's health.
Researchers at Kyoto University's Institute for the Advanced Study of Human Biology have developed a new method to culture human fetal immature germ cells into oocytes. The study found that essential controlling mechanisms are similar across mouse, monkey, and human species, while certain genes are expressed only in humans and monkeys.
Researchers from the University of Tokyo have proposed a two-step regulatory mechanism that shapes centromere distribution, revealing its role in maintaining genome integrity. The study found that precise control of centromere spatial arrangement is required for organ growth in response to DNA damage stress.
Researchers at SLAC National Accelerator Laboratory have discovered that nickelate superconductors are always magnetized, whether in their normal or superconducting state. This finding highlights the fundamental properties of these materials and provides insight into how unconventional superconductors carry electric current with no loss.
A team of scientists used modeling to reveal that Ceres's interior decays radioactive elements, generating heat and powering geological activity. This process is different from the typical hot-cool pattern seen in larger planets, with similarities to Uranus's moons
A new review paper assesses recent progress in controlling quantum systems and applies it to emerging technologies, highlighting the need for a unified theoretical framework. The authors identify roadblocks that must be overcome to manifest a future quantum technological landscape.
A new study introduces a novel epigenetic predictor, PCBrainAge, that captures aging heterogeneity across multiple brain regions. The tool demonstrates stronger associations with AD dementia and pathologic AD compared to existing age predictors.
Scientists develop new approaches to combating poxviruses, including exploring substances that interfere with viral transcription and visualizing gene expression machinery at the atomic level.
Projected rates of cardiovascular risk factors and disease will increase significantly among minorities while decreasing among White persons. All four CV risk factors are expected to increase from 2025 to 2060, with the largest percentage increase in diabetes.
A large-scale study of nearly 12,000 children aged 9-10 found that disordered eating behaviors are more common than previously thought, with a prevalence of up to 5% in some cases. Children with higher BMIs and those further along in puberty face an elevated risk, highlighting the need for targeted prevention efforts.
Researchers at Nagoya Institute of Technology created a simple synthesis method for producing ultra-bright carbon nano-onions from fish scales in under 10 seconds. The process yields functionalized CNOs with high crystallinity and exceptional optical properties.
The prevalence of past-year quit attempts among adult smokers decreased in 2020, while nicotine replacement therapy sales dropped. This suggests that reengaging smokers who faced negative outcomes during the pandemic should be a priority for quit attempt assistance.
A study reveals that an ADAR1 gene mutation activates ZBP1 protein, leading to programmed cell death and inflammatory responses. This causes damage to organs like the kidneys and liver in genetically modified mouse models.
A University of Michigan-led analysis found that training patients to voice their concerns and advocate for themselves can reduce the impact of physicians' racial biases on care. The study showed that 'patient activation' creates more equitable interactions between patients and physicians.
A new fusion simulation code was developed to project and analyze Toroidal-Alfvén-Eigenmode (TAE) instabilities in Tokamaks. The code, improved by Dr. Youngwoo Cho, enables electromagnetic analysis of TAEs and will optimize fast ion confinement performance.
Researchers discovered the earliest direct evidence of brood care among insects in the Middle-Late Jurassic Daohugou Biota. Fossils of a water boatman insect showed it carrying a cluster of eggs on its left mesotibia, providing protection from predation and environmental risks.
Researchers from Boston University School of Medicine have created functional lung epithelial cells from CF patients' blood cells, enabling the testing of effective treatments and potentially discovering novel therapies.
A new study from UC San Diego's Rady School of Management found that referrals and recommendations can act as a gatekeeping process in elite occupational contexts. Female candidates recommended by highly tenured female sponsors are most likely to be hired, contrary to initial findings suggesting male sponsors are more persuasive.
Aerosol particles in the atmosphere have a bigger impact on cloud cover than previously thought, increasing it by approximately 10%. Clouds hold more water before rainfall occurs due to smaller and more numerous droplets, leading to reduced precipitation. The study uses satellite data and machine learning to improve climate models.
A study predicts Japan's permafrost area will significantly decrease in the future due to global warming. The research used climate projection data to estimate areas that can sustain permafrost, revealing a broader distribution than previously thought.
A team of Chan Zuckerberg Biohub scientists developed a deep-learning method, dubbed
Researchers at Hebrew University of Jerusalem have identified a group of molecules that enable cells to repair damaged components, making it possible for those tissues to retain proper function. These molecules were found to protect human cells from damage and may significantly delay the development of age-related diseases.
Researchers propose that arthropod shells evolved from a common ancestral structure, contrary to the prevailing gene co-option theory. This discovery suggests that many 'novel' structures in arthropods are actually homologous and share a single origin dating back to the Cambrian period.
A study published in NeuroReport reveals that ultrasound exposure improves depressive behavior in a rat model of depression. OB rats exposed to USV had significantly lower hyperemotionality scores and plasma corticosterone levels than unexposed rats, suggesting potential anti-depressant effects.
Researchers found that asexual whiptail lizards accumulate more harmful genetic mutations than their sexual counterparts due to relaxed natural selection. This study supports the theory that sex is more efficient at removing harmful mutations and maintaining genomic health.
A study by the OPik group found that job insecurity is significantly associated with poor mental health in both men and women. The study's findings suggest that wage level and vulnerability are key factors in this relationship.
A novel subset of CD8+ regulatory-like T cells (CD8+TRLs) has been identified as 'first responders' to stroke, providing fast-acting and lasting protection. These cells reach the brain within 24 hours after stroke onset, releasing molecules that provide direct neuroprotective effects.
A new study suggests that photos with high color saturation can increase sales by making food appear fresher and tastier to viewers. The study found that color saturation had a stronger effect when the food appeared more distant in the photos.
Researchers discovered that contact electrification causes the formation of reactive oxygen species in water droplets on solid surfaces. Hydroxyl radicals combine to form small amounts of hydrogen peroxide, which can be detected in humid environments, including fogs and raindrops.
A recent study published in Autism Research suggests that autistic adults are only slightly less accurate than non-autistic peers at recognizing human face emotion expressions. The findings contradict the common perception that individuals with autism struggle to understand others' emotions.
The Polyphenols Applications 2022 World Congress will focus on the latest findings and emerging trends in polyphenol research, covering various topics such as microbiota, adipose tissue, nervous system, senolytic activity, ageing, endothelial function, radioprotection, atherosclerosis, and more. Over 300 international participants will...
Researchers warn that climate change poses a significant threat to global food supply and stability, potentially triggering famine, conflicts, and new disease outbreaks. The study proposes a research agenda to explore worst-case scenarios, including 'warm wars' and ecosystem collapse, highlighting the need for urgent action.
Researchers used microwaves from the cosmic microwave background to measure dark matter distribution around distant galaxies. The findings suggest a different clumpiness measurement than predicted by the Lambda-CDM model, hinting at a possible flaw in the current cosmology theories.
Engineers at UIC have been awarded a grant to build a system that selectively removes and destroys PFAS, commonly called 'forever chemicals,' from industrial and municipal wastewaters. The team will develop a prototype of their system and deploy it for scale-up and pilot testing in California's Orange County Water District.
Research from Aarhus University shows that EU's high gas prices are driving the green transition and making it easier to meet 1.5-degree climate target. The study suggests that cutting off Russian gas would force European countries to invest in renewable energy sources, such as solar and wind power.
The 'Aspire' program has shown significant success in providing stable housing and comprehensive supports to individuals experiencing chronic homelessness. After three years, 575 participants have found secure housing and are on the path to a better life.
Researchers developed a new framework to measure stability during walking by analyzing mechanical energetics, enabling deeper insights into human movement and fall responses. The approach can help pinpoint specific muscles or joints to target with rehabilitation therapy and inform advanced exoskeleton design.